ライフサイエンスコーパス: p-cresol

1 ys503 to the p-hydroxybenzyl radical to form p-cresol.

2 2-dependent hydroxylation of toluene to form p-cresol.

3 sulfate (PCS) but no detectable unconjugated p-cresol.

4 -dependent hydroxylation of toluene to yield p-cresol.

5 es the hydroxylation of toluene to yield 96% p-cresol.

6 thylaniline, 3,4-dimethylphenol, and 2-amino-p-cresol.

7 )-dependent hydroxylation of toluene to form p-cresol.

8 Derivatives of p-cresol 1-4 were synthesized, and their photochemical r

9 r for butyric acid, 1 x 10(-4) mug/L air for p-cresol, 1 x 10(-5) mug/L air for indole, and 1 x 10(-5

10 ower than the pK(a) of tyrosine (10.1) or of p-cresol (10.2).

11 amounts (in %) are 2-methyladenine (60.6%), p-cresol (16.3%), adenine (12.5%), 2-(methylthio)adenine

12 umed 4 electron equiv/mol when titrated with p-cresol (2 electrons from p-cresol and 2 from 4-hydroxy

13 ophen, diclofenac, carbamazepine, clozapine, p-cresol, 4-ethylphenol, and 3-methylindole in human liv

14 e, derived from phenolic compounds including p-cresol, 4-hydroxybenzoate and numerous lignin monomers

15 seudomonas mendocina KR1 oxidizes toluene to p-cresol (96%) and oxidizes benzene sequentially to phen

16 gues that contain the bases-2-methyladenine, p-cresol, adenine, and 2-(methylthio)adenine.

17 he infrared spectrum of 4-methylimidazole or p-cresol alone.

18 esol did not increase Tf saturation with Al. p-Cresol also increased Tf-Al uptake in Friend erythrole

19 In the presence of tyrosine or p-cresol, an unusual tricyclo[4.3.3.0] adduct has been c

20 rent Km value of 250 microM and produced 90% p-cresol and 10% m-cresol.

21 hen titrated with p-cresol (2 electrons from p-cresol and 2 from 4-hydroxybenzyl alcohol), PchF(C) ac

22 T4MO, in comparison, produces 97% p-cresol and 3% m-cresol.

23 Odorants such as p-cresol and a sweet-character unknown component were co

24 The second-order rate constants for p-cresol and ferrocyanide reduction of the mutant compou

25 enerates myriad toxic metabolites, including p-cresol and indoxyl sulfate.

26 Conversely, the A107T variant produced >98% p-cresol and p-nitrophenol from toluene and nitrobenzene

27 Interestingly, p-cresol and phenol, which are the lower ligand in Sporo

28 e enzyme HydG lyses free tyrosine to produce p-cresol and the CO and CN(-) ligands of the [2Fe](H) cl

29 the electronic and redox properties of bound p-cresol and the covalently bound FAD.

30 Our studies suggest that p-cresol and uremic fractions 4 to 8, 12, 14, and 15 inc

31 the higher acidity of the S1 states of these p-cresols and the ability for excited-state intramolecul

32 methylbenzimidazole, 5-methoxybenzimidazole, p-cresol, and phenol were determined.

33 l)phenylacetonitrile, cyclobutanone, phenol, p-cresol, aniline) to form ammonia and trans-(DMPE)(2)Ru

34 ogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into alpha-ribotides, which are i

35 alpha-amino group (the aromatic hydrogens of p-cresol are far less subject to exchange) and by imidaz

36 tion of biphenyl, naphthalene, m-xylene, and p-cresol are predicted to be distributed among 15 gene c

37 urally characterized cell permeable diformyl-p-cresol based receptor (HL) selectively senses the AsO3

38 ening addition and fragmentation reaction of p-cresol-based N-phenylbenzoxazine with aliphatic and ar

39 e identified compounds including 2,6-dinitro-p-cresol, bisphenol S, clonixin, and triclopyr.

40 functionalised with 2-(2'-benzothiazolylazo)-p-cresol (BTAC).

41 The degradation of the toxic phenol p-cresol by Pseudomonas bacteria occurs by way of the pr

42 steady-state rate constant for oxidation of p-cresol by various forms of PCMH and PchF; both nu(m) a

43 This study examined the form in which p-cresol circulates and quantified its removal by hemodi

44 We conclude that p-cresol circulates in the form of its sulfate conjugate

45 n (Cl(ind)), p-cresol sulfate (Cl(pcs)), and p-cresol (Cl(pc)) averaged only 5 +/- 1, 4 +/- 1, and 14

46 The sensor probe is characterized for p-cresol concentration range from 0microM (reference sam

47 s showed increased Al uptake and toxicity at p-cresol concentrations of 3 mg/dl in culture media.

48 lfatase resulted in recovery of this peak as p-cresol, confirming its identity.

49 p-Cresol did not increase Tf saturation with Al. p-Creso

50 , BHA, creosol, isoeugenol and di-o-propenyl p-cresol, fewer radicals were trapped by a single phenol

51 yielded shifts of regiospecificity away from p-cresol formation, with F205I giving an approximately 5

52 ptake and cell toxicity were proportional to p-cresol from 1.5 mg/dl to 3 mg/dl in culture media.

53 Furthermore, G103S/A107T formed 100% p-cresol from toluene; hence, a better para-hydroxylatin

54 e involved in the fermentative production of p-cresol from tyrosine in clostridia.

55 It was demonstrated that p-cresol has a charge-transfer interaction with FAD when

56 in the product distribution, and gave o- and p-cresol in a 1:1 ratio.

57 nalysis confirmed the structural identity of p-cresol in samples containing the product of hydroxylat

58 p-Cresol increased Tf-associated Al uptake only because

59 studies of the reaction of PCMH[Y384F] with p-cresol indicated that the K(m) for this substrate was

60 p-Cresol is a simple molecular model for the para phenol

61 The alpha(2)beta(2) flavocytochrome p-cresol methylhydroxylase (PCMH) from Pseudomonas putid

62 PchF) of the alpha(2)beta(2) flavocytochrome p-cresol methylhydroxylase (PCMH) from Pseudomonas putid

63 Each flavoprotein subunit (PchF) of p-cresol methylhydroxylase (PCMH) has flavin adenine din

64 protein component (PchF) of flavocytochrome, p-cresol methylhydroxylase (PCMH), and cytochrome-free P

65 The first enzyme in this pathway, p-cresol methylhydroxylase (PCMH), is a flavocytochrome

66 These proteins are (1) the flavocytochrome c p-cresol methylhydroxylase (rPCMH, 1.85 A resolution) an

67 ee variants of the flavoprotein component of p-cresol methylhydroxylase that contain noncovalently or

68 ybenzyl alcohol, the intermediate product of p-cresol oxidation by PCMH, reduced PchF(NC) fairly quic

69 relation was found between the efficiency of p-cresol oxidation by these proteins and E(CT), the ener

70 mg of protein were obtained for o-, m-, and p-cresol oxidation by wild-type T4MO, which are comparab

71 d also that 4-hydroxybenzaldehyde, the final p-cresol oxidation product, is an efficient competitive

72 styrene (S), o-cresol (o-C), phenol (PhAl), p-cresol (p-C), indole (ID), and skatole (SK)).

73 water at 25 degrees C for benzene, p-xylene, p-cresol, p-dicyanobenzene, and hydroquinone from statis

74 m PCS by decreasing intestinal production of p-cresol, prevented these metabolic derangements.

75 In contrast, p-cresol rapidly reduced PchF with covalently bound FAD

76 ient coupling and high regiospecificity with p-cresol representing >96% of total products from toluen

77 entical to that of the natural isoform, with p-cresol representing 90-95% of the total product distri

78 , and a decrease in regiospecificity so that p-cresol represents approximately 60% of total products.

79 Its response time is also better than the p-cresol sensor currently available in the market for th

80 btained as compared to the recently reported p-cresol sensor.

81 ture, 4-methylimidazole covalently linked to p-cresol, show that a feature near 1540 cm(-1) is unique

82 iously, Siamwiza and co-workers investigated p-cresol solutions to identify Raman spectroscopic signa

83 0.16-fold), indoxyl sulfate (0.21-fold), and p-cresol sulfate (0.39-fold) were much lower than the ra

84 (108-fold), indoxyl sulfate (116-fold), and p-cresol sulfate (41-fold) were much greater than the co

85 the protein-bound solutes indican (Cl(ind)), p-cresol sulfate (Cl(pcs)), and p-cresol (Cl(pc)) averag

86 eak whose mobility corresponded to synthetic p-cresol sulfate (PCS) but no detectable unconjugated p-

87 In cultured cells, indoxyl sulfate and p-cresol sulfate activated the EGF receptor and downstre

88 Although p-cresol sulfate and indoxyl sulfate are well studied ex

89 HPLC confirmed the colonic origin of p-cresol sulfate and indoxyl sulfate, but levels of hipp

90 tomized mice treated with indoxyl sulfate or p-cresol sulfate as study models.

91 Low clearance of hippurate or p-cresol sulfate associated with greater risk of death i

92 g results suggested that indoxyl sulfate and p-cresol sulfate dock on a putative interdomain pocket o

93 Indoxyl sulfate and p-cresol sulfate have been suggested to induce kidney ti

94 In conclusion, indoxyl sulfate and p-cresol sulfate may induce kidney tissue remodeling thr

95 treatment: from no reduction in the level of p-cresol sulfate or asymmetric dimethylarginine to signi

96 Treatment of mice with indoxyl sulfate or p-cresol sulfate significantly activated the renal EGF r

97 ecreted solute (hippurate, cinnamoylglycine, p-cresol sulfate, and indoxyl sulfate) clearance using l

98 amine, 5-hydroxyindole, indoxyl glucuronide, p-cresol sulfate, and indoxyl sulfate.

99 c toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include

100 hotometric absorption of indoxyl sulfate and p-cresol sulfate.

101 ode resonance (LMR) based sensor for urinary p-cresol testing on optical fiber substrate is developed

102 etylene, cyclobutanone, aniline, phenol, and p-cresol, the reaction was observed to proceed via ion p

103 PCMH oxidizes p-cresol to 4-hydroxybenzyl alcohol, which is oxidized s

104 ylhydroquinone (9%), to oxidize m-cresol and p-cresol to 4-methylcatechol (100%), and to oxidize o-me

105 The enzyme first catalyzes the oxidation of p-cresol to p-hydroxybenzyl alcohol, utilizing one atom

106 interpret the Raman and infrared spectra of p-cresol vapor and extend the previous correlation to th

107 icant Al uptake by MH was observed only when p-cresol was added together with Tf-Al.

108 p-Cresol was not toxic to MH in the absence of Tf-Al in

109 N-o-Vanillidine-2-amino-p-cresol was used as a chelating ligand and 1-undecanol

110 It was found that p-cresol was virtually incapable of reducing PchF with n

111 substitution of 4-(fluoroethynyl)benzenes by p-cresol were determined by (1)H NMR spectroscopy, and t

112 otope distributions of 5'-deoxyadenosine and p-cresol were evaluated using deuterium-labeled tyrosine

113 mation of CYP2B4-specific benzyl alcohol and p-cresol were inhibited, whereas that of CYP1A2-specific

114 most extensively studied of these solutes is p-cresol, which has been shown to be toxic in vitro.

115 ons also show a clear preference for binding p-cresol with the hydroxyl group hydrated rather than in

116 proton transfer to this 4OB(*) radical forms p-cresol, with the conversion of this dehydroglycine lig

117 eviously from these ultrafiltrate fractions (p-cresol, xanthine, tryptophan, hippuric acid, and o-hyd

118 icotinate mononucleotide (NaMN) to phenol or p-cresol, yielding alpha-O-glycosidic ribotides.