ライフサイエンスコーパス: paired helical

1 Paired helical and straight filaments differ in their in

2 esolution and corresponding atomic models of paired helical and straight filaments from the brain of

3 ates and becomes hyperphosphorylated forming paired helical and straight filaments, which can further

4 osits, where it takes the form of aggregated paired helical and straight filaments.

5 crotubule-binding protein tau assembled into paired helical and straight filaments.

6 Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau f

7 n and intermolecular interactions leading to paired helical filament (PHF) formation.

8 isease (AD), immunohistochemistry of WT1 and paired helical filament (PHF) in serial sections was car

9 The paired helical filament (PHF) is the major component of

10 formation of amyloid fibrils displaying the paired helical filament (PHF) morphology characteristic

11 Ser 262 is phosphorylated extensively in paired helical filament (PHF) tau from Alzheimer's disea

12 m the progressive pattern of neuropathology [paired helical filament (PHF)-tau and amyloid-beta] in A

13 r AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer

14 Paired helical filament (PHF)-tau, alpha-synuclein, and

15 Paired helical filament (PHF)/tau immunoreactive dystrop

16 a fragment of tau containing the aggregating paired helical filament (PHF6*).

17 idue amino-acid sequence, referred to as the paired helical filament 6 (PHF6), which may play an impo

18 ide (Abeta) concentration, Abeta deposition, paired helical filament formation, cerebrovascular amylo

19 sociated protein, has not been implicated in paired helical filament formation.

20 nucleation and lead to filaments displaying paired helical filament morphology.

21 a tangle-like appearance that coevolves with paired helical filament pathology within neurons.

22 ur phosphospecific probes also revealed that paired helical filament preparations exhibited phospho-t

23 ognizing independent phospho-epitopes in the paired helical filament proteins (PHF) found in AD brain

24 portant roles in tau aggregation kinetics or paired helical filament structure.

25 ylated at the same amino acid residues as AD paired helical filament tau (PHFtau), but they exhibited

26 vasive analyses in cortical regions in which paired helical filament tau accumulation is expected in

27 vasive analyses in cortical regions in which paired helical filament tau accumulation is expected in

28 d in clinical studies) provides estimates of paired helical filament tau burden in good correlation w

29 d in clinical studies) provides estimates of paired helical filament tau burden in good correlation w

30 t analysis, Tau-nY29 detects soluble tau and paired helical filament tau from severely affected Alzhe

31 rol of the microRNA miR-128a, which can tune paired helical filament Tau levels in neurons.

32 a did not alter endogenous tau production or paired helical filament tau phosphorylation.

33 ripts of SORL1 and ABCA7 was associated with paired helical filament tau tangle density, and the expr

34 ific hallmarks of AD, namely, Abeta load and paired helical filament tau tangle density.

35 Amyloid load and the density of paired helical filament tau tangles were also quantified

36 e phosphorylation site consistently found in paired helical filament tau, serine 413, is modified by

37 global pathology score, and as amyloid load, paired helical filament tau-positive (PHFtau) tangle den

38 tic subtypes, as well as amyloid beta 42 and paired helical filament tau.

39 n have the deposition of Alzheimer's disease paired helical filament type hyperphosphorylated tau.

40 tau hyperphosphorylation further extended to paired helical filament-1 and TG3 epitopes.

41 was a significant decrease in the density of paired helical filament-1-positive neurons in the immuni

42 vidence for hyperphosphorylated tau protein (paired helical filament-I tau), which has been associate

43 Full-length MAP-2c formed paired helical filament-like polymers.

44 We now describe the assembly of paired helical filament-like structures from MAP-2 polyp

45 Abeta and paired helical filament-tau were reduced (61.0% and 44.1

46 h wt mice, prominent inner retinal Abeta and paired helical filament-tau, and decreased retinal gangl

47 ain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzhe

48 t et al reports that antibodies generated to paired helical filaments (AMY antibodies) unexpectedly l

49 bodies which recognize phosphorylated tau in paired helical filaments (AT8 and PHF-1) show positive i

50 Paired helical filaments (PHF) are abnormal, approximate

51 Paired helical filaments (PHF) composed of hyperphosphor

52 The paired helical filaments (PHF) formed by the intrinsical

53 hosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients

54 Paired helical filaments (PHF) occur in Alzheimer's dise

55 of several solvents to solubilize insoluble paired helical filaments (PHF) of Alzheimer disease.

56 orylation is implicated in the biogenesis of paired helical filaments (PHF) seen in Alzheimer's disea

57 The formation of paired helical filaments (PHF), which are composed of hy

58 Paired helical filaments (PHFs) accumulate in the brains

59 drated tau 2-19 and collagen I and insoluble paired helical filaments (PHFs) and collagen I of weak h

60 ng of tau protein leads to the generation of paired helical filaments (PHFs) and neurofibrillary tang

61 generation of muscle fibers characterized by paired helical filaments (PHFs) composed of phosphorylat

62 s the neurofibrillary tangle, which contains paired helical filaments (PHFs) composed of the microtub

63 o determine if the high phosphate content of paired helical filaments (PHFs) in Alzheimer's disease (

64 ion of human Alzheimer high-molecular-weight paired helical filaments (PHFs) in the dentate gyrus of

65 Paired helical filaments (PHFs) in the neurofibrillary t

66 lzheimer disease (AD) is the accumulation of paired helical filaments (PHFs) of hyperphosphorylated m

67 The tight bundles of paired helical filaments (PHFs) of tau protein found in

68 Tau protein assembles into paired helical filaments (PHFs) that constitute the neur

69 table aggregates leading to the formation of paired helical filaments (PHFs) which deposit into neuro

70 specific serine/threonine residues found in paired helical filaments (PHFs), and its expression is u

71 Alzheimer's disease (AD) paired helical filaments (PHFs), building blocks of neur

72 that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microt

73 rous neurons with neurofibrillary tangles of paired helical filaments (PHFs).

74 ough the repeat domain to form intraneuronal paired helical filaments (PHFs).

75 ontain aberrantly hyperphosphorylated Tau as paired helical filaments (PHFs).

76 two distinct aggregates, amyloid fibrils and paired helical filaments (PHFs).

77 ents (SFs) in vitro, only the Tau MTBR forms paired helical filaments (PHFs).

78 cal tau conformation detectable in authentic paired helical filaments (PHFtau).

79 tion and vacuolated muscle fibers containing paired helical filaments and 6- to 10-nm fibrils, both r

80 mmunoelectron microscopy localized mainly to paired helical filaments and 6- to 10-nm filaments.

81 at in Alzheimer's disease, the copresence of paired helical filaments and Abeta-amyloidosis indicates

82 he formation and/or stabilization of NFT and paired helical filaments and provide a model system to i

83 ation of isolated tau filaments demonstrated paired helical filaments and ribbon-like structures.

84 ylated tau (P-tau) in the form of tangles of paired helical filaments and/or straight filaments is on

85 nd beta-amyloid precursor protein, and their paired helical filaments are composed of phosphorylated

86 idely regarded as the principal component of paired helical filaments comprising Alzheimer neurofibri

87 ly hyperphosphorylated tau polymers known as paired helical filaments constitute one of the major cha

88 angles in neuronal somata or axons, nor were paired helical filaments evident ultrastructurally.

89 recognition of the role of proteoglycans in paired helical filaments formation makes proteoglycans o

90 ments by a method used for the extraction of paired helical filaments from Alzheimer's disease brain.

91 No paired helical filaments have yet been observed in the h

92 hreonine(214), a tau epitope associated with paired helical filaments in AD patients.

93 ongly binds to tau lesions primarily made of paired helical filaments in Alzheimer brains (eg, intran

94 mentia through its deposition in the form of paired helical filaments in Alzheimer's disease neurofib

95 We document the first case of tauopathy with paired helical filaments in an aged chimpanzee (Pan trog

96 phosphorylated tau is the major component of paired helical filaments in neurofibrillary lesions asso

97 tau (microtubule-binding protein that forms paired helical filaments in neurons of the Alzheimer's d

98 s disease (AD) and accumulates as tangles of paired helical filaments in neurons undergoing degenerat

99 Although paired helical filaments in the form of neurofibrillary

100 eadily bound thioflavin-S, a dye that stains paired helical filaments in the histochemical diagnosis

101 ociated protein tau is found aggregated into paired helical filaments in the intraneuronal neurofibri

102 cytochemistry, including colocalization with paired helical filaments in the neuropil and perikarya.

103 The aggregation of Tau into paired helical filaments is involved in the pathogenesis

104 s dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis

105 otein tau that is the major component of the paired helical filaments observed in Alzheimer's disease

106 s of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylat

107 We also found that paired helical filaments of aggregated and hyperphosphor

108 differ in diameter and periodicity from the paired helical filaments of Alzheimer disease.

109 tern blots, similar to cross-linked tau from paired helical filaments of Alzheimer's disease.

110 ed, ribbon-like morphology distinct from the paired helical filaments of Alzheimer's disease.

111 of neuritic plaques (NPs) and from the 24 nm paired helical filaments of neurofibrillary tangles (NFT

112 tau is the major structural component of the paired helical filaments present in the brains of Alzhei

113 mbling straight filaments or Pronase-treated paired helical filaments raises fundamental questions co

114 nds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosph

115 were highly correlated with neuritic plaque, paired helical filaments tau neurofibrillary tangle and

116 SP), tau proteins assemble into straight and paired helical filaments that form intraneuronal deposit

117 nds microtubules, and self-assembles to form paired helical filaments that likely contribute to neuro

118 ormation of either sarkosyl-insoluble tau or paired helical filaments was not induced by Abeta42.

119 lary tangles consisted of tau-immunoreactive paired helical filaments with a diameter and helical per

120 e-associated protein tau into fibers termed "paired helical filaments" (PHFs).

121 ulofilaments (previously shown, by us, to be paired helical filaments).

122 phorylated tau is the principal component of paired helical filaments, a pathological hallmark of Alz

123 , amyloid-beta immunoreactive filaments, and paired helical filaments, all of which are pathological

124 They are composed of paired helical filaments, are labeled with antibodies th

125 curred on material in close proximity to the paired helical filaments, but never was on the paired he

126 endent epitope of tau in Alzheimer's disease paired helical filaments, demonstrates positivity in the

127 n IBM muscle and AD brain phenotypes include paired helical filaments, hyperphosphorylated tau protei

128 rus neurons showed cytoplasmic inclusions of paired helical filaments, P-tau aggregates characteristi

129 specific Serine/Threonine residues found in paired helical filaments, suggesting its role in tauopat

130 onoclonal antibody Alz50 much like authentic paired helical filaments, suggesting that the conformati

131 Tau proteins isolated from paired helical filaments, the major building blocks of A

132 demonstrates two novel components of the IBM paired helical filaments, which may lead to better under

133 ngle-associated epitopes and accumulation of paired helical filaments-(PHF-) like fibrils.

134 are major components of Alzheimer's disease paired helical filaments.

135 believed to play a role in the formation of paired helical filaments.

136 sitive inclusions, and structures resembling paired helical filaments.

137 cally by vacuolated muscle fibres containing paired helical filaments.

138 the dentate gyrus and midbrain demonstrated paired helical filaments.

139 poradic myositis was localized mainly to the paired helical filaments.

140 cally by vacuolated muscle fibers containing paired helical filaments.

141 l repeat region formed structures resembling paired helical filaments.

142 ired helical filaments, but never was on the paired helical filaments.

143 but may also play a role in the formation of paired helical filaments.

144 e-associated protein Tau forms intracellular paired helical filaments.

145 antibodies, and electron microscopy revealed paired helical filaments.

146 cytochemistry using antibodies against human paired helical filaments.

147 immuno-electron microscopy were confined to paired helical filaments.

148 Paired-helical filaments (PHFs) are an important diagnos

149 osphorylated form, aggregates into insoluble paired-helical filaments (PHFs) in Alzheimer's disease (

150 amorphous tufts adjacent to the muscle fiber paired-helical filaments.

151 rm a right-handed, double-stranded, and base-paired helical form.

152 with three microtubule-binding repeats form paired helical-like filaments under physiological condit

153 ons, where oxidation may contribute to final paired helical morphology, but is not a necessary prereq

154 synthetic straight filaments gradually adopt paired helical morphology.

155 n of pRNA for gp16 interaction was the 5'/3' paired helical region.

156 es, reflecting the presence of the same base paired helical regions and GNRA tetraloop in each.

157 and C634 to C651 and is composed of two base paired helical regions that flank a phylogenetically con

158 use they form potentially informational base paired helical structures.

159 euron loss, intracytoplasmic tau aggregates, paired helical tau filaments, increased 4R tau messenger