ライフサイエンスコーパス: palmitoylate

1 d only the monomeric forms of p8 and p12 are palmitoylated.

2 lasmic Cys residues in the gamma subunit are palmitoylated.

3 Constructs with an N-terminal Ala were not palmitoylated.

4 een transmembrane domains 1 and 2 (M1-M2) is palmitoylated.

5 identified both Cys-40 and Cys-42 of PLM as palmitoylated.

6 how that dHIP14 binds to Sog and that Sog is palmitoylated.

7 bunits revealed that Cys-43 and Cys-557 were palmitoylated.

8 determine whether channel subunits were Cys-palmitoylated.

9 d [(3)H]palmitate, demonstrating that it was palmitoylated.

10 a (gammaCys-33 and gammaCys-41) subunits are palmitoylated.

11 mouse hepatitis coronavirus A59 E protein is palmitoylated.

12 ed that wtRPE65 and both of the mutants were palmitoylated.

13 t N-terminal cysteine residues in SPEC2 were palmitoylated.

14 subunit, betaCys-43 and betaCys-557, are Cys-palmitoylated.

15 p when phosphorylated and inhibiting it when palmitoylated.

16 main-containing protein 3; membrane protein, palmitoylated 3; calcium/calmodulin-dependent serine pro

17 These were rarely seen with the palmitoylated A(2A)-R309C receptor, the preferred diffus

18 by increasing the levels of cardiolipins and palmitoylated acylphosphatidylglycerols within the OM.

19 oyl acyltransferase DHHC2 interacts with and palmitoylates AKAP79/150 to regulate these plasticity si

20 in signaling (RGS)-binding protein (R7BP), a palmitoylated allosteric modulator of R7 RGS proteins th

21 ptic localizations onto SAP97, targeting the palmitoylated alpha-isoform to the postsynaptic density

22 ide (i.e., PBP10, RhB-QRLFQVKGRR-OH) and the palmitoylated alpha-peptide/beta-peptoid hybrid Pam-(Lys

23 ng either double cysteines that normally are palmitoylated (alpha-isoforms) or an L27 domain (beta-is

24 bstrate specificity of LRAT is explored with palmitoylated amino acids and dipeptides as RPE65 surrog

25 Both O- and S-substituted palmitoylated analogues are excellent substrates for tLR

26 6ORF105, which is predicted to be multispan, palmitoylated and androgen-responsive.

27 However, this triple Cys mutant was still palmitoylated and associated with the membrane, although

28 cysteines (Cys(13)-Cys(15)) results in a non-palmitoylated and cytoplasmic Env7.

29 inantly to the lysosomes; it was dynamically palmitoylated and dephosphorylated in vivo following his

30 pe subunit 2B (GluN2B) subunits] only in its palmitoylated and extended conformation.

31 d three endogenous cysteines predicted to be palmitoylated and found that the gating behavior of this

32 , and Cys330, in RPE65 have been shown to be palmitoylated and have been suggested to be responsible

33 Cys residue in the C-terminal region that is palmitoylated and mediates methyl-beta-cyclodextrin-sens

34 f Vac8 was swapped for that of Meh1, another palmitoylated and N-myristoylated protein in yeast.

35 sufficient, we examined raft association of palmitoylated and nonpalmitoylated LAT transmembrane pep

36 Although it is known that SNAP-25 can be palmitoylated and phosphorylated in brain, we now reveal

37 CKAP4 is a reversibly palmitoylated and phosphorylated protein that links the

38 23/25/26) at the N terminus of the enzyme is palmitoylated and required for membrane localization and

39 We also report that G5 but not G8 is S-palmitoylated and that palmitoylation is not essential f

40 e that HGAL protein can be myristoylated and palmitoylated and that these modifications localize HGAL

41 proteins 6K and TF have been reported to be palmitoylated and to positively regulate budding.

42 ivity-based probes for PATs as well as other palmitoylating and 2-BP-binding enzymes.

43 ion in PSDs resulting from the clustering of palmitoylating and depalmitoylating enzymes into AMPAR n

44 stal structures were determined for the apo, palmitoylated, and carboxypalmitoylated forms.

45 one thousand proteins are annotated as being palmitoylated, and for some of these, including several

46 Here we show that SynDIG1 is palmitoylated, and investigate the effects of palmitoyla

47 d expressed dopamine transporters (DATs) are palmitoylated, and using the palmitoyl acyltransferase i

48 In later compartments, palmitoylated APP (palAPP) was specifically enriched in

49 ting two interconverting thioesterase pools: palmitoylated APT on the Golgi and depalmitoylated APT i

50 We identify cysteines 3 and 5, which are palmitoylated, as sites of nitrosylation, suggesting a c

51 ort that DLK, but not homologous kinases, is palmitoylated at a conserved site adjacent to its kinase

52 The cytoplasmic tail of the protein can be palmitoylated at a cysteine residue, but this residue is

53 S-palmitoylated at Cys(689), and APH-1 is S-palmitoylated at Cys(182) and Cys(245).

54 By mutagenesis we show that nicastrin is S-palmitoylated at Cys(689), and APH-1 is S-palmitoylated

55 In addition, beta2AR S-palmitoylated at Cys-265 are selectively preserved under

56 The N-terminus is myristoylated at Gly2 and palmitoylated at Cys3 and Cys22.

57 We find that G14alpha and G16alpha are palmitoylated at distinct polycysteine sequences in thei

58 ings indicate that G14alpha and G16alpha are palmitoylated at distinct polycysteine sequences, and th

59 We show that PAR1 is basally palmitoylated at highly conserved C-tail cysteines.

60 LMO4 is palmitoylated at its C-terminal cysteine, and deletion o

61 on of palmitoylated Mucin 2, which must be S-palmitoylated at its N terminus for proper secretion and

62 Coronavirus spike (S) proteins are palmitoylated at several cysteine residues clustered nea

63 ions in CQC3RRK revealed that MUC1 is dually palmitoylated at the CQC motif independent of RRK.

64 idence using mass spectrometry that DHHC3 is palmitoylated at the cysteine in the DHHC motif.

65 These results show that VSPs are palmitoylated at the cysteine within the conserved tail

66 by SNARE proteins, which subsequently become palmitoylated at the plasma membrane.

67 proportionally to the relative reduction in palmitoylated barttin.

68 Drd3 is presumed to be palmitoylated, based on sequence homology with Drd2, but

69 Our data reveal a novel mechanism by which palmitoylated beta4-subunit controls surface expression

70 Importantly, palmitoylated beta4-subunits promote the ER exit and sur

71 Prenylated and palmitoylated brain Cdc42 did not interact with RhoGDIal

72 ed surface expression that can be rescued by palmitoylated, but not depalmitoylated, beta4-subunits.

73 e M3-M4 cytoplasmic loop do not appear to be palmitoylated, but replacing all of the cysteines in the

74 Here we report that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase en

75 gth protein was lost, and the SH4 domain was palmitoylated by all five of the yeast DHHC proteins tes

76 in palmitoylation, and we found that UL20 is palmitoylated by GODZ using a GODZ dominant-negative pla

77 f UL20 and glycoprotein K; and (iii) UL20 is palmitoylated by GODZ, and this UL20 palmitoylation is r

78 h the Shh precursor and mature protein are N-palmitoylated by Hhat, and the reaction occurs during pa

79 It has been suggested that Rpe65 is S-palmitoylated by lecithin:retinol acyl transferase (LRAT

80 alpha-helix and the FWC signature, which is palmitoylated by palmitoyltransferase Pfa4.

81 but also ergosterol present in protozoa was palmitoylated by PlaC.

82 ished both in vivo and in vitro that Vac8 is palmitoylated by the Asp-His-His-Cys (DHHC) protein Pfa3

83 Yeast Ras is palmitoylated by the DHHC cysteine-rich domain-containin

84 directed mutagenesis, implicating a role for palmitoylated C243 in modulating voltage sensing through

85 In the presence of CaVbeta subunit, the palmitoylated CaV2.2 I-II loop was protected from degrad

86 n factor-like GTPase 13b (ARL13b) as a model palmitoylated ciliary protein.

87 act that DHHC17 interacted with ClipR-59 and palmitoylated ClipR-59 at Cys534 and Cys535.

88 By palmitoylating ClipR-59, DHHC17 directly regulates ClipR

89 Biochemical studies indicate that HIP14 palmitoylates CSP and that CSP is not palmitoylated in h

90 Mutation of the palmitoylated Cys residue to Ala or inhibition of protei

91 ine 192 and prenylated cysteine 193, but not palmitoylated cysteine 189, are required for RhoB tumor-

92 steine 192 alone is sufficient and that both palmitoylated cysteine 192 and prenylated cysteine 193,

93 membranes, and the cysteine mutants of each palmitoylated cysteine cluster were seen not only at the

94 The palmitoylated cysteine in NCX1 is found in all vertebrat

95 amma-tubulin when a non-essential putatively palmitoylated cysteine is mutated.

96 74A mutant revealed that the position of the palmitoylated cysteine relative to LLY573, a motif that

97 analyses of the IP3R protein identified two palmitoylated cysteine residues and another potentially

98 t a polybasic domain immediately upstream of palmitoylated cysteine residues within an alternatively

99 ed cysteine residues and another potentially palmitoylated cysteine, and mutation of these three cyst

100 stingly, two exocytic components known to be palmitoylated, cysteine string protein (CSP) and SNAP25,

101 We find that the palmitoylated cysteines and Met182 have dual contributio

102 s demonstrates that regions distant from the palmitoylated cysteines are important for recognition by

103 The number and location of palmitoylated cysteines in the autoacylated intermediate

104 vestigated, revealing that a central core of palmitoylated cysteines is essential for aggregation of

105 meable pore, whose opening is facilitated by palmitoylated cysteines near the pore-lining helix.

106 process and found that mutants lacking three palmitoylated cysteines remained in transitional folding

107 amino acids in the inner loop of CD82 or of palmitoylated cysteines that flank the inner loop dimini

108 Palmitoylated cysteines typically target transmembrane p

109 ifelin levels were markedly reduced when two palmitoylated cysteines were replaced with serine (C95S

110 two distinct elements, a polybasic motif and palmitoylated cysteines, which when combined are suffici

111 f a peptidyl-prolyl bond in proximity to the palmitoylated cysteines.

112 identified on a subset of peptides that were palmitoylated, demonstrating for the first time co-ident

113 (Asp-His-His-Cys) proteins, which presumably palmitoylate different sets of protein substrates.

114 Mutants in which TF is not palmitoylated display drastically reduced plasma membran

115 However, exchangers that cannot be palmitoylated do not inactivate normally (leading to sub

116 bunit, whereas beta4-subunits that cannot be palmitoylated do not increase ER exit or surface express

117 l surface was delayed, and a pool of the non-palmitoylated Dsg2 co-localized with lysosomal markers.

118 morphogenetic protein and further argue that palmitoylated E proteins operate by allowing the primary

119 Here we show that Pfa3 was capable of palmitoylating each of the three N-terminal cysteines of

120 Compared to the wild-type EGF receptor, the palmitoylated EGF receptor was significantly impaired in

121 While both the wild-type and the palmitoylated EGF receptors exhibited a similar propensi

122 We identify enzymes that palmitoylate eNOS in vivo.

123 We have identified DHHC7 as a JAM-C palmitoylating enzyme by screening all known palmitoyltr

124 asing the accessibility of cysteines for the palmitoylating enzyme, with interesting theoretical impl

125 protein biochemistry and functions, relevant palmitoylating enzymes were not known.

126 In contrast, 6K is not palmitoylated, even on these shared residues.

127 genesis and mass spectrometry that AnkG is S-palmitoylated exclusively at Cys-70, which is located in

128 The palmitoylated form has heightened immunogenicity, exhibi

129 n, resulting in aberrant accumulation of the palmitoylated form in trans-Golgi membranes.

130 for imaging the subcellular distribution of palmitoylated forms of cellular proteins with high resol

131 n and that phosphorylation at Ser-41 directs palmitoylated GAP43 to the plasma membrane.

132 in mobility and plasma membrane targeting of palmitoylated GAP43.

133 the principal palmitoyl acyltransferase that palmitoylates gephyrin.

134 Palmitoylated GRIP1b is targeted to trafficking endosome

135 This enzyme is known to palmitoylate H-Ras, a modification required for proper m

136 alyze depalmitoylation of membrane-anchored, palmitoylated H-Ras and growth-associated protein-43 (GA

137 y associated with the plasma membrane, while palmitoylated H-Ras is visualized at various cellular lo

138 DHHC9.GCP16 exhibits substrate specificity, palmitoylating H- and N-Ras but not myristoylated G (alp

139 le imaging methods, the trafficking route of palmitoylated Hedgehog has remained unclear in secretory

140 the enzyme in the endoplasmic reticulum that palmitoylates Hedgehog proteins, is a member of a small

141 dgehog (Hh) is regulated by Raspberry, which palmitoylates Hh.

142 ses the synthesis of enzymes that deacylate, palmitoylate, hydroxylate, and attach aminoarabinose to

143 results demonstrate that multiple ZDHHCs can palmitoylate IFITM3 to ensure a robust antiviral respons

144 Rat NCX1 is substantially palmitoylated in all tissues examined.

145 ed, membrane proteins are significantly less palmitoylated in CLL cells compared with normal B cells.

146 aining cysteines at positions 3/6, which are palmitoylated in Fyn) exhibited fast cytoplasmic diffusi

147 d mutagenesis reveals that C191 and C192 are palmitoylated in heterologous cells and positively regul

148 HIP14 palmitoylates CSP and that CSP is not palmitoylated in hip14 mutants.

149 Further, these Cys residues are not palmitoylated in Rpe65 by mass spectrometric analysis.

150 ipitated from ARVM identified cysteine 40 as palmitoylated in some peptides, but no information was o

151 onstrate that the human Kv1.1 ion channel is palmitoylated in the cytosolic portion of the S(2)-S(3)

152 These experiments reveal that Nmnat2 is palmitoylated in vitro, and this modification is require

153 We found that barttin is palmitoylated in vivo and in vitro and identified two co

154 Furthermore, we observed that MIR2 is palmitoylated in vivo during lytic infection.

155 n-superoxide dismutase (SOD1) is S-acylated (palmitoylated) in vitro and in amyotrophic lateral scler

156 chor, as many different types of protein are palmitoylated, including transmembrane proteins.

157 The palmitoylated LAT peptide and a FLAG-tagged LAT transmem

158 , like K-Ras4B; in state 2, farnesylated and palmitoylated, like N-Ras.

159 Additionally, palmitoylated lipid A was observed only in wild-type Sal

160 lting in inflammation is not seen with other palmitoylated lipid A, indicating a unique role for this

161 0, which contains phosphoethanolamine but no palmitoylated lipid A, suggests that phosphoethanolamine

162 ar infusion of saturated fatty acid had less palmitoylated LMO4, less oxidized PTP1B, and increased P

163 gesting that the location at which IFITM3 is palmitoylated may influence its activity.

164 broadly applicable to different classes of S-palmitoylated membrane proteins.

165 embrane fusion proteins by their extensively palmitoylated membrane-associated tails.

166 Whereas the palmitoylated membrane-bound pool is catalytically activ

167 Interestingly, palmitoylated monomers of ANCL CSPalpha mutants were sho

168 tions and reveal a change in the lifetime of palmitoylated monomers of the mutant proteins.

169 FAS deficiency blocked the generation of palmitoylated Mucin 2, which must be S-palmitoylated at

170 In addition, membrane localization of non-palmitoylated mutant VSPH7 changes from a pattern simila

171 identical to that of wild-type VSPH7 but non-palmitoylated mutants fail to undergo complement-indepen

172 Palmitoylated N-Ras and H-Ras signal from early endosome

173 domains (CRDs) with high affinity through a palmitoylated N-terminal "thumb" and a disulfide-stabili

174 We find that a short palmitoylated N-terminal fragment of Sonic Hedgehog bind

175 f the pool consists of farnesylated, but not palmitoylated, N-Ras that is associated with a high mole

176 perpendicular to the PSD membrane, with its palmitoylated, N-terminal domain at the membrane.

177 of growth-associated protein-43 (GAP-43), a palmitoylated neuronal protein, is elevated in the brain

178 mass spectrometry, we show that Rpe65 is not palmitoylated nor does it appear to undergo other post-t

179 Pig SLN is also fully palmitoylated/oleoylated on its Cys-9 residue, but in a

180 for co-crystallization with SERCA1a is also palmitoylated/oleoylated, but is not visible in crystal

181 The discovery that Wnts are palmitoylated on a conserved cysteine residue suggests t

182 cal analysis indicates that MIR2 is directly palmitoylated on cysteine 146.

183 In this study, we found that nSMase2 is palmitoylated on multiple cysteine residues via thioeste

184 We further show that HHAT is palmitoylated on multiple cytosolic cysteines that maint

185 e, we report that murine IFITM1 (mIFITM1) is palmitoylated on one nonconserved cysteine and three con

186 here that the beta(1)-adrenergic receptor is palmitoylated on three cysteine residues at two sites in

187 The prototypical GPCR, rhodopsin, is S-palmitoylated on two adjacent C-terminal Cys residues at

188 All AMPA receptor subunits are palmitoylated on two cysteine residues in their transmem

189 that the human beta4-subunit is S-acylated (palmitoylated) on a juxtamembrane cysteine residue (Cys-

190 cysteine clusters of the enzyme are multiply palmitoylated; one cluster is located between the two hy

191 ly modifying some proteins while dynamically palmitoylating others.

192 Palmitoylated PA lipid A alters host innate immune respo

193 wortmannin, or sequestration of PIP2 using a palmitoylated peptide (PIP2-PP), slowed adaptation rate

194 strated in normal platelets treated with the palmitoylated peptide and a physiologic agonist.

195 Intrathecal administration of a palmitoylated peptide corresponding to the Y382-384 site

196 show that the lo domain partitioning of the palmitoylated peptide nucleic acid (PNA) can be influenc

197 Unlike the palmitoylated peptide, the nonpalmitoylated beta3 peptid

198 Palmitoylated peptides as short as 10 residues inhibited

199 We identified 2,190 S-palmitoylated peptides corresponding to 883 S-palmitoyla

200 Efr3/rolling blackout, which we found was a palmitoylated peripheral membrane protein.

201 The localization and signaling of S-palmitoylated peripheral membrane proteins is sustained

202 Mass spectrometric analyses of palmitoylated PFK-1 revealed four sites of acylation, in

203 /calmodulin, which attenuated the binding of palmitoylated PFK-1 to membrane vesicles.

204 nsferases (Asp-His-His-Cys (DHHC) PATs) that palmitoylate PI4KIIalpha and show for the first time tha

205 DHHC3 and DHHC7 PATs, which robustly palmitoylated PI4KIIalpha and were colocalized with PI4K

206 Here we report that GABARAPs recruit palmitoylated PI4KIIalpha, a lipid kinase that generates

207 itoylation of PLM controls its turnover, and palmitoylated PLM inhibits the sodium pump.

208 nd silencing experiments indicate that DHHC5 palmitoylates PLM at two juxtamembrane cysteines, C40 an

209 Here we show that a palmitoylated pool of Bright is diverted to lipid rafts

210 ion and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 and cysteine

211 n the interactions of micelles composed of a palmitoylated, pro-apoptotic peptide derived from p53 tu

212 associated guanylate kinase protein membrane palmitoylated protein 3 (MPP3) as an essential protein f

213 Membrane palmitoylated protein 4 (Mpp4) is a member of the membra

214 e therefore needed to specifically capture S-palmitoylated protein complexes in cellular membranes fo

215 Vac8p is the first N-myristoylated, palmitoylated protein identified as a substrate for a DH

216 The major palmitoylated protein in erythrocytes is MPP1, a member

217 Strikingly, 41% of synaptic genes encode a palmitoylated protein in the compendium.

218 ently, we identified Env7 as a conserved and palmitoylated protein kinase involved in negative regula

219 We report here that yeast Env7 is a novel palmitoylated protein kinase ortholog that negatively re

220 mical probes and proteomic methods to detect palmitoylated protein substrates have been reported, no

221 V-1) UL51 gene encodes a 244-amino-acid (aa) palmitoylated protein that is conserved in all herpesvir

222 We determined that TLT-1 is a palmitoylated protein using metabolic labeling with [(3)

223 te, chemical stability studies of the [(3)H]-palmitoylated protein, and site-directed mutagenesis, C2

224 monstrates that BBLF1 is a myristoylated and palmitoylated protein, as are UL11 and UL99.

225 s, RGS9-2 is tightly associated with a novel palmitoylated protein, R7BP (R7 family binding protein).

226 impairs the cleavage of thioester linkage in palmitoylated proteins (constituents of ceroid), prevent

227 Other palmitoylated proteins (e.g. PSD95 and Wnt) are not subs

228 s proteomic protocol purifies and identifies palmitoylated proteins (i.e., S-acylated proteins) from

229 62% of sites map to known palmitoylated proteins and 102 individual palmitoylation

230 was non-toxic, cleaved thioester linkage in palmitoylated proteins and mediated lysosomal ceroid dep

231 and a diazirine, for metabolic labeling of S-palmitoylated proteins and photo-cross-linking of their

232 hat constitutes the definitive complement of palmitoylated proteins even in well-studied tissues such

233 We distinguished stably palmitoylated proteins from those that turn over rapidly

234 ments in the detection and identification of palmitoylated proteins have led to multiple palmitoylati

235 Many palmitoylated proteins have regulatory roles in dynamic

236 omic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensiv

237 51 known palmitoylated proteins, 61 putative palmitoylated proteins identified in other palmitoylatio

238 e propose a high confidence set of bona fide palmitoylated proteins in brain and provide a resource t

239 Studying the functions of S-palmitoylated proteins in cells can be challenging due t

240 labeling, identification and verification of palmitoylated proteins in human cells.

241 roach, we report a comprehensive analysis of palmitoylated proteins in T. gondii, identifying a total

242 s function as release factor of mislocalized palmitoylated proteins in the acylation cycle.

243 esterases (APTs) depalmitoylate mislocalized palmitoylated proteins on endomembranes.

244 he synaptic vesicles (SVs), in which several palmitoylated proteins play critical roles.

245 e inhibitor identified a pool of dynamically palmitoylated proteins regulated by palmitoyl-protein th

246 However, palmitoylated proteins require depalmitoylation for recy

247 n be metabolically incorporated into known S-palmitoylated proteins such as H-Ras and IFITM3, a poten

248 mic methodology that purifies and identifies palmitoylated proteins to characterize the palmitoyl pro

249 saturase, which converts membrane-associated palmitoylated proteins to their respective palmitoleated

250 Palmitoylated proteins were enriched from membranes isol

251 This collection includes 51 known palmitoylated proteins, 61 putative palmitoylated protei

252 reveal the spatial localization of specific palmitoylated proteins, as exemplified by sonic Hedgehog

253 platform to identify specific modulators of palmitoylated proteins, demonstrated here for Ras and Fy

254 We identified approximately 125 predicted palmitoylated proteins, including G proteins, receptors

255 falciparum parasites and identified over 400 palmitoylated proteins, including those involved in cyto

256 nit of the L-type Ca(2+) channel CaV1.1 as S-palmitoylated proteins, indicating that S-palmitoylation

257 r if these enzymes act constitutively on all palmitoylated proteins, or if additional depalmitoylases

258 Consistent with the prevalence of palmitoylated proteins, palmitoylation is essential for

259 almitoylated peptides corresponding to 883 S-palmitoylated proteins.

260 ism for a specific subset of rapidly cycling palmitoylated proteins.

261 ific proteomic studies, and 103 new putative palmitoylated proteins.

262 er to reveal the full cellular complement of palmitoylated proteins.

263 e compendium containing 1,838 genes encoding palmitoylated proteins; representing approximately 10% o

264 T1 cleaves thioester linkages in s-acylated (palmitoylated) proteins and facilitates their degradatio

265 leavage of thioester linkages in S-acylated (palmitoylated) proteins and its deficiency leads to abno

266 T1 cleaves thioester linkages in S-acylated (palmitoylated) proteins and its mutation causes abnormal

267 kable chemical reporters to label the entire palmitoylated proteome, followed by proximity ligation o

268 Compared with nonpalmitoylated R7BP, palmitoylated R7BP greatly augments the ability of RGS7

269 plasma membrane-bound heterotrimers bearing palmitoylated R7BP.

270 The multiple signaling states of palmitoylated Ras isoforms question the completeness of

271 ata strongly demonstrate that sp-Erf2/zDHHC9 palmitoylates Ras proteins in a highly selective manner

272 By contrast, the palmitoylated receptor exhibited only low-affinity EGF b

273 urface area/volume ratios are increased, the palmitoylated regulatory protein, phospholemman (PLM), a

274 with cysteine-to-alanine substitution at the palmitoylated residues (4CA mice).

275 Viruses with fewer palmitoylated S protein cysteines entered cells slowly a

276 t is a 40 amino acid peptide containing an O-palmitoylated Ser-39.

277 and Porcupine, a putative Wnt PAT, does not palmitoylate Shh.

278 structures, although flanking sequences of S-palmitoylated sites are enriched in positively-charged a

279 Palmitoylated sonic Hedgehog is found in the endoplasmic

280 ggesting that immature SOD1 is the primarily palmitoylated species.

281 functional availability is regulated by the palmitoylated state of the beta(2a)-subunit.

282 portantly, H-Ras has two, singly and doubly, palmitoylated states that may also serve distinct functi

283 caused persistent membrane anchorage of the palmitoylated SV proteins, which hindered the recycling

284 From this large set of palmitoylated targets, we validate palmitoylation of pro

285 , we found that only 31% of total H-Ras is S-palmitoylated, tethering the small GTPase to the plasma

286 palmitoylation of TF at the N terminus, and palmitoylated TF is preferentially trafficked to the pla

287 the DHHC family of enzymes that are able to palmitoylate the gamma2 subunit in heterologous cells.

288 ported to localize primarily to Golgi and to palmitoylate the neuronal proteins synaptosome-associate

289 We show here that App promotes growth by palmitoylating the intracellular domain of Fat, and that

290 adjacent to cysteines that are not normally palmitoylated, they became palmitoylation sites.

291 ds of the Hedgehog and Wnt families are also palmitoylated; this modification, which requires the rel

292 for activation of T cells (LAT) is a dually palmitoylated transmembrane adaptor protein essential fo

293 erized protein encoded by MHCIII locus, is a palmitoylated transmembrane adaptor protein.

294 Palmitoylated tubulin is found along microtubule tracks

295 ylation in vivo and partially purified Pfa3p palmitoylated Vac8p in vitro, establishing Vac8p as a su

296 in signaling was specifically inhibited by a palmitoylated version of a beta3 peptide corresponding t

297 Although the alpha subunit is not palmitoylated, we now show that the two cytoplasmic Cys

298 owever, the APTs are themselves reversibly S-palmitoylated, which localizes thioesterase activity to

299 Palmitoylated Wnt ligands engage cell-surface frizzled (

300 iled information on the eight differentially palmitoylated ZDHHC6 species.