ライフサイエンスコーパス: p16 protein

1 o significantly induce levels of p130 and/or p16 protein.

2 unohistochemical analysis, all NFs expressed p16 protein.

3 ease the IC0.5 approximately fivefold in the p16 protein.

4 nohistochemistry (IHC) for expression of the p16 protein.

5 mas and two low-grade gliomas that expressed p16 protein.

6 Of the 30 tumors that lacked p16 protein, 27 also lacked mRNA, 1 had detectable p16 m

7 es and oligomerization state of seven mutant p16 proteins; all of them are deficient in function.

8 umor specimens that stained positive for the p16 protein, an indicator that human papillomavirus had

9 in which is equivalent to 0.49 ng mL(-1) for p16 protein and 28 cells for HeLa cervical cancer cells.

10 -negative HNSCC, including overexpression of p16 protein and formation of more basaloid cancers.

11 mors, 16 (34.7%) of the 46 showed detectable p16 protein and mRNA; of these, 12 had no DNA abnormalit

12 rs were further tested for the expression of p16 protein and type-specific HPV mRNA.

13 wed expression of p16 transcript, but not of p16 protein as indicated by Western blot analysis.

14 ty of cells have a hypermethylated p16, lack p16 protein, but no longer express E7.

15 loxone abolished the increased expression of p16 protein by OGF.

16 ressor protein (residues 84-103 of the human p16 protein) can bind to cdk4 and cdk6 and inhibit cdk4-

17 as and that the restoration of the wild-type p16 protein could have clinical and therapeutic utility.

18 ecular mechanisms underlying this absence of p16 protein expression are not completely understood.

19 Loss of p16 protein expression correlated with methylation of p1

20 In addition, p16 protein expression could not be detected in five out

21 of RB function has been associated with high p16 protein expression in several other tumor types.

22 There is considerable evidence that lack of p16 protein expression is a frequent event in human glio

23 We also show that p16 protein expression is neither necessary nor sufficie

24 We now report that p16 protein expression status of T-ALL cells influences

25 In addition P15 and P16 protein expression was assessed.

26 Although p16 protein expression, a surrogate marker of oncogenic

27 increased cyclin-dependent kinase inhibitor p16 protein expression.

28 ive cancers, and was associated with loss of p16 protein expression.

29 ysis involving serology, tumor DNA, RNA, and p16 protein expression.

30 ted beta-galactosidase marker, and increased P16 protein expression.

31 We hypothesized that loss of p16 protein function could be related to RB overexpressi

32 ptosis; and 6) HaCaT cells have undetectable p16 protein (hypermethylation of the promoter), dysfunct

33 its performance for detection of solubilized p16 protein in cell lysates obtained from patients.

34 antibody has confirmed an over-expression of p16 protein in cervical cancer cells and its association

35 The absence of P16 protein in every case was confirmed by immunohistoch

36 Moreover, restoration of the p16 protein in glioma cells inhibits the alpha(v)beta(3)

37 We examined the CDKN2A/p16 gene and p16 protein in NFs and MPNSTs from patients with NF1.

38 N2 gene to infect and express high levels of p16 protein in p16-null SNB19 glioma cells.

39 ines directed the biosynthesis of functional p16 protein in the majority of the exposed cells, signif

40 his correlated with continuous expression of p16 protein in these cells.

41 oviral-mediated overexpression of functional p16 protein, indicating the existence of a defect(s) dow

42 companied with the age-dependent increase of p16 protein levels in the confluent culture.

43 MIS increases p16 protein levels, and 5'-Aza-2'-deoxycytidine (AzadC)

44 line (SK-OV-3) that expressed Rb but lacked p16 protein, resulted in a G1 growth arrest.

45 Reduced levels of p16 protein stabilize p53 protein through inhibition of

46 ontaining the p16 gene (AdRSVp16) produced a p16 protein that suppressed cellular proliferation and i

47 veloped that allowed the detection of mutant p16 proteins that did not interact with DnaB.

48 In addition to the p16 protein, the INK4A encodes for a second product, ter

49 Like the full length p16 protein, the p16 peptide does not inhibit cyclin E d

50 As a result of deficient p16 protein, these cancers lack a critical mechanism for

51 le arrest was associated with binding of the p16 protein to cyclin-dependent kinase 4 and dephosphory

52 Although p16 protein was expressed at a similar level in tumor an

53 e HMEC express readily detectable amounts of p16 protein, whereas normal or E6-expressing HMEC that e

54 and detection limit of 1.3 ng mL(-1) for GST-p16 protein which is equivalent to 0.49 ng mL(-1) for p1