ライフサイエンスコーパス: pM

1 The detection limit is found to be 1.0 pM (S/N ratio=3).

2 determination of Cl(-) was found at the 1.0 pM level for both sensing systems.

3 s an excellent linear dynamic range of 100.0 pM to 10.0 nM Hg(2+) concentration with R(2) = 0.982.

4 e level for quantification purposes is 100.0 pM.

5 model target miRNA-21 in the 100 fM to 25.0 pM range.

6 It had a limit of detection equal to 5.0 pM AST (0.10 U L(-1)) with no need for the incubation pe

7 iRNA can detect in a range from 0.1 to 500.0 pM with a relatively low detection limit of 84.3 fM.

8 the target miRNA ranging from 2.0 fM to 8.0 pM, and the detection limit was 0.6 fM.

9 sensor exhibits high sensitivity (0.7859 m(0)pM(-1)) towards complementary DNA and can be used to det

10 ndwich assays were found as 0.3 pM and 0.008 pM, respectively.

11 the limit of detection was achieved as 0.02 pM.

12 Lys at wide linear concentration range (0.1 pM to 0.10 mM) with detection limit of 60 fM.

13 ble of ultra-low (limit of quantitation: 0.1 pM) detection.

14 from below the method detection limit (<0.1 pM) to as high as 2.64 pM.

15 Exposure to 0.1 pM, 10 pM, and 1 nM 17 beta-estradiol (E2) resulted in m

16 th a limit of detection of approximately 0.1 pM, is shown to scale with the magnetic focusing time an

17 51 nm and a limit of detection as low as 0.1 pM.

18 A limit of detection of 25.1 pM was obtained with our new system, with a single misma

19 th detection limits of 1.2 nM, 1.3 muM and 1 pM, respectively.

20 n human serum at a concentration as low as 1 pM for a total cycle time of about 1 min in a prototype

21 e method offers to detect HRP-II as low as 1 pM without any interference from some common salts and t

22 t 1 pM 22-OH-MaR1 and approximately 25% at 1 pM 14-oxo-MaR1, whereas 14-oxo-MaR1 was less active than

23 phage phagocytosis of approximately 75% at 1 pM 22-OH-MaR1 and approximately 25% at 1 pM 14-oxo-MaR1,

24 of 110, 235, 419, and 1613 nucleotides at 1 pM to 1 fM and found that the LOD decreased as DNA lengt

25 assay achieves a limit of detection below 1 pM, at a specificity down to single mismatch discriminat

26 o offers very good signal dynamics between 1 pM and 1 nM, thus, allowing reliable quantification of t

27 selectivity with a wide dynamic range from 1 pM to 100 nM.

28 0.85 pM in 60min with a dynamic range from 1 pM to 1000 pM, and could discriminate target DNA from mi

29 r with extremely different EC50 values of 1 pM and 50 nM, respectively.

30 ZnO-NFs with the lowest detection limit of 1 pM which is 100 times better than conventional enzyme-li

31 ay detected DNA molecule with LOD value of 1 pM with the ability to differentiate a spurious target c

32 The detection limits of less than 1 pM for the single-stranded ampR oligonucleotide and 4 pM

33 played so far among CEST agents (less than 1 pM of cells), and the natural origin of this system make

34 ensitive with a limit of detection down to 1 pM of thrombin.

35 strategy could detect target miRNA down to 1 pM with a dynamic range from 5 pM to 100 nM, and was suc

36 The sensitivity improved 100 times (to 1 pM) allowing us to detect low-abundance miRNAs in an RNA

37 finities with a limit of detection down to 1 pM, regardless of the analyte size.

38 ter DJB (SI = 1.14 +/- 0.32 x 10(-4) min(-1) pM(-1)) and jejunectomy (SI = 0.80 +/- 0.14 x 10(-4) min

39 nectomy (SI = 0.80 +/- 0.14 x 10(-4) min(-1) pM(-1)), but not after ileectomy or sham operation/pair

40 e observed for the detection of H2O2: (1) 10 pM-0.19 nM with sensitivity of 1.99 (+/- 0.058) microA p

41 U-87 MG cells was determined to be 92 +/- 10 pM.

42 surface-adsorbed mass, and approximately 10 pM for the glycan/lectins studied here.

43 The system detected as low as 10 pM of FR and captured 87% of the spiked KB cells at a vo

44 tched sequences, able to detect as low as 10 pM target ssDNA with a dynamic range from 10 pM to 100 n

45 his approach, as little as 500 attomoles (10 pM) could be detected with single nucleotide resolution.

46 Dialysate concentrations were below 10 pM for these peptides.

47 sis to achieve a limit of detection below 10 pM.

48 resents a very low detection limit of ca. 10 pM, (S/N=3) and a very high selectivity towards structur

49 pM target ssDNA with a dynamic range from 10 pM to 100 nM.

50 or 69-base single-stranded DNA targets is 10 pM (about 10 million copies for our sample volume) with

51 atic reactions and with a sensitivity of <10 pM target RNA.

52 We have found a limit of detection of 10 pM and a dynamic range of about two orders of magnitude,

53 nd thrombin concentration in the range of 10 pM-100 nM, and limit of detection (LOD) was 1.5 pM.

54 an impressive limit of detection (LOD) of 10 pM.

55 oncentration with a limit of detection of 10 pM.

56 o 100 nM, with a detection limit (LOD) of 10 pM.

57 1) to 5x10(-8) M and a detection limit of 10 pM.

58 Using these platforms, 10 pM platelet-derived growth factor (PDGF) are detected wi

59 Exposure to 0.1 pM, 10 pM, and 1 nM 17 beta-estradiol (E2) resulted in monotoni

60 mit from 6.1 nM (without NSs labeling) to 10 pM (with NSs labeling).

61 xhibits a large linear range from 1 fM to 10 pM, with a limit of detection (LOD) of 152.93 aM.

62 near dynamic range was observed from 1 to 10 pM.

63 e concentration (EC50 ) approximately 80-100 pM).

64 it is highest at the low ( approximately 100 pM) ART levels required for neurite outgrowth.

65 use of working concentrations as low as 100 pM enzyme.

66 a(2+) and Cd(2+) capable of detection at 100 pM concentrations was designed and synthesized.

67 ity was detectable in samples containing 100 pM of kinase.

68 tion constant, KD,eff, which varies from 100 pM to 1 muM for IgG concentrations from 1 ng mL(-1) to 1

69 it of 100 pM with a detection range from 100 pM to 3.5nM for norovirus was obtained.

70 d" inhibitor 1 (XAV939)(5), i.e., IC50 = 100 pM vs TNKS2 and IC50 = 6.5 muM vs PARP1 for 14.

71 rgets (LOD = 10 nM), PCR products (LOD = 100 pM), and direct, amplification-free detection from a bla

72 tection limit of this biosensor was low, 100 pM, and the materials used to fabricate this biosensor c

73 d the desired profiles (EC50 (hGLP-2R) < 100 pM, CL in rat <0.3 mL/min/kg, selective vs hGLP-1R and h

74 127 nm and have a limit of detection of 100 pM in serum.

75 ange from target ssDNA concentrations of 100 pM to 25 nM.

76 tammetric analysis, a detection limit of 100 pM with a detection range from 100 pM to 3.5nM for norov

77 in in human serum with a linear range of 100 pM-100 nM.

78 w 1 nM with a minimum detection level of 100 pM.

79 T4) (100 nM), and triiodothyronine (T3) (100 pM) alter intrafollicular mitochondrial energy metabolis

80 s the concentration range from 0.1 aM to 100 pM with a LOD of 1.8 aM.

81 Stimulation of the cells with 100 pM ART activated RET at the rate of approximately 10 mol

82 ensor responded linearly in the range 1-1000 pM of miRNA-21, with a limit of detection of 0.3 pM, goo

83 60min with a dynamic range from 1 pM to 1000 pM, and could discriminate target DNA from mismatched se

84 displays an inhibition potency (IC50) of 104 pM for the CT B-subunit (CTB), which is the most potent

85 ith a limit of detection (LOD) as low as 105 pM.

86 biosensor for 17beta-estradiol in the 0.9-11 pM range.

87 umor marker, with a limit of detection of 11 pM and C-reactive protein with a limit of detection of 2

88 based on the same binders (0.26 ng/mL or 11 pM).

89 the PD-1 ectodomain as a high-affinity (110 pM) competitive antagonist of PD-L1.

90 PDGF-AA:R2 KD = 530 nM, PDGF-AB:R2 KD = 110 pM, PDGF-BB:R2 KD = 40 nM, and PDGF-CC:R2 KD = 70 pM.

91 achieved a limit of detection (LOD) of 0.12 pM (3.0 attomoles) for the synthetic target and showed a

92 or GCSF, GCSF-Fc and PEG-GCSF were 37 +/- 12 pM, 75 +/- 13.5 pM and 46 +/- 5.5 pM, respectively.

93 ertain cell lines [e.g., Tb32 with IC50 = 12 pM against MES SA (uterine sarcoma) cell line and 2 pM a

94 A detection limit of 12 pM fluorescein was achieved when sampling 20 droplets, a

95 165 in sample solution in the range of 1-120 pM with a limit of detection of 0.32p M.

96 gher alphavbeta6 integrin affinities (23-120 pM) than the monomers (260 pM), the best results-that is

97 gher alphavbeta6 integrin affinities (23-120 pM) than the monomers (260 pM), the best results-that is

98 rom 1.2 to 240 nM and detection limit of 120 pM.

99 ffers an estimated limit of detection of 130 pM, which is the lowest ever reported among all syntheti

100 ct cocaine in serum with a LOD as low as 136 pM.

101 label-free impedimetric detection of OTA (14 pM; 5.65 ng/kg).

102 consensus design with a Kd approximately 140 pM.

103 sed 3-fold in response to LPS, to 116 +/- 15 pM, but remained below the approximate threshold for eli

104 n (LLOQ) values of 24 pM (=300 pg/mL) and 15 pM (=700 pg/mL), for total ProGRP and gamma-NSE, respect

105 This method offered a detection limit of 15 pM for free insulin present in serum.

106 ch, we have achieved a detection limit of 15 pM in LRET assays of human immunodeficiency viral DNA.

107 50 values over a wide range of potencies (15 pM to 9 mM).

108 concentration (S/N approximately 4.6 at 150 pM).

109 BSA at concentrations in the range from 150 pM to 15 muM (down to 3 orders of magnitude lower than t

110 cells in vitro with an affinity of 45 +/- 16 pM.

111 ensitive assays that can detect as low as 16 pM Ebola Virus DNA, 0.01ng/mL carcinoembryonic antigen (

112 y, the limit of detection was 0.38 ng/mL (16 pM), which was comparable to the limit of detection for

113 echnology has a detection limit of about 160 pM and a dynamic range of about two orders of magnitude.

114 st potent compound (ML10) has an IC50 of 160 pM in a PfPKG kinase assay and inhibits P. falciparum bl

115 ibits an in vitro inhibition constant of 165 pM against the BoNT/A catalytic chain.

116 to detect it in the concentration range, 180 pM to 5 pM with detection limit as 4.21 pM.

117 S,S,S,S)-stereochemistry (EC50 = 3.4 +/- 0.2 pM, HCV replicon genotype 1b), was dramatically more act

118 were replaced with lower concentrations (1-2 pM) of hydrophilic ferrioxamine siderophores.

119 affinities (Kd, Adnectin1 approximately 6.2 pM vs Kd, Adnectin2 approximately 46 nM).

120 ower limit of detection (LLOD) values of 7.2 pM (=90 pg/mL) and 4.5 pM (=210 pg/mL) and lower limit o

121 Compound 15 h, with PDE10A Ki of 8.2 pM, LE of 0.49, and >5000-fold selectivity over other PD

122 nst MES SA (uterine sarcoma) cell line and 2 pM against HEK 293T (human embryonic kidney) cell line],

123 edented limit of detection (LOD) as low as 2 pM.

124 FIAVSAANRFKKIS) in presence of calcium (KD~2 pM), which can be reversed by EDTA allowing controlled "

125 igated in the concentration range of 0.01-20 pM and the limit of detection was achieved as 0.02 pM.

126 in the concentration range from 0.16 to 1.20 pM with a detection limit of 28 fM.

127 The Fab has a 20 pM affinity for ticagrelor, which is 100 times stronger

128 pTEFb was determined to be approximately 20 pM, and only 7% of purified Tat was found to be active i

129 es from their whole genome template to be 20 pM.

130 ange (0.1-100 nM), a low detection limit (20 pM) and high reproducibility (4.4% RSD) for complementar

131 A detection limit (DL) of 20 pM (20 femtomoles, 1 mL) is estimated from the sigmoidal

132 ated in terms of sensitivity and a LOD of 20 pM was achieved on fluorescent glass microarray.

133 served in the same cells treated with 20-200 pM EGF in vitro.

134 trated the detection of 100 KB cells and 200 pM FR spiked into healthy human blood to simulate detect

135 3 immunosensor was found between 0.2 and 200 pM with a calculated limit of detection of 22.8 fM.

136 n constants (Kd) are low, between 10 and 200 pM.

137 rleukin-2 concentrations from <20 fM to >200 pM were demonstrated, surpassing the conventional NWFET

138 s found in the sub-nanomolar range (LOD ~200 pM), which is 1-4 orders of magnitude higher than necess

139 n by 25-fold compared with the 75-mer to 200 pM.

140 ith a limit of detection (LOD) as low as 209 pM.

141 180 pM to 5 pM with detection limit as 4.21 pM.

142 gh sensitivity (with a detection limit of 22 pM for Hg(2+) and 20 nM for Pb(2+)) and selectivity with

143 er limit of quantitation (LLOQ) values of 24 pM (=300 pg/mL) and 15 pM (=700 pg/mL), for total ProGRP

144 pyoS2 (pyoS2(NTD)) bound to FpvAI (Kd = 240 pM) reveals that the pyocin mimics Fe-Pvd, inducing the

145 The FR concentration was measured to be 244 pM (including the intrinsic FR present in the blood), an

146 ted potassium channel-complex antibody (2442 pM).

147 apable of measuring Ki values as low as 0.25 pM, is well-suited for characterizing the next generatio

148 ion in an activity assay to be reduced to 25 pM, which is close to the Kd value of the protease dimer

149 tion of rhodopsin to 11CR and opsin has a 25-pM equilibrium dissociation constant, which corresponds

150 The assay gave a linear range of 2-250 pM for both targets, with LOD values of 650 fM (160 amol

151 entration of VEGF165 in the range of 2.5-250 pM with a limit of detection of 0.48 pM.

152 Rs in water and concentrations as low as 250 pM in the circulation of living mice.

153 current response (83 pA) and frequency (0.26 pM(-1) s(-1)) were on the same order of magnitude as the

154 ffinities (23-120 pM) than the monomers (260 pM), the best results-that is, low background uptake and

155 ffinities (23-120 pM) than the monomers (260 pM), the best results-that is, low background uptake and

156 ines with a limit of detection as low as 266 pM for tetracycline.

157 with a limit of detection (LOD) as low as 27 pM.

158 mplex was applied, a detection limit of 1.28 pM for the fully complementary target was obtained.

159 mit of detection (LoD) based on 3sigma is 28 pM Hg(2+), while the lowest detectable level for quantif

160 tive protein with a limit of detection of 28 pM.

161 ct cocaine in serum with a LOD as low as 293 pM.

162 direct and sandwich assays were found as 0.3 pM and 0.008 pM, respectively.

163 ent from ca. 4.7 pM in a simple assay to 0.3 pM in the amplified reported scheme.

164 ear range of 6 orders of magnitude (from 0.3 pM to 3 aM) with limit of detection (LOD) down to 52.5 z

165 f miRNA-21, with a limit of detection of 0.3 pM, good reproducibility (Relative Standard deviation (R

166 ic evaluation software, and found to be 15.3 pM (KD) and 81.02m degrees (Bmax) with probe 1 and 54.9p

167 CV inhibitor, with an EC50 range of 1.7-19.3 pM against GT1a, -1b, -2a, -2b, -3a, -4a, and -5a and 36

168 M-500microM at pH=7.4 and LOD is 2.8 and 3.3 pM at pH=7.4 and 9.0, respectively, which were reported

169 A limit of detection of 0.2 ng/mL (3.3 pM) capsid proteins was achieved with convenient UV abso

170 the comparison coastal sites (average = 0.30 pM), and were as high as 9.5 pM during the M. angustiros

171 FP, have very high affinities of about 10-30 pM, and extremely slow off-rates.

172 BRD4 protein at concentrations as low as 30 pM in the RS4;11 leukemia cell line, achieves an IC50 va

173 ted in a range of concentrations between 300 pM and 100 nM, in buffer and in diluted bovine serum.

174 to 10(-8) M with a limit of detection of 300 pM (calculated) and 10 nM (measured).

175 aptamer targeting interferon-gamma (KD of 33 pM) survived in human serum at 37 degrees C after 3 days

176 interaction for the first time with KD = 340 pM.

177 with a dissociation constant of less than 35 pM, as measured by surface plasmon resonance.

178 of EV concentration ranging from 35 fM to 35 pM, which matches the typical range of EV concentration

179 se against EIS from 0.1 to 100pg/ml 3.5-3500 pM.

180 1a, -1b, -2a, -2b, -3a, -4a, and -5a and 366 pM against GT6a.

181 8, 25.08), fasting proinsulin (betaPFOS=1.37 pM; 95% CI: 0.50, 2.25; betaPFOA=1.71 pM; 95% CI: 0.72,

182 low limits of detection for Cyt c (LOD = 370 pM) and for BSA (LOD = 1.8 nM) have been achieved even f

183 d with a picomolar binding affinity (Ki = 38 pM), coupled with a single-digit micromolar activity aga

184 M) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor.

185 ed DNA target with a detection limit of 1.39 pM.

186 half-maximal effective concentration of 0.4 pM.

187 be specific, with an affinity of 6.4 +/- 0.4 pM.

188 ced by a factor of 17,000 from 110 nM to 6.4 pM as the PS density in the membrane was increased from

189 e single-stranded ampR oligonucleotide and 4 pM for the double-stranded target can reliably be achiev

190 and CeO2 NPs with high affinity (135 and 40 pM, respectively) and to Al2O3 NPs with moderate affinit

191 an exceedance of the permissible 10 ng/L (40 pM) limit for B[a]P is detectable in an unprecedented sh

192 ge J software, and the detection limit of 40 pM was obtained.

193 f the 32 patients with low-positive (100-400 pM) levels were considered definitely autoimmune, 3 with

194 Of the 23 patients with high-positive (>400 pM) levels, 12 were given immunotherapies, 11 of whom sh

195 a limit of detection (LOD) of 10 ng/mL (400 pM), attributed to the significant reduction of the net

196 o-4H-chromene-3-carboxamide (20) (IC50 = 403 pM) and N-(3',4'-dimethylphenyl)-4-oxo-4H-chromene-3-car

197 ifference of SD of residuals: Abeta40, -7.42 pM; P < .001; Abeta42, -3.72 pM; P < .001).

198 y high binding affinity by 2 (41-nt, KD = 45 pM) and high specificity by 10, was used successfully to

199 ith a limit of detection (LOD) as low as 450 pM.

200 icol with a limit of detection as low as 451 pM.

201 nd a limit of detection of 70 mug L(-1) (460 pM) was achieved.

202 current response (75 pA) and frequency (0.47 pM(-1) s(-1)) of single Escherichia coli collisions.

203 2.5-250 pM with a limit of detection of 0.48 pM.

204 ates for the detection of miRNA222 (LOD: 485 pM), paving the way for the application of the developed

205 est discrimination was obtained using TF 0.5 pM and assay measures: endogenous thrombin potential (ET

206 ion of PvuII at concentrations as low as 0.5 pM in a volume of 0.025 muL (corresponding to ~7500 prot

207 ssay allows detection of PDGF BB down to 0.5 pM, with linearity of the Raman signal of 4-MBA against

208 miRNAs in EL at concentrations as low as 0.5 pM.

209 100 nM, and limit of detection (LOD) was 1.5 pM.

210 and PEG-GCSF were 37 +/- 12 pM, 75 +/- 13.5 pM and 46 +/- 5.5 pM, respectively.

211 entrations around the rookery (average = 2.5 pM) were markedly higher than those at the comparison co

212 y revealed a limit of detection (LOD) of 3.5 pM for atrazine, which, to the best of our knowledge, is

213 ction limit as low as 0.0025 mug L(-1) (32.5 pM) was achieved.

214 (LLOD) values of 7.2 pM (=90 pg/mL) and 4.5 pM (=210 pg/mL) and lower limit of quantitation (LLOQ) v

215 37 +/- 12 pM, 75 +/- 13.5 pM and 46 +/- 5.5 pM, respectively.

216 (average = 0.30 pM), and were as high as 9.5 pM during the M. angustirostris molting season.

217 RNA down to 1 pM with a dynamic range from 5 pM to 100 nM, and was successfully applied to the determ

218 added oxidant, and a limit of detection of 5 pM.

219 his detection limit was further lowered to 5 pM by designing serum insulin conjugates with poly(acryl

220 t it in the concentration range, 180 pM to 5 pM with detection limit as 4.21 pM.

221 ly sensitive detection of thrombin down to 5 pM.

222 s deposition time and the LOD is equal to 5 pM.

223 against the concentration of PDGF over 1-50 pM.

224 be assayed from concentrations as low as 50 pM (an order of magnitude lower than that detectable by

225 ylori MTAN with dissociation constants of 50 pM or below.

226 and investigations resulted in an LOD of 50 pM.

227 , MAIT cell activation potencies (EC50 3-500 pM), and chemical stabilities are described.

228 interactions with Kds ranging from below 500 pM to above 300 muM.

229 Addition of recombinant human sDLK1 (500 pM) to pre-adipocyte cultures reduced adipogenesis, as a

230 emia cell line, achieves an IC50 value of 51 pM in inhibition of RS4;11 cell growth and induces rapid

231 to be approximately 16 and approximately 53 pM, respectively.

232 ompetitive inhibitor with an affinity of 545 pM for thrombin and is 4 orders of magnitude more select

233 dissociation constant was estimated to be 55 pM.

234 ust 5 min, achieving a detection limit of 55 pM (1.1 fmol), and the combined competitive-amplificatio

235 , and m338 was even higher: 99, 820, and 560 pM, respectively.

236 ction limit of the proposed strategy is 0.58 pM, which is about 3 orders of magnitude better than the

237 h LC50 values of 1.5 +/- 0.5 and 2.0 +/- 0.6 pM, respectively, and selectivities of >11.6 versus the

238 for ALP was estimated to be 0.02 units/L (~6 pM; 1 ng/mL).

239 displayed lowest detection limit (LOD) of 6 pM which is the lowest LOD ever achieved for the detecti

240 e SNP (G-T mismatches) in the range of 2-600 pM.

241 otein expression at low doses in vitro (<600 pM) and in vivo (1 mg kg(-1) ).

242 new ISRIB analogs, improving its EC50 to 600 pM in cell culture.

243 l in milk and serum with LODs of 697 and 601 pM, respectively.

244 detection limit (<0.1 pM) to as high as 2.64 pM.

245 ent) rounds, showing high senstivity (KD ~65 pM).

246 o-4H-chromene-3-carboxamide (27) (IC50 = 669 pM), acting as competitive and noncompetitive reversible

247 itions, the limit of detection (LOD) was 0.7 pM miR-221 (15% RSD).

248 The detection limit is estimated to be 0.7 pM.

249 V) across a range from nearly 27.4 fM to 1.7 pM using the described collection method.

250 detection, with an improvement from ca. 4.7 pM in a simple assay to 0.3 pM in the amplified reported

251 ity for quantum dot quantification down to 7 pM.

252 nm diameter with a binding constant of k=1.7(pM)(-1), sensitivity of 6.9nm/ng/mm(2) and limit of dete

253 DGF-BB:R2 KD = 40 nM, and PDGF-CC:R2 KD = 70 pM.

254 c working range of 3 orders of magnitude (70 pM to 70 nM) for visual quantification.

255 fied by relatively small increases (15 to 70 pM) in plasma insulin concentrations.

256 S=1.37 pM; 95% CI: 0.50, 2.25; betaPFOA=1.71 pM; 95% CI: 0.72, 2.71), and glycated hemoglobin (HbA1c)

257 k and serum samples with LODs of 740 and 710 pM, respectively.

258 Abeta40, -7.42 pM; P < .001; Abeta42, -3.72 pM; P < .001).

259 ing 100-fold more active (IC50 values, 50-75 pM vs. 7 nM; HCT116), and that are now accessible becaus

260 for both ENRO and CIPRO were achieved at 2.8 pM.

261 The limit of detection is as low as 80 pM.

262 (interquartile range) MBG was 583 (383-812) pM.

263 anavir were determined to be 135, 10, and 82 pM, respectively.

264 electrochemical biosensor is found to be 83 pM.

265 target DNA at the concentration down to 0.85 pM in 60min with a dynamic range from 1 pM to 1000 pM, a

266 )RHigh (mean inhibition constant [K(i)] = 85 pM) and excellent selectivity against the low-affinity s

267 g Apta-PCR achieving a detection limit of 85 pM (25 ng mL(-1)).

268 s B virus (HBV) with a detection limit of 85 pM.

269 trations in iron-deficient waters averaged 9 pM, up to fivefold higher than in iron-rich coastal and

270 ction limit of the sensor is found to be ~90 pM or ~11 ng/ml, which is in the clinically relevant ran

271 25 nM with a limit of detection (LOD) of 90 pM.

272 3002 in these same cells was from 490 to 920 pM.

273 ly lower than those from California (154-933 pM; p<0.0001) showing IMMULITE's robustness against the

274 oncentrations from Bangladeshi women (72-959 pM) were significantly lower than those from California

275 ilibrium dissociation constants as low as 97 pM: >200-fold better than either component aptamer.

276 avy chain germlines generated high affinity (pM) antibodies that neutralize the two IsdB NEAT domains

277 ic current are linear from 1 to 30 ng/mL and pM concentrations can be detected without the need for m

278 proach has been explored to detect beta-A at pM levels within 30-40 min compared to 6-8h of ELISA tes

279 EBOV immunosensing can detect virus level at pM concentration within approximately 40min compared to

280 surements showed that this platform exhibits pM-range sensitivity, high specificity and good reproduc

281 is performed over a concentration range from pM to nM.

282 m samples at clinically relevant levels (low pM range) was also demonstrated, thus illustrating the p

283 antification goal of single-digit ng/ml (low pM) at a signal-to-background ratio greater than 5, (iii

284 bound HIV-1 RT with KD,app values in the low pM range under different ionic conditions.

285 At low (pM) concentrations, the hydroxymethylated cytosine produ

286 odexetimide displayed high affinity for M1R (pM range), with modest selectivity over other mAchRs.

287 with sensitivity of 1.99 (+/- 0.058) microA pM(-1)cm(-2) and (2) 0.25 nM-2.24 microM with sensitivit

288 limits of detection (LODs) in the picoMolar (pM) range.

289 ar, with in vitro activity in the picomolar (pM) to low nanomolar (nM) range.

290 A sub-pM concentration of plasminogen (but not plasmin) acting

291 NTAdeCage binds Zn(2+) with sub-pM affinity using a modified nitrilotriacetate chelator

292 We have achieved a LOD in the pM order and have assessed the feasibility of directly m

293 -based assays showed detection limits in the pM range and polymer-coated microplates are stable to st

294 sor showed a Limit of Detection (LoD) in the pM range, stability (up to 42 days) and re-usability (up

295 tide sequences with a detection limit in the pM range.

296 6h, which were substantially higher than the pM concentrations required for therapeutic activity.

297 cy by >1,000-fold, restoring activity to the pM range.

298 quantification can be estimated in the nM to pM range.

299 The prototype assay was sensitive to pM concentration of analyte.

300 catalyst and substrate (S) are ultradilute (pM-low muM) and the oxidant is very dilute (high nM-low