ライフサイエンスコーパス: pS

1 pS(9)-GSK3beta and CDC25A were selectively expressed in

2 la) residues increases gamma to 36.5 +/- 1.0 pS.

3 od junctional conductance to approximately 0 pS, regardless of the time of day or the mouse strain.

4 The 100, 700, and 1,000 pS conductances exhibited different channel characterist

5 (8.04 +/- 0.02 pS) and absence (7.6 +/- 0.01 pS) of 10 microM retigabine.

6 e conductance in the presence (8.04 +/- 0.02 pS) and absence (7.6 +/- 0.01 pS) of 10 microM retigabin

7 d normalized conductance values of 0.02-0.05 pS mum(-2) and breakdown voltages of 400-600 mV.

8 wed a mean unitary conductance of 13.1+/-0.1 pS in 15 cells, which corresponded with I(K1) in sheep a

9 sponded with I(K1) in sheep atria (9.9+/-0.1 pS in 32 cells).

10 small conductance subtype, G25, was 22 +/- 1 pS; the intermediate conductance channel, G35, was 33 +/

11 diate conductance channel, G35, was 33 +/- 1 pS; and the large conductance channel, G45, was 45 +/- 1

12 ings to a single conductance level (41 +/- 1 pS, n = 12).

13 large conductance channel, G45, was 45 +/- 1 pS.

14 ance levels (28 +/- 2, 38 +/- 1 and 46 +/- 1 pS, n = 7, one level per cluster, all levels being detec

15 Levels of IRS-1 pS(6)(1)(6) and IRS-1 pS(6)(3)(6)/(6)(3)(9) and their ac

16 in IRS-1 phosphorylated at serine 616 (IRS-1 pS(6)(1)(6)) and IRS-1 pS(6)(3)(6)/(6)(3)(9).

17 Levels of IRS-1 pS(6)(1)(6) and IRS-1 pS(6)(3)(6)/(6)(3)(9) and their activated kinases correl

18 at serine 616 (IRS-1 pS(6)(1)(6)) and IRS-1 pS(6)(3)(6)/(6)(3)(9).

19 the opening of large-conductance (237 +/- 10 pS; BK) channels.

20 oligomers producing ion conductances of <10 pS/pore.

21 nnels (i.e. single channel conductance of 10 pS and sensitivity to intracellular Ca(2+)) in PDGFRalph

22 ed the appearance of spontaneously active 10-pS channels.

23 gonucleotide experiments showed that this 10-pS channel is formed from alpha- and beta-ENaC.

24 s revealed gamma(j) of the size range 40-100 pS.

25 , a ranging conductance of approximately 100 pS that is reduced to 54% by calcium, permeating calcium

26 annel had a conductance of approximately 100 pS, consistent with the hypothesis that it underlies an

27 ied the existence of 71 +/- 6 and 161 +/- 11 pS single-channel K(+) currents that were sensitive to c

28 conductance of the channels to be 244 +/- 11 pS (n = 17; symmetrical 150 mm K(+) ) with open probabil

29 channel conductance of AMPARs in SCs is 8-11 pS, which is comparable to that in neurons.

30 e lowest conductance state (approximately 11 pS) was the most sensitive to Zn(2+) inhibition in accor

31 wer main conductance state (approximately 11 pS).

32 nrectifying single channel conductance of 11 pS, substates, and an approximately 3:1 Na(+)/K(+) perme

33 57 pS) is only 2-fold smaller than Cx43 (110 pS).

34 e principal unitary conductance - 22 pS, 111 pS and 178 pS.

35 ion in the prevalence of a TEA-sensitive 113 pS channel in neurones from TG2576 mice with a correspon

36 al unitary conductances of around 18 pS, 118 pS and 185 pS were also observed in cell-attached record

37 pe conductance at negative potentials was 12 pS.

38 average a single-channel conductance of 125 pS in 150 mM KCl and were found to be cation selective.

39 Cx40 single channel conductance was 129 pS in the presence of 2-mM spermine and channel open pro

40 me of small conductance K(+) channels (13-14 pS) from 0.0007 +/- 0.0007 to 0.0053 +/- 0.0042.

41 er conductance channel of approximately 7-14 pS.

42 hannels, in addition to the approximately 14 pS (TASK-1-like) channel.

43 with conductance levels of approximately 14 pS and approximately 32 pS were recorded at a membrane p

44 operties similar to TASK-1 (approximately 14 pS), TASK-3 (approximately 32 pS) and TASK-1/3 heteromer

45 tance in symmetrical K+ was approximately 14 pS.

46 tween dark-adapted rods is approximately 140 pS, regardless of the time in the circadian cycle.

47 sed SR Ca(2+) indicator), IP(3) activated 15 pS sarcolemmal cation channels, generated a whole-cell c

48 , which increased from ~12 (proximal) to 150 pS mum(-2) (distal).

49 er limit for the membrane conductance of 158 pS.

50 wild-type in density in RyR1 KO (195 +/- 16 pS/pF) and was significantly enhanced in double beta1/Ry

51 uctance 13 picosiemens (pS) at +60 mV and 16 pS at -60 mV.

52 subunits and has a unitary conductance of 16 pS.

53 nitary junctional conductance (gamma(j); 160 pS) was only slightly altered, and the relative cation/a

54 NMCC exhibits a unitary conductance of ?160 pS and high, voltage-independent open probability.

55 e a single-channel conductance (gamma) of 17 pS and that an average of just seven receptors mediates

56 unitary conductance - 22 pS, 111 pS and 178 pS.

57 enhanced in double beta1/RyR1 KO (115 +/- 18 pS/pF) myotubes.

58 principal unitary conductances of around 18 pS, 118 pS and 185 pS were also observed in cell-attache

59 ad a single-channel conductance of around 18 pS, and inactivated with a time constant of 98 +/- 4 ms

60 Between 18 pS and 41 pS conductance levels, direct transitions were

61 annel in Task-1(-/-) cells and a smaller (18 pS) K(+)-channel in Task-3(-/-) cells.

62 conductances of around 18 pS, 118 pS and 185 pS were also observed in cell-attached recordings from t

63 lta1-54 produced approximately 90 pS and 188 pS channels, respectively.

64 exhibited a limiting slope conductance of 19 pS and were not observed in dendritic membrane patches.

65 tance reached a maximum of approximately 190 pS at saturating [K(+)], a value 4- to 5-fold larger tha

66 ed to the 1.8 pS level and an additional 1.2 pS channel conductance was resolved.

67 onductance (gamma) from gamma = 6.9, to 11.2 pS, when glutamate was increased from 10 mum to 10 mm.

68 r that those of KCNQ4 and KCNQ5 (2.1 and 2.2 pS, respectively).

69 channel conductance was determined to be 3.2 pS, but unlike any other known wild-type human potassium

70 urrents had a unitary conductance of about 2 pS.

71 Icat2) with a conductance of approximately 2 pS.

72 had unitary conductances of approximately 2 pS.

73 PTA), 1 nm and 10 nm Ang II activated both 2 pS TRPC1/C5 channels and 15-45 pS TRPC6 channels in the

74 and with excellent detection sensitivity (~2 pS).

75 YM 2081 exhibited conductance levels of 2-20 pS.

76 estimated to be 115 +/- 34 pS and 74 +/- 20 pS, at 150 mV and 75 mV, respectively, in satisfactory a

77 K), indirectly activates an approximately 20 pS channel in isolated glomus cells.

78 of mCx30.2 hemichannels was approximately 20 pS, about twice the cell-cell channel conductance.

79 tion with single-channel conductances of 20 pS for inward currents and 80 pS for outward currents.

80 threshold [Ca(2+)]i for activation of the 20 pS channel in cell-attached patches was approximately 20

81 The reversal potential of the 20 pS channel was estimated to be -28 mV.

82 The 20 pS channel was not sensitive to voltage.

83 The 20 pS channel was permeable to K(+), Na(+) and Cs(+) but no

84 a(2+) channel with FPL64176 activated the 20 pS channel when 1 mm Ca(2+) was present in the external

85 side of inside-out patches activated the 20 pS channel.

86 ons between the closed and approximately 200-pS conductance state.

87 ons between the closed and approximately 200-pS open state while simultaneously reducing transitions

88 EK-2L phenotype shows a full open state (202 pS) with several short-lived sub-conductance levels.

89 However, membrane stretch can activate a 21-pS nonselective cation channel.

90 m) reduced the frequency of observance of 21-pS alpha-ENaC channels and simultaneously induced the ap

91 educed the frequency of observance of the 21-pS alpha-ENaC channel but induced the appearance of a 5-

92 el currents had a unitary conductance of 210 pS, typical of Cx50.

93 ere three principal unitary conductance - 22 pS, 111 pS and 178 pS.

94 Na+ and K+ and has a slope conductance of 22 pS.

95 d a channel conductance of approximately 220 pS in Ca(2+)-free saline.

96 imately 52 pS) and large ( approximately 220 pS) unitary conductance levels.

97 arge-conductance channel ( approximately 220 pS).

98 y coupled with an average conductance of 220 pS, whereas coupling is undetectable in blue-green cone

99 etrical junctional conductances G(j) (40-223 pS) and a rank order: Rod(C)-large single cone, rod-larg

100 conductance channel ( approximately 185-224 pS).

101 ether, these findings identified a novel 225 pS channel as the native mitochondrial ryanodine recepto

102 The 225 pS cation-selective channel exhibited multiple subconduc

103 nnels have a conductance of approximately 23 pS.

104 23C single-channel conductance from 40 to 23 pS but did not produce complete block.

105 e sum of these two conductances averaged 235 pS.

106 ction and caused a reduction in NPo of a 238 pS arterial KCa channel current and an increase in [Ca(2

107 mallest conductance state of alamethicin (24 pS) at an unprecedentedly high bandwidth of 10.7 kHz.

108 +) current with a unitary conductance of 246-pS in freshly isolated coronary SMCs.

109 eta2 subunits seemed responsible for long 25 pS nAChR events, whereas those containing beta2 subunits

110 as a low conductance (7 pS) channel and a 25-pS channel, the most striking finding was the presence o

111 nels x open probability (NP(o)) of a 230-250 pS K(+) channel was significantly increased after FN app

112 conductance states in the range of 15 to 250 pS, with a larger open probability at 0 mV as compared w

113 ngle channels had a conductance close to 250 pS, within the range of all known BKCa channels.

114 M) K(+) the channel mean conductance was 265 pS, the current reversing at approximately 0 mV.

115 vealed that the channel conductance of 25-27 pS was unaffected by the agonists.

116 high main conductances (approximately 25-28 pS) for gamma2 or delta subunit-containing receptors whe

117 two main conductance levels of 45 pS and 28 pS when the extracellular Ca(2+) concentration was 0.5 m

118 >288 pS for most flickers, but within 15-288 pS for the remaining flickers.

119 ef capacitance flicker (<2 s) with G(p) >288 pS for most flickers, but within 15-288 pS for the remai

120 Large G(p) (>288 pS) might discharge transmitter rapidly and thereby caus

121 y >375 pS and increased rapidly at > or =299 pS ms(-1).

122 increased with depolarization from 15 +/- 3 pS/pF at -80 mV to 29 +/- 5 pS/pF at -40 mV.

123 n of openings to conductance levels above 30 pS, resulting in larger peak ensemble currents that deca

124 n of openings to conductance levels above 30 pS, resulting in larger peak ensemble currents that deca

125 TP and glibenclamide sensitivities of the 30 pS K channel in TAL cells were absent in mice lacking CF

126 R has been proposed as a regulator of the 30 pS, ATP-sensitive renal K channel (Kir1.1, also known as

127 f 500 picosiemens (pS) in mammals and of 300 pS in yeast.

128 of approximately 14 pS and approximately 32 pS were recorded at a membrane potential of -60 mV.

129 proximately 14 pS), TASK-3 (approximately 32 pS) and TASK-1/3 heteromer (approximately 32 pS).

130 pS) and TASK-1/3 heteromer (approximately 32 pS).

131 nductance Ca(2+)-activated K(+) channels (32 pS at -100 mV) which were sensitive to charybdotoxin and

132 nels with a single-channel conductance of 33 pS.

133 -1 cells with a main conductance state of 33 pS.

134 f the hexamer was estimated to be 115 +/- 34 pS and 74 +/- 20 pS, at 150 mV and 75 mV, respectively,

135 have unitary conductance of approximately 35 pS with symmetrical 150 mM KCl solutions.

136 nal conductances averaging approximately 350 pS.

137 The coupling was characterized by small (350 pS or less) junctional conductance (G(j)), which showed

138 nalysis of cultured astrocytes revealed a 37 pS lactate-permeable ion channel activated by cell depol

139 ion pore conductance (G(p)) was usually >375 pS and increased rapidly at > or =299 pS ms(-1).

140 out patches from CG neurones containing a 38 pS channel, two types of responses to ruthenium red were

141 In its place we observed a larger (38 pS) K(+)-channel in Task-1(-/-) cells and a smaller (18

142 trophysiological studies show that native 38 pS K+ channels of the TASK family in cultured CG neurone

143 herms with gamma(max)(Ca(2+)) of 9.5 +/- 0.4 pS and gamma(max)(Ba(2+)) of 10.3 +/- 0.5 pS.

144 reduced gamma to 8.7 +/- 0.5 and 6.7 +/- 0.4 pS, respectively, both significantly below that of chann

145 (QCA) construct with a gamma of 17.7 +/- 0.4 pS.

146 cetylcholine receptor channels (42.7 +/- 1.4 pS, n = 8, compared with 70.9 +/- 1.6 pS for wild-type,

147 ger when activated by 4BP-TQS (100.3 +/- 2.4 pS) than when activated by ACh (90.0 +/- 2.7 pS), provid

148 t K(+) channels with a conductance of 55+/-4 pS (mean+/-S.E.M.; n=3), were observed in cell-attached

149 uced the channel conductance to 8 pS and 8.4 pS, respectively.

150 (10 microM) did not affect conductance (9.4 pS), but did increase P(o) and short and long open times

151 ingly in heterologous cells (approximately 4 pS).

152 GABA(C) receptor gamma is estimated to be 4 pS.

153 ntaining beta2 subunits mediated the long 40 pS nAChR events that dominate single-channel records.

154 activities with a unitary conductance of 40 pS.

155 hannel events, and mixed-duration 25- and 40-pS nAChR events.

156 s an outwardly rectifying, noisily gated, 40-pS channel, very similar to that described in SACCHAROMY

157 mine and Mg(2+) induced flickery block of 40-pS single channels.

158 ers of Hg (1 mmHg = 133 Pa) activate the 400-pS Yvc1p conductance in whole-vacuole recording mode as

159 Between 18 pS and 41 pS conductance levels, direct transitions were asymmetri

160 so caused the appearance of approximately 42 pS (TASK-1/3-like) and approximately 74 pS (TASK-3-like)

161 tates with a conductance of approximately 42 pS; transitions between fully open and closed states wit

162 The 42 pS channel was the most abundant, contributing approxima

163 increased those of TASK-1/3 and TASK-3 to 42 pS and 74 pS, respectively.

164 ivated both 2 pS TRPC1/C5 channels and 15-45 pS TRPC6 channels in the same outside-out patches.

165 h conductances states of about 15, 30 and 45 pS.

166 lycine had two main conductance levels of 45 pS and 28 pS when the extracellular Ca(2+) concentration

167 ying, high conductance channels (gamma = 470 pS).

168 the single channel conductance from 96 to 49 pS.

169 f 98 pS during the subjective day and of 493 pS during the subjective night.

170 e average chord conductance was 24.4 +/- 0.5 pS (n = 11), between 0 and -200 mV, and was 9.6 +/- 0.7

171 th substantially reduced gamma (11.4 +/- 0.5 pS).

172 d a single-channel conductance of 19 +/- 0.5 pS, and made up the majority of the sustained K(+) curre

173 .4 pS and gamma(max)(Ba(2+)) of 10.3 +/- 0.5 pS.

174 ective and had a conductance of 224 +/- 11.5 pS in symmetrical 150 mM K(+) solutions were identified.

175 ddition, a subconductance state at 124 +/- 5 pS was identified.

176 onductance decreased thus: Ba2+ > Ca2+ (14.5 pS) > Mg2+ > Zn2+ (20 mM external cation, 1 mM H2O2).

177 on from 15 +/- 3 pS/pF at -80 mV to 29 +/- 5 pS/pF at -40 mV.

178 With inside-out patches, the 3.5 pS channel current predominated at 50 nM [Ca2+]i, but at

179 ave a single channel conductance of 42 +/- 5 pS for T(4)Vpu and 76 +/- 5 pS for T(5)Vpu in 0.5m KCl.

180 orming subunits is larger (approximately 7.5 pS) than that of Kv4 channels expressed singly in hetero

181 ance of 42 +/- 5 pS for T(4)Vpu and 76 +/- 5 pS for T(5)Vpu in 0.5m KCl.

182 conductances of KCNQ2 and KCNQ3 (6.2 and 8.5 pS, respectively) were much higher that those of KCNQ4 a

183 aC channel but induced the appearance of a 5-pS channel, presumably a alphabetagamma-ENaC channel.

184 HTC hepatoma cells evoked the opening of 50 pS K+-permeable channels, consistent with intermediate c

185 onal conductance between paired rods was 500 pS and the coupling coefficient (the ratio of voltage re

186 states with conductance of approximately 52 pS in magnitude occur at substantially lower ( approxima

187 lian cells exhibits small ( approximately 52 pS) and large ( approximately 220 pS) unitary conductanc

188 small-conductance channel ( approximately 52 pS).

189 ad 3 subconductance states of 14, 32, and 53 pS.

190 f 7 kcal/mol and a maximum conductance of 53 pS compared to the experimental value of 6 pS.

191 se reconstituted into lipid bilayers form 53-pS channels activated by Ca(2+) and thiol oxidants and i

192 four chord conductances of 18, 30, 41 and 54 pS.

193 isy open state with a mean conductance of 54 pS (+40 mV).

194 ed three conductance levels of 15, 35 and 55 pS.

195 with unitary conductance of approximately 56 pS.

196 43, while its single channel conductance (57 pS) is only 2-fold smaller than Cx43 (110 pS).

197 d bilayers, with a unitary conductance of 57 pS in 1 M KCl and numerous larger conductance levels.

198 ad a single-channel conductance of 6 +/- 0.6 pS, inactivated with a time constant of 23 +/- 2 ms at +

199 /- 1.4 pS, n = 8, compared with 70.9 +/- 1.6 pS for wild-type, n = 6).

200 2+) chelator BAPTA-AM activated the same 2.6 pS SOC in coronary artery.

201 l currents with a unitary conductance of 2.6 pS which were not inhibited by either ET(A) or ET(B) rec

202 rees C, LDS-P5 formed narrow pores (58 +/- 6 pS) with low open probability, whereas OG-P5 formed larg

203 single-channel conductance was measured as 6 pS with open probability of < or =0.03.

204 ously observed single-channel conductance (6 pS at pH 3) implies an open channel probability of 10(-6

205 increases gamma to the resolvable range (>6 pS).

206 3 pS compared to the experimental value of 6 pS.

207 ls, a most frequent conductance of 96(+/- 6) pS in lipid bilayers.

208 tween this open state and a approximately 65-pS subconductance state.

209 average junctional conductance is about 650 pS.

210 single-channel conductance is as low as 1.67 pS and that channel activation is a one-step process.

211 uctance states of about 18, 34 and 51 and 68 pS, and a reversal potential of 0 mV.

212 d), with conductances ranging from 28 to 689 pS, except for their ionic selectivity, which was slight

213 14.2 +/- 0.4, 37.8 +/- 0.7 and 38.1 +/- 0.7 pS (-60 mV), respectively.

214 , between 0 and -200 mV, and was 9.6 +/- 0.7 pS (n = 8), between 0 and 50 mV; these magnitudes and th

215 increasedgamma to 23 +/- 1.0 and 26 +/- 0.7 pS, respectively.

216 pS) than when activated by ACh (90.0 +/- 2.7 pS), providing evidence that activation by allosteric an

217 6 +/- 9 pS/pF) or in beta1/RyR1 KO (34 +/- 7 pS/pF) myotubes.

218 single MCU conductance is approximately 6-7 pS (105 mM [Ca(2+)]), and MCU flux appears to be modulat

219 openings with an apparent conductance of 9.7 pS, consistent with recent reports of native and recombi

220 As well as a low conductance (7 pS) channel and a 25-pS channel, the most striking findi

221 ocked by Gd(3+), have a conductance of 50-70 pS and, like many other TRP channels, open at very posit

222 S and the embryonic DmInsP(3)R isoform is 70 pS; 3), ug3 mutation affects sensitivity of the DmInsP(3

223 at S368, reduced the incidence of 55- to 70-pS channels, and reduced by 10-fold the selective permea

224 those of TASK-1/3 and TASK-3 to 42 pS and 74 pS, respectively.

225 y 42 pS (TASK-1/3-like) and approximately 74 pS (TASK-3-like) channels, in addition to the approximat

226 ol (OAG) induced single channel activity (75 pS) that was not observed in TRPC7-/- cells but was resc

227 ith alpha4beta2 nAChRs (gamma = 31.3 +/- 0.8 pS), replacement of MA 0' residues by arginine in alpha4

228 d a single-channel conductance of 11 +/- 0.8 pS, did not inactivate with prolonged membrane depolariz

229 0 nM [Ca2+]i most channels opened to the 1.8 pS level and an additional 1.2 pS channel conductance wa

230 mode, two conductance states of 3.5 and 1.8 pS were recorded either spontaneously or in response to

231 y rectified, K+-specific current with a 10.8 pS unitary conductance at -100 mV.

232 nt has a unitary conductance of 61.7 +/- 5.8 pS, similar to that reported for wild-type alpha7, but a

233 ) channels with a unitary conductance of 7.8 pS were resolved in excised patches of ICC.

234 e similar in conductance to ANO1 channels (8 pS) expressed in HEK293 cells.

235 (1 mM), reduced the channel conductance to 8 pS and 8.4 pS, respectively.

236 transition conductances (gamma(j)) of 30-80 pS.

237 9 pA and single-channel conductance is 74-80 pS; 2), in optimal recording conditions the maximal sing

238 tances of 20 pS for inward currents and 80 pS for outward currents.

239 patches, nicotine activated brief 60- and 80-pS single nAChR channel events, and mixed-duration 25- a

240 f the fully open channel is approximately 85 pS, and it is permeable to Lucifer yellow, Alexa Fluor(3

241 e of the adult head DmInsP(3)R isoform is 89 pS and the embryonic DmInsP(3)R isoform is 70 pS; 3), ug

242 l currents with a unitary conductance of 1.9 pS.

243 tion with a mean conductance of 66.2 +/- 1.9 pS.

244 y Ca(2+) current either in RyR1 KO (36 +/- 9 pS/pF) or in beta1/RyR1 KO (34 +/- 7 pS/pF) myotubes.

245 1-44 and Delta1-54 produced approximately 90 pS and 188 pS channels, respectively.

246 satisfactory agreement with the value of 90 pS measured at 75 mV.

247 audin-2 channels display conductances of ~90 pS.

248 reatment or during perinatal development, 90-pS stretch-activated cation channels that could be block

249 ctional conductance has a median value of 98 pS during the subjective day and of 493 pS during the su

250 n1 with three related ligands that include a pS-P substrate peptide, and two pS-P substrate analogue

251 Anti-pS(133)-CREB antibody was raised against the phospho-CRE

252 vealed that VH1 is highly active toward both pS/pT and pY peptides.

253 es that are phosphorylated (i.e., containing pS, pT, or pY) from those that are nonphosphorylated (i.

254 phase, phosphorylation of Emi1 generates a D-pS-G-X-X-pS degron to recruit the SCF(betaTrCP) ubiquiti

255 p-ACC1 peptide, with the sequence 1258-DSPPQ-pS-PTFPEAGH-1271), which provides molecular evidence for

256 Fam20C is a kinase that phosphorylates S-x-E/pS motifs on proteins in milk and in the extracellular m

257 gnostic phosphate OH stretch (indicative for pS, pT, or pY) can be distinguished from the alcohol OH

258 nalysis of the monophosphorylated peptide FQ[pS]EEQQQTEDELQDK shows that in the resulting c- and z-ty

259 w a high variety of conductance states (from pS to nS) that are dependent both on the lipid compositi

260 e oligonucleotide d(CGCAAA2'FUTGGC)*d(GCCAAT(pS)TT GCG) (A3T2) upon binding of the drug distamycin A

261 basis of a recurrent GSK-3 consensus motif ((pS/pT)XXX(S/T)), but this prediction has not been tested

262 previously unrecognized 14-3-3-binding motif-pS/pT (X1-2)-COOH, referred to here as mode III.

263 of these moieties (i.e., containing neither pS, pT, pY nor S, T, Y).

264 gh increased IFN-gamma induced activation of pS(727)-Stat1 and inhibition of pY(705)-Stat3 phosphoryl

265 sies did not show significant correlation of pS(9)-GSK3beta and CDC25A expression (P<0.2).

266 NPM-ALK in 293T cells led to an increase of pS(9)-GSK3beta (glycogen synthase kinase 3 beta) compare

267 Phosphorylation of pS(9)-GSK3beta by NPM-ALK was mediated by the PI3K/AKT s

268 (ESCs), we found that approximately 2.4% of (pS/pT)XXX(S/T) sites are phosphorylated in a GSK-3-depen

269 Akt while enhancing serine phosphorylation (pS(307)) of IRS1.

270 t exhibits no activity toward phosphoserine (pS) or phosphothreonine (pT) peptides.

271 tified in each sample in vivo phosphoserine (pS) phosphorylation sites at pS434, pS440, and pS441, as

272 of protein phosphatases toward phosphoseryl (pS) and phosphothreonyl (pT) peptides.

273 ly 700, and approximately 1,000 picosiemens (pS) in symmetrical 150 mm CsCl were observed.

274 e single channel conductance 13 picosiemens (pS) at +60 mV and 16 pS at -60 mV.

275 mean conductance of 224 +/- 26 picosiemens (pS).

276 from 7.8 +/- 0.5 to 5.0 +/- 0.5 picosiemens (pS).

277 possessing a conductance of 500 picosiemens (pS) in mammals and of 300 pS in yeast.

278 how that KSHV Rta protein contains potential pS/T-P motifs and binds directly to Pin1.

279 isomerization of phosphorylated-Ser/Thr-Pro (pS/T-P) motifs found in numerous signaling proteins regu

280 phosphoserine- or phosphothreonine-proline (pS/T-P) motifs in target proteins.

281 or threonine residues that precede prolines (pS/T-P), such as the transcription factors p53 and c-Jun

282 e only phosphorylated residue in the protein pS(16); therefore, changes in the LRAP-HAP interaction a

283 hosphosite-specific antibody that recognizes pS(355,356).

284 to be 300 zmol for the phosphopeptide RRREEE(pS)EEEAA using multishot accumulation of the ions from 1

285 RSX(pS/pT)XP and RXPhiX(pS/pT)XP are two canonical consensus

286 RSX(pS/pT)XP and RXPhiX(pS/pT)XP are two canonical consensus binding motifs for

287 kinase B substrate consensus sequence RXRXX(pS/pT) and a phosphospecific antibody that recognizes se

288 which lacks a PBD consensus binding site (S(pS/pT)(P/X)), and that Dbf4 inhibits Cdc5 function durin

289 s mapped to residues 146 to 148 within the S(pS/T)P motif, and the phosphorylation site was identifie

290 cal; it does not require either a complete S-pS/pT-P motif in Mtrm or key residues in the Polo-box do

291 els, enhanced its phosphorylation at serine (pS) 279/282, and increased VSMC proliferation both in vi

292 found that Pin1 binds c-Fos through specific pS/T-P sites within the c-Fos TAD, and that this interac

293 on in the phosphorylation of Ser(727)-Stat1 (pS(727)-Stat1), and IFN-gamma induced dephosphorylation

294 by the amino acid residues C-terminal to the pS, pT, or pY residue.

295 omoting the cis-trans isomerization of these pS/T-P bonds.

296 intrinsically low catalytic activity toward pS and pT substrates, suggesting that its primary physio

297 d more stringent sequence specificity toward pS/pT than pY substrates.

298 at include a pS-P substrate peptide, and two pS-P substrate analogue inhibitors locked in the cis and

299 anonical 14-3-3 binding site (RSXpSXP, where pS denotes phosphoserine) located in the amino-terminal

300 osphorylation of Emi1 generates a D-pS-G-X-X-pS degron to recruit the SCF(betaTrCP) ubiquitin ligase,