ライフサイエンスコーパス: p90 ribosomal S6 kinase

1 This elevation depended on activation of p90 ribosomal S6 kinase.

2 ttenuated TPA-induced phosphorylation of ERK/p90 ribosomal S6 kinase.

3 so sufficient to activate both NF-kappaB and p90 ribosomal S6 kinase.

4 eviously we showed that the inactive form of p90 ribosomal S6 kinase 1 (RSK1) interacts with the regu

5 p90 ribosomal S6 kinase 1 (RSK1) is a serine/threonine k

6 ribosomal protein S6 kinase 1 (S6K1) but not p90 ribosomal S6 kinase 1 (RSK1) or Akt.

7 in cultured cells, interacts with mammalian p90 ribosomal S6 kinase 1 (RSK1), and causes a decrease

8 nt protein kinase (PKAc) binds to the active p90 ribosomal S6 kinase 1 (RSK1).

9 ERK1/2, and its dependent protein, p90RSK-1 (p90 ribosomal S6 kinase 1 or RSK-1), was abolished by me

10 iated activation of their direct target, the p90 ribosomal S6 kinase 1/2 (RSK1/2).

11 p90 ribosomal S6 kinase 2 (p90RSK2) is important in dive

12 However, cells deficient in p90 ribosomal S6 kinase 2 (Rsk2(-/-)) totally block this

13 covered a novel regulatory mechanism whereby p90 ribosomal S6 kinase 2 (RSK2) interacts with 5-hydrox

14 The p90 ribosomal S6 kinase 2 (RSK2) is a serine/threonine k

15 Here we show that the p90 ribosomal S6 kinase 2 (RSK2) phosphorylates actin-bi

16 ly, we discovered that the ERK/MAPK effector p90 ribosomal S6 kinase 2 (RSK2) phosphorylates the 5-HT

17 We report here that genetic deletion of p90 ribosomal S6 kinase 2 (RSK2) potentiates GPCR signal

18 Here, we report that p90 ribosomal S6 kinase 2 (RSK2) promotes human HNSCC ce

19 We previously demonstrated that p90 ribosomal S6 kinase 2 (RSK2) promotes tumor metastas

20 nscriptional regulation, in which docking of p90 ribosomal S6 kinase 2 (Rsk2) to the hormone-binding

21 he activity of its downstream substrate, the p90 ribosomal S6 kinase 2 (RSK2), by 1.4-fold, but it ha

22 We found that the p90 ribosomal S6 kinase 2 (RSK2)-cAMP response element-b

23 extracellular signal-regulated kinase 2 and p90 ribosomal S6 kinase 2 but not mitogen- and stress-ac

24 exercise protocol, MAPK phosphorylation and p90 ribosomal S6 kinase 2, MAP kinase kinase 1, and Raf-

25 he activity of its downstream substrate, the p90 ribosomal S6 kinase 2.

26 The p90 ribosomal S6 kinase-3 gene (p90 Rsk-3, RPS6KA2) maps

27 The RPS6KA6 gene encodes the p90 ribosomal S6 kinase-4 (RSK4) that is still largely u

28 ctivated protein kinase phosphorylation, and p90 ribosomal S6 kinase activation, but did not affect t

29 nase C (PKC), but not by casein kinase II or p90 ribosomal S6 kinase, also activates PKA (7-fold).

30 mitogen-activated protein kinase (MAPK) and p90 ribosomal S6 kinase and consequent cell proliferatio

31 ing threonine 26 and serine 82, whereas PKC, p90 ribosomal S6 kinase, and casein kinase II, can phosp

32 ivo by isoforms of p70 S6 protein kinase and p90 ribosomal S6 kinase, and there is good evidence that

33 ts support the hypothesis that NF-kappaB and p90 ribosomal S6 kinase are involved in MEK5-ERK5-depend

34 induced phosphorylation of ERK1/2, CREB, and p90 ribosomal S6 kinase, as well as a decreased level of

35 not alter the TPA-induced phosphorylation of p90 ribosomal S6 kinase but caused a approximately 50% d

36 inhibition of the proteasome (by MG-132) or p90 ribosomal S6 kinases (by BI-D1870) is further increa

37 n in B cells was regulated by an ERK1/2- and p90 ribosomal S6 kinase-dependent mechanism, unlike in m

38 The p90 ribosomal S6 kinase family (RSK1-4) is a group of hi

39 RSKs (p90 ribosomal S6 kinases) have emerged as central regula

40 e p38 MAPK docking site of MAPKAPK2 converts p90 ribosomal S6 kinase into a stress-activated kinase i

41 RSK (p90 ribosomal S6 kinase) is a MAPK-activated protein kin

42 ble magnitude of phosphorylation of ERK-1/2, p90 ribosomal S6 kinase-l and Akt, although phosphorylat

43 rminal phosphorylation by p70 S6 kinases and p90 ribosomal S6 kinases on four conserved Ser residues

44 Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, res

45 In addition, we show that p90 ribosomal S6 kinase (p90(RSK)) is a key NHE-1 kinase

46 ivate p70 ribosomal S6 kinase (p70(S6K)) and p90 ribosomal S6 kinase (p90(RSK)).

47 osomal S6 kinase 2 (RSK2) is a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins and

48 serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins.

49 p90 ribosomal S6 kinase (p90RSK) is activated in cardiom

50 ctor receptor (EGFR) that is coupled to MAPK/p90 ribosomal S6 kinase (p90RSK), but not phosphatidylin

51 MAPK and its downstream effector, p90 ribosomal S6 kinase (p90RSK), phosphorylate transcri

52 lly important downstream effector of PKCs is p90 ribosomal S6 kinase (p90RSK), which plays an importa

53 ant downstream effector of Src and ERK1/2 is p90 ribosomal S6 kinase (p90RSK), which plays an importa

54 hosphorylation of the known ERK1/2 substrate p90 ribosomal S6 kinase (p90RSK).

55 Here, we report the critical role of the p90 ribosomal S6 kinase (p90RSK)/ERK5 complex in EC dysf

56 PI3K/Akt or mitogen-activated protein kinase/p90 ribosomal S6 kinase pathways and subsequent tuberous

57 ated protein kinase (MAPK)-activated kinase, p90 ribosomal S6 kinase (RSK) 1, was found to interact w

58 iral proteins, ORF45, mediates sustained ERK-p90 ribosomal S6 kinase (RSK) activation during KSHV lyt

59 n CCT as a novel physiological substrate for p90 ribosomal S6 kinase (RSK) and p70 ribosomal S6 kinas

60 Here we report the identification of p90 ribosomal S6 kinase (RSK) as a target of salicylate.

61 ree enzymes that can phosphorylate GMF, only p90 ribosomal S6 kinase (RSK) enhances the inhibitory fu

62 While the p90 ribosomal S6 kinase (RSK) family has been implicated

63 p90 ribosomal S6 kinase (RSK) family members are effecto

64 pe I cAMP-dependent protein kinase (PKA) and p90 ribosomal S6 kinase (RSK) in cardiomyocyte apoptosis

65 The present study evaluated the function of p90 ribosomal S6 kinase (RSK) in the Drosophila circadia

66 p90 ribosomal S6 kinase (RSK) is an important downstream

67 We demonstrate that p90 ribosomal S6 kinase (RSK) is recruited to the NFAT-D

68 involved in regulating transcription is the p90 ribosomal S6 kinase (RSK) isozyme, RSK2.

69 taining the carboxyl-terminal tails of three p90 ribosomal S6 kinase (RSK) isozymes (RSK1, RSK2, and

70 o regulate signaling through the Raf/MEK/ERK/p90 ribosomal S6 kinase (RSK) kinase cascade and show ho

71 af/MEK/extracellular signal-regulated kinase/p90 ribosomal S6 kinase (RSK) pathway.

72 We found that p90 ribosomal S6 kinase (RSK) phosphorylated serine 703

73 ied extracellular regulated kinase (ERK) and p90 ribosomal S6 kinase (RSK) proteins, we found several

74 In addition, depletion of p90 ribosomal S6 kinase (RSK) via siRSK1/2 completely ab

75 The p90 ribosomal S6 kinase (RSK), a cytosolic substrate for

76 tPA induced the phosphorylation of Erk1/2, p90 ribosomal S6 kinase (RSK), and p38 in a temporal ord

77 svirus (KSHV) causes sustained activation of p90 ribosomal S6 kinase (RSK), which is crucial for KSHV

78 te MAPK signaling by binding directly to the p90 ribosomal S6 kinase (RSK).

79 cribe a new negative regulator of IRS-1, the p90 ribosomal S6 kinase (RSK).

80 ent phosphorylation required the activity of p90 ribosomal S6 kinase (RSK).

81 osphorylation of serine 703 (Ser(P)(703)) by p90 ribosomal S6 kinase (RSK).

82 gated the role of the MEK kinase (MEKK)1/ERK/p90 ribosomal S6 kinase (RSK)1-dependent C/EBPbeta signa

83 kinase C (PKC), protein kinase B (PKB), p70/p90 ribosomal S6 kinases (RSK and S6K), and the catalyti

84 e demonstrate that DAPK is a novel target of p90 ribosomal S6 kinases (RSK) 1 and 2, downstream effec

85 The p90 ribosomal S6 kinases (RSK) are implicated in various

86 NTES induced phosphorylation of MEK, ERK1/2, p90 ribosomal S6 kinases (RSK), and cAMP-response elemen

87 ORF45 is a robust activator of the p90 ribosomal S6 kinases (RSK), and we found that this a

88 ERK leading to increased phosphorylation of p90-ribosomal S6 kinase (RSK) and a concomitant activati

89 lated by ERK via the "alternative" S6 kinase p90-ribosomal S6 kinase (RSK), as evidenced by the site

90 p90 ribosomal S6 kinase (RSK1) is an effector of both Ra

91 nd IL-15, but not IL-7, rapidly activate the p90 ribosomal S6 kinases, Rsk1 and Rsk2, in human T lymp

92 virus (KSHV), causes sustained activation of p90 ribosomal S6 kinases (RSKs) and extracellular regula

93 arcoma-associated herpesvirus interacts with p90 ribosomal S6 kinases (RSKs) and strongly stimulates

94 The p90 ribosomal S6 kinases (RSKs) are direct substrates of

95 The p90 ribosomal S6 kinases (RSKs) comprise a family of ser

96 The carboxyl-terminal domain (CTD) of the p90 ribosomal S6 kinases (RSKs) is an important regulato

97 p90 ribosomal S6 kinases (RSKs), containing two distinct

98 ed structure/function analysis of Drosophila p90 ribosomal S6 kinase (S6KII) or its mammalian homolog

99 extracellular signal-regulated kinase (ERK)/p90 ribosomal S6 kinase-signaling cassette.

100 s after phorbol ester stimulation in the ERK/p90 ribosomal S6 kinase-signaling targets, the tuberous

101 ate its substrates such as p70 S6-kinase and p90 ribosomal S6 kinase that do not interact with phosph

102 nt mechanism, unlike in macrophages in which p90 ribosomal S6 kinase was not required.

103 In addition, Raf-dependent activation of p90 ribosomal S6 kinase was only slightly impaired.

104 , extracellular signal-regulated kinase, and p90 ribosomal s6 kinase was suppressed by CPF or procyan

105 over, replacement of the ERK docking site of p90 ribosomal S6 kinase with the p38 MAPK docking site o

106 cardiac-specific overexpression of wild-type p90 ribosomal S6 kinase (WT-p90RSK-Tg) and a dominant-ne