ライフサイエンスコーパス: oxytocin receptor

1 tant had all the activities of the wild type oxytocin receptor.

2 Rs and that this effect does not involve the oxytocin receptor.

3 pette, suggesting activation of postsynaptic oxytocin receptors.

4 gestation, and delayed induction of uterine oxytocin receptors.

5 reatment suppresses intake through action at oxytocin receptors.

6 The oxytocin receptor agonist WAY267464 (10 mg/kg) inhibited

7 Oxytocin receptor and connexin-43 mRNA expression were r

8 ression of the contraction-associated genes, oxytocin receptor and connexin-43, and block oxytocin-in

9 e generated specific antibodies to the mouse oxytocin receptor and examined receptor expression throu

10 otection, especially the interaction between oxytocin receptor and GABAA receptor (GABAAR), remains t

11 polarization is sensitive to blockade of the oxytocin receptor and is mediated by a voltage-dependent

12 plasticity and memory in rats via acting on oxytocin receptors and regulating ERK activity.

13 ating adrenal steroids affect the density of oxytocin receptors and the angiotensin receptor subtypes

14 d intraspecies variation of the geography of oxytocin receptors and vasopressin V1a receptors in the

15 potency in vitro (Ki = 4.1 nM, cloned human oxytocin receptor) and in vivo (intravenous AD50 = 0.71

16 he oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor

17 th agonist-activated neurotensin-1 receptor, oxytocin receptor, angiotensin II type 1A receptor, and

18 end of the injection and (b) injection of an oxytocin receptor antagonist ([d(CH2)5-Tyr (Me)2-Orn8]-V

19 by injection into the fourth ventricle of an oxytocin receptor antagonist [d(CH(2))(5), Tyr (Me)(2),

20 to immobilization, whereas injections of an oxytocin receptor antagonist blocked the effects of the

21 II type 1 receptor antagonist losartan, the oxytocin receptor antagonist desGly-NH2 , d(CH2 )5 [D-Ty

22 ist SR121463B, but not by treatment with the oxytocin receptor antagonist GW796679X.

23 juvenile and adult female prairie voles, and oxytocin receptor antagonist infused into the nucleus ac

24 tivity in the anterior cingulate cortex, and oxytocin receptor antagonist infused into this region ab

25 Additionally, the oxytocin receptor antagonist L-368,899 inhibited the oxy

26 ing with their male partner with a selective oxytocin receptor antagonist or vehicle.

27 cular administration of saline, oxytocin, or oxytocin receptor antagonist was used to measure the eff

28 In contrast, the oxytocin receptor antagonist WAY162720 (10 mg/kg) inhibi

29 omethacin and decorated with clinically used oxytocin receptor antagonist were designed and evaluated

30 ckling before and after administration of an oxytocin receptor antagonist.

31 GABAA receptor antagonists as well as by an oxytocin receptor antagonist.

32 Next we examined the effects of two oxytocin receptor antagonists, (d(CH2)5(1),Tyr(Me)(2),Or

33 In the last few hours of pregnancy, oxytocin receptors appear in high concentrations in the

34 us subcortical regions where vasopressin and oxytocin receptors are adjacently expressed and which ar

35 , but it is unknown precisely when and where oxytocin receptors are expressed or which neural circuit

36 Expression of oxytocin, oxytocin receptor, arginine vasopressin, arginine vasopr

37 red by the blockade of spinal vasopressin or oxytocin receptors at T1-T4.

38 twork comprising regions expected to express oxytocin receptors, based on histologic evidence, and in

39 in the paraventricular nucleus and increased oxytocin receptor binding in the central amygdala.

40 Oxytocin receptor binding in the MPOA and LS was reduced

41 duced exploratory behavior, maternal LG, and oxytocin receptor binding in the offspring of high LG mo

42 TAMOX and EE increased oxytocin receptor binding in the ventromedial nucleus of

43 hment enhanced exploration, LG behavior, and oxytocin receptor binding of low LG offspring.

44 ein kinases before assaying for behavior and oxytocin receptor binding.

45 nandamide degradation offsets the effects of oxytocin receptor blockade on both social place preferen

46 o uncontrollable stress and is enriched with oxytocin receptors, but their interactive influences on

47 on-associated and progestin-sensitive genes (oxytocin receptor, connexin 43, and cyclooxygenase-2) an

48 Although the nucleus accumbens receives oxytocin-receptor-containing inputs from several brain r

49 the functional relationship between accumbal oxytocin receptor density and social behavior in prairie

50 to demonstrate a direct relationship between oxytocin receptor density in the nucleus accumbens and v

51 Oxytocin receptor density in the nucleus accumbens is po

52 ot only upon release of oxytocin but also on oxytocin receptor distribution within the brain, becomes

53 We found that oxytocin-receptor-expressing neurons in the parabrachial

54 tion of glutamatergic neurotransmission, and oxytocin receptor expression in both suicide and depress

55 es in female prairie voles, and suggest that oxytocin receptor expression in the accumbens is not suf

56 tion of observational fear and downregulates oxytocin receptor expression in the amygdala.

57 In contrast, dopamine controlled tonic oxytocin receptor expression in the central nucleus of t

58 Thus, individual variation in oxytocin receptor expression in the striatum may contrib

59 in dependent rats and humans with increased oxytocin receptor expression.

60 Several common alleles in the oxytocin receptor gene (OXTR) are associated with altere

61 the extent to which genetic variants in the oxytocin receptor gene (OXTR) are associated with pair-b

62 -allele of a common variant (rs53576) in the oxytocin receptor gene (OXTR) has been associated with p

63 A common variant (rs53576) in the oxytocin receptor gene (OXTR) has been implicated in soc

64 The oxytocin receptor gene (OXTR) has been studied as a risk

65 The oxytocin receptor gene (OXTR) polymorphism rs53576, whic

66 cts as its receptor, which is encoded by the oxytocin receptor gene (OXTR).

67 l stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a cor

68 pulation differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in f

69 Ablation of the oxytocin receptor in aromatase-expressing neurons of the

70 These data confirm a role for oxytocin receptor in the accumbens in the regulation of

71 Adult female prairie voles that overexpress oxytocin receptor in the nucleus accumbens displayed acc

72 d resistance to stress-induced modulation of oxytocin receptors in amygdala nuclei, which is indicati

73 Here we show a pronounced upregulation of oxytocin receptors in brain tissues of alcohol-dependent

74 more, prairie voles have higher densities of oxytocin receptors in the accumbens than nonmonogamous r

75 Oxytocin receptors in the nucleus accumbens have been im

76 We hypothesized that oxytocin receptors in the ventral tegmental area (VTA) m

77 We conclude that oxytocin receptors in the VTA play a physiologic role in

78 l behaviors that are especially enriched for oxytocin receptors, including the piriform cortex, the l

79 We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female

80 in nonmonogamous meadow voles by introducing oxytocin receptor into the nucleus accumbens.

81 ructural similarity, yet in many species the oxytocin receptor is only 30 to 50% homologous with vaso

82 1 residues from the COOH terminus of the rat oxytocin receptor is required for interaction with G(q/1

83 Blockade of oxytocin receptors largely attenuated activation in thes

84 no published reports describing activity of oxytocin receptor ligands on mammalian circadian rhythms

85 Non-peptide oxytocin receptor ligands that cross the blood brain bar

86 our in vitro constructs did not express any oxytocin receptors, meaning that the observed interactio

87 Oxytocin receptor (OTR) activates the GTP-binding protei

88 first high-affinity fluorescent ligands for oxytocin receptor (OTR) are described.

89 Although oxytocin (OT) and oxytocin receptor (OTR) are known for roles in parturiti

90 amic OT levels and a concomitant increase of oxytocin receptor (OTR) binding in the lateral septum an

91 as sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal

92 The oxytocin receptor (OTR) is differentially expressed in t

93 autoradiography to assess whether forebrain oxytocin receptor (OTR) or vasopressin V1a receptor (V1a

94 ifferences in vasopressin receptor (V1aR) or oxytocin receptor (OTR) related to social recognition.

95 when developing tocolytics targeting the OT/oxytocin receptor (OTR) system.

96 The oxytocin receptor (OTR), a member of the seven-transmemb

97 is nearly identical to the E2 region of the oxytocin receptor (OTR), we set out to ascertain whether

98 essing either ER also coexpress mRNA for the oxytocin receptor (OTR).

99 s associated with a specific upregulation of oxytocin receptor (OTR, oxtr) and vasopressin V1a recept

100 Oxytocin receptors (OTR) and vasopressin V1a receptors (

101 ith the aim of imaging and quantification of oxytocin receptors (OTRs) in living brain using positron

102 er magnitude boost in G-protein signaling of oxytocin receptors (OTRs) in vitro and a 100- and 40-fol

103 f [Arg(8)]-vasopressin receptors (AVPRs) and oxytocin receptors (OTRs) suggests that G protein-couple

104 tabotropic glutamate receptor 5 (mGluR5) and oxytocin receptor (Oxtr) affect social affiliation and s

105 s assayed from adults who were genotyped for oxytocin receptor (OXTR) and CD38 risk alleles associate

106 croarray analysis, including upregulation of oxytocin receptor (Oxtr) and FBJ osteosarcoma oncogene (

107 g region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the

108 ed on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously

109 oxytocin (OXT) in 29 primate species and the oxytocin receptor (OXTR) in 21 of these species.

110 rginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brai

111 Oxytocin receptor (Oxtr) signaling in neural circuits me

112 Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological r

113 invasive nature of resistant cells, and the oxytocin receptor (OXTR), a potential new therapeutic ta

114 ig contains at least 36 genes, including the oxytocin receptor (OXTR), hOGG1, the von Hippel-Lindau t

115 gement and subsequent endocytosis toward the oxytocin receptor (OXTR).

116 n levels and with genetic alterations of the oxytocin receptor (OXTR).

117 egular spiking interneurons that express the oxytocin receptor (OxtrINs).

118 ence of long-term SRM.SIGNIFICANCE STATEMENT Oxytocin receptors (OXTRs) are abundantly expressed in h

119 As the oxytocin receptor plays a key role in parturition and la

120 nt, we explored the behavioral expression of oxytocin receptor polymorphism (OXTR) rs53576, a gene pr

121 l motoneurones showed an increased number of oxytocin receptors present on GABAergic terminals of CRF

122 gamous rodent species, and blocking accumbal oxytocin receptors prevents mating-induced partner prefe

123 on-specific levels of Oxtr messenger RNA and oxytocin receptor protein with established neuroanatomic

124 naturally occurring genetic variation of the oxytocin receptor relates to both empathy and stress pro

125 e tested how a polymorphism (rs53576) of the oxytocin receptor relates to two key social processes re

126 lamus (VMH), estrogen-dependent induction of oxytocin receptors required protein kinase C activation,

127 A common SNP in the oxytocin receptor (rs237887) was strongly associated wit

128 studies suggest that stimulation of central oxytocin receptors selectively suppresses carbohydrate i

129 ions, including the nucleus accumbens, where oxytocin receptor signaling facilitates social attachmen

130 It is believed that oxytocin receptor signaling in the brain is critical for

131 pharmacological manipulations, we show that oxytocin receptor signaling is crucial for entrainment o

132 Pharmacological blockade of oxytocin receptors stops this response, whereas chemogen

133 in and V1a vasopressin receptors but not the oxytocin receptor) to stimulate adenylyl cyclase.

134 We previously showed that the rat oxytocin receptor transfected into Chinese hamster ovary

135 t glutamate-releasing ARC neurons expressing oxytocin receptor, unlike ARC(POMC) neurons, rapidly cau

136 al profile at AVP V(2)R, V(1a)R, V(1b)R, and oxytocin receptor was measured by binding assay and func

137 presumably Galpha1-coupled M1 muscarinic and oxytocin receptors was completely inhibited by pretreati

138 nalysis of the cerebral cortex revealed that oxytocin receptors were mainly expressed at synapses, as

139 spinal iGLURs, and 4) spinal vasopressin and oxytocin receptors were not involved in the mediation of

140 by oxytocin in the left auditory cortex, and oxytocin receptors were preferentially expressed in the

141 , CD9, activating transcription factor 3 and oxytocin receptor, were dominantly regulated by histone

142 of estrogen receptor alpha and beta and the oxytocin receptor (when LG is assessed across the light-