ライフサイエンスコーパス: pacemaking

1 also restores the precision of Purkinje cell pacemaking.

2 these processes interferes with SCN cellular pacemaking.

3 sues, revealing its global role in circadian pacemaking.

4 ent generators and their potential for alpha pacemaking.

5 results in small net inward currents during pacemaking.

6 er the range (10-50 mV/s) typical of natural pacemaking.

7 ) flies suggest that CRY is involved in core pacemaking.

8 induces a reversion to the juvenile form of pacemaking.

9 re in more detail the contribution of NCX to pacemaking.

10 ), pancreatic insulin secretion, and cardiac pacemaking.

11 icked the effects of D2 receptor agonists on pacemaking.

12 ed to a reduction in Na+ currents underlying pacemaking.

13 robust, spontaneous, tetrodotoxin-sensitive pacemaking.

14 rizing current capable of modulating regular pacemaking.

15 ls suggesting that it is important in normal pacemaking.

16 modulation of spine Ca(2+) signaling during pacemaking.

17 R-mediated Ca(2+) cycling that regulates SAN pacemaking.

18 s an important role in sinoatrial node (SAN) pacemaking.

19 ersistent" sodium current important for such pacemaking.

20 ptoms reminiscent of severe human disease of pacemaking.

21 a repolarizing current capable of modulating pacemaking.

22 nt generators and assess their potential for pacemaking.

23 decipher the multigenic control of circadian pacemaking.

24 ogy are poorly defined for the generation of pacemaking.

25 In cell-attached recordings of spontaneous pacemaking, 10 mM 4-AP slowed rather than speeded firing

26 Pacemaking activity in adult substantia nigra (SN) dopam

27 r cell types and their possible relevance to pacemaking activity in cells of the DRN.

28 studies show that, in normal conditions, the pacemaking activity in DA neurons is inhibited by the TR

29 ation-activated current (Ih) and its role in pacemaking activity in rat hippocampal stratum oriens-al

30 ucleotide-gated (HCN) channels contribute to pacemaking activity in specialized neurons and cardiac m

31 l fibrillation is often triggered by ectopic pacemaking activity in the myocardium sleeves of the pul

32 xposure to nicotine doubles the frequency of pacemaking activity in these neurons.

33 to measure the effect of the NCX current on pacemaking activity in vivo, ex vivo, and in isolated SA

34 udies in Caenorhabditis elegans suggest that pacemaking activity may be controlled in part by microRN

35 The pacemaking activity of specialized tissues in the heart

36 These neurons respond with a pause in their pacemaking activity, enabling synaptic integration with

37 ch inhibition by simultaneously reducing the pacemaking activity.

38 a feasible modality to regulate the cardiac pacemaking activity.

39 and cardiac Nav1.5 isoforms are involved in pacemaking, although the cardiac Nav1.5 isoform alone is

40 arge transfer through L-type channels during pacemaking and bursting.

41 The cardiac pacemaking and conduction system sets and maintains the

42 iac myocytes and specifically in the cardiac pacemaking and conduction system.

43 may be preferentially associated with early pacemaking and conduction tissue development.

44 de a basis for tissue engineering of cardiac pacemaking and conductive cells.

45 eat is dependent on a specialized network of pacemaking and conductive cells.

46 s critical for distinguishing mechanisms for pacemaking and coordination of sequential population act

47 For the SAN to show pacemaking and drive atrial muscle, theoretically, there

48 The cellular and molecular determinants of pacemaking and fast spiking in GPe neurons are not fully

49 Viral delivery of HCN2 subunits restored pacemaking and reduced burst spiking in GPe neurons.

50 Na as well as TTX-sensitive iNa, slowed both pacemaking and SA node conduction.

51 ility, we found that 100 nM 2-AG accelerated pacemaking and steepened the frequency-current relations

52 medullary raphe neurons, which exhibit slow pacemaking and strong spiking adaptation.

53 In these Nav1.6 null neurons, pacemaking and the capacity for fast spiking were impair

54 ge-gated calcium channels are well suited to pacemaking and to supporting calcium flux near the resti

55 n substantia nigra (SN) dopamine (DA) neuron pacemaking and vulnerability to Parkinson's disease.

56 TTX had broader, smaller spikes than normal pacemaking and was stopped by removal of external calciu

57 ether BMAL1 ubiquitination affects circadian pacemaking and what ubiquitin ligase(s) is involved.

58 A major consequence of this is that pacemaking and, even more so, bursting are associated wi

59 ct center and drive atrial muscle as well as pacemaking) and the aim was to study expression in both

60 t by regulating coronary blood flow, cardiac pacemaking, and contractility.

61 elayed gastric emptying, impaired electrical pacemaking, and reduced motor neurotransmission.

62 rhythms to the intercellular control of SCN pacemaking are poorly understood.

63 s of impulse generation, that is, defects in pacemaking, are often life-threatening.

64 l setting, and can provide new insights into pacemaking, arrhythmogenesis and suppression or cardiove

65 SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecul

66 voltage-clamp experiments, using records of pacemaking as command voltage, cobalt-sensitive current

67 y determinants of the regularity and rate of pacemaking as well as striatal resetting of this activit

68 ce caused a significant reduction in ICC and pacemaking at distances up to 5 cm from the anastomosis

69 e that Ih is an important contributor to the pacemaking behavior of the intact heart.

70 e essential for proper sinoatrial node (SAN) pacemaking, but the influence of intracellular Ca(2+) on

71 d the role of subthreshold sodium current in pacemaking by performing voltage-clamp experiments using

72 ation current (I(h)), and calcium current to pacemaking by using the cell's own firing as a voltage c

73 Biological pacemaking can be achieved by modulating ionic currents

74 We conclude that there are specialised pacemaking cells in the rabbit urethra that may be respo

75 er culture allowed for the identification of pacemaking cells using the multielectrode array platform

76 itivity to Cav1.3 variants during SN DA-like pacemaking compared with Cav1.2 during aSM-like activity

77 l matrix, we found that calcium entry during pacemaking created a basal mitochondrial oxidant stress.

78 pe calcium channels during normal autonomous pacemaking created an oxidant stress that was specific t

79 Pacemaking current is carried by the Na+-Ca2+ exchanger,

80 c nucleotide-gated (HCN) channels generate a pacemaking current, I(h), which regulates neuronal excit

81 ric oxide exerts a facilitatory influence on pacemaking currents in the sino-atrial node.

82 e show a form of bidirectional plasticity of pacemaking currents induced by chronic heavy drinking wi

83 voltage-clamp experiments using a cell's own pacemaking cycle as voltage command.

84 ensitive sodium current flows throughout the pacemaking cycle, even at voltages as negative as -70 mV

85 CN) channels regulate neuronal excitability, pacemaking, dendritic integration, and homeostatic plast

86 To determine whether neuronal pacemaking depends on active glucose metabolism, we swit

87 he rate of spontaneous depolarization during pacemaking, did evoke subthreshold outward currents.

88 nnels by dihydropyridines re-establishes the pacemaking driven by sodium and HCN channels found in ju

89 tivity after pauses and positively regulated pacemaking during slow heart rate in a numerical model o

90 The reduced models capture normal pacemaking dynamics with a small complement of ionic cur

91 For example, the pacemaking electrical signal is known to originate in th

92 rigin of periodicity consists of specialized pacemaking elements that synchronize and drive the rest

93 These results show that the pacemaking "engine" from I(NaP) is an inherent property

94 Nimodipine produced a slowing of pacemaking frequency.

95 o the suprachiasmatic nucleus, regulation of pacemaking function by PIP(2) in the IGL may influence s

96 nduce Hcn4 expression and suggest a temporal pacemaking function for the DMP during early cardiogenes

97 Shox2 in the regulation of SAN formation and pacemaking function in addition to several other organs.

98 demonstrate a fully developed SAN and normal pacemaking function in Shox2(KI/KI) mice.

99 Shox2 dose appears to be critical for normal pacemaking function.

100 ragranular generator acting as primary local pacemaking generator.

101 ragranular generator acting as primary local pacemaking generator.

102 4C and deep layers containing primary local pacemaking generators, suggesting the involvement of the

103 Biological pacemaking has been performed with viral vectors, human

104 ronal signaling, muscle contraction, cardiac pacemaking, hormone secretion and cell proliferation.

105 A synchronized heart beat is controlled by pacemaking impulses conducted through Purkinje fibers.

106 c heart beat is coordinated by conduction of pacemaking impulses through the cardiac conduction syste

107 f CHZ successfully restored the precision of pacemaking in a dose-dependent manner.

108 ese properties of Ca(v)1.3 affect sinoatrial pacemaking in a mathematical model.

109 y the influence of IP3 signalling on cardiac pacemaking in a system where periodic intracellular Ca(2

110 sufficiently powerful to maintain circadian pacemaking in arrhythmic Cry-null SCN, deficient in esse

111 f TTX, which block TTX-sensitive iNa, slowed pacemaking in both intact SA node preparations and isola

112 e of these mutations is loss of precision of pacemaking in cerebellar Purkinje cells.

113 ntity of calcium channels that contribute to pacemaking in DCN neurons of juvenile rats.

114 We analyzed ionic currents that regulate pacemaking in dopaminergic neurons of the mouse ventral

115 We analyzed the ionic currents that drive pacemaking in dopaminergic VTA neurons, studied in mouse

116 The loss of the precision of pacemaking in EA2 is the consequence of reduced activati

117 ,5-trisphosphate receptors (IP3 Rs) modulate pacemaking in embryonic heart, but their role in adult s

118 ls are important for signal transduction and pacemaking in eukaryotes.

119 Previous studies suggest that pacemaking in ICC is dependent upon metabolic activity 1

120 e hypothesis that the precision of intrinsic pacemaking in Purkinje cells is essential for motor coor

121 estores the severely diminished precision of pacemaking in Purkinje cells of EA2 mutant mice by prolo

122 interneuronal signals responsible for robust pacemaking in SCN cells and circuits, we have developed

123 restore cellular synchrony and amplitude of pacemaking in SCN circuits lacking vasoactive intestinal

124 ehavior in vivo alongside cellular molecular pacemaking in SCN slices in vitro demonstrated that such

125 mitochondria is a prerequisite of electrical pacemaking in the gastrointestinal tract.

126 s with mutant circadian periods we show that pacemaking in the host SCN is specified by the genotype

127 SK channels have demonstrable effects on SAN pacemaking in the mouse.

128 To investigate the contribution of NCX to pacemaking in the SAN, we performed optical voltage mapp

129 determines cell- and circuit-level circadian pacemaking in the SCN.

130 cently been shown to play important roles in pacemaking in the sino-atrial node.

131 Circadian pacemaking in the suprachiasmatic nucleus (SCN) revolves

132 rstanding of the ionic mechanisms underlying pacemaking in these neurons is rapidly evolving, yieldin

133 activity nor does disruption of the SR alter pacemaking in these primary pacemaker cells.

134 Pacemaking in tissues was studied by intracellular elect

135 eostatic responses to ASOX (e.g., stressless pacemaking) in DMV neurons.

136 Cardiac pacemaking initiated by the sinus node is attributable t

137 RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activate

138 approach to show that the binding of cGMP to pacemaking ion channels is weakened by a slower internal

139 ire spontaneously because of the activity of pacemaking ion channels.

140 Pacemaking is a property that this type of retinal amacr

141 The irregular pacemaking is caused by reduced activation of calcium-ac

142 ith their own firing patterns, we found that pacemaking is driven by two kinds of subthreshold sodium

143 Cardiac pacemaking is governed by specialized cardiomyocytes loc

144 mutant mice, the precision of Purkinje cell pacemaking is lost such that there is a significant degr

145 an clock, but in vivo evidence for intrinsic pacemaking is still lacking.

146 er, carry no CREs, and how CRY-dependent SCN pacemaking is synchronized remains unclear.

147 ut their role in adult sinoatrial node (SAN) pacemaking is uncertain.

148 ium channel, a key mediator of Purkinje cell pacemaking, is improperly spliced in RbFox2 and Rbfox1 m

149 on, which could affect their contribution to pacemaking, is unknown.

150 Although not necessary for pacemaking, L-type channels helped support pacemaking wh

151 nt neurons, separate elements of the central pacemaking machinery regulate pdf or its product in nove

152 The pacemaking mechanism in VTA neurons differs from that in

153 These findings demonstrate that the pacemaking mechanism of cholinergic MHb neurons controls

154 tes spiking frequency and contributes to the pacemaking mechanism.

155 ns in the substantia nigra pars compacta use pacemaking mechanisms common to neurons not affected in

156 Circadian (~24 hour) pacemaking mechanisms exist within single cells.

157 important for the stable rhythmic firing of pacemaking neurons and could significantly affect synapt

158 avior by synchronizing a small population of pacemaking neurons and maintaining rhythmicity in a larg

159 In fact, the relevant pacemaking neurons are themselves circadian photorecepti

160 ated mouse tuberomammillary nucleus neurons, pacemaking neurons with large I(A) currents in which sub

161 y of terminals emanating from PDF-containing pacemaking neurons, indicating a functional connection b

162 ior are controlled by a circuit of circadian pacemaking neurons.

163 Pacemaking occurred in all NRVM-Cx43 HEK pairs with cell

164 , calcium current plays only a minor role in pacemaking of dissociated SCN neurons, although it can d

165 TTX-sensitive sodium current in driving the pacemaking of many central neurons has been proposed, bu

166 oltage-dependent calcium channels in driving pacemaking of midbrain dopamine neurons and suggest that

167 ast two ion conductances are involved in the pacemaking of the circadian rhythms.

168 m pump dysfunction that alters the intrinsic pacemaking of these neurons, resulting in erratic burst

169 This selective enhancement of "stressful pacemaking" of DA SN neurons in vivo defines a functiona

170 Cardiac pacemaking offers a unique opportunity for direct gene t

171 underlie the dependence of gastrointestinal pacemaking on oxidative metabolism.

172 nd peripheral regions (center is adapted for pacemaking only, whereas periphery is adapted to protect

173 During SN DA-like pacemaking, only Cav1.3 variants conducted Ca(2+) curren

174 n understanding of the underlying biology of pacemaking opens up new prospects for better alternative

175 he issue of how a metabolite remote from the pacemaking origin of the oscillation may nevertheless co

176 We discover that an independent RhoA pacemaking oscillator controls this instability, generat

177 The role of T-type Ca(2+) channels in pacemaking outside the sinus node is unknown.

178 has been suggested to play a role in cardiac pacemaking, particularly in association with Ca2+ releas

179 During the later phase of pacemaking (positive to -60 mV), TTX-sensitive sodium cu

180 els reflected the multichannel nature of the pacemaking process.

181 s with exogenous buffer had little effect on pacemaking rate.

182 the cardiac maximal diastolic potentials and pacemaking rates recorded in cell pairs, whereas reprodu

183 he substantia nigra pars compacta (SNc), the pacemaking relies more on Ca(2+) channels and that the d

184 of L-type Ca(2+) channels during autonomous pacemaking renders SNc DA neurons susceptible to mitocho

185 channels to drive their maintained, rhythmic pacemaking renders them vulnerable to stressors thought

186 ue using wild-type (WT) "graft" SCN to drive pacemaking (reported by PER2::LUCIFERASE bioluminescence

187 ourth, simulation of cholinergic interneuron pacemaking revealed that a modest increase in the entry

188 SCN pacemaking revolves around feedback loops in which expre

189 d it is not known which ones actually play a pacemaking role in vivo.

190 r cells also have a SR-dependence of cardiac pacemaking since the rate of beating of guinea-pig SA no

191 Before isoproterenol, the earliest pacemaking site occurred in the inferior SAN, and LDCAE

192 micromol/L) increased sinus rate and shifted pacemaking site to superior SAN, concomitant with the ap

193 ers T-type channels a capacity to serve as a pacemaking sodium current in the primitive heart and bra

194 Slow inactivation of the pacemaking sodium currents promotes a constant frequency

195 clear and cytoplasmic processes in circadian pacemaking, such that the pacemakers of some species mig

196 ck is an integral component of the circadian pacemaking system.

197 entify cardiac structures that are potential pacemaking targets with low optical excitation threshold

198 gal motoneurons acquire a stressless form of pacemaking that diminishes mitochondrial and cytosolic o

199 During normal pacemaking, the early phase of spontaneous depolarizatio

200 ation of an ion channel that is essential in pacemaking, the hyperpolarization and cyclic nucleotide-

201 ronal physiology, specifically Purkinje cell pacemaking, through their shared control of sodium chann

202 rs to be a common mechanism in many types of pacemaking tissue since the rate reducing effects of rya

203 h more abundant SK channels in the atria and pacemaking tissues compared with the ventricles.

204 two components of sodium current during the pacemaking trajectory using action potential clamp.

205 dritic Ca2+ oscillations but left autonomous pacemaking unchanged.

206 The robustness of pacemaking underscores its biological importance and pro

207 as not reversed, suggesting that the loss of pacemaking was a consequence, rather than a cause, of ke

208 Normal pacemaking was also consistently silenced by replacement

209 Pacemaking was also slowed by the P/Q-channel blocker om

210 transient striatal GABAergic input to reset pacemaking was dependent on dendritic HCN2/HCN1 channels

211 Damage to ICC and pacemaking was greatly attenuated in the absence of NO d

212 Pacemaking was not inhibited by blocking hyperpolarizati

213 Lastly, activating spines during pacemaking, we observed an unexpected enhancement of spi

214 ICC networks and pacemaking were protected in iNOS(-/-) mice.

215 Cell doses >700,000 are sufficient for pacemaking when administered to left ventricular myocard

216 r pacemaking, L-type channels helped support pacemaking when challenged with cationic channel blocker

217 ence was critical to fast spiking but not to pacemaking, which appeared to be dependent on the positi

218 was a progressive decline in autonomous GPe pacemaking, which normally serves to desynchronize activ

219 At a cellular level, cardiac pacemaking, which sets the rate and rhythm of the heartb