ライフサイエンスコーパス: packing interaction

1 ing that this face is involved in a critical packing interaction.

2 stacking, loop-helix interaction, and helix packing interaction.

3 ifferent C-X...NR3 (X = I, Br) distances and packing interactions.

4 metry is not simply a consequence of crystal-packing interactions.

5 is associated with loop dynamics and crystal-packing interactions.

6 rogen bonds but locally disrupted side-chain packing interactions.

7 idues participate in favorable van der Waals packing interactions.

8 to visualize directly the goodness-of-fit of packing interactions.

9 bdomain and likely contains some native-like packing interactions.

10 cal structure, apparently due to the loss of packing interactions.

11 His in the crystals is influenced by crystal packing interactions.

12 in the molecule or complex and/or by crystal packing interactions.

13 de possible by a series of changes in steric packing interactions.

14 lyproline II structure, and lacks pronounced packing interactions.

15 ndicating significant tertiary or quaternary packing interactions.

16 y structure that permit inter-helix tertiary packing interactions.

17 to identify RNAs that form extensive helical packing interactions.

18 at it also engages in tertiary or quaternary packing interactions.

19 rface recognition and favorable intersubunit packing interactions.

20 changes that could be suppressed by crystal packing interactions.

21 vironment appear to be mainly due to crystal packing interactions.

22 terogeneity and often have extensive crystal packing interactions.

23 ments of orientation dependence in molecular packing interactions.

24 gen bonding, buried hydrophobic surface, and packing interactions.

25 sult from signal propagation through crystal packing interactions.

26 , and are more important than specific tight packing interactions.

27 lightly from exact symmetry, possibly due to packing interactions.

28 nal domain, as well as in the inter-filament packing interactions.

29 ared with a region lacking native side-chain packing interactions.

30 transient disruption of lipid and/or protein packing interactions.

31 Likely, strong crystal packing interactions account for this observation.

32 We conclude that AS2/AS2' packing interactions alone can play an important role in

33 Packing interactions also play a significant role in the

34 stabilize the N- and C-terminal interhelical packing interactions also reduce viral infectivity.

35 wever, with additional mutations that affect packing interactions, an IL-8 variant specific for recep

36 imer showed most of the predicted side-chain packing interactions and a main-chain conformation indis

37 egulate receptor function are linked through packing interactions and a network of hydrogen bonds, su

38 re more straightforward to predict than core-packing interactions and can be selected to avoid affect

39 es a further compaction, additional tertiary packing interactions and further uptake of magnesium ion

40 results suggest that a detailed interplay of packing interactions and interactions with water determi

41 e two crystal forms exhibit mostly unrelated packing interactions and local crystallographic disorder

42 as revealed by the unusual crystallographic packing interactions and other biochemical analysis.

43 Fine-tuning of the packing interactions and the final condensation of the s

44 gy function based primarily on Lennard-Jones packing interactions and the Lazaridis-Karplus implicit

45 the structural and energetic basis of helix packing interactions and their role in folding, we prepa

46 lone does not dominate function; helix-helix packing interactions appear to also contribute.

47 ane proteins are more tightly packed and the packing interactions are more diverse than those found i

48 stability of the I form, specific side-chain packing interactions are not.

49 rks of canonical knobs-into-holes side-chain packing interactions are observed at each helical interf

50 are segments of b2 within that region where packing interactions are quite loose.

51 The results demonstrate that crystal packing interactions are the molecular basis for the for

52 s as a homodimer using beta-sheet/beta-sheet packing interactions as observed for several other PAS d

53 where classically described knobs-into-holes packing interactions at interhelical contact surfaces ar

54 nts can be explained primarily by changes in packing interactions at the protein-protein interface.

55 y uncharacterized type of "knobs-into-holes" packing interaction between interfacial Trp side chains,

56 Importantly, we obtained evidence for a packing interaction between Val-335 in M4 and Gln-783 in

57 of the side chain conformation allowing for packing interactions between adjacent helices, which sug

58 Packing interactions between AQP0 tetramers in the cryst

59 ng to probe the fold within the core and the packing interactions between beta-sheets.

60 ulfonate binding sites and two for examining packing interactions between bound ligands and the bindi

61 lso examined hydrogen bonding and side chain packing interactions between D44 and R55 and between F47

62 show that the structural interplay of helix-packing interactions between HAMP and the adjoining meth

63 r around the active site, a set of conserved packing interactions between helices alpha(2) and alpha(

64 lvent exposure of residue 108 and heightened packing interactions between M108 and helices alpha2, al

65 he hydrophobic effect, hydrogen bonding, and packing interactions between residues in the protein int

66 The study shows that the packing interactions between the alpha2 and alpha1 helic

67 dues are important determinants of conserved packing interactions between the amino- and carboxyl-ter

68 These results identify conserved packing interactions between the N and C helices of gp41

69 es upon complexation and, possibly, enhanced packing interactions between the protein and DNA in the

70 proteins depend in part on a precise set of packing interactions between transmembrane helices.

71 These structures reveal the details of the packing interactions by which the constituent beta-stran

72 ins, detailed structural features, including packing interactions, cannot be designed a priori.

73 pi-pi, Cation-pi, and hydrophobic packing interactions contribute specificity to protein f

74 The large hydrophobic packing interactions contributed by all the helices of b

75 nd AahI and with combining loops involved in packing interactions, denoting expulsion of the bound an

76 pairs (UBPs), which rely on hydrophobic and packing interactions for pairing and which are well repl

77 it is the ability to establish differential packing interactions for the helix segments, rather than

78 importance of tyrosine hydrogen-bonding and packing interactions for the stability of FIS and demons

79 Together, helix alpha6 and its packing interactions function as a simple central proces

80 NMR measurements also show that a packing interaction in rhodopsin between Trp265(6.48) an

81 ps underpinning direct carbohydrate-aromatic packing interactions in aqueous solution have been diffi

82 nstead, it comprises in excess of 50% of all packing interactions in crystals of A-form RNA and has a

83 ors are among the most widespread long-range packing interactions in large ribozymes.

84 e the importance of optimizing van der Waals packing interactions in protein design but demonstrate t

85 CH-pi interactions to carbohydrate-aromatic packing interactions in proteins.

86 he asymmetric unit and devoid of significant packing interactions in regions involved in the alloster

87 ary structure (1D/3D) together with pairwise packing interactions in the core (threading).

88 transient disruption of lipid and/or protein packing interactions in the course of particle fusion an

89 Packing interactions in the crystal structure suggest ho

90 strongly suggest that conserved interhelical packing interactions in the F protein fusion core are im

91 strong evidence that conserved interhelical packing interactions in the gp41 core are important dete

92 ts suggest the possibility of non-native B/E packing interactions in the kinetic intermediate.

93 t is noteworthy that one of the intersubunit packing interactions in the MJ0796 crystal involves anti

94 to be primarily the result of the perturbed packing interactions in the native state of the Ile -->

95 dynamics of the side chain as well as on the packing interactions in the solid state of peptides.

96 f 45 transmembrane (TM) helices and 88 helix packing interactions in three independent transmembrane

97 of alpha-helicity and decreased interhelical packing interactions in transmembrane regions are promot

98 Both solution studies and crystal packing interactions indicate that the TRPV2-ARD does no

99 To test the hypothesis that a close-packing interaction involving this patch is important fo

100 Crystal packing interactions involving a highly conserved, expos

101 th the monomer and dimer due to intrahelical packing interactions involving the beta-methyl groups, a

102 , is called into question by the presence of packing interactions involving the Na(+) site and the ac

103 he overall conclusion is that improvement of packing interactions is a mechanism to confer stability

104 demonstrates that the inclusion of specific packing interactions is necessary for the design of nati

105 re modest and might simply represent crystal packing interactions, it is interesting to speculate tha

106 lex structures are similar, although crystal-packing interactions lead to differences between identic

107 Here, we test whether rigid side-chain packing interactions like those in holomyoglobin persist

108 ion selectivity defects, suggesting that the packing interaction may be conformation-sensitive.

109 Our results also suggest that needle-packing interactions may be different among these bacter

110 These results suggest that crystal packing interactions may influence their stability.

111 s often condensed through long-range helical packing interactions mediated by loop-receptor motifs.

112 cleosome complex consistent with key crystal packing interactions mediated by RCC1.

113 Both end-to-end and end-to-groove packing interactions occur in the crystal lattice, the l

114 is suggests that native-like helix B/helix C packing interactions occur in the folding intermediate.

115 ve and Ag+-sensitive and suggests a possible packing interaction of TMH1 with TMH2 and TMH3.

116 The interfacial elastic packing interactions of different galactosylceramides (G

117 These data together suggest that the packing interactions of the hydrophobic core determine I

118 fibrils is likely the result of stabilizing packing interactions of the protofilaments.

119 can be related to differences in the crystal packing interactions of the two monomers in the asymmetr

120 viding models that delineate potential close packing interactions on the cell surface.

121 gle crystal showing the influence of crystal packing interactions on the course of enzymatic reaction

122 he results reveal the importance of specific packing interactions on the kinetics of amyloid formatio

123 two populations of b subunits with different packing interactions or to helical bending within this r

124 rring in the G/U shallow groove pocket--like packing interactions (P-interactions) and some phosphate

125 In these locations, nonbonded van der Waals packing interactions predominate over hydrogen bonding a

126 rt to successfully capture specific tertiary packing interactions produced specific three-dimensional

127 These altered packing interactions propagated subtle changes between t

128 the stability of the dimer, indicating that packing interactions rather than hydrogen-bonding provid

129 A crystal packing interaction replicates the lateral contacts betw

130 These packing interactions suggest that the protofilament subu

131 th the crystal structures found with crystal-packing interactions that are effectively equivalent to

132 apparently reflecting particularly favorable packing interactions that are possible for the most comm

133 side surface of the membrane affects lateral packing interactions that cause perturbations in the org

134 hat A-minor motifs are integral to the helix packing interactions that define the 5'-splice site of t

135 t the design method is sensitive to the core packing interactions that specify the protein structure.

136 rative analysis of the atomic details of the packing interactions that surround the evolutionarily co

137 ink can facilitate the formation of tertiary packing interactions that would otherwise not be possibl

138 rnase; bs, barstar), deletes a van der Waals packing interaction; the second complex, bnLys27-->Ala-b

139 Sequence divergence and crystal packing interactions under low pH conditions are likely

140 The data further show that while packing interactions unique to triple and quadruple muta

141 er arises from transient disruption of lipid packing interactions upon disk-to-vesicle fusion.

142 ly disrupting a known and persistent crystal packing interaction, we have crystallized the poliovirus

143 espective of the degree of native side-chain-packing interactions, we anticipate that overpacking rep

144 Aromatic packing interactions were completely lost, although hydr

145 ecific helix-helix contacts via knob-in-hole packing interactions were identified in the adaptation,

146 n close proximity to each other via aromatic packing interactions, whereas the positively charged res

147 pe structure stabilized by aromatic-aromatic packing interactions with extended N- and C-termini.

148 G25A) and to promote native-like hydrophobic packing interactions with helix G (in the mutant H24L/H1

149 al helix is well formed and is stabilized by packing interactions with residues in the hydrophobic co

150 e active site that modify hydrogen bonds and packing interactions with substrate, as well as disrupt

151 e motions, apparently due to modification of packing interactions with the chameleon peptide.

152 the inhibitory helix without perturbing its packing interactions with the ETS domain.

153 s that disrupt side-chain hydrogen bonds and packing interactions with the iNOSox C-terminus (N83, D9

154 ntain a helical conformation even though the packing interactions with the remainder of the protein a

155 ion structures show impressively well-fitted packing interactions, with some regions thoroughly inter

156 whereby stimulus-induced changes in lateral packing interactions within an array of receptor-sensing

157 ns of the substrate protein compete with the packing interactions within the aggregate.

158 Here, we used packing interactions within the core of a protein to sta

159 imic effects, most likely by contributing to packing interactions within the HAMP bundle.

160 the hydrophobic surface of A2AR, increasing packing interactions within the receptor and stiffening