ライフサイエンスコーパス: oxytocin

1 5) and an attenuated contractile response to oxytocin.

2 ivity, which, in males, involve signaling by oxytocin.

3 sed after nasal delivery of the neuropeptide oxytocin.

4 a decrease in the release of vasopressin and oxytocin.

5 e modulated by the hypothalamic neuropeptide oxytocin.

6 s, mediated by the expression of the hormone oxytocin.

7 ons have attempted to explain the effects of oxytocin.

8 ch neural circuits are directly sensitive to oxytocin.

9 nd mirror neurons; and it is associated with oxytocin.

10 ptom severity did show beneficial effects of oxytocin.

11 e and do not express arginine vasopressin or oxytocin.

12 oral synchrony with their infants and plasma oxytocin.

13 nses within the network and decreased plasma oxytocin.

14 Oxytocin (1 IU in 20 mul of ACSF) or placebo was injecte

15 We assessed the effect of intranasal oxytocin (24 IU) administered to 29 healthy, fasted male

16 social male drinkers showed that intranasal oxytocin (24 IU) decreased neural cue-reactivity in brai

17 crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise h

18 normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomize

19 ident victims) were randomized to intranasal oxytocin (8 days/40 IU twice daily) or placebo (8 days/1

20 for females is eliminated in mutants lacking oxytocin, a neuropeptide modulating social behaviors in

21 elf-defense response, freezing, is gated via oxytocin acting in the centro-lateral amygdala (CeL).

22 s and brain region-specific manipulations of oxytocin activity.

23 ntinued with artificial membrane rupture and oxytocin, administered through a micro-drip gravity infu

24 Both intranasal oxytocin administration and chemogenetic stimulation of

25 Oxytocin administration early after trauma did not atten

26 Intranasal oxytocin administration early after trauma may prevent P

27 e, we investigated the effects of intranasal oxytocin administration early after trauma on subsequent

28 Evidence shows that acute oxytocin administration improves numerous markers critic

29 Our results show that oxytocin administration in nonhuman primates influences

30 on is warranted, these findings suggest that oxytocin administration is a promising preventive interv

31 Furthermore, our data indicate that oxytocin administration reduces activation in homeostati

32 Oxytocin administration reduces the BOLD signal in rewar

33 Intranasal oxytocin administration suppressed hypothalamic activati

34 frontopolar cortex) brain regions following oxytocin administration vs placebo.

35 early after trauma may prevent PTSD, because oxytocin administration was previously found to benefici

36 Following oxytocin administration, compared to placebo, participan

37 social anxiety disorders, may be reduced by oxytocin administration.

38 aviors; the fear/stress theory suggests that oxytocin affects social performance by attenuating stres

39 However, the molecular mechanism by which oxytocin affords neuroprotection, especially the interac

40 Effects of intranasal oxytocin also need proper dose-response studies, and suc

41 Evidence indicates that oxytocin, an endogenous peptide well known for its role

42 s selective to common interferences, such as oxytocin analogs and potential metabolites.

43 ly, a correlation between different forms of oxytocin and behavioral phenotypes has been described in

44 g adult neurogenesis in disrupted rats using oxytocin and conditionally suppressing the production of

45 Notably, oxytocin and estrogen receptor polymorphisms temper acce

46 ferences in the association between salivary oxytocin and generosity.

47 neurons reveal that both the application of oxytocin and optogenetic stimulation of oxytocinergic te

48 Here we depict the interplay between oxytocin and serotonin in the nonhuman primate brain.

49 controlled by brain neuromodulators, such as oxytocin and serotonin.

50 These activations weakened with oxytocin and vasopressin administration such that neural

51 Furthermore, the endogenous IRAP substrates oxytocin and vasopressin are known to facilitate learnin

52 This biased modulation is mediated by oxytocin and vasopressin G-protein-coupled receptors.

53 of evidence has implicated the neuropeptides oxytocin and vasopressin in the modulation of human neur

54 n to determine how intranasally administered oxytocin and vasopressin modulated neural activity when

55 motion processing; however, the influence of oxytocin and vasopressin on neural activity elicited dur

56 Our results show effects of both oxytocin and vasopressin on the brain network involved i

57 ich were designed to mimic the N terminus of oxytocin and vasopressin, were assessed and compared bas

58 receptor agonist against 1) no treatment, 2) oxytocin, and 3) saline in a randomized, placebo-control

59 ow that three neuropeptides (beta-endorphin, oxytocin, and dopamine) play particularly important role

60 mine, orexin, melanin-concentrating hormone, oxytocin, and vasopressin.

61 o believe in the effectiveness of intranasal oxytocin appears to be widespread and needs to be guarde

62 ulating evidence reveals that the effects of oxytocin are dependent on a variety of contextual aspect

63 re unknown and critical to study to consider oxytocin as a neurohormonal weight loss treatment.

64 l-economic (BE) procedure in rats to examine oxytocin as a pharmacotherapy for methamphetamine (meth)

65 Using the neuropeptide oxytocin as a tool to increase neurogenesis in the hippo

66 laining some of the contradictory effects of oxytocin as products of the balance between two networks

67 Oxytocin attenuated the peak excursion of plasma glucose

68 uture studies are required to assess whether oxytocin augmentation following misoprostol can be repla

69 In this review, we explore the potential of oxytocin-based therapies for social impairments in autis

70 all, these data indicate that development of oxytocin-based therapies may be a promising treatment ap

71 One of those candidates is oxytocin because of its interaction with several alcohol

72 Primary rat neural cells were exposed to oxytocin before induction of experimental acute stroke m

73 These results argue that central oxytocin biology may be related to individual face perce

74 The newly discovered oxytocin bivalent ligands represent a powerful tool for

75 hibition may be a general mechanism by which oxytocin can act throughout the brain to regulate parent

76 st that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish betwee

77 Oral minimal model analyses revealed that oxytocin compared with placebo induced a pronounced incr

78 predicts cerebrospinal fluid, but not blood, oxytocin concentrations up to five years after behaviour

79 fferences in face recognition and endogenous oxytocin concentrations.

80 , the way by which a single molecule such as oxytocin contributes to contrasting emotions and opposit

81 cial behavior, the hypothalamic neuropeptide oxytocin contributes to metabolic control by suppressing

82 reinstatement of meth seeking, and systemic oxytocin decreased demand for meth and attenuated reinst

83 Oxytocin decreases meth demand and seeking in both sexes

84 tside health facilities, and misoprostol and oxytocin delivered via Uniject have been deemed viable a

85 espectively, do not appear to be involved in oxytocin-dependent adult food-leaving.

86 odifies the behaviour of adult animals in an oxytocin-dependent manner increasing their probability o

87 diagnostic microfluidic platform devised for oxytocin determination in both synthetic serum samples a

88 Although oxytocin did not affect the glutathione-related cellular

89 de with substantial structural similarity to oxytocin, did not alter ethanol effects at delta-GABA(A)

90 However, introduction of oxytocin during OGD/R did not induce neuroprotection.

91 urobiological mechanism for the anorexigenic oxytocin effects in humans.

92 to link these changes in brain activation to oxytocin effects on food intake and weight.

93 atic drop of reporter gene expression of the oxytocin exon 1-intron-exon 2-EGFP construct was also id

94 upregulation stems most likely from reduced oxytocin expression in hypothalamic nuclei.

95 POU3F2 lies downstream of SIM1 and controls oxytocin expression in the hypothalamic neuroendocrine p

96 In summary, oxytocin generates states for optimized information extr

97 omen in the misoprostol group and 402 in the oxytocin group received study drug and had recorded pre-

98 ed-14 to the misoprostol group and 14 to the oxytocin group.

99 soprostol group and 2.7 g/L (SD 17.8) in the oxytocin group.

100 in the misoprostol group, and nausea in the oxytocin group.

101 nts with high baseline CAPS scores receiving oxytocin had significantly lower CAPS scores across foll

102 Oxytocin has a conserved role in regulating animal socia

103 pread reports that intranasal application of oxytocin has a variety of behavioral effects, very littl

104 The phylogenetically ancient neuropeptide oxytocin has been linked to a plethora of social behavio

105 Although pharmacological administration of oxytocin has implicated this neuropeptide in face percep

106 Oxytocin has received much attention as a prosocial and

107 Moreover, MHFD offspring had fewer oxytocin immunoreactive neurons in the hypothalamus.

108 ear, although pilot experiments suggest that oxytocin improves glucose homeostasis.

109 studies that address the complex effects of oxytocin in a mechanistic approach, using genetic animal

110 the pivotal role of the hypothalamic peptide oxytocin in augmenting the salience and rewarding value

111 ications for the therapeutic applications of oxytocin in conditions characterized with aberrant socia

112 ighlighted, and implications for the role of oxytocin in cooperation and competition within and betwe

113 r intracerebroventricular injection of 10 nM oxytocin in dependent rats.

114 nisms underlying the anorexigenic effects of oxytocin in humans are unknown and critical to study to

115 Hence, these results implicate oxytocin in observational fear in mice (rather than fear

116 work that focuses on the overarching role of oxytocin in regulating the salience of social cues throu

117 pport this argument by examining the case of oxytocin in relation to the sentiment of love.

118 e studies suggest that the multiple roles of oxytocin in social and fear behavior are due to its loca

119 imal and human studies highlight the role of oxytocin in social cognition and behavior and the potent

120 ystem and further support a central role for oxytocin in social cognition.

121 Here we characterize the involvement of oxytocin in the capacity of mice to display emotional st

122 The presence of the hormone oxytocin in the central amygdala makes a mother rat will

123 tional role for the well-described action of oxytocin in the central amygdala, and demonstrates that

124 Here, we discuss the role of oxytocin in the modulation of emotional memories in rode

125 Among the upregulated genes was oxytocin in the NAc and CARTpt in the striatum of SR rat

126 to either 600 mug oral misoprostol or 10 IU oxytocin in Uniject (intramuscular), stratified by repor

127 and behavior and the potential of intranasal oxytocin (IN-OT) to treat social impairment in individua

128 The programmatic limitations of oxytocin, including short shelf life outside the cold ch

129 Pretreatment with oxytocin increased cell viability, decreased the cell da

130 Oxytocin induced a switch of this rhythmic activity to t

131 Oxytocin-induced contractions were unaffected by pre-inc

132 TAS2R10 inhibits ChQ's reversal effect on an oxytocin-induced rise in [Ca(2+)]i Finally, ChQ prevents

133 en myometrial contractility (spontaneous and oxytocin-induced), PKA activity, HSP20 phosphorylation a

134 e calcium-channel blocker nifedipine and the oxytocin inhibitor atosiban in women with threatened pre

135 HT1AR) function is modified after intranasal oxytocin intake.

136 ng such approaches are now required, placing oxytocin into the autism context.

137 dependent of angiotensin II receptor type 1, oxytocin, ionotropic glutamate and GABAA receptors.

138 mediated via angiotensin II type 1 receptor, oxytocin, ionotropic glutamate or GABAA receptors but in

139 s that the hypothalamic neuropeptide hormone oxytocin is a key central nervous system factor in the r

140 The neurohormone oxytocin is a key player in the modulation of reproducti

141 Despite popular assumptions that oxytocin is a molecule of social bonding in the infant b

142 Oxytocin is a neuropeptide important for social behavior

143 Oxytocin is a nonapeptide that also serves as a neuromod

144 Here, we argue that the action of oxytocin is not restricted to the downstream level of em

145 nergic projections also target the striatum, oxytocin is poised to bias the balance of DA tone throug

146 in humans involves the neuropeptide hormone oxytocin, known to influence trust, coordination, and so

147 both sexes had significantly higher urinary oxytocin levels immediately before and during intergroup

148 Furthermore, higher oxytocin levels in the Jewish-Israeli majority and tight

149 fied a single commensal strain that corrects oxytocin levels, LTP, and social deficits in MHFD offspr

150 attitudes toward the regional conflict, and oxytocin levels.

151 Recently an oxytocin-like neuropeptide, nematocin, and its cognate r

152 The prosocial account argues that oxytocin mainly enhances affiliative prosocial behaviors

153 Oxytocin may optimize these circuits and enhance reward,

154 Reports in the literature of oxytocin measurements include many that have been made w

155 iated with the cytoplasm were released after oxytocin-mediated contraction of the myoepithelium.

156 These studies suggest that oxytocin might be used as an anticraving medication and

157 bivalent ligands consisting of two identical oxytocin-mimetics that induce a three order magnitude bo

158 The circuit mechanisms through which oxytocin modifies olfactory processing are incompletely

159 ione-related cellular metabolism before OGD, oxytocin modulated the expression levels of GABAAR subun

160 Oxytocin-modulated DA neurons give rise to canonical str

161 nctional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cu

162 These studies show that oxytocin modulates various aspects of social behaviors s

163 ERbeta-EGFP cells expressed oxytocin more abundantly in the rostral (71 +/- 3%) than

164 It appears that oxytocin motivates and enables humans to 1) like and emp

165 ditionally, we report the novel finding that oxytocin mRNA localized to these human projections and c

166 n-to-treat sample included 107 participants (oxytocin: n = 53; placebo: n = 54).

167 ionally characterize axonal projections from oxytocin neurons in the hypothalamic paraventricular nuc

168 xtr(PBN) neurons were directly innervated by oxytocin neurons in the paraventricular hypothalamus (Ox

169 ministration and chemogenetic stimulation of oxytocin neurons render males sensitive to the distress

170 Thereby, oxytocin neurons seem essential for neuropeptide S-induc

171 thalamic mechanism involving paraventricular oxytocin neurons that express the neuropeptide S recepto

172 ng polymer, molecular cavities selective for oxytocin nonapeptide, an autism biomarker, were designed

173 fects on haemoglobin concentrations, neither oxytocin nor misoprostol was significantly better than t

174 ted the effects of systemic and microinfused oxytocin on demand for self-administered intravenous met

175 Further characterization of the effects of oxytocin on neural circuits in the hypothalamus is neede

176 The effect of oxytocin on reversing non-social attention deficits is a

177 hways with specific neurotransmitters (i.e., oxytocin, opioids).

178 behaviors in infancy and preschool, assayed oxytocin (OT) and vasopressin (AVP), and measured copare

179 thesis and secretion of vasopressin (VP) and oxytocin (OT) by the neurohypophysis.

180 Oxytocin (OT) has become a focus in investigations of au

181 Oxytocin (OT) has been implicated in mediating natural r

182 Over the last decade, oxytocin (OT) has received focus in numerous studies ass

183 The neuropeptides vasopressin (AVP) and oxytocin (OT) have been implicated in the regulation of

184 al evidence toward improving the efficacy of oxytocin (OT) in treating social dysfunction, we tested

185 The neuropeptide oxytocin (OT) is a key regulator of social and emotional

186 Oxytocin (OT) is a neuropeptide elaborated by the hypoth

187 Oxytocin (OT) is a neuropeptide, which can be seen to be

188 Oxytocin (OT) is a nonapeptide that, in addition to its

189 Oxytocin (OT) is a potential treatment for multiple neur

190 The neuropeptide oxytocin (OT) is associated with a plethora of social be

191 Oxytocin (OT) is considered to be a stress-buffering hor

192 One of the most established roles of oxytocin (OT) is in inducing uterine contractions and la

193 Oxytocin (OT) is increasingly studied for its therapeuti

194 ning human research suggest that the hormone oxytocin (OT) may be important for metabolic regulation.

195 ffected both medium and slow AHP currents in oxytocin (OT) neurons of the supraoptic nucleus.

196 Plasma oxytocin (OT) originates from secretion from the pituita

197 Importantly, hypothalamic oxytocin (OT) signaling increased coincident with stress

198 The oxytocin (OT) system is known to be implicated in the re

199 Oxytocin (OT), a nonapeptide signaling molecule originat

200 ABSTRACT: Oxytocin (OT)- and vasopressin (VP)-secreting magnocellu

201 Prior studies show that oxytocin (Oxt) and vasopressin (Avp) have opposing actio

202 The neuropeptide oxytocin (OXT) has been revealed as a profound anxiolyti

203 fundamental role of the hypothalamic peptide oxytocin (OXT) in the formation and maintenance of socia

204 ging evidence suggests that the neuropeptide oxytocin (OXT) may be a blood-based biomarker of social

205 Oxytocin (OXT) modulates several aspects of social behav

206 Oxytocin (OXT) receptors (OXTRs) are prominently express

207 Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VT

208 The neuropeptide oxytocin (OXT), a key mediator in the regulation of soci

209 ropeptides, such as neuropeptide S (NPS) and oxytocin (OXT), represent potential options for the trea

210 ose observed in the no-treatment (p < .004), oxytocin (p < .001), and saline (p < .015) groups.

211 ting on loci within the arginine vasopressin-oxytocin pathway explains how genetic diversity at Avpr1

212 Acute intranasal oxytocin penetrates the brain and enhances cellular acti

213 cts for peripheral effects, by administering oxytocin peripherally and by blocking peripheral actions

214 Following oxytocin/placebo administration, participants completed

215 suggests that the hypothalamic neuropeptide oxytocin plays a central role in the regulation of mamma

216 ions and behavior, it is now recognized that oxytocin plays a role in a wide range of social relation

217 These results indicate that oxytocin plays a significant role in the acute regulatio

218 Thus, oxytocin potentially contributes to the development of c

219 Oxytocin-pretreated cells significantly increased the ch

220 ntracellular levels of Ca(2+)to oscillate in oxytocin-primed hMSMCs.

221 Oxytocin promotes social interactions and recognition of

222 Oxytocin protects against ischemia-induced inflammation

223 We found that oxytocin provokes the release of serotonin, which in tur

224 when developing tocolytics targeting the OT/oxytocin receptor (OTR) system.

225 rginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brai

226 Oxytocin receptor (Oxtr) signaling in neural circuits me

227 gement and subsequent endocytosis toward the oxytocin receptor (OXTR).

228 Oxytocin receptor and connexin-43 mRNA expression were r

229 e generated specific antibodies to the mouse oxytocin receptor and examined receptor expression throu

230 otection, especially the interaction between oxytocin receptor and GABAA receptor (GABAAR), remains t

231 II type 1 receptor antagonist losartan, the oxytocin receptor antagonist desGly-NH2 , d(CH2 )5 [D-Ty

232 tivity in the anterior cingulate cortex, and oxytocin receptor antagonist infused into this region ab

233 omethacin and decorated with clinically used oxytocin receptor antagonist were designed and evaluated

234 tion of glutamatergic neurotransmission, and oxytocin receptor expression in both suicide and depress

235 tion of observational fear and downregulates oxytocin receptor expression in the amygdala.

236 in dependent rats and humans with increased oxytocin receptor expression.

237 Several common alleles in the oxytocin receptor gene (OXTR) are associated with altere

238 -allele of a common variant (rs53576) in the oxytocin receptor gene (OXTR) has been associated with p

239 The oxytocin receptor gene (OXTR) polymorphism rs53576, whic

240 l stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a cor

241 pulation differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in f

242 Ablation of the oxytocin receptor in aromatase-expressing neurons of the

243 We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female

244 on-specific levels of Oxtr messenger RNA and oxytocin receptor protein with established neuroanatomic

245 ions, including the nucleus accumbens, where oxytocin receptor signaling facilitates social attachmen

246 It is believed that oxytocin receptor signaling in the brain is critical for

247 t glutamate-releasing ARC neurons expressing oxytocin receptor, unlike ARC(POMC) neurons, rapidly cau

248 We found that oxytocin-receptor-expressing neurons in the parabrachial

249 ith the aim of imaging and quantification of oxytocin receptors (OTRs) in living brain using positron

250 er magnitude boost in G-protein signaling of oxytocin receptors (OTRs) in vitro and a 100- and 40-fol

251 ence of long-term SRM.SIGNIFICANCE STATEMENT Oxytocin receptors (OXTRs) are abundantly expressed in h

252 , but it is unknown precisely when and where oxytocin receptors are expressed or which neural circuit

253 d resistance to stress-induced modulation of oxytocin receptors in amygdala nuclei, which is indicati

254 Here we show a pronounced upregulation of oxytocin receptors in brain tissues of alcohol-dependent

255 nalysis of the cerebral cortex revealed that oxytocin receptors were mainly expressed at synapses, as

256 twork comprising regions expected to express oxytocin receptors, based on histologic evidence, and in

257 l behaviors that are especially enriched for oxytocin receptors, including the piriform cortex, the l

258 Pharmacological validation showed that oxytocin reduced cue-induced reinstatement response in d

259 Claims that peripheral measurements of oxytocin reflect central release are questionable at bes

260 This study provides evidence that oxytocin regulated GABAAR subunits in affording neuropro

261 and the in-/out-group approach proposes that oxytocin regulates cooperation and conflict among humans

262 Oxytocin release directly activates DA neurons and indir

263 re, we observed that optogenetically induced oxytocin release enhanced olfactory exploration and same

264 ransient Ca(2+) increase and somatodendritic oxytocin release following neuropeptide S stimulation.

265 Consistent with oxytocin's function in the anterior olfactory cortex, pa

266 These results uncover the critical role of oxytocin signaling in a molecularly defined neuronal pop

267 Finally, acute manipulation of oxytocin signaling in adults is sufficient to alter soci

268 Furthermore, blocking oxytocin signaling in the CeL prevented the suppression

269 However, if oxytocin signaling in the dam had been blocked, pups fai

270 g in both sexes, and these effects depend on oxytocin signaling in the nucleus accumbens.

271 tation of conspecific cues in the absence of oxytocin signaling.

272 needed to establish the utility of targeting oxytocin signalling in obesity.

273 We conclude oxytocin signals within a novel neural circuit that regu

274 dy examined the association between salivary oxytocin (sOT) levels and generosity in preschoolers.

275 metabolism in healthy humans and render the oxytocin system a potential target of antidiabetic treat

276 hanisms in the description of the endogenous oxytocin system and further support a central role for o

277 rols were analyzed for the expression of the oxytocin system by qRT-PCR, in situ hybridization, recep

278 These data indicate that the oxytocin system is involved in social-separation respons

279 s co-occurring with enhanced activity of the oxytocin system reduce the effects of xenophobia by faci

280 cological and chemogenetic inhibition of the oxytocin system.

281 Embedding of the oxytocin template, and then its extracting from the mole

282 ter focus on specific interventions, such as oxytocin, that have a strong basis in the fundamental ne

283 Oxytocin transiently increased the drive of the anterior

284 Functionally, oxytocin transiently reduced synaptic inhibition in mult

285 vidence of therapeutic benefit from extended oxytocin treatment remains very limited.

286 These deficits were attenuated with oxytocin treatment.

287 aptic dysfunctions, abnormalities in central oxytocin, vasopressin, and serotonin neurotransmission,

288 We isolated the insect oxytocin/vasopressin orthologue inotocin from the black

289 investigated to gain novel insights into the oxytocin/vasopressin peptide-receptor interaction, which

290 ld play an important role for development of oxytocin/vasopressin receptor modulators that would enab

291 cological properties on the insect and human oxytocin/vasopressin receptors.

292 ary conservation of the 600-million-year-old oxytocin/vasopressin signalling system.

293 While in the past oxytocin was conceived merely as a prosocial molecule th

294 Oxytocin was most effective at decreasing meth demand an

295 Finally, these effects of systemic oxytocin were mediated by actions in the nucleus accumbe

296 No effects of intranasal oxytocin were seen in reward circuits or on ad libitum f

297 hage was diagnosed in one woman allocated to oxytocin, who was referred and transferred to a higher-l

298 and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reprodu

299 This tendency was only countered by pairing oxytocin with peer-derived altruistic norms, resulting i

300 We hypothesized that oxytocin would reduce the blood oxygenation level-depend