ライフサイエンスコーパス: pKa

1 pKa values are noticeably different for both amino acids

2 pKa values for 5H(-) and 5H(2-) differ by about 4 units,

3 racy of these predictions is approximately 1 pKa unit and allows for a comparison of the acidity betw

4 ch smaller compared to that of pyridine 14a (pKa = 12.33), implying that the basicity, nucleophilicit

5 lated from the two-proton P(+)-Fe(III)(OH2)2 pKa(obs) and the porphyrin oxidation potentials, despite

6 r reactants with higher basic pK(a) > ca. 2 (pKa of conjugate acid).

7 an zero to 50 with a standard deviation of 3 pKa units for complexes of the metals chromium to nickel

8 mate of pKa) of 35 and spanning more than 30 pKa units, has been compiled.

9 xation to CB[7] increased the pKa for 4H(+) (pKa = 6.9) and changed its photochemical reactivity.

10 n of A1 toward neutrality by approximately 5 pKa units.

11 A pKa of 10.6 was estimated for [CpRe(PPh3)(NO)(CHOH)](+)

12 A pKa of 15.83 +/- 0.11 in acetonitrile was determined.

13 The activation step is enabled by a pKa > 8.6 deprotonation, which is assigned to Mn(II)-bou

14 peratively on two Mn(II) and is enabled by a pKa 7.6 double deprotonation.

15 is demonstrated that this residue exhibits a pKa of 10.5 +/- 0.1 that is insensitive to the presence

16 the protonation event (Hred/HredH(+)) has a pKa approximately 7.2.

17 NMR measurements indicated that D46 has a pKa of 5.6, approximately 2 units above the expected pKa

18 These nucleophiles have a pKa of >/=50, more than 25 orders of magnitude more basi

19 neutral forms of kyotorphin, resulting in a pKa value that is similar to the one obtained in water.

20 aring with the correlation, this indicated a pKa of about -2 units.

21 Raman spectroscopy tentatively assigns it a pKa of 7.4.

22 ion state of residue D198, which possesses a pKa above 8 and functions as a general acid to initiate

23 By NMR spectroscopy, a pKa value of 5.1 was determined for a (13) C2-labeled ad

24 l when G40 has an elevated pKa rather than a pKa shifted toward neutrality, although a balance among

25 This species is basic with a pKa of 24.3.2 is competent for concerted proton-electron

26 linear free energy relationship between acid pKa and second-order rate constants is observed for weak

27 are similar or more acidic than acetic acid (pKa = 13.5 (3(1)), 9.5 (3(2)), 7.3 (3(3)) vs 12.6 (HOAc)

28 most acidic (pKa(LAC) -18) to least acidic (pKa(LAC) 50).

29 e and dihydrogen complexes from most acidic (pKa(LAC) -18) to least acidic (pKa(LAC) 50).

30 t that factors other than the Lewis acidity (pKa) of the boronic acid are at play.

31 In agreement, pKa values for the buried histidines bridging internal A

32 es for biophysical studies, as their altered pKa values, relative to histidine, allow for studies of

33 optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active si

34 to observed trends in proton affinities and pKa values of 2,6-diarylanilines.

35 do ligand, together with the Sterimol B5 and pKa of HX, representing the X ligand.

36 nd its dependence upon the concentration and pKa of the external Bronsted acid proton source (water,

37 free-energy relationship between log kon and pKa, which provides information on the free-energy lands

38 There are links between pKa(LAC) and pKa(THF), pKa(DCM), pKa(MeCN) for neutral and cationic a

39 ods for calculating reduction potentials and pKa's for molecular electrocatalysts, as well as insight

40 hemical properties including log D, PSA, and pKa.

41 cular mechanical free energy simulations and pKa calculations, as well as experimental measurements o

42 e parameters such as metabolic stability and pKa.

43 four necessary and sufficient structural and pKa criteria that robustly predict the ability of nanopa

44 s (determined through cyclic voltammetry and pKa measurements) rule out a stepwise mechanism, and kin

45 lated through use of a weak acid (anilinium, pKa = 10.6 in CH3CN) to avert protonation of the singly

46 c, whereas at pH7.4, MAA chains are anionic (pKa approximately 5.2).

47 important, ionizable group with an apparent pKa of 7.5, which corresponds to the general base in ca

48 s as a steep function of pH with an apparent pKa of 7.4.

49 t variation of pH of the medium and apparent pKa values of the ionisable groups of curcuminoids.

50 pH units within the dynamic range (apparent pKa 7.23 +/- 1.0) of the nanosensors.

51 Second, the apparent pKa for the insertion transition (State I --> State III)

52 is coupled to protein folding; the apparent pKa of aspartic acid in the folded protein is 6.4.

53 within the H-cluster increasing the apparent pKa of its one electron reduced state.

54 conformational changes to raise the apparent pKa of protonated nucleobases to values above physiologi

55 tive and active configurations with apparent pKa values of 5.5-5.8.

56 using the pH(abs)(H(2)O) values and aqueous pKa values than by using the alternative means of expres

57 n free MD simulations and predicted an Arg52 pKa upshift with respect to PYP in solution.

58 of using simple reference equilibria such as pKa values as measures of leaving group ability.

59 e inactivation, could be related to the base pKa by means of a Bronsted relationship.

60 ar compounds and seven weak acids and bases (pKa = 3-5.2) selected from among industrial chemicals an

61 , pH-jump spectrophotometry revealed a basic pKa of 10.0 for the Fe(IV)-O-H of APO-II, indicating tha

62 There are links between pKa(LAC) and pKa(THF), pKa(DCM), pKa(MeCN) for neutral a

63 hts further explain the relationship between pKa and chloride anion affinity of these receptors that

64 nstrate the influence of acid choice, beyond pKa, on the kinetics of hydride formation.

65 A hydrogen-bonded, pKa (where Ka is the acid dissociation constant)-perturb

66 to deprotonate very weakly acidic C-H bonds (pKa > 40), generating carbon-centred nucleophiles that r

67 onated imidazolium state, but its calculated pKa is too low for this to provide the means to create a

68 olecule at particular pH based on calculated pKa values and provides the downloadable file in PQR for

69 Unconjugated Ch and CDC (pKa values of approximately 5.0) showed pronounced diffe

70 le of Fis1 Glu-78, whose elevated side chain pKa suggests participation in protein interactions.

71 with a perturbed pKa suggest that side chain pKa values inferred from routine NMR sample pH optimizat

72 ors contribute to the rise of the side-chain pKa (> 6) and to reduced polarity around the TM3 C termi

73 The polycation chitosan (pKa 6.4) has been used to efficiently purify DNA by bind

74 ially open beta-barrel where the chromophore pKa of 6.8 is shifted by over 20 units from that of the

75 bonds (CAHB) with solutes having comparable pKa.

76 explore a range of carefully chosen compound pKa values as part of an overall chemistry strategy or d

77 , whereas we used the theoretically computed pKa values for the isomerization steps.

78 within the range reported for the conducting pKa value of the His37 tetrad, we believe that this inte

79 ule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic

80 the mcb compounds) provided self-consistent pKa* values.

81 indicate aqueous acid dissociation constant (pKa) values of 1.5 +/- 1 for NH3Cl(+), 0.8 +/- 1 for NH3

82 The ionization constant (pKa) values at 8.3 and 8.0 reported for compounds A and

83 two resolved proton dissociation constants (pKa's) of 7.1 and 5.4, which differ from the TM result b

84 groups with low acid dissociation constants (pKa) as the main contributors to zeta-potentials and thu

85 These results support a mechanism of D198 pKa elevation through the unexpected sharing of a proton

86 n dA* is flanked by dA, the increased dA(*+) pKa results in DNA damage arising from hole transfer.

87 nks between pKa(LAC) and pKa(THF), pKa(DCM), pKa(MeCN) for neutral and cationic acids.

88 PUFA analogs with a decreased pKa value, to preserve their negative charge at neutral

89 Computationally derived pKa values, NICS aromaticity calculations, and electrost

90 The selection of calculated descriptors (pKa, EHOMO, and Eox) was based on validation with experi

91 two self-assembling DBS-acids have different pKa values, and as such, their self-assembly is triggere

92 The different pKa of the pyridine nitrogen in the closed spiropyran (4

93 (95%) was achieved based on their different pKa values.

94 nt cation solvation, resulting in diminished pKa(MeCN) values.

95 Measured DMSO pKa values for a series of rigid tricyclic adamantane-li

96 with the catalytic activity better than DMSO pKa values and appear to be a better measure of aciditie

97 found to increase with their basicity (i.e., pKa of their conjugated acids, BH(+)), consistent with t

98 atalysis is optimal when G40 has an elevated pKa rather than a pKa shifted toward neutrality, althoug

99 termination of the hydricities and estimated pKa's of the Rh(I) hydride complexes using the appropria

100 for BPS and BPAF, which have lower estimated pKa values than those for BPA.

101 ysis by forming an energetically exceptional pKa-matched hydrogen bond.

102 .6, approximately 2 units above the expected pKa of aspartate, due to a hydrogen-bond between protona

103 The differences in experimental pKa values between the isomers was found to arise from s

104 2 X, and a direct correlation with the first pKa of H2 X.

105 potential and pH plot occurred at the first pKa of succinic acid (pH 4.2), indicating succinate as t

106 The variability of the abiotic FnY pKa's (6.4 to 7.8) and reduction potentials (-30 to +130

107 ith the decrease in water concentration from pKa values of 3.8 in water to approximately 4.8 in water

108 spanning a wide range of base strength from pKa 9.64 to 5.24.

109 e-associated glycine-conjugated GC and GCDC (pKa values of approximately 3.9), no differences in the

110 hways gradually reduces as the leaving group pKa increases and creates mechanistic ambiguity for reac

111 plore the effect of modulating leaving group pKa on the competition between solvent- and substrate-as

112 turing gel electrophoresis and surface group pKa measurement.

113 NMR spectra allow the extraction of four H37 pKas and show that the pKas are more clustered in the mu

114 Amino-acid residues with high pKa are seldom considered as active transport elements i

115 ts are able to activate substrates with high pKa values, but background reactions are often unavoidab

116 m concentrations in case of thiols with high pKa values.

117 ccess to experimentally supported very high (pKa > 40) basicities in acetonitrile, which cannot be di

118 This suggests how high-pKa residues within a proton wire can act as a 'tunnel d

119 amino ozonides, consistent with their higher pKa and lower log D7.4 values.

120 We attribute this higher pKa to direct and indirect effects of the cytoplasmic do

121 hat the His-27 tetrad protonates with higher pKa values than His-19, indicating that the solvent-acce

122 Surprisingly the yield went down at higher pKas.

123 We show that it is 9.14, one of the highest pKa values ever reported for this amino group, providing

124 The average His37 pKa is higher for M2(21-97) than for the shorter constru

125 reduction substantially increases the His378 pKa Consistent with coupling between ASQ formation and H

126 H2(+) + X(-)) and allows very weak acids HX (pKa >/= 7.0) that cannot normally be detected by SCAC to

127 discussed a role for an elevated compound II pKa in diminishing the compound I reduction potential.

128 n selectivity through differential change in pKa of the peptides.

129 tronger acids, however, further increases in pKa do not correlate to increases in rate constants.

130 ximum (lambdamax) at pHs above the indicator pKa (the negative logarithm of the acid dissociation con

131 act angle titrations demonstrate interfacial pKa shifts for the lipid phosphate but not for the amine

132 tainty regarding the densities and intrinsic pKa values of edge functional groups.

133 oblem in light of new knowledge on intrinsic pKa values obtained over the past decade using ab initio

134 -tRNA cleavage revealed a single ionization (pKa approximately 8.7) important for catalysis, consiste

135 Tyr(71) , which should potentially lower its pKa.

136 in a specific binding pocket that raises its pKa toward neutrality, juxtaposes its N3 with the O5' to

137 elationship was discovered between the known pKa's of strong acids and the computed numbers of micros

138 This event is accompanied by a large pKa change of the imine similar to the pKa changes obser

139 on known analyte properties (lipophilicity, pKa, and polar surface area) using one preliminary exper

140 differed with regard to their lipophilicity, pKa values, and the size of their hydrophilic moiety.

141 es good estimates of the over 170 literature pKa values that range from less than zero to 50 with a s

142 quilibration of CO2 with carbonic acid-a low pKa acid.

143 Due to its relatively low pKa value, N-Cl-DCAM tends to deprotonate under typical

144 The strong influence of thiols with low pKa values emphasizes the relevance of the protonation s

145 larger acid-dissociation constants or lower pKa's.

146 tallography revealed a significantly lowered pKa of Tyr7 and how pH and Tyr proximity to Zn affect hy

147 We showed that NAC and acetic acid at pH < pKa can penetrate the matrix and eventually kill 100% of

148 bound Mg(2+)(H2O)5 complex lowers the lysine pKa and engages the NAD(+) alpha phosphate, but the beta

149 Spectrophotometrically measured pKa values are in excellent agreement with calculated va

150 The measured pKa was determined to be 23.8, in good agreement with th

151 nvironment causes a shift of the microscopic pKa at the N3 position of A1 toward neutrality by approx

152 The microscopic pKa values of titratable residues in BACE-1 including it

153 A new pKa prediction web server is released, which implements

154 ulfoglucosamine is explored through (1)H NMR pKa measurements but is not supported by the experimenta

155 The use of stabilized nucleophiles (pKa < 25, where Ka is the acid dissociation constant) in

156 RNA and DNA, which extends the capability of pKa calculations beyond proteins.

157 Conversely, the effect of pKa on the rate of dark recovery is markedly reduced in

158 ases in THF, reaching a pKalpha (estimate of pKa) of 35 and spanning more than 30 pKa units, has been

159 Estimation of pKa values of the acidic residues in the transport sites

160 A combination of measurements of pKa values, structural analyses of 2,6-diarylanilinium c

161 structures vary smoothly across the range of pKas studied and that the pathways remain discrete mecha

162 ervation indicated that Tyr7 has a perturbed pKa compared with free tyrosine.

163 ained by mutating a residue with a perturbed pKa suggest that side chain pKa values inferred from rou

164 are present in sufficient proportions (pH = pKa +/- 1.6): (i) self-/autocatalysis and (ii) sequentia

165 one to assess the ionized form of phenytoin (pKa~8.2) that corresponds to a negatively monocharged io

166 in the presence of a base, and the potential-pKa method considers stepwise transfer of a proton and t

167 , probing their 1 e(-) reduction potentials, pKa values, and 2 e(-)/2 H(+) reduction potentials.

168 MMS simulations with implicit sites produced pKas of all 9 ionizable groups and the results agree qua

169 In combination with pH-rate profiles, pKa and DeltaS() values, kinetic isotope effects ((2)H,

170 Protein pKa calculations of the transport site residues and stru

171 We performed protein pKa calculations and molecular dynamics (MD) simulations

172 c method for the deuteration of pseudoacids (pKa,DMSO = 14-19) with chloroform-d1.

173 ing to an enhanced basicity of the pyridine (pKa* approximately 12) and enhanced acidity of pyrrole (

174 imately 12) and enhanced acidity of pyrrole (pKa* approximately 8-9) enabling excited-state proton tr

175 I values based on the sum of protein residue pKa values.

176 Reversible pKa values in the range of 4-6.3 have been measured for

177 hat causes the large deviation in lysine66's pKa.

178 "(DMA)C" exhibits the same pKa and base pairing characteristics as native cytosine

179 with different steric profiles, but the same pKa.

180 In nanospheres, this pH-sensitive (pKa = 7.3), photochemically stable dye fluoresces in the

181 PrP/RaPrP, exhibited a markedly down shifted pKa 5 for both proteins.

182 aining "buried" residues with highly shifted pKa's, where local solvation around the protonation site

183 purpose [Hammett sigma constants (sigma(-)), pKas of the amines, and energies of the highest occupied

184 afluorophenylboronic acids but has a similar pKa.

185 ith a series of carboxylate bases of similar pKa but varying size.

186 ructed showing metal acids above the solvent pKa scales and organic acids below to summarize a large

187 roxide complex transitions to a new species (pKa = 13.1) with Mossbauer parameters that are indicativ

188 Residue-specific pKa values of D31, D33, D25, and D14 were determined to

189 mcb compounds had very similar ground state pKa's of 2.31 +/- 0.07, and their characterization enabl

190 ity of these compounds in the excited state (pKa* < 0).

191 Subsequent pKa studies demonstrated a remarkable electronic effect

192 contributed to suppression of the substrate pKa The same residues were critical for enzymatic cataly

193 c C-H bonds of ketone and alkyne substrates (pKa from 18.7 to 28.8) was found at room temperature.

194 y self-sorted nanostructures based on subtle pKa differences, whereas HCl addition leads to a rapid f

195 The results suggest pKa values of less than 3 for His(12) and about 3-5 for

196 Surface pKa prediction based on bond valence analysis suggests t

197 t hydrophilicity and hydrophobicity, surface pKa of the sorbent, and chemical structure of the parent

198 s triggers due to their approximate textbook pKa value of 6.1 for their side chains.

199 The pKa determined for RA was 4.31.

200 The pKa for the protonation of the pyridine nitrogen in 2-4

201 The pKa of amine conjugate acid and electronics of alcohol w

202 The pKa of His-305 is raised to 9.0, indicating the salt bri

203 The pKa of histidines in these domains are determined from t

204 The pKa of lysine side chains is around 10.5 and hence E3 li

205 The pKa of the nucleophilic cysteine, as well as the redox a

206 The pKa values calculated for acids that have bulky or large

207 The pKa values determined in acetonitrile range from 9.3 to

208 The pKa values of His residues in the studied oligopeptides

209 The pKa values of the conjugate acids of 1A and 9 in acetoni

210 low and N atom oxidation processes above the pKa value of the substituted aniline's conjugate acid.

211 Additionally, the pKa of KP1212 was measured to be 7.0, meaning a substant

212 ard neutrality, although a balance among the pKa's of A-1, G40, and the nonbridging oxygen is essenti

213 form of the imidazole compounds (B) and the pKa of their conjugated acids (BH(+)).

214 ge solvent isotope effect was found, and the pKa value was shifted to approximately 8.3 in D2O.

215 e H-bonding properties of the anions and the pKa values of the conjugate acids.

216 As the pKa of ionizable residues depends on their environment,

217 a-1H-pyrrolo[3,2-b]pyridine increased as the pKa of the amine buffer decreased.

218 vated Ascaris eggs when the pH was below the pKa for the acids, causing them to exist primarily in th

219 Tuning both the pKa and steric properties of an acid-additive is critica

220 ugar on either side of the membrane, but the pKa (the affinity for H(+)) decreases markedly.

221 threshold for protonation, determined by the pKa of the lipid head groups.

222 ynamic standard potential as dictated by the pKa of the proton donor.

223 use an EAAT3 homology model to calculate the pKa of several titratable residues around the glutamate

224 Ligand binding can change the pKa of protein residues and influence enzyme catalysis.

225 LHCII sensitivity to DeltapH by changing the pKa values of interacting LHCII residues.

226 In contrast, the pKa of N-terminal alpha-amino groups of proteins can var

227 udy we use NMR spectroscopy to determine the pKa for the N-terminal alpha-amino group of methionine1

228 dues of an iM structure and to determine the pKa of an iM.

229 independently varied by changing either the pKa of the base or the reduction potential (E degrees )

230 Finally, we evaluated the pKa of the substrate N5 position in closed and disordere

231 as reflected in a prominent decrease in the pKa of the primary proton acceptor residue (D97) and slo

232 However, reduction of 3.5 pH units in the pKa of Y21 increases the rate of dark state recovery by

233 reviously been attributed to a change in the pKa value of surface immobilized groups from that of sol

234 partially offset by opposite changes in the pKa, leading to modest differences in BDE among the thre

235 His-143 and His-189 also increase the pKa of the pyridine nitrogen but, more significantly, in

236 Complexation to CB[7] increased the pKa for 4H(+) (pKa = 6.9) and changed its photochemical

237 led to the pyridinyl nitrogen, increases the pKa of the pyridine nitrogen and stabilizes the pyridini

238 e different upon changing, for instance, the pKa of the acid HA versus the concentration or partial p

239 At pH 2.0, which is the pKa of the gum Arabic, the dissociation of precipitate o

240 red for proofreading; one helps to lower the pKa of the attacking water molecule, and the other helps

241 Its catalytic function is to lower the pKa of the hydroxyl group, making it a highly effective

242 p by Ca(2+) in the active site, lowering the pKa of the 3'-OH group.

243 rate of enzyme inactivation by lowering the pKa of their alpha-protons.

244 The catalytic metal lowers the pKa of O3' of the growing primer terminus, and the nucle

245 lytic" metal coordination complex lowers the pKa of the lysine nucleophile and stabilizes the transit

246 Mg(2+)(H2O)5 coordination complex lowers the pKa of the lysine nucleophile and stabilizes the transit

247 network in human serine racemase lowers the pKa of the Ser(84)re-face base.

248 In this manuscript, we measured the pKa values of histidines within the propeptides of furin

249 r [CpRe(PPh3)(NO)(CHOH)](+) by measuring the pKa for the analogous [CpRe(PPh3)(NO)(CMeOH)](+).

250 yrosine (F-Tyr) analogues that modulated the pKa and reduction potential of Y21 by 3.5 pH units and 2

251 portant electrostatic role in modulating the pKa of the N5 of DHF to enable the preprotonation of DHF

252 have developed an approach that monitors the pKa variations of ionizable residues over the course of

253 Comparison of the pKa values of 3-fluoro- and 3,3-difluoro-GABA with that

254 Estimation of the pKa values of all the ionizable groups in GLP-1 suggest

255 tivity for Na(+) Theoretical analysis of the pKa values of ion-coordinating acidic amino acid residue

256 the pH and ionic strength of the BGE on the pKa and actual mobility of each constituent in the syste

257 served shallow dependence of activity on the pKa of the substituted Tyr residues suggests that the KS

258 (P113S) appear to result from optimizing the pKa of Tyr-111, which acts as the catalytic acid during

259 chemical methods are employed to predict the pKa's of several families of dual hydrogen-bonding organ

260 To further probe the pKa of this residue, NMR spectroscopic measurements of [

261 ng the Na2 ion and the substrate reduces the pKa of this residue and favors the release of the proton

262 e ternary redox switch enables us to set the pKa to three different values, encompassing more than se

263 ly produced oxidants or through shifting the pKa values of His residues.

264 from positive to negative greatly shifts the pKa of tertiary amines of the PAMAM dendrimer interior.

265 We show that the pKa of an ammonium site located on the axle component of

266 We also find that the pKa of the catalytic His substantially increases in CmpI

267 Finally, we demonstrate that the pKa of the conserved histidine in proprotein convertase

268 Further, we predict that the pKa of the water molecule bridging two Mg cations is aro

269 large pKa change of the imine similar to the pKa changes observed in bacteriorhodopsin and visual ops

270 ich is significantly shifted compared to the pKa of the same adenine in the substrate alone.

271 When the pKa of the ammonium group is lower than that of the phen

272 e of 3 ionizable residues, we calculated the pKas of those residues both with all explicit states and

273 olvent effects and enabling estimates of the pKas in RSeOH and RSOH of ca. 15 and 10, respectively.

274 xtraction of four H37 pKas and show that the pKas are more clustered in the mutant channel compared t

275 lectronic features, were prepared, and their pKa values were determined using the bracketing indicato

276 est that the Lys-132 homolog modulates their pKa values.

277 O) values is possible if the change of their pKa values with solvent composition change is taken into

278 s indicate that the amine groups shift their pKa values due to the confined environment upon adsorpti

279 Given that their pKa's generally lie between those of typical hydrogen bo

280 n(3+) -bound water protons even though their pKa 's are much higher than the observed CEST or T2ex ef

281 ere are links between pKa(LAC) and pKa(THF), pKa(DCM), pKa(MeCN) for neutral and cationic acids.

282 Thiol pKa values are key indicators of thiol reactivity and fu

283 ation between intrinsic reactivity and thiol pKa, and the absence of deuterium solvent kinetic isotop

284 d therefore have broad application for thiol pKa determinations and verification.

285 hat enables reliable quantification of thiol pKa values for both mono- and dithiols in water.

286 or the first time the first and second thiol pKa values for 1,2-benzenedithiol in water.

287 The thiol pKa values and Raman activity relative to its internal r

288 rmined by UV-vis and fluorescence titration (pKa = 5.5 for 4).

289 n the crossover frequencies corresponding to pKa differences in the phenylboronic acid derivatives di

290 on enabled accurate determination of the two pKa values for the commonly utilized dcb ligand, pKa1 =

291 relation with hydrophobicity (log P values), pKa, and the inverse calculated surface tension was sign

292 induced desorption mechanism associated with pKa of the functionalized ligand as responsible for the

293 en fiber and water of anionic compounds with pKa approximately 5 (i.e., alkyl carboxylates) was domin

294 S-nitrosylation show little correlation with pKa values predicted from structures, although flanking

295 ized S = 9/2 forms as a function of pH, with pKa values in the range 8.3-9.0, because of protonation

296 Anionic surfactants with pKa </= 2 (i.e., alkyl sulfates and alkyl sulfonates) sh

297 idually, Glu-23 and Lys-36 both titrate with pKa values near 7.

298 hotoreaction was observed, the change in Y21 pKa led to a 4000-fold increase in the rate of dark-stat

299 e, we directly explore the effect of the Y21 pKa on dark state recovery by replacing Y21 with fluorot

300 In particular, a decrease in Y8 pKa by 2 or more pH units prevents formation of a stable

301 rast to AppABLUF, modulation in the Tyr (Y8) pKa has a profound impact on the forward photoreaction.