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1 in Escherichia coli, or Sae2 in eukaryotes, palindromic amplifications arise and propagate in cells.
2 e for the role of this core duplicon and its palindromic architecture in promoting the evolutionary a
5 uity at the central nucleotide in the pseudo-palindromic cis-element CAATNATTG that is recognised by
6 ts(7-9), and it has been suggested that this palindromic consensus arises as a consequence of the str
11 The androgen response element (ARE) is a palindromic, dihexameric motif present in promoters or e
12 within the 5'-leader of the RNA, including a palindromic dimer initiation signal (DIS) that has been
13 of DNA libraries enriched with tumor-derived palindromic DNA (Genome-wide Analysis of Palindrome Form
14 ere designed and implemented, using either a palindromic DNA attached to both ends of the polymer or
15 ssor and two complexes each bound to a 20-bp palindromic DNA duplex containing its consensus operator
19 ucleases (REases) recognize and cleave short palindromic DNA sequences, protecting bacterial cells ag
24 ough the mechanism that repeatedly generates palindromic DNA, such as Breakage-Fusion-Bridge cycles.
25 y shift assays, and we identified a specific palindromic DNA-binding site 5'-TTGATN4ATCAA-3' in these
26 , a mechanism characterized by the inverted (palindromic) duplication of genomic segments, in HER2-po
27 RPA dysfunction increased the frequency of palindromic duplications in Sae2 or Mre11 nuclease-defic
29 nverted repeats drive the formation of large palindromic duplications, the major class of chromosomal
30 e IIP restriction endonuclease, recognizes a palindromic eight base pair (bp) symmetric sequence, 5-A
31 s GRIP1 toward GR binding sites dominated by palindromic GC response elements (GRE), suggesting a non
33 breaks is one mechanism proposed to initiate palindromic gene amplification, a common feature of canc
34 he ERBB2 oncogene at 17q12 is susceptible to palindromic gene amplification, a mechanism characterize
38 e as a consequence of the existence of a non-palindromic nucleotide motif that occurs in approximatel
39 ricted T-cell receptor repertoire, increased palindromic nucleotides in the complementarity determini
40 GATA1 bivalently bind to two GATA motifs in palindromic (Pal-GATA) and direct-repeat (Tandem-GATA) a
41 el electrophoresis and repetitive extragenic palindromic-PCR), multilocus sequence type (MLST) analys
42 ) to a novel mutant devoid of the 3'RR quasi-palindromic region (3'PAL KO), we pinpointed common feat
44 ly, mutagenesis of the repetitive extragenic palindromic (REP) elements within the yqjH-yqjI intergen
50 s into clustered regularly interspaced short palindromic repeat (CRISPR) loci as spacer segments.
51 s into clustered regularly interspaced short palindromic repeat (CRISPR) loci in prokaryotes and by V
52 d into Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) loci, providing a molecular
53 tly, pooled clustered regularly interspersed palindromic repeat (CRISPR) mutagenesis screens of nonco
56 he bacterial clustered regularly interspaced palindromic repeat (CRISPR) system and its subsequent ad
57 ryotic clustered regularly interspaced short palindromic repeat (CRISPR) system, recently harnessed f
58 ogy to clustered regularly interspaced short palindromic repeat (CRISPR)-based knockout by analysis o
59 only clustered, regularly interspaced short palindromic repeat (CRISPR)-Cas systems provide adaptive
61 velop pooled clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 guide RNA libraries to
62 e II clustered, regularly interspaced, short palindromic repeat (CRISPR)-Cas9 nucleases, along with t
63 lls by clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 revealed that it is ess
64 sing a clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system and measured the
65 th the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system showed that PYCR
66 used a clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 technology, gene-specif
67 ts and clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9-mediated approaches in
68 y, and clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9-mediated knockout of th
69 using clustered regularly interspaced short palindromic repeat (CRISPR)-caspase 9 (Cas9) gene-editin
70 ryotic clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated (Cas) immu
71 pe III clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) syst
72 The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas
73 rcheal clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein (C
74 uch as clustered regularly interspaced short palindromic repeat (CRISPR)-derived genome editing provi
75 overed clustered regularly interspaced short palindromic repeat (CRISPR)-mediated virus defense repre
76 system clustered regularly interspaced short palindromic repeat (CRISPR)/Cas evolved as a natural res
77 llular clustered regularly interspaced short palindromic repeat (CRISPR)/Cas loci and dual viral and
78 ridium clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system, and in vivo sel
79 Using clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology, we demonstr
80 pplied clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-mediated genome-editing
81 n with clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
82 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
83 ing by clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
84 s) and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
85 unity clustered regularly interspersed short palindromic repeat (CRISPR)/CRISPR-associated protein 9
86 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
87 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
89 evelop clustered regularly interspaced short palindromic repeat interference (CRISPRi) to repress gen
91 y of CRISPR (clustered regularly interspaced palindromic repeat) biology from its initial discovery t
92 RISPR (clustered regularly interspaced short palindromic repeat) system is an RNA-guided immune syste
93 RISPR (clustered regularly interspaced short palindromic repeat)-associated Cas9 nuclease has been co
94 RISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) system cleav
95 RISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR associated protein 9) k
96 RISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR-associated protein 9) s
97 RISPR (clustered regularly interspaced short palindromic repeat)/Cas9-mediated genome editing coupled
98 R-Cas (clustered regularly interspaced short palindromic repeat, CRISPR associated) immune system, wh
99 aCas9 (clustered regularly interspaced short palindromic repeat-associated 9 from Staphylococcus aure
101 ied by clustered regularly interspaced short palindromic repeat-Cas9 (CRISPR-Cas9) to determine wheth
102 R-Cas (clustered regularly interspaced short palindromic repeat-CRISPR-associated) system, has been a
103 A, for clustered regularly interspaced short palindromic repeat-mediated editing, repression, and act
105 sed on clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) technology, here w
106 e used clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9)-mediated genome ed
108 ans of clustered regularly interspaced short palindromic repeat/CRISPR-associated 9 gene editing elic
109 ell as clustered regularly interspaced short palindromic repeats (CRISPR) and associated protein (Cas
110 ing of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas)
111 we use clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated prote
113 und in clustered regularly interspaced short palindromic repeats (CRISPR) bacterial immune systems, i
118 geting clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas13a (previously
119 at the clustered regularly interspaced short palindromic repeats (CRISPR) genes as well as several hy
120 t uses clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi) to d
121 Clustered, regularly interspaced, short palindromic repeats (CRISPR) loci and their associated g
122 nce of clustered regularly interspaced short palindromic repeats (CRISPR) loci has been reported in a
123 otic clustered, regularly interspaced, short palindromic repeats (CRISPR) loci have recently been rep
124 e-wide clustered regularly interspaced short palindromic repeats (CRISPR) loss-of-function screen for
125 ltiple clustered regularly interspaced short palindromic repeats (CRISPR) single guide RNAs (sgRNAs)
126 A) and clustered regularly interspaced short palindromic repeats (CRISPR) studies did not reveal any
127 ure based on clustered regularly interspaced palindromic repeats (CRISPR) system and examine approach
128 terial clustered regularly interspaced short palindromic repeats (CRISPR) system, we constructed a ge
131 the clustered, regularly interspaced, short palindromic repeats (CRISPR) tool shows that mir-276a in
132 N) and clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR-associated (Cas
134 a, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) DNA-target
135 using clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)-guide RNA
138 ryotic clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 (Cas9) endonuc
139 The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease (Ca
140 diated clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease (Ca
141 nomous Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9)
142 ics of clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9)
143 lease termed clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9)
144 active clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (dCas9
145 The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated protein Cas9 fro
146 using clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein-9 nuclea
147 sed on clustered regularly interspaced short palindromic repeats (CRISPR)-associated proteins (Cas) t
148 R-cas [clustered regularly interspaced short palindromic repeats (CRISPR)-associated] bacterial immun
150 q) and clustered regularly interspaced short palindromic repeats (CRISPR)-based perturbations to perf
151 ciency Clustered regularly interspaced short palindromic repeats (CRISPR)-based phenotypic screen of
152 The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas nuclease system is a po
153 The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system is used by bacte
155 of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 bacterial immune syste
156 overed clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 endonuclease has the a
157 AV) of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 endonucleases coupled
158 of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome-editing system.
159 the clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 nuclease system is a p
160 s) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nucleases are the most
161 RA), a clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 platform for in situ h
162 t with clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 resulted in largely fe
163 er the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system to the mdx mous
164 the clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 system, have enabled t
166 guided clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 together with the pigg
167 ins by clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9-mediated homology-dire
170 ng via clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) con
171 tional clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) sys
172 II, clustered, regularly interspaced, short palindromic repeats (CRISPR)-CRISPR-associated (Cas) sys
173 terial clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) sys
174 ced by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-Associated Protein 9
175 eloped clustered regularly interspaced short palindromic repeats (CRISPR)-Display (CRISP-Disp), a tar
176 er via clustered regularly interspaced short palindromic repeats (CRISPR)-enzymatically inactive Cas9
177 ncy of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated mutagenesis in pla
180 cells using Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 did not abolish the in
181 ed the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing system to
182 n with clustered regularly-interspaced short palindromic repeats (CRISPR)/Cas9 genome editing in huma
183 s) and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 in model organisms als
184 nd the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, are systematiz
185 ray of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 target sites, marks ce
186 eloped clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology to knock ou
187 em of clustered regularly interspersed short palindromic repeats (CRISPR)/Cas9, thereby yielding graf
188 e used clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based genome editing t
189 ingly, clustered regularly-interspaced short palindromic repeats (CRISPR)/Cas9-mediated deletion of t
190 using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated gene correcti
191 cus by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editin
192 Using clustered regularly interspaced short palindromic repeats (CRISPR)/clustered regularly intersp
193 The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR associated (Cas)9 pr
194 plying clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9
195 ered regularly interspaced short [corrected] palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 n
196 ype II clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) sys
197 Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) sys
198 nd the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9)
199 icient clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated caspase 9
200 on and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
201 e used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
204 sing a clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
205 ng the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9
206 e used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9
207 using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9
208 r nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins
210 d with clustered regularly interspaced short palindromic repeats (CRISPR-Cas9)-mediated gene editing.
212 ) or clustered, regularly interspaced, short palindromic repeats (CRISPR/Cas9), resulted in a much gr
216 using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and Transcription Activato
217 sed of clustered regularly interspaced short palindromic repeats (CRISPRs), together with CRISPR-asso
218 Clustered, regularly interspaced, short palindromic repeats - CRISPR-associated (CRISPR-Cas) sys
220 ces in clustered regularly interspaced short palindromic repeats and clustered regularly interspaced
221 tion of CRISPR arrays consisting of multiple palindromic repeats and intervening spacers through the
222 y of clustered, regularly interspaced, short palindromic repeats and the Cas9 RNA-guided nuclease (CR
223 (iii) clustered regularly interspaced short palindromic repeats combined with multi-virulence-locus
224 Use of clustered regularly interspaced short palindromic repeats mediated genome editing in HepG2 cel
225 The Clustered Regularly Interspaced Short Palindromic Repeats system allows a single guide RNA (sg
226 term 'clustered regularly interspaced short palindromic repeats' (CRISPR) has recently become synony
227 ISPRs (clustered regularly interspaced short palindromic repeats) and CRISPR-associated (Cas) protein
228 RISPR (clustered regularly interspaced short palindromic repeats) and the nearby Cas (CRISPR-associat
229 RISPR (Clustered Regularly Interspaced Short Palindromic Repeats) associated proteins, but little is
230 RISPR (clustered regularly interspaced short palindromic repeats) bacterial immune systems, is emergi
231 icates clustered regularly interspaced short palindromic repeats) gene mutation, together with expres
232 RISPR (clustered regularly interspaced short palindromic repeats) immune system has been adapted for
233 RISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loci, termed 'Adaptation', which is
235 RISPR (clustered regularly interspaced short palindromic repeats) mechanism allows bacteria to adapti
236 RISPR (clustered regularly interspaced short palindromic repeats) RNA-guided adaptive immune systems
237 SPR (clustered, regularly interspaced, short palindromic repeats) RNAs (crRNAs) to target foreign nuc
238 RISPR (clustered regularly interspaced short palindromic repeats) spacers from the host Acaryochloris
239 RISPR (clustered regularly interspaced short palindromic repeats) system protects archaea and bacteri
240 RISPR (clustered regularly interspaced short palindromic repeats) systems that serve as defence mecha
241 SPR (clustered, regularly interspaced, short palindromic repeats) to build mapping panels with target
242 RISPR (clustered regularly interspaced short palindromic repeats) to efficiently mutate specific loci
243 RISPR (clustered regularly interspaced short palindromic repeats)-associated (Cas) protein Cas9 begin
244 RISPR (clustered regularly interspaced short palindromic repeats)-associated (Cas) proteins together
245 RISPR (clustered regularly interspaced short palindromic repeats)-associated (Cas) proteins together
246 RISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease Cas9 to modify
247 otic CRISPR (clustered regularly interspaced palindromic repeats)-associated protein, Cas9, has been
248 RISPR (clustered regularly interspaced short palindromic repeats)-Cas system of Escherichia coli can
249 RISPR (clustered regularly interspaced short palindromic repeats)-Cas9 (CRISPR-associated protein 9)
250 SPR (clustered, regularly interspaced, short palindromic repeats)-Cas9 platform is a promising techno
252 SPR (clustered, regularly interspaced, short palindromic repeats)-Cas9 targeting to delete DNA region
253 RISPR (clustered regularly interspaced short palindromic repeats)-induced deletion of the NBM-encodin
254 RISPR (clustered regularly interspaced short palindromic repeats)-mediated genome editing on dystroph
255 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated gene 9) sys
256 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9)
257 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9)
258 ISPR (clustered regularly interspersed short palindromic repeats)/Cas9 (CRISPR-associated protein 9)
259 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 system, first identified in ba
260 es and clustered regularly interspaced short palindromic repeats, provide a platform to delete endoge
261 ts and clustered regularly interspaced short palindromic repeats-associated 9 technology, the impact
262 -Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) genome editing
263 RISPR)/clustered regularly interspaced short palindromic repeats-associated protein-9 nuclease (Cas9)
264 es, or clustered regularly interspaced short palindromic repeats-based nucleases) raise prospects for
265 Clustered, regularly interspaced, short palindromic repeats-CRISPR associated (CRISPR-Cas) syste
266 Clustered, regularly interspaced, short palindromic repeats-CRISPR associated (CRISPR-Cas) syste
267 R-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems allow bac
268 R-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems, which pr
269 R-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated), to provide resis
270 -Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated 9) nucleases, whic
271 -Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated 9) system, transcr
273 R-Cas (Clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) is a pro
274 R-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) is a defense syst
275 sis of clustered regularly interspaced short palindromic repeats-generated TFEB/MITF/TFE3/TFEC single
277 e used clustered regularly interspaced short palindromic repeats/Cas9-mediated genomic modification t
278 ng the Clustered Regularly Interspaced Short Palindromic Repeats/Crispr associated 9 (CRISPR/Cas9) sy
279 /Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9) gene-ed
280 The clustered regularly interspaced short palindromic repeats/CRISPR-associated (CRISPR-Cas) syste
281 using Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated gene9 (CRISPR/Cas9
282 The clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/
283 CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9)-based D
284 of the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease
285 CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated) homology-directed
286 P restriction endonuclease AgeI recognizes a palindromic sequence 5-A/CCGGT-3 and cuts it ('/' denote
287 The DIS folds a hairpin structure with a palindromic sequence in the loop that allows RNA dimeriz
291 y favoring GR homodimer occupancy at classic palindromic sites at the expense of monomeric binding.
293 are single-stranded DNA viruses that use the palindromic structures at the ends of the viral genome f
297 our results suggest that methylation on non-palindromic TAGGAG motifs in the bacterial genome guides
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