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1 ulofilaments (previously shown, by us, to be paired helical filaments).
2 cally by vacuolated muscle fibres containing paired helical filaments.
3 the dentate gyrus and midbrain demonstrated paired helical filaments.
4 poradic myositis was localized mainly to the paired helical filaments.
5 cally by vacuolated muscle fibers containing paired helical filaments.
6 l repeat region formed structures resembling paired helical filaments.
7 ired helical filaments, but never was on the paired helical filaments.
8 but may also play a role in the formation of paired helical filaments.
9 e-associated protein Tau forms intracellular paired helical filaments.
10 antibodies, and electron microscopy revealed paired helical filaments.
11 cytochemistry using antibodies against human paired helical filaments.
12 immuno-electron microscopy were confined to paired helical filaments.
13 are major components of Alzheimer's disease paired helical filaments.
14 believed to play a role in the formation of paired helical filaments.
15 sitive inclusions, and structures resembling paired helical filaments.
16 amorphous tufts adjacent to the muscle fiber paired-helical filaments.
18 was a significant decrease in the density of paired helical filament-1-positive neurons in the immuni
19 idue amino-acid sequence, referred to as the paired helical filament 6 (PHF6), which may play an impo
20 phorylated tau is the principal component of paired helical filaments, a pathological hallmark of Alz
21 , amyloid-beta immunoreactive filaments, and paired helical filaments, all of which are pathological
22 t et al reports that antibodies generated to paired helical filaments (AMY antibodies) unexpectedly l
23 tion and vacuolated muscle fibers containing paired helical filaments and 6- to 10-nm fibrils, both r
25 at in Alzheimer's disease, the copresence of paired helical filaments and Abeta-amyloidosis indicates
26 he formation and/or stabilization of NFT and paired helical filaments and provide a model system to i
27 ation of isolated tau filaments demonstrated paired helical filaments and ribbon-like structures.
28 ylated tau (P-tau) in the form of tangles of paired helical filaments and/or straight filaments is on
29 nd beta-amyloid precursor protein, and their paired helical filaments are composed of phosphorylated
31 bodies which recognize phosphorylated tau in paired helical filaments (AT8 and PHF-1) show positive i
32 curred on material in close proximity to the paired helical filaments, but never was on the paired he
33 idely regarded as the principal component of paired helical filaments comprising Alzheimer neurofibri
34 ly hyperphosphorylated tau polymers known as paired helical filaments constitute one of the major cha
35 endent epitope of tau in Alzheimer's disease paired helical filaments, demonstrates positivity in the
37 ide (Abeta) concentration, Abeta deposition, paired helical filament formation, cerebrovascular amylo
39 recognition of the role of proteoglycans in paired helical filaments formation makes proteoglycans o
40 ments by a method used for the extraction of paired helical filaments from Alzheimer's disease brain.
42 n IBM muscle and AD brain phenotypes include paired helical filaments, hyperphosphorylated tau protei
43 vidence for hyperphosphorylated tau protein (paired helical filament-I tau), which has been associate
45 ongly binds to tau lesions primarily made of paired helical filaments in Alzheimer brains (eg, intran
46 mentia through its deposition in the form of paired helical filaments in Alzheimer's disease neurofib
47 We document the first case of tauopathy with paired helical filaments in an aged chimpanzee (Pan trog
48 phosphorylated tau is the major component of paired helical filaments in neurofibrillary lesions asso
49 tau (microtubule-binding protein that forms paired helical filaments in neurons of the Alzheimer's d
50 s disease (AD) and accumulates as tangles of paired helical filaments in neurons undergoing degenerat
52 eadily bound thioflavin-S, a dye that stains paired helical filaments in the histochemical diagnosis
53 ociated protein tau is found aggregated into paired helical filaments in the intraneuronal neurofibri
54 cytochemistry, including colocalization with paired helical filaments in the neuropil and perikarya.
56 s dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis
60 otein tau that is the major component of the paired helical filaments observed in Alzheimer's disease
61 s of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylat
66 of neuritic plaques (NPs) and from the 24 nm paired helical filaments of neurofibrillary tangles (NFT
67 rus neurons showed cytoplasmic inclusions of paired helical filaments, P-tau aggregates characteristi
70 isease (AD), immunohistochemistry of WT1 and paired helical filament (PHF) in serial sections was car
72 formation of amyloid fibrils displaying the paired helical filament (PHF) morphology characteristic
73 Ser 262 is phosphorylated extensively in paired helical filament (PHF) tau from Alzheimer's disea
74 m the progressive pattern of neuropathology [paired helical filament (PHF)-tau and amyloid-beta] in A
75 r AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer
81 hosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients
84 orylation is implicated in the biogenesis of paired helical filaments (PHF) seen in Alzheimer's disea
89 drated tau 2-19 and collagen I and insoluble paired helical filaments (PHFs) and collagen I of weak h
90 ng of tau protein leads to the generation of paired helical filaments (PHFs) and neurofibrillary tang
91 generation of muscle fibers characterized by paired helical filaments (PHFs) composed of phosphorylat
92 s the neurofibrillary tangle, which contains paired helical filaments (PHFs) composed of the microtub
93 o determine if the high phosphate content of paired helical filaments (PHFs) in Alzheimer's disease (
94 ion of human Alzheimer high-molecular-weight paired helical filaments (PHFs) in the dentate gyrus of
96 lzheimer disease (AD) is the accumulation of paired helical filaments (PHFs) of hyperphosphorylated m
99 table aggregates leading to the formation of paired helical filaments (PHFs) which deposit into neuro
100 specific serine/threonine residues found in paired helical filaments (PHFs), and its expression is u
102 that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microt
109 osphorylated form, aggregates into insoluble paired-helical filaments (PHFs) in Alzheimer's disease (
112 ur phosphospecific probes also revealed that paired helical filament preparations exhibited phospho-t
113 tau is the major structural component of the paired helical filaments present in the brains of Alzhei
114 ognizing independent phospho-epitopes in the paired helical filament proteins (PHF) found in AD brain
115 mbling straight filaments or Pronase-treated paired helical filaments raises fundamental questions co
117 specific Serine/Threonine residues found in paired helical filaments, suggesting its role in tauopat
118 onoclonal antibody Alz50 much like authentic paired helical filaments, suggesting that the conformati
119 ylated at the same amino acid residues as AD paired helical filament tau (PHFtau), but they exhibited
120 vasive analyses in cortical regions in which paired helical filament tau accumulation is expected in
121 vasive analyses in cortical regions in which paired helical filament tau accumulation is expected in
122 d in clinical studies) provides estimates of paired helical filament tau burden in good correlation w
123 d in clinical studies) provides estimates of paired helical filament tau burden in good correlation w
124 t analysis, Tau-nY29 detects soluble tau and paired helical filament tau from severely affected Alzhe
127 ripts of SORL1 and ABCA7 was associated with paired helical filament tau tangle density, and the expr
130 e phosphorylation site consistently found in paired helical filament tau, serine 413, is modified by
131 global pathology score, and as amyloid load, paired helical filament tau-positive (PHFtau) tangle den
133 nds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosph
134 were highly correlated with neuritic plaque, paired helical filaments tau neurofibrillary tangle and
136 h wt mice, prominent inner retinal Abeta and paired helical filament-tau, and decreased retinal gangl
137 ain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzhe
138 SP), tau proteins assemble into straight and paired helical filaments that form intraneuronal deposit
139 nds microtubules, and self-assembles to form paired helical filaments that likely contribute to neuro
141 n have the deposition of Alzheimer's disease paired helical filament type hyperphosphorylated tau.
142 ormation of either sarkosyl-insoluble tau or paired helical filaments was not induced by Abeta42.
143 demonstrates two novel components of the IBM paired helical filaments, which may lead to better under
144 lary tangles consisted of tau-immunoreactive paired helical filaments with a diameter and helical per
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