ライフサイエンスコーパス: ozonide

1 y scalable to produce gram quantities of the ozonides.

2 system, as well as the primary and secondary ozonides.

3 s, avoiding the need to isolate or decompose ozonides.

4 oselective reduction of peroxides, including ozonides.

5 For primary amino ozonides, addition of polar functional groups decreased

6 For tertiary amino ozonides, addition of polar functional groups with H-bon

7 For secondary amino ozonides, additional functional groups had variable effe

8 pical oxidation products identified included ozonides, aldehydes (hexanal, pentenal, nonanal and none

9 provide direct experimental evidence for the ozonide and establish its propensity for the solution-va

10 findings, showing that water stabilizes the ozonide and lowers the energy of the transition state at

11 mation and unimolecular reactions of primary ozonides and carbonyl oxides arising from the O(3)-initi

12 Ozonides and carboxylic acids were generated in certain

13 ol(-1) above the ground state of the primary ozonide, and the decomposition energies range from -5 to

14 The observed secondary ozonides are consistent with the formation of mainly sec

15 Ozonides are known to generate cytotoxic free radicals i

16 It is evident that these tetrasubstituted ozonides are quite stable to triphenylphosphine, borohyd

17 ivity relationship (SAR) of the antimalarial ozonide artefenomel (OZ439).

18 led to the discovery of a second-generation ozonide, artefenomel (OZ439, 2), which has overcome this

19 ained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structur

20 CTs and the first generation fully synthetic ozonide, arterolane (OZ277, 1), suffer from rapid cleara

21 Acetolysis of these ozonides at low temperature allowed selective cleavage o

22 progressing from quinine and artemisinin to ozonide-based compounds.

23 des collisional stabilization of the primary ozonide by roughly an order of magnitude in pressure.

24 ide, sulfone, and heterocycle-functionalized ozonides by a wide range of post-ozonolysis transformati

25 In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of ou

26 er metabolic stabilities than tertiary amino ozonides, consistent with their higher pKa and lower log

27 Ozonide decomposition resulted in omega-aldehyde and ome

28 Secondary ozonide formation is important even for syn-isomer Crieg

29 evidence for a rate limiting, surface active ozonide formed at the interface.

30 process at low carbon number to a secondary ozonide-forming process at high carbon number.

31 t, ozone-free synthesis of bridged secondary ozonides from 1,5-dicarbonyl compounds and H2 O2 .

32 Primary and secondary amino ozonides had higher metabolic stabilities than tertiary

33 ts imply enhanced production of a persistent ozonide in airway-lining fluids acidified by preexisting

34 The primary ozonides initially generated upon ozonolysis can be redu

35 involved charge remote fragmentation of the ozonide initiated by homolytic cleavage of the peroxide

36 er interface through the formation of (1) an ozonide intermediate, (2) a hydroperoxide, and (3) cis,c

37 tion pathway for either positive or negative ozonide ion species involved charge remote fragmentation

38 The structure of this ozonide is confirmed by tandem mass spectrometry and its

39 ones reveals that the major tetrasubstituted ozonide isomers possess cis configurations, suggesting a

40 These ozonides lose O(2) through thermolysis or photolysis to

41 acid plus a previously unreported ascorbate ozonide (m/z = 223) below pH approximately 5.

42 The initial products are two ozonide monoadducts, identified as a,b- and c,c-C(70)O(3

43 ore 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439, we compared the antimalarial a

44 The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is re

45 ion produces high-molecular-weight secondary ozonides (SOZ), which are known skin irritants, and a mo

46 ied to the phospholipid yielded a mixture of ozonide species with the maximum number of ozone molecul

47 hosphocholine lipids results in formation of ozonides that can be directly analyzed by mass spectrome

48 hyl sulfide gave a mixture of diastereomeric ozonides that proved to be stable for weeks at room temp

49 Cleavage of primary ozonides to form carbonyl oxides occurs with a barrier o

50 The high curative efficacy of these ozonides was most often associated with high and prolong

51 Five new ozonides with antimalarial efficacy and ADME profiles su

52 Primary and tertiary amino ozonides with cycloalkyl and heterocycle substructures w

53 eaction enables the selective preparation of ozonides without the use of ozone.