ライフサイエンスコーパス: pace

1 g/m(2) per day on days 1 to 3 every 21 days (PaCE).

2 atients received CE and 94 patients received PaCE.

3 initiated, has been occurring at an alarming pace.

4 The oceans are deteriorating at a fast pace.

5 nalysis times have not benefited at the same pace.

6 partially redundant manner to promote clock pace.

7 while the visualization tools have not kept pace.

8 nable simulations at this scale has not kept pace.

9 in wearable medical devices at a tremendous pace.

10 an genomes are accelerating at an astounding pace.

11 ators is currently mushrooming at a dizzying pace.

12 advancing many scientific fields at a rapid pace.

13 al burdens on the research community to keep pace.

14 ndents to walk 2.5 m at their normal walking pace.

15 elopment of effective therapies has not kept pace.

16 to migrate to these new methods at their own pace.

17 ortable alcohol detection systems is gaining pace.

18 imilarly sedated and ventilated but were not paced.

19 dle pacing, and endocardial left ventricular pacing.

20 characteristics were analyzed during atrial pacing.

21 cal results with conventional single-chamber pacing.

22 ynamics of an atrial cell subjected to rapid pacing.

23 nction and caused missed pumps during 3.7 Hz pacing.

24 arrhythmic pauses alternating with bursts of pacing.

25 patients benefit from upfront biventricular pacing.

26 options, with particular focus on His-bundle pacing.

27 tantial cytotoxicity, which hindered optical pacing.

28 left ventricular (LV) pacing, and His-bundle pacing.

29 e interval, 0-3) required rescue ventricular pacing.

30 ction fraction </=50% to biventricular or RV pacing.

31 guideline-based indications for ventricular pacing.

32 ross the valve ring during rapid ventricular pacing.

33 plemented controls during physiological 1-Hz pacing.

34 inotropic agents, volume resuscitation, and pacing.

35 induced vasovagal syncope compared with sham pacing.

36 14 versus 0%; P=0.004), and need for chronic pacing (10% versus 0%; P=0.008).

37 significantly smaller in the ventilated-not paced (17.9 mum(2)/kg; IQR, 15.3-23.7; P = 0.005) but no

38 sinus rhythm, and reinduction of AF by burst pacing (50 Hz) was prevented in 8 of 8 pigs.

39 By week 4, 20% of beats were electronically paced, 60% to 80% of beats were matching, and mean and m

40 a median of 14.3 (range, 13.4-17.6) years of pacing, 7 patients continue with their original lead.

41 logy) trial, which demonstrated a benefit of pacing among patients with recurrent syncope and asystol

42 milar between both arms with 10.03 months on PaCE and 10.37 months on CE ( P = .096).

43 /Cas system are expanding at a breath-taking pace and are revolutionizing approaches to gain a better

44 The pace and chronicity of ophthalmic manifestations lacked

45 In this issue of the JCI, Pace and colleagues present evidence that there are sex-

46 mic MSC injections significantly improve the pace and degree of nerve regeneration after nerve injury

47 g habitat preferences, and complexity in the pace and mode of geomorphic channel responses to altered

48 fer significantly between patients receiving PaCE and those receiving CE.

49 ular proarrhythmia because of competition of paced and intrinsic rhythm in ICD patients.

50 uction over the experiment in the ventilated-paced and ventilated-not paced groups.

51 adenine dinucleotide fluorescence following pacing and 2) increased distance between mitochondria an

52 battery life reset to ventricular inhibited pacing and could not be reprogrammed; the device was sub

53 Implantable cardiac pacing and defibrillation devices are effective and comm

54 nic devices enabling, for example, multisite pacing and implantation of internal cardiac defibrillato

55 These studies demonstrate that electric pacing and mechanical stimulation promote maturation of

56 diac implantable electronic devices includes pacing and perhaps defibrillation without a lead travers

57 ntracellular calcium dynamics during control pacing and reveals the high-resolution 3-D spatial struc

58 d trials and observational studies examining pacing and syncope, and the bibliographies of known syst

59 ationship between the variance of stochastic pacing and the occurrence of spatially discordant altern

60 oping HF in the setting of right ventricular pacing and to determine whether these patients benefit f

61 ical function, allowing simultaneous optical pacing and Vm mapping.

62 xia, neurohormonal stimulation, and electric pacing, and are amenable to patch clamp and adenoviral g

63 hniques such as multisite pacing, His bundle pacing, and endocardial left ventricular pacing.

64 biventricular pacing, left ventricular (LV) pacing, and His-bundle pacing.

65 Synchronized LV pacing, multisite LV pacing, and LV endocardial pacing offer promise as novel

66 b/ligand was also suitable for cardiomyocyte pacing, as shown in experiments performed on zebrafish h

67 We estimated the projected pace at which climatic conditions may redistribute acros

68 Mitigation slows the pace at which multiple drivers emerge, allowing an addit

69 tate space, which compensates for the slower pace at which they traverse the cycle.

70 ChR2-expressing cultures could be optically paced at multiple sites, with significantly reduced over

71 cing for 12 months followed by sham DDI mode pacing at 30 pulses/min for 12 months (group A), or sham

72 on, action potential properties under steady pacing at different rates, restitution properties, block

73 Antitachycardia pacing (ATP) in implantable cardioverter-defibrillators

74 In addition, worse performance on the Paced Auditory Serial Addition Test correlated with volu

75 ysis), Frontal Assessment Battery (FAB), and Paced Auditory Serial Addition Test.

76 As the number of paced beats increased from 1 to 5, SR Ca content (assess

77 d as the leading candidate for physiological pacing because it provides nearly normal electrical acti

78 hat past climate change occurred at a linear pace between widely spaced (usually, >/=1,000 years) cli

79 ugh alternate RV pacing sites, minimizing RV pacing, biventricular pacing, left ventricular (LV) paci

80 owed a significant decline in ventilated-not paced but not in ventilated-paced subjects (0.84 [interq

81 Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound

82 The latter excursion is paced by obliquity and is therein similar to Mesozoic in

83 , which forms a spherical terminal shell, is paced by the diurnal light/dark cycle.

84 t is caused by the complex interplay between paced Ca release and triggered waves.

85 Although right ventricular pacing can contribute to cardiomyopathy, the impact of c

86 e percentage of patients with low and stable pacing capture thresholds at 6 months (</=2.0 V at a pul

87 After catheterization, a transvenous pacing catheter was placed and adenosine was given follo

88 t to obtain for these two countries, as fast-paced changes in economy and environmental regulations h

89 t Pangea nonlinearly amplified the orbitally paced chemical weathering that drove BSi burial during t

90 ng the most sensitive recorders of obliquity-paced climate variability in interior Antarctica, in con

91 med the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n

92 hin the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association betwe

93 rging from approximately 2500 generations of PACE contains 20 non-silent mutations, cleaves human IL-

94 Six pigs served as never-ventilated, never-paced control animals.

95 apy (CRT) with defibrillation (CRT-D) versus pacing (CRT-P) for patients with nonischemic cardiomyopa

96 tation to shifts in the tempo of an auditory pacing cue: (8-13 Hz) mu rhythm and (13-35 Hz) beta band

97 ng mode was changed to asynchronous mode for pacing-dependent patients and to demand mode for other p

98 Successful CRT using coronary venous pacing depends on appropriate patient selection, lead im

99 Walking pace, distance, and overall walking score, leisure-time

100 k simulations to reveal the conditions (i.e. pacing, drugs, sympathetic stimulation) required for tri

101 luo-4 to image intracellular Ca were rapidly paced during exposure to elevated extracellular Ca (2.7

102 How often and at what pace ecological speciation proceeds to yield strong repr

103 ChR2-expressing cultures were then paced electrically or optically with a blue light-emitti

104 underwent implantation of an LV endocardial pacing electrode and a subcutaneous pulse generator.

105 a wireless left ventricular (LV) endocardial pacing electrode.

106 In this issue of the Journal, Pace et al.:1115-1124) clearly documented that both gest

107 are being produced at an increasingly faster pace, exacerbating the problem.

108 to have a higher burden of right ventricular pacing, experienced an increased risk of new-onset HF af

109 ial damage to the immune system, setting the pace for later disease progression.

110 Intercellular communication sets the pace for transformed cells to survive and to thrive.

111 m DDI mode for 12 months followed by DDD-CLS pacing for 12 months (group B).

112 Patients were randomized to either DDD-CLS pacing for 12 months followed by sham DDI mode pacing at

113 The evidence does not support the use of pacing for reflex-mediated syncope beyond patients with

114 Antarctic archives that favour eccentricity-paced forcing over the same time period.

115 body temperature and found that 1) at a low pacing frequency of 0.5 Hz, the upper and lower bounds c

116 pharynx either locked in pumping at half the pacing frequency or stopped pumping altogether, possibly

117 )]sm value to approximately 9 mM; 2) at 2 Hz pacing frequency, [Na(+)]sm is bounded between 9 mM at r

118 an 77.2% of baseline QRS duration) confirmed pacing from a late activated RV area.

119 pacemakers are limited to right ventricular pacing, future advanced, communicating, multicomponent s

120 odel accounts for the dominance of obliquity-paced glacial-interglacial cycles early in the Quaternar

121 e last 1.5 million years (Ma) of orbitally-paced glacial/interglacial cycles (GIC).

122 3-23.7; P = 0.005) but not in the ventilated-paced group (24.9 mum(2)/kg; IQR, 16.6-27.3; P = 0.351).

123 t in the ventilated-paced and ventilated-not paced groups.

124 ce <2 mph, those that habitually walked at a pace >3 mph had a lower risk of coronary heart disease (

125 Permanent His-bundle pacing has emerged as the leading candidate for physiolo

126 previously established as an optogenetically paced heart model.

127 for alternative techniques such as multisite pacing, His bundle pacing, and endocardial left ventricu

128 ation to connect brain-pituitary rhythms and pace hormone secretion.

129 gated stability changes of APs observed in a paced human ventricular myocyte model by decreasing and/

130 tion (MPT; 1,200-800 kya), Earth's orbitally paced ice age cycles intensified, lengthened from approx

131 By contrast, HIS-LV pacing improved hemodynamic indexes at all AVD (stroke v

132 sts, and continued to accumulate at a slower pace in forests aged 20-100 years.

133 Whether Mg-heterogeneity is also diurnally paced in species with more complex shell morphologies is

134 ch block by atrial-synchronized RV free wall pacing in complete fusion with spontaneous ventricular d

135 Structural heart disease or inadvertent pacing in scar was not associated with changes in E12; h

136 AF was initiated by applied ectopic pacing in the pulmonary veins, which led to the generati

137 Pacing in vasovagal syncope remains controversial.

138 e deleterious effects of long-term RV apical pacing in vulnerable populations has created tremendous

139 effective refractory periods and acute burst pacing-induced AF were examined in anaesthetized open ch

140 by, neurons of the preBotzinger complex that paces inspiration.

141 ), to assess autonomic regulation, then self-paced intensity (30 min work trial), to assess behaviour

142 l mapping to match the P wave morphology and paced intracardiac activation sequence recorded from mul

143 ace ECG at the successful ablation site, and paced intracardiac activation sequence was identical to

144 Cardiac pacing is an effective treatment for patients with brady

145 d to establish permanent placement of an LVS pacing lead in patients using a transvenous approach thr

146 r usage in universities, but also suits self-paced learning and blended learning programmes.

147 g sites, minimizing RV pacing, biventricular pacing, left ventricular (LV) pacing, and His-bundle pac

148 decreased) Purkinje cell output during self-paced locomotion.

149 For example, in comparison with a walking pace <2 mph, those that habitually walked at a pace >3 m

150 in phototransduction, olfaction, and cardiac pace making.

151 In all patients, pace mapping obtained best-matched P wave morphology in

152 Pace mapping was systematically performed in the areas o

153 predominantly AF and secondary SND, cardiac pacing may be the mainstay of therapy for patients with

154 suggest that early transvenous phrenic nerve pacing may mitigate ventilator-induced diaphragm dysfunc

155 multicentre, open-label, dose-finding study (PACE-MDS), with long-term extension, eligible patients w

156 The pacing mode was changed to asynchronous mode for pacing-

157 Synchronized LV pacing, multisite LV pacing, and LV endocardial pacing o

158 5), or biventricular (n = 4) or bradycardia pacing (n = 1).

159 of SPN ensemble activity in mice during self-paced, natural movements using microendoscopic imaging.

160 The rapid pace of advancement in endophyte ecology warrants a paus

161 unique among brain regions for its distinct pace of angiogenesis and selective vulnerability to hemo

162 Finally, by controlling the timing and pace of cell fate specification, the embryo temporally m

163 acts from natural factors, the magnitude and pace of climate shifts, since the Last Glacial Maximum,

164 re meaningful estimates of the magnitude and pace of climate shifts, the location and timing of drive

165 ne testing system will facilitate the global pace of clinical tuberculosis vaccine development.

166 al cost-effectiveness ratios for (1) Current Pace of detection, linkage, retention, and virologic sup

167 stems for internal gas transport is the slow pace of diffusion [1].

168 These are exciting times and the pace of discovery is remarkable.

169 e or following four months of treatment, the pace of dose increase, or the number or severity of reac

170 And hence the pace of drug development could be substantially expedite

171 erties, thereby substantially expediting the pace of drug development.

172 Driven by the ever-increasing pace of drug discovery and the need to push the boundari

173 (DDI) is necessary to prevent ADR, the rapid pace of drug discovery makes it challenging to maintain

174 Identifying genes regulating the pace of epigenetic ageing represents a new frontier in g

175 in which chemorepulsive signals control the pace of forward migration.

176 ntal development and inferred an accelerated pace of general growth.

177 an any fundamental difference in the overall pace of growth in this extinct human.

178 de a novel way to quantify the magnitude and pace of improvement in neonatology.

179 he scale of human population and the current pace of its growth contribute substantially to the loss

180 Compared with microalgae, the pace of knowledge acquisition in seaweeds is slower desp

181 We found that the overall pace of marsh development was largely unaffected by whet

182 Such variation in the pace of migration arising from a single stopover site, l

183 acquired at stopover sites on the subsequent pace of migration has not been quantified.

184 departure date, carry-over to influence the pace of migration, contributing to differences in travel

185 mutualistic strategy profoundly affects the pace of morphological change in traits involved in the i

186 Because the pace of nanomaterial innovation far outstrips acquisitio

187 sion in three dimensions will accelerate the pace of neuroscience research.

188 Concomitantly, the pace of offspring life history is recalibrated to partly

189 elocity of 1.27 km yr(-1) , about double the pace of prior distribution shift estimates across terres

190 INTERPRETATION: The rapid pace of privatisation was a significant factor in the ma

191 n support of the health benefits of a slower pace of privatisation, this study can assist policy make

192 f material stocks' dynamics demonstrates the pace of product replacement as a function of its usefuln

193 Yet the pace of progress toward these goals substantially varied

194 ty in keeping the review up to date with the pace of publication of new research.

195 The pace of reduction in mortality and DALYs in many leading

196 challenges in medicine, but the accelerating pace of research and early hints of clinical successes t

197 coevolution will be hampered by the measured pace of research on the socio-cultural side of cetacean

198 application fields, and could thus slow the pace of resistance development.

199 , so the aging of the workforce may slow the pace of scientific progress.

200 borative approach is not scalable at today's pace of sequence generation.

201 Per2 in the liver resulted in a dysregulated pace of the circadian rhythm.

202 1 and 6 months of age, with the severity and pace of the degeneration consistent with the extent to w

203 ty nature of the social activity setting the pace of these choices.

204 The level and pace of this health transition might vary across regions

205 facilitative interactions may accelerate the pace of tree expansions upward near timberline.

206 th emergency and has greatly accelerated the pace of ZIKV research and discovery.

207 The pacing of glacial-interglacial cycles during the Quatern

208 Epicardial pacing of the injection site identified matching beats a

209 perform phage-assisted continuous evolution (PACE) of TEV protease, which canonically cleaves ENLYFQS

210 on other traits that can be associated with pace-of-life and are related to either reproductive inve

211 Pace-of-life can vary in relation to local environmental

212 s, we predict that urban birds have a slower pace-of-life compared to rural birds and thus invest mor

213 ral life-history traits along a slow-to-fast pace-of-life continuum, with long lifespans, low reprodu

214 nization gradient, and suggest that applying pace-of-life framework to studies of variation in physio

215 dence for covariance between personality and pace-of-life in a natural population.

216 The concept of a pace-of-life syndrome describes inter- and intraspecific

217 The pace-of-life syndrome hypothesis (POLS) suggests that in

218 l meta-analysis of two key traits related to pace-of-life, survival and breeding investment (clutch s

219 ing, multisite LV pacing, and LV endocardial pacing offer promise as novel pacing options in select p

220 d to stop for breath when walking at his own pace on level ground]).

221 nd mechanically ventilated for 2.5 days with pacing on alternate breaths at intensities that reduced

222 primary performance endpoint, biventricular pacing on the 12-lead electrocardiogram at 1 month, was

223 amics, electrotonic coupling, and stochastic pacing on the nodal dynamics of spatially discordant alt

224 which typically takes place at an even lower pace, only becoming relevant for structures held in vacu

225 LV endocardial pacing offer promise as novel pacing options in select patients.

226 aper reviews the current status of available pacing options, with particular focus on His-bundle paci

227 has created tremendous interest in alternate pacing options.

228 ented by a 12-lead electrocardiogram without pacing or atrial fibrillation noted on their baseline Ja

229 walking for recreation, walking at a faster pace, or taking longer-duration walks.

230 tion, defibrillation, cardioversion, cardiac pacing, or treatments targeted at the underlying disease

231 Compared with Current Pace over 20 years, NHAS averted 280000 HIV transmission

232 The combination of paced P wave morphology and intracardiac activation sequ

233 PACE (Patients With Intermittent Claudication Injected W

234 de partially suppressed the arrhythmic burst pacing pattern of intact NCX KO SAN tissue.

235 nd QRS morphological change when restricting pacing points to areas of voltage >0.5 mV.

236 Nine hundred thirty-five pacing points were collected, generating 6219 pacing sit

237 y leads to aperiodic response of Ca at rapid pacing rates that is caused by the complex interplay bet

238 on and produced EADs, in particular, at slow pacing rates.

239 the participant volitionally performed self-paced reaches to drink a mug of coffee (successfully com

240 review of the biomedical literature, whether pacing reduces risk of recurrent syncope and relevant cl

241 sis without regurgitation, and possibly more pacing runs, earlier date of procedure, and no dual anti

242 Right ventricular pacing (RVP) increases risk of atrial fibrillation in pa

243 output when compared with clinically derived pacing settings in the postoperative period.

244 Patients with biventricular pacing showed greater improvement in NYHA functional cla

245 DDD-CLS pacing significantly reduced syncope burden and time to

246 The q-RV interval at the RV free wall pacing site (mean 77.2% of baseline QRS duration) confir

247 acing points were collected, generating 6219 pacing site pair combinations (3087 [50%] ventricular bo

248 hnological advances, the optimal ventricular pacing site to mimic normal human ventricular physiology

249 he search has continued through alternate RV pacing sites, minimizing RV pacing, biventricular pacing

250 least, the changes are related to obliquity-paced solar radiation, manifest as variations in total s

251 surgical epilepsy patients performing a self-paced spatial memory task in a virtual environment.

252 During a self-paced spatial task, awake hippocampal replay occurring e

253 Compared with the current pace strategy, over 5 years the UNAIDS target strategy w

254 n ventilated-not paced but not in ventilated-paced subjects (0.84 [interquartile range (IQR), 0.78-0.

255 uring stimulation assisted breaths in all 22 paced subjects (range, 9.9-48.6%; p < 0.001).

256 ulation, whereas three of six ventilated-not paced subjects did not (P = 0.055).

257 of mechanical ventilation all six ventilated-paced subjects tolerated 8 minutes of intense phrenic st

258 failed to reach a new steady state following pacing, suggesting impaired matching of energy supply an

259 A leadless intracardiac transcatheter pacing system has been designed to avoid the need for a

260 emonstrated a remote-controlled miniaturized pacing system with low power consumption, thereby provid

261 rect randomized comparison with conventional pacing systems, will be required to define the proper cl

262 hed healthy controls completed a right-hand, paced tapping fMRI paradigm.

263 lation; engineering can be accomplished at a pace that rivals the development of chemical synthetic m

264 th the notion that the neural sequences that pace the song are generated by global synaptic chains in

265 It has been hypothesized that electrically pacing the diaphragm during mechanical ventilation could

266 "Milankovitch" climate change in timing and pacing the Late Devonian mass extinction.

267 on and tools materialize at an unprecedented pace, the field is now ripe for systematic and functiona

268 al synchronous right ventricular (RV) apical pacing, the search has continued through alternate RV pa

269 ne catheter-based, transvenous phrenic nerve pacing therapy for protecting the diaphragm in sedated a

270 Cumulative duration of pacing therapy ranged from 19.7 to 35.7 hours.

271 to conventional CRT (n = 10), and a high CS pacing threshold or phrenic nerve capture (n = 5).

272 Changes in lead impedance, pacing threshold, battery voltage, and P-wave and R-wave

273 Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of cancer-relate

274 Hearts were paced to increase workload and perfusate was deoxygenate

275 Larger leadless pacing trials, with long-term follow-up and direct rando

276 main finding is that when an atrial cell is paced under Ca overload conditions, Ca waves can then nu

277 Temporary transvenous phrenic nerve pacing using a novel electrode-bearing catheter may prov

278 tient population by performing biventricular pacing via a wireless left ventricular (LV) endocardial

279 o terminate re-entrant AT (induced via rapid pacing) via optogenetic stimulation.

280 iveness ratio for NHAS compared with Current Pace was $68900 per quality-adjusted life-year ($38300 f

281 2 peak ) at a speed approximating 20 km race pace was reduced in HCHO and PCHO (90% CI: -7.047, -2.55

282 pen-label (unblinded) studies, we found that pacing was associated with a 70% reduction in recurrent

283 e most common indications for endocardial LV pacing were difficult CS anatomy (n =12), failure to res

284 to also analyze these data struggle to keep pace with advancing instrument capabilities and increasi

285 pecies' ranges, but such shifts may not keep pace with climate changes because seed dispersal distanc

286 s will be able to shift their ranges to keep pace with climate-driven environmental changes.

287 Production of energy in a cell must keep pace with demand.

288 eding practices, however, are unable to keep pace with demand.

289 Repair that cannot keep pace with destruction results in progressive loss of mye

290 es to perform syphilis screening at a faster pace with lower labor costs.

291 mprovements in crop yield are needed to keep pace with population growth and climate change.

292 arrival dates, 9 of 48 species did not keep pace with rapidly changing green-up and across all speci

293 he Mississippi Delta (SE Louisiana) may keep pace with RSLR, whereas 58% of the sites in the Chenier

294 nclear to what extent these shifts have kept pace with the changing environment.

295 the research laboratory have failed to keep pace with the rapid advances in automization and parelle

296 st decade by using automated methods to keep pace with the rapid increase in genomic data.

297 show that these efforts are failing to keep pace with the rate of wilderness loss, which is nearly d

298 facilitates variant classification and keeps pace with variant discovery.

299 In this First-in-Human series, diaphragm pacing with a temporary catheter was safe and effectivel

300 The authors evaluated dual-chamber pacing with closed loop stimulation (DDD-CLS) in patient

301 t RyR2(R4497C), were unable to follow 3.7 Hz pacing, with progressive defects during long stimulus tr