ライフサイエンスコーパス: painful

1 intact, and range of motion was full, though painful.

2 uli that reach the brain may be perceived as painful.

3 atic, whereas adenoid cystic carcinomas were painful.

4 However, intra-TMJ injections are painful.

5 or inflammation in the area perceived to be painful.

6 twisting, repetitive movements or sometimes painful abnormal postures.

7 postsynaptic current and to the detection of painful acidosis.

8 able and functional form, preferably without painful administration.

9 peripheral neuropathy (CIPN) is a severe and painful adverse reaction of cancer treatment in patients

10 rgeries associated to a new onset of sudden, painful AHP with normal ocular exam).

11 Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints

12 (and 19 confederates) to equally unpleasant painful and disgusting stimulations, as well as unfair m

13 s have to undergo unnecessary but physically painful and expensive procedure such as prostate biopsie

14 Electrophysiological studies are painful and expensive.

15 at risk for postherpetic neuralgia (PHN), a painful and long-lasting complication.

16 The painful and non-painful stimuli can be differentiated ba

17 the major challenge is that this approach is painful and the effects are restricted to the injection

18 Acanthamoeba keratitis (AK) is a very painful and vision-impairing infection of the cornea tha

19 tially been painless but recently had become painful and was causing difficulty in speaking and swall

20 asured on a scale of 0 to 100 (least to most painful) and hand performance testing.

21 ral mucositis (OM) is among the most common, painful, and debilitating toxicities of cancer regimen-r

22 A positive painful arc test result and a positive external rotation

23 or RCD (3.7 [95% CI, 1.9-7.0]), and a normal painful arc test result had the lowest negative LR (0.36

24 Among pain provocation tests, a positive painful arc test result was the only finding with a posi

25 epeated intravitreal injections which may be painful, are incompletely efficacious, and represent a s

26 ed orthopedic procedure for the treatment of painful arthritis, osteonecrosis, or fracture.

27 A solitary, painful, black, crusted ulcer with a peripheral erythema

28 (n = 7), infection (n = 2), and hypotony and painful blind eye (1 each).

29 children, who develop symptoms ranging from painful blisters around their mouths and hands to neurol

30 Patients responding to reirradiation of painful bone metastases experience superior QOL scores a

31 Patients should be offered re-treatment for painful bone metastases in the hope of reducing pain sev

32 ose fractionation schedules in patients with painful bone metastases needing repeat radiation therapy

33 In patients with painful bone metastases requiring repeat radiation thera

34 ctor for treatment response in patients with painful bone metastasis treated with palliative RT.

35 skin reaction to prolonged sun exposure (for painful burn with blisters vs. practically no reaction,

36 ontact with skin or is ingested, it causes a painful burning sensation.

37 th Doppler analysis of the right breast were painful but were performed with the least pressure possi

38 1.6 years +/- 11.6; range, 24-69 years) with painful calcific tendinopathy diagnosed at US were prosp

39 lying inflammatory pain hypersensitivity and painful chemotherapy-induced neuropathy.

40 Total pancreatectomy for presumed painful chronic pancreatitis remains controversial.

41 fective and can be utilized in patients with painful chronic pancreatitis, although randomized trials

42 Hidradenitis suppurativa is a painful, chronic inflammatory skin disease with few opti

43 ctions by herpes simplex viruses (HSV) cause painful cold sores or genital lesions in many people; le

44 2015, the patient experienced relapse, with painful collapse of L3 vertebral body.

45 d to increased numbers of patients with this painful complication.

46 ing particularly associated with the risk of painful complications.

47 In the case of phantom pains, the painful component too is sometimes illustrated, again, a

48 onic disease that results in a disabling and painful condition as it progresses to destruction of the

49 and contributes to our understanding of the painful condition observed in patients submitted to chro

50 afflicted with shingles risk developing the painful condition of postherpetic neuralgia (PHN), which

51 formation, which has been implicated in the painful condition of postherpetic neuralgia, is regulate

52 ecause limbs are protected from use during a painful condition, this sensitization of LTMRs may perpe

53 (13.4% vs 3.1%), depression (17.3% vs 9.1%), painful conditions (15.4% vs 8.4%) and dyspepsia (10.9%

54 The generation of such painful conditions by small quantities of simultaneously

55 Painful conditions contribute to the risk of prescriptio

56 ytic-like and ability to relieve neuropathic painful conditions evaluated in CCI and STZ murine model

57 because the prevalence of both dementia and painful conditions increases with age.

58 Polyneuropathy is one of the most common painful conditions managed within general and specialty

59 Given that other painful conditions of the distal extremities (ie, neurop

60 This is found in many painful conditions, particularly arthritis.

61 Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases

62 n the pain type or underlying mechanism (eg, painful cramps, nociceptive pain, or neuropathic pain).

63 ate of vaso-occlusive crisis, a composite of painful crisis or acute chest syndrome.

64 SCA-related clinical outcome (vaso-occlusive painful crisis, dactylitis, acute chest syndrome, spleni

65 based chemical warfare agent known to induce painful cutaneous inflammation and blistering.

66 Medical management of painful cutaneous leiomyomas is generally unsatisfactory

67 The use of botulinum toxin to treat painful cutaneous leiomyomas was associated with improve

68 ng brain responses to visual, olfactory, and painful cutaneous stimulation, and functional connectivi

69 its diagnosis suggested by the presence of a painful cutaneous ulcer showing rapid progression.

70 ory neutrophilic dermatosis characterized by painful cutaneous ulcerations and often associated with

71 Pain referred to the perianal region, painful defecation and weight loss have predictive value

72 tivariate regression analysis perianal pain, painful defecation and weight loss were significantly as

73 The presentation of painful defecation, anal fissures, and macroscopic blood

74 th a history of lumbar and perineal pain and painful defecation.

75 ure, as well as choices between hypothetical painful dental appointments at time points of up to appr

76 e density were demonstrated in patients with painful diabetic neuropathy compared with healthy contro

77 elp identify patients with spinally mediated painful diabetic neuropathy who may respond optimally to

78 ay be effective for short-term management of painful diabetic neuropathy, although their comparative

79 er of spinal inhibitory dysfunction in human painful diabetic neuropathy.

80 may contribute to the clinical phenotype in painful diabetic neuropathy.

81 Multiple treatments for painful diabetic peripheral neuropathy are available.

82 carcinoma, one of the most feared lethal and painful diseases, is increasing in incidence.

83 s, we included data for non-gastrointestinal painful disorders and specific symptoms of pain, nausea,

84 terogeneous group of highly debilitating and painful disorders characterized by thickening of the ski

85 tations/variants have been identified in the painful disorders inherited erythromelalgia and small-fi

86 hanges that contribute to pain in many human painful disorders.

87 sed either financial penalty or demonstrably painful electric shock to their co-participant, thereby

88 off decisions combining monetary rewards and painful electric shocks, administered to the participant

89 ynamically changing values of cues signaling painful electric shocks, which predict behavioral suppre

90 nt amounts of money and different numbers of painful electric shocks.

91 puncture and aversiveness and habituation of painful electrical stimulation in mediating the analgesi

92 tentials (ERPs) while participants underwent painful electrical stimulation or witnessed that another

93 years or younger who received sedation for a painful emergency department procedure were enrolled in

94 after surgery with several days' history of painful, enlarging, pulsatile subcutaneous masses.

95 ing to blood vessel occlusion accompanied by painful episodes and even death.

96 ted with fevers, joint pains, and widespread painful eruptions.

97 However, injections are painful, especially considering that they have to be giv

98 Painful events are suggested to elicit two opponent resp

99 Dentin hypersensitivity (DH) is a painful, exaggerated response to normal stimuli, such as

100 onal principles by which the brain creates a painful experience from nociception are still unknown.

101 refrontal cortical areas deactivated after a painful experience had been reached.

102 ental appointment commonly prompts fear of a painful experience, yet we have never fully understood h

103 iated with stronger brain responses, whereas painful experiences (e.g., skin punctures, tube insertio

104 Painful experiences are multilayered, composed of sensor

105 Our empirical results show that sharing painful experiences produces "identity fusion" - a visce

106 brain regions have been implicated in human painful experiences, but none have been proven to be spe

107 surgery in 40 % of cases followed by a blind painful eye secondary to glaucoma (19 %) in the enucleat

108 n our tertiary care center followed by blind painful eyes and endophthalmitis.

109 with FD, particularly those with ulcer-like (painful) FD.

110 ing evidence has shown that social pain--the painful feelings that follow from social rejection, excl

111 tive reversal, such as the "hedonic flip" of painful feelings.

112 r treating chronic gastrointestinal pain and painful FGIDs and serotonin noradrenergic reuptake inhib

113 is a chronic cutaneous disease with acutely painful flares that require appropriate and timely treat

114 cancer is cystoscopy, which is invasive and painful for patients.

115 eolar lavage that are uncomfortable, or even painful, for the patient.

116 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation.

117 y was low for most questions except those on painful gums and tooth mobility.

118 nsitive to temperatures from noxious cold to painful heat (-5 to 55 degrees C) by ablating several di

119 Sixty participants experience painful heat and warmth and view photos of ex-partners a

120 e pain while experiencing multiple levels of painful heat during functional magnetic resonance imagin

121 , objects were presented (1) alone, (2) with painful heat stimuli, or (3) with auditory stimuli that

122 direction for development of treatments for painful herpes zoster.

123 tial modality used to evaluate patients with painful hip joints.

124 Among adults with painful hip osteoarthritis, physical therapy did not res

125 We report a case of a 22-year old male with painful hips in whom on the basis of the imaging studies

126 hanisms and treatment.SIGNIFICANCE STATEMENT Painful HIV-associated sensory neuropathy is a neurologi

127 Mast cells were upregulated in painful human IVD tissue and induced an inflammatory, ca

128 C), a disorder typified by dystrophic nails, painful hyperkeratotic calluses in glabrous skin, and le

129 sium channels, a potential mechanism for the painful hypersensitivity (that we term "noxacusis" to di

130 studied the role of IKD in damage-triggered painful hypersensitivity to innocuous cold.

131 which impairs inactivation, in patients with painful I-SFN.

132 s or older who had radiologically confirmed, painful (ie, pain measured as >/=2 points using the Brie

133 of immune cells that naturally accumulate in painful inflamed areas.

134 apy and disposed to mucositis, which creates painful inflammation and ulceration in the oral cavity.

135 Acute pancreatitis (AP) is a painful inflammatory disorder of the exocrine pancreas,

136 ented to our hospital for a rapidly growing, painful inflammatory skin lesion of the left leg.

137 Arsenicals are painful, inflammatory and blistering causing agents deve

138 e to adverse side effects such as nausea and painful injections, which can occur during treatment wit

139 bnormal alertness/mental status, distracting painful injury, and tenderness to chest wall palpation).

140 in the case of hyperhidrosis means multiple painful intradermal injections by a skilled clinician at

141 Painful IVD degeneration is associated with an acidic in

142 -old male patient presented with swollen and painful knee.

143 es hyperthermia and decreased sensitivity to painful levels of heat in animals and humans.

144 RPV1), a thermo-TRP ion channel activated by painful levels of heat, is an important contributor beca

145 w decreased attention to some stimuli on the painful limb and increased attention to others, a parado

146 al of 115 patients who underwent PVP for 216 painful long-standing OVCFs were prospectively followed

147 h as severe mental illness, alcohol abuse, a painful loss, exposure to violence, or social isolation.

148 enting with regular menses, dysmenorrhea and painful lump in hypogastric region on the left side of m

149 exible normal variant of growth, to stiff or painful manifestations of tarsal coalition, collagen abn

150 ted ion channel(s) must account for noxious (painful) mechanosensation.

151 emales; median age, 58 years) diagnosed with painful meningoradiculitis (Bannwarth syndrome) who were

152 escents and young women, is characterized by painful menstrual cramps.

153 as performed in 26 patients (47 tumors) with painful metastatic posterior vertebral body tumors, some

154 monitor their own actions in order to avoid painful mistakes, which are often associated with harsh

155 f traumatic peripheral nerve injury, causing painful mononeuropathy.

156 a brain disorder causing involuntary, often painful movements.

157 Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are depe

158 primary enucleation in 1 patient because of painful neovascular glaucoma.

159 Radiculopathy, a painful neuroinflammation that can accompany interverteb

160 or sources of disability and often result in painful neuropathies or the impairment of muscle movemen

161 D in diabetic rodents exhibiting features of painful neuropathy and the translational potential of th

162 ate that a variant of NaV1.7 associated with painful neuropathy depolarizes resting membrane potentia

163 therapy drugs for treating many cancers, and painful neuropathy is a major dose-limiting adverse effe

164 ility and familial episodic pain disorder or painful neuropathy, while mutations evoking larger membr

165 to paclitaxel-induced acute pain and chronic painful neuropathy.

166 clearest in maternal-child consultations for painful NSPS and for specific bodily systems including g

167 Gastrointestinal attacks are painful, of sudden onset and often mistaken for acute ab

168 ons by associating a neutral stimulus with a painful one, resulting in a stable threat memory.

169 is a rare clinical syndrome characterized by painful ophthalmoplegia and ipsilateral cranial neuropat

170 bA1c had a much greater risk of developing a painful or autonomic neuropathy than those individuals w

171 ring pain by introducing a motor task during painful or nonpainful stimulation.

172 ffects millions of people worldwide, causing painful oral and genital lesions, in addition to a multi

173 Painful oral mucositis (OM) is a significant toxicity du

174 mon candidal infection that may give rise to painful oral symptoms, as well as be a reservoir for inf

175 presented with a 10-week history of multiple painful oral ulcers.

176 nts have proven efficacy in the treatment of painful osseous metastases from prostate cancer and brea

177 eceptor in the joint nerves of patients with painful osteoarthritis.

178 als refraining from actions that resulted in painful outcomes, whereas others favor actions that help

179 with distinct forms of striatal responses to painful outcomes.

180 Painful palmar-plantar keratoderma (PPK) severely impair

181 on is an effective therapy for children with painful pancreatitis that failed medical and/or endoscop

182 current leg pain that progresses to constant painful paraesthesias in the feet and later the hands.

183 he likelihood that external events evoke the painful paroxysm typical of this condition.

184 Unfortunately, current treatment for painful PDN has been limited by nonspecific systemic dru

185 ovel specific therapies for the treatment of painful PDN.

186 Priapism is featured with prolonged and painful penile erection and is prevalent among males wit

187 ed frontolateral theta-band connectivity for painful percepts.

188 Painful peripheral neuropathy represents a significant p

189 459 patients who were referred for possible painful peripheral neuropathy, and confirmed the diagnos

190 d therapeutic target in chemotherapy-induced painful peripheral neuropathy, establish a mechanistic i

191 pids may contribute to chemotherapy- induced painful peripheral neuropathy, which can be a critical d

192 y missense mutations of Nav1.9 as a cause of painful peripheral neuropathy.

193 ense mutations of Nav1.9 in individuals with painful peripheral neuropathy.

194 with the chief dose-limiting side effect of painful peripheral neuropathy.

195 ys, can contribute to the pathophysiology of painful peripheral neuropathy.

196 rmatoses presenting with variable degrees of painful phototoxicity that markedly affects quality of l

197 The highly visible nail changes and painful plantar thickening exert a psychosocial effect o

198 both feasible and safe for the treatment of painful posterior vertebral body metastatic tumors.

199 Observation Tool scores between baseline and painful procedures (mean difference, 3.13 +/- 1.56; p <

200 s of gestation) are exposed to stressful and painful procedures during neonatal intensive care.

201 Procedural sedation for children undergoing painful procedures is standard practice in emergency dep

202 arterial line insertion were the three most painful procedures, with median pain scores of 5 (3-7),

203 gesics to treat pain in their children after painful procedures.

204 In patients presenting with painful proptosis and vision loss, a diagnosis of BL sho

205 an female presented with rapidly progressive painful proptosis of the right eye and poor visual acuit

206 rkitt lymphoma (BL) with rapidly progressive painful proptosis of the right eye is rarely encountered

207 ation treatment, she experienced progressive painful pruritic breast fullness, skin dimpling, and ski

208 o a PTM or radiotherapy was development of a painful PTM within the radiotherapy field that required

209 ith symptomatic infection characterized by a painful purulent urethral discharge, while in women, the

210 The most common clinical symptoms were painful radiculitis (65.9%), cranial nerve palsy (43.4%)

211 Not only does genital herpes cause painful, recurrent symptoms, it is also a significant ri

212 Patients commonly present with painful retiform to stellate purpuric lesions that often

213 temperatures cause a paradoxical, sometimes painful, sensation of burning heat.

214 In this Review, we discuss how painful sensations arise.

215 ut how the human brain adaptively translates painful sensations into actions.

216 decrease in frontoparietal connectivity for painful sensations was also identified in the gamma-band

217 racterised by the acute-to-subacute onset of painful sensory and motor deficits that result from infl

218 Late-onset painful sensory neuropathies are usually acquired condit

219 Why some individuals develop an acute painful sensory neuropathy on sustained cold exposure is

220 amily with a dominantly inherited late-onset painful sensory neuropathy.

221 Two patients with painful SFN were evaluated by skin biopsy, quantitative

222 ne choices made between different numbers of painful shocks to be delivered faithfully at different t

223 flammation, with symptoms defining the acute painful sickle-cell crisis.

224 Patients showed inattention to the painful side for visual processing of body parts but not

225 voidance becomes particularly important when painful signals are involved, and as the climbing fibre

226 link these factors to abnormal processing of painful signals are only just beginning to be explored.

227 ene phosphonate (EDTMP) with 153Sm-EDTMP for painful skeletal metastases.

228 Painful small fibre neuropathy (SFN) represents a signif

229 av1.7 and Nav1.8 have recently been found in painful small fibre neuropathy, the aetiology of periphe

230 ritable pain disorders, and in patients with painful small-fibre neuropathy.

231 cting patients for palliative RF ablation of painful solitary osseous metastases.

232 Reaction times were fastest during painful stimulation and correlated with CCZ activation.

233 Uncontrollable, compared with controllable, painful stimulation can lead to increased pain perceptio

234 After tissue damage, sensitivity to painful stimulation develops in undamaged areas (seconda

235 ivity during the anticipation and receipt of painful stimulation in the rostral anterior cingulate co

236 whenever we observe another person receiving painful stimulation to the hand.

237 ied through the transition of a neutral to a painful stimulation.

238 enced no control over the hand that received painful stimulation.

239 the observer has over the hand that receives painful stimulation.

240 annels in sensory neurons are integrators of painful stimuli and heat, yet how they integrate diverse

241 choices to reapportion social allocations of painful stimuli and, for comparison, also elicited equiv

242 The painful and non-painful stimuli can be differentiated based on their sig

243 We hypothesized that early exposure to painful stimuli during a period of rapid brain developme

244 itive teeth were tested using nonpainful and painful stimuli in a clinical setting.

245 direct evidence that, despite not mediating painful stimuli in naive mice, activation of VGluT3(+) s

246 participants' time preferences for the same painful stimuli in one-off choices, allowing us to asses

247 There was increased sensitivity to painful stimuli in the group with pain as compared to th

248 sential role in initiating pain by detecting painful stimuli in the periphery.

249 teers to test whether spatial information of painful stimuli is represented in areas of the descendin

250 especially important to do in the context of painful stimuli since most animals in these studies cann

251 al transducers of sensory stimuli, including painful stimuli, from the periphery to central sensory a

252 and weak pain signals; however, upon strong painful stimuli, the recruitment of endogenous opioids w

253 nurses at baseline and after nonpainful and painful stimuli.

254 f a limited budget of relief from moderately painful stimuli.

255 that itch-mediating neurons also respond to painful stimuli.

256 vation is believed to reduce transmission of painful stimuli.

257 he transduction and transmission of noxious (painful) stimuli and innocuous stimuli that do not reach

258 In visceral organs of mammals, most noxious (painful) stimuli as well as innocuous stimuli are detect

259 ch as walking or withdrawing the limb from a painful stimulus rely upon integrative multimodal sensor

260 In response to a sustained painful stimulus, we found no effect of A118G on pain-in

261 pathway of predators by inflicting intensely painful stings.

262 at modulate nociception, stabilize or unload painful structures, influence physiological processes th

263 onfounding factors (e.g., lifetime number of painful sunburns), we found a modest increase in risk of

264 red seven parents whose children underwent a painful surgical procedure requiring an opioid prescript

265 Hodgkin's disease of bone is manifested with painful swelling in geared area.

266 ogy department for neck ultrasound (US) with painful swelling in the right parotid gland region.

267 chronic autoimmune disease characterized by painful swollen joints and significant disabilities.

268 Spasticity is a painful symptom and can severely restrict everyday life,

269 c sensitization of peripheral nociceptors in painful syndromes is a complex molecular process poorly

270 cystic duct and sphincter of Oddi can cause painful syndromes is attractive and popular, at least in

271 cognitive deficits observed in patients with painful syndromes.

272 to identify risk factors for development of painful temporomandibular disorder (TMD).

273 psychological stress predicts development of painful temporomandibular disorder (TMD).

274 Smaller chest tubes may be less painful than larger tubes, but efficacy in pleurodesis h

275 AL was lower than a single RBL, HAL was more painful than RBL.

276 Stapled haemorrhoidopexy was less painful than traditional excisional surgery in the short

277 markedly reduced when participants received painful thermal stimuli following hypnotic analgesia on

278 d judgments that a group of people made to a painful thermal stimulus, before receiving the same stim

279 integration mechanism is sufficient to evoke painful thermal TCE, an essential step in transforming t

280 of pressure or friction become inflamed and painful, thus significantly impacting quality of life.

281 barriers to service use were that it was too painful to speak about the loss (64%) and too difficult

282 We compared placebo improvement of painful touch (analgesia) with placebo improvement of pl

283 ransmit information about both innocuous and painful touch and inhibitory populations that serve as a

284 Primary nociceptors relay painful touch information from the periphery to the spin

285 ly-life experiences (e.g., supportive versus painful touch) interact to shape the development of the

286 In 22 subjects with painful trigeminal neuropathy and 44 pain-free controls,

287 , or the ventral trigeminothalamic tracts in painful trigeminal neuropathy subjects compared with con

288 rolonged, and associated with development of painful ulcers.

289 ciated stimulus (reliefCS) presented after a painful US was varied from immediately (Study1), 3 secon

290 of the relief following the termination of a painful US.

291 rized by acute onset of singular or multiple painful vaginal ulcers.

292 ned 21 patients at steady state and 6 during painful vaso-occlusive crises (pVOC).

293 the microcirculation and is characterized by painful vaso-occlusive crises in deep tissues.

294 ited blood disorder that is characterized by painful vaso-occlusive crises, for which there are few t

295 Painful venoms are used to deter predators.

296 ve and therapeutic approaches to combat this painful viral disease in humans.

297 ost-operative-day, she presented with sudden painful, visual loss.

298 ns were nominally but not significantly more painful with 30-gauge needles (mean [SD] VAS ratings for

299 ent pain perception in humans, we contrasted painful with nonpainful sensations delivered at the indi

300 The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10.