ライフサイエンスコーパス: p90(rsk)

1 p90(rsk) is a distal member of the mitogen-activated pro

2 p90(rsk) was also detected in the GM-CSF-dependent eryth

3 racellular signal-regulated protein kinase 1-p90(rsk) signaling pathway.

4 Moreover, S6 kinase activity and p90(rsk) immunoreactivity co-immunoprecipitate with L1 f

5 t failed to prevent the increases in ERK and p90(rsk) activities.

6 increased J(H), as well as cellular ERK and p90(rsk) activities.

7 duced increases in J(H) and cellular ERK and p90(rsk) activities.

8 We hypothesize that FGF and p90(rsk) play heretofore unsuspected roles in modulating

9 mitogen-activated protein kinase (MAPK), and p90(rsk) activities were indexed on the basis of analysi

10 The clone p90(rsk-mo-1), isolated by others from a mouse library,

11 endogenous FGF signaling, leads to decreased p90(rsk) kinase activity.

12 evation of free beta-catenin levels, ectopic p90(rsk) was unable to rescue dorsal cell fate in embryo

13 of ERK, JNK, p38 and the downstream elements p90(rsk) and PP-1 in vivo suggest that JNK, but neither

14 -regulatory GSK-3 residue serine 9, we found p90(rsk) to be a potential upstream regulator of GSK-3.

15 s Raf-1, ERK2, and the previously identified p90(rsk) in brain.

16 dermal growth factor, the immunoprecipitated p90(rsk-mo-1) protein showed no measurable kinase activi

17 rophoretic mobility shifts in immunoreactive p90(rsk).

18 substrate RRLSSLRA evidenced an increase in p90(rsk) activity (3.4-fold).

19 er species and suggests that the deletion in p90(rsk-mo-1) may be a cloning artifact.

20 Instead, p90(rsk) overexpression increases the levels of beta-cat

21 ation of the ERK1 and the 90-kDa rpS6 kinase p90(rsk).

22 The ribosomal S6 kinase p90(rsk) was studied in mature and proliferating hemopoi

23 endent translocation of multifunction kinase p90rsk to polyribosomes; concomitantly, there is enhance

24 not of another putative IkappaBalpha kinase, p90(rsk).

25 this site was co-eluted with the S6 kinase, p90(rsk).

26 e p90rsk-activating kinase ERK-2 and a known p90rsk substrate, glycogen synthase kinase 3beta, which

27 tudy indicates the presence of a full-length p90(rsk-1) mRNA in mouse tissues that is homologous to t

28 the mitogen-activated protein kinase (MAPK)/p90(rsk) signaling cascade in a p53-independent fashion.

29 OSNs through Ca2+ activation of the ERK/MAPK/p90rsk pathway.

30 trated that the Ikappakappa complex, but not p90(rsk), is activated by HIV infection and mediates HIV

31 so demonstrate that the IKK complex, but not p90(rsk), is responsible for the in vivo phosphorylation

32 trates that I kappa B kinases (IKKs) but not p90rsk are selectively activated following CD23 cross-li

33 However, the activity of p90(rsk) in cytokine-starved cells increased dramaticall

34 onclusion that the first catalytic domain of p90(rsk) is responsible for its enzymatic activity towar

35 Overexpression of p90(rsk) in Xenopus embryos leads to increased steady-st

36 ated protein kinase activity (a substrate of p90(rsk)).

37 ated the presence of the full-length form of p90(rsk-1) in the mouse and showed no conclusive evidenc

38 y-dependent translation via translocation of p90rsk to ribosomes.

39 p90RSK2 (also referred to as MAPKAP-K1b, or p90rsk) immunoprecipitated the active 90-kDa kinase from

40 tive isoforms of protein kinase-C, p70S6K or p90rsk (all of which phosphorylate CREB at Ser133 in vit

41 activates both endogenous and overexpressed p90(rsk).

42 By comparison, expression of rat p90(rsk-1) resulted in significant kinase activity.

43 vity was transmitted to a downstream target, p90(rsk).

44 We show that p90(rsk) is a downstream target of fibroblast growth fac

45 The p90(rsk) isoform rapidly activated by insulin is identif

46 ique 33-nucleotide deletion not found in the p90(rsk) clones from any other species that have been ex

47 missing in the p90(rsk-mo-1) clone from the p90(rsk-rat-1) cDNA abolished kinase activity in the res

48 n of the 33-nucleotide region missing in the p90(rsk-mo-1) clone from the p90(rsk-rat-1) cDNA abolish

49 hese 33 nucleotides were introduced into the p90(rsk-mo-1) cDNA, the expressed protein showed signifi

50 mong the polyribosome bound proteins are the p90rsk-activating kinase ERK-2 and a known p90rsk substr

51 Thus, p90(rsk) is present in mature hemopoietic cells, but the

52 In turn, p90(rsk) interacts with the IkappaB kinase 2 (IKK-2) cat

53 d that the ERK-mediated effect may occur via p90(rsk).

54 To determine whether this 90-kD kinase was p90rsk (RSK), VSMCs were stimulated with 100 nmol/L angi

55 When p90(rsk-mo-1) was expressed in Cos-7 cells that were sub