ライフサイエンスコーパス: palmitoylation

1 t a DHHC7 catalytic mutant, enhances JAM-C S-palmitoylation.

2 tly screen for small molecular inhibitors of palmitoylation.

3 erapeutic benefit by activating MC1R protein palmitoylation.

4 ioning, namely TMD surface area, length, and palmitoylation.

5 rmacological tools to interfere with protein palmitoylation.

6 ha-helix whose properties facilitate Cys-739 palmitoylation.

7 in of Dsg2 that, when mutated, eliminate its palmitoylation.

8 olgi to the plasma membrane due to enzymatic palmitoylation.

9 c-S3C/S6C interferes with its myristoylation/palmitoylation.

10 knock-out cells decreased endogenous IFITM3 palmitoylation.

11 pathways of host cells, ubiquitination and S-palmitoylation.

12 hance our understanding of Hhat-mediated Shh palmitoylation.

13 ing property and dynamic nature of protein S-palmitoylation.

14 , which is posttranslationally modified by S-palmitoylation.

15 ar loop is necessary and sufficient for NCX1 palmitoylation.

16 w palmitoylation or low phosphorylation-high palmitoylation.

17 an understanding of the mechanism of protein palmitoylation.

18 ng (HTS) campaigns for modulators of protein palmitoylation.

19 identify the structural determinants of NCX1 palmitoylation.

20 in adipose tissue and muscle decreased Glut4 palmitoylation.

21 cysteine residue that undergoes LPS-induced palmitoylation.

22 e of the helix significantly reduced FL-NCX1 palmitoylation.

23 large intracellular loop that controls NCX1 palmitoylation.

24 cortex is mediated by the N-terminus, likely palmitoylation.

25 beta-dependent fashion and decreased Galphaq palmitoylation.

26 -terminal side of Cys-739 abolished YFP-NCX1 palmitoylation.

27 IFITM3 is activated by palmitoylation, a lipid posttranslational modification.

28 257R mutation displayed diminished levels of palmitoylation, a post-translational modification crucia

29 Here, we show that Nav1.5 is subject to palmitoylation, a reversible post-translational lipid mo

30 tant mice resulted in lower levels of Drp1 S-palmitoylation accompanied by altered mitochondrial dyna

31 ses of mutant proteins, we propose that Drd3 palmitoylation acts as a molecular switch for Drd3-biase

32 ever, details regarding the mechanism of how palmitoylation affects cilia protein localization and fu

33 Mutation of Cys that blocked ENaC palmitoylation also reduced channel open probability.

34 ith Bartter syndrome type IV, reduce barttin palmitoylation and CLC-K/barttin channel activity.

35 lex that is associated with the sequential S-palmitoylation and depalmitoylation of a previously unde

36 futile cycles, folded LRP6 molecules undergo palmitoylation and ER export, while unsuccessfully folde

37 of the amphipathic helix strongly attenuated palmitoylation and Golgi localization of GobX.

38 tions in palmitoyltransferases decrease MCAM palmitoylation and have impaired ability to suppress cel

39 light on the enzymatic regulation of NMNAT2 palmitoylation and highlight individual thioesterases an

40 These hydrophobic modifications resemble S-palmitoylation and hydroxyfarnesylation, thus discouragi

41 is susceptible to both phosphorylation and S-palmitoylation and is enriched in the tips of extending

42 ly lacking ZDHHCs 1-24 and found that IFITM3 palmitoylation and its inhibition of influenza virus inf

43 The reversibility of protein palmitoylation and its profound effect on protein functi

44 iously unrecognized effect of NAC on Galphaq palmitoylation and phospholipase C beta-mediated signali

45 ered in 4CA mice despite the lack of BACE1 S-palmitoylation and reduced lipid raft association.

46 Furthermore, inflammation enhances PLCbeta1 palmitoylation and signalling activity, effects signific

47 palmitoyltransferases that influence NMNAT2 palmitoylation and subcellular localization, among which

48 ts cilia localization, and one that prevents palmitoylation and thus membrane binding, in assays of t

49 n polymorphism S738F, which enhanced FL-NCX1 palmitoylation, and D741A, which modestly reduced it.

50 -proximal Cys residues (Cys88/91) suppresses palmitoylation, and this STING mutant cannot induce STIN

51 GODZ is involved in palmitoylation, and we found that UL20 is palmitoylated

52 Dynamic changes in protein S-palmitoylation are critical for regulating protein local

53 t-translational modifications (PTMs) such as palmitoylation are critical for the lytic cycle of the p

54 se of AKAP79/150, indirect CaMKII effects on palmitoylation are more important than the effects of di

55 These findings reveal IP3R palmitoylation as a critical regulator of Ca(2+) flux in

56 We recently identified protein palmitoylation as a mechanism regulating desmosome dynam

57 Here, we introduce palmitoylation as a novel posttranslational modification

58 Our results identify barttin palmitoylation as a novel posttranslational modification

59 has shed some light on the putative role of palmitoylation as a reversible switch for dopaminergic r

60 the C terminus of K-Ras4A contains a site of palmitoylation as well as a bipartite polybasic region.

61 Palmitoylation at a membrane proximal cysteine residue e

62 BACE1 is modified by S-palmitoylation at four juxtamembrane cysteine residues.

63 In contrast, HGAL myristoylation and palmitoylation avert its inhibitory effects on chemoattr

64 Further, we show that palmitoylation by App functions antagonistically to phos

65 eptors (GABAARs) is thought to be subject to palmitoylation by both Golgi-associated DHHC-type zinc f

66 Our data indicate that alterations in palmitoylation can substantially control Nav1.5 function

67 oyltransferase, ZDHHC16, revealing the first palmitoylation cascade.

68 Palmitoylation commonly confers resistance to cationic a

69 These results indicate that in PSDs, PSD95 palmitoylation, conformation, and its interactions are d

70 Env7 contains a palmitoylation consensus sequence, and substitution of i

71 otably, phosphorylation, ubiquitination, and palmitoylation control the stability, trafficking, and s

72 simulations, we evaluated in silico how Drd3 palmitoylation could elicit significant remodeling of th

73 ER stress in primary beta-cells perturbs the palmitoylation cycle controlling GAD65 endomembrane dist

74 Cys residue to Ala or inhibition of protein palmitoylation decreased HCMV gB export via Gag particle

75 Here, we show that a palmitoylation-defective Fas C194V mutant is defective i

76 ation was markedly reduced in assays using a palmitoylation-defective mutant of FCRL4.

77 Palmitoylation-dependent preferential containment of Fyn

78 ontrast, we find that the inhibition of CD82 palmitoylation disrupts the formation and organization o

79 Surprisingly, palmitoylation does not influence trafficking or localiz

80 Disrupting PRCD palmitoylation either chemically or by genetically elimi

81 Palmitoylation enhances the hydrophobicity of proteins,

82 Further studies reveal that blocking AMA1 palmitoylation enhances the release of AMA1 and other in

83 LK localization, interactions, and activity, palmitoylation ensures that only vesicle-bound DLK is ac

84 Palmitoylation enzymes have been assumed to select their

85 Trafficking of palmitoylation enzymes via Rab27a regulates mVEGFR1 stab

86 NOS-M) that is targeted to the sarcolemma by palmitoylation, even in the absence of the DPC.

87 -needed resource for cell biologists and the palmitoylation field, providing new perspectives for can

88 our study allows for a systematic view of S-palmitoylation for identification of ZDHHC13 substrates

89 subunit a1 of the V0 sector (V0a1) requires palmitoylation for interacting with adaptor protein-2 (A

90 ifferences in associated PAT specificity and palmitoylation function.

91 Furthermore, gamma subunit palmitoylation had a dominant role over beta subunit pal

92 t the functional attributes afforded by Drd3 palmitoylation have not been studied.

93 the involvement of DHHC21-mediated PLCbeta1 palmitoylation in endothelial inflammation.

94 ilarly, NAC treatment also decreased Galphaq palmitoylation in ischemic and nonischemic hindlimbs in

95 transgenic zebrafish embryos and the role of palmitoylation in its organization using single plane il

96 edge for the first time, a specific role for palmitoylation in leaf senescence.

97 he role of Ser-7 phosphorylation and Cys-580 palmitoylation in mediating steady-state transport kinet

98 ystrophic neurites in the absence of BACE1 S-palmitoylation in mouse models of AD amyloidosis.

99 he results highlight a central role for MC1R palmitoylation in pigmentation and protection against me

100 optosis through Fas is dependent on receptor palmitoylation in primary immune cells, and Fas may prev

101 Changing PSD95 palmitoylation in PSDs altered PSD95 and AMPAR levels bu

102 istent with differential regulation of PSD95 palmitoylation in PSDs resulting from the clustering of

103 lation had a dominant role over beta subunit palmitoylation in regulating ENaC.

104 These novel roles for palmitoylation in the spatial control of actin dynamics

105 acyltransferases (PATs) that mediate protein palmitoylation, including active site thioester-linked p

106 ons that promote low phosphorylation or high palmitoylation increase transport Vmax and suppress PKC-

107 Palmitoylation increases channel availability and late s

108 In contrast, blocking palmitoylation increases closed-state channel inactivati

109 Importantly, expression of a palmitoylation-independent lipidated AKAP mutant in DHHC

110 Treatment with palmitoylation inhibitor 2-bromopalmitate (2-BP) suppres

111 ed fast cytoplasmic diffusion insensitive to palmitoylation inhibitors, suggesting defective fatty ac

112 rmat and is sensitive to known, non-specific palmitoylation inhibitors.

113 Palmitoylation involves the reversible posttranslational

114 Palmitoylation is a critical post-translational modifica

115 S-palmitoylation is a dynamic posttranslational modificati

116 Palmitoylation is a reversible post-translation modifica

117 Protein S-palmitoylation is a reversible post-translational modifi

118 Palmitoylation is a reversible post-translational protei

119 Palmitoylation is a reversible, posttranslational modifi

120 Palmitoylation is a widespread, reversible lipid modific

121 role for zDHHC17 (HIP14) in neuronal NMNAT2 palmitoylation is best supported by our data.

122 t-hairpin RNA knockdown/rescue, we find that palmitoylation is critical for DLK-dependent retrograde

123 Palmitoylation is critical for LIMK1 function because th

124 so have demonstrated that GODZ-mediated UL20 palmitoylation is critical for UL20 membrane targeting a

125 ockdown/rescue experiments reveal that LIMK1 palmitoylation is essential for normal spine actin polym

126 NCX1 palmitoylation is governed by a distal secondary structu

127 veral oncogenes of the Ras and Src families, palmitoylation is indispensable for protein function.

128 While palmitoylation is involved in invasion, motility, and ce

129 Palmitoylation is involved in several neuropsychiatric a

130 Cys-265 S-palmitoylation is mediated by the Golgi-resident palmito

131 Studies in cultured neurons suggest that S-palmitoylation is required for dendritic spine localizat

132 UL20 is palmitoylated by GODZ, and this UL20 palmitoylation is required for HSV-1 infectivity.

133 S-Palmitoylation is the only reversible post-translational

134 Palmitoylation is the posttranslational modification of

135 These findings suggest that palmitoylation is ubiquitous throughout the T. gondii pr

136 Protein S-acylation (palmitoylation) is a reversible lipid modification that

137 Lck palmitoylation kinetics are consistent with the activati

138 Our findings demonstrate highly dynamic Lck palmitoylation kinetics that are essential for signaling

139 By combination of palmitoylation, lactam-bridging, and Nalpha-methylation,

140 Moreover, DHHC7 knockdown decreases the S-palmitoylation level of JAM-C.

141 Moreover, the palmitoylation levels correlated with targeting to deter

142 an extremely rapid and transient increase in palmitoylation levels of the tyrosine kinase Lck.

143 Enzymatically raised palmitoylation levels restored the surface expression of

144 tly altering expression of the basal protein palmitoylation machinery is sufficient to promote cell i

145 Pharmacological manipulation of protein palmitoylation may be a strategy to alter cilia function

146 that the sensitivity of ARL13b stability to palmitoylation may be exploited by the cell to accelerat

147 among the top five, suggesting that aberrant palmitoylation may play a pivotal role in the balance of

148 ng and posttranslational modifications, like palmitoylation, may improve the prospects for drug devel

149 icking of some GABRG2 mutations by enhancing palmitoylation might be an interesting therapeutic appro

150 Finally, the lack of BACE1 S-palmitoylation mitigates cognitive deficits in 5XFAD mic

151 Including a palmitoylation motif at the N terminus of CaV2.2 I-II lo

152 Distinct palmitoylation motifs and site topology were identified

153 Utilizing a palmitoylation mutant form of CD82 with disrupted membra

154 ng the intracellular domain of Fat, and that palmitoylation negatively regulates Fat function.

155 Inhibiting Lck palmitoylation not only disrupts proximal Fas signaling

156 Palmitoylation occurs in two steps.

157 r, and in vivo studies, we found that ARL13b palmitoylation occurs in vivo in mouse kidneys and that

158 Using these mutants, we determined that TF palmitoylation occurs primarily in the N terminus.

159 feres with M-channel signaling by inhibiting palmitoylation of a signaling scaffold protein, AKAP79/1

160 sitol 4,5-bisphosphate and is facilitated by palmitoylation of a single cysteine at position 739 with

161 Furthermore, we have demonstrated that S-palmitoylation of all three IFITM proteins is essential

162 monstrate that intrinsic posttranslational S-palmitoylation of BACE1 has a significant impact on amyl

163 face or of helix-breaking prolines impaired palmitoylation of both YFP-NCX1 and FL-NCX1.

164 Trafficking of myomaker is regulated by palmitoylation of C-terminal cysteine residues that allo

165 ta indicates that N-linked glycosylation and palmitoylation of CD82 are both critical modifications t

166 Basal S-palmitoylation of Cys-265 is negligible, but agonist-ind

167 nhibition of depalmitoylation reveals that S-palmitoylation of Cys-265 may stabilize the receptor at

168 Cys-265 is not conserved in beta1AR, and S-palmitoylation of Cys-265 may thus be associated with fu

169 stably attached to the cell membrane through palmitoylation of cysteine residues.

170 ein-2 (Dsg2) and characterized the role that palmitoylation of Dsg2 plays in its localization and sta

171 Taken together, these data suggest that palmitoylation of Dsg2 regulates protein transport to th

172 Diminished DHHC3-dependent palmitoylation of ERGIC3 protein likely played a key rol

173 Palmitoylation of gamma2 and a second substrate, growth-

174 In aggregate, our study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dyn

175 that this process is critically dependent on palmitoylation of Glut4 at Cys-223.

176 Altogether, these results uncover the palmitoylation of HCMV gB and its role in gB multimeriza

177 n cytomegalovirus (HCMV) gB depends on the S-palmitoylation of its endodomain for an efficient intera

178 se Pfa4 DHHA or DHHR mutants also results in palmitoylation of its substrate Chs3.

179 These results suggest that S-palmitoylation of JAM-C can be potentially targeted to c

180 Palmitoylation of JAM-C promotes its localization to tig

181 Post-translational palmitoylation of mVEGFR1 is a binary stabilization swit

182 bility, as reduced levels of Rab27a impaired palmitoylation of mVEGFR1, decreased its stability, and

183 Palmitoylation of NCX1 occurs in the Golgi and anchors t

184 lmitoyl acyltransferase (PAT), catalyzes the palmitoylation of PRCD in the Golgi compartment.

185 In conclusion, we find that the palmitoylation of PRCD is crucial for its trafficking to

186 nt in the mouse retina demonstrates that the palmitoylation of PRCD is important for its proper local

187 ge set of palmitoylated targets, we validate palmitoylation of proteins involved in motility (myosin

188 Palmitoylation of proteins is primarily mediated by zinc

189 Evidence that palmitoylation of proteins occurs with the kinetics requ

190 show that Zdhhc8-deficient mice have reduced palmitoylation of proteins that regulate axonal growth a

191 Palmitoylation of PSD95 changed its conformation from a

192 tify small molecules that interfere with the palmitoylation of Ras, a high value therapeutic target t

193 ygen species via NADPH oxidase, reducing the palmitoylation of receptor-associated Galphai in a JNK-d

194 Palmitoylation of Shh by Hhat is critical for short and

195 Palmitoylation of SP-C had an indirect effect on the ext

196 inhibitor 2-bromopalmitate (2-BP) suppresses palmitoylation of STING and abolishes the type I interfe

197 Here we show that palmitoylation of STING at the Golgi is essential for ac

198 These data demonstrate that palmitoylation of SynDIG1 is regulated by neuronal activ

199 del where the C terminus of TF modulates the palmitoylation of TF at the N terminus, and palmitoylate

200 In this study, we show that the palmitoylation of TF regulates its localization to the p

201 Palmitoylation of the accessory subunit barttin might th

202 Here, we identify direct palmitoylation of the actin regulator LIM kinase-1 (LIMK

203 We previously demonstrated that palmitoylation of the AMPAR-linked scaffold protein A-ki

204 Here we show that activity-dependent palmitoylation of the atypical AMPA receptor auxiliary t

205 lity of these mutant aggregates is linked to palmitoylation of the cysteine-string domain, however th

206 In this study, we have focused on the palmitoylation of the desmosomal cadherin desmoglein-2 (

207 n synapses by proposing a mechanism by which palmitoylation of the immobilized scaffold protein PSD-9

208 ding of phosphorylation, ubiquitination, and palmitoylation of the NMDA and AMPA subtypes of glutamat

209 Palmitoylation of the peptide was essential to facilitat

210 ls in the context of previously unrecognized palmitoylation of the receptor.

211 cysteine (Cys) mutants to test differential palmitoylation of the Sindbis virus 6K and TF proteins.

212 anslational modification of such channels by palmitoylation of their accessory subunit barttin.

213 Recent studies have shown that the palmitoylation of Wnt3 by Porcupine, a membrane-bound O-

214 nhibitor (C59), confirming the importance of palmitoylation of Wnt3 for its association with choleste

215 , techniques have been developed to identify palmitoylation on a proteome-wide scale in order to reve

216 almitoylated, and investigate the effects of palmitoylation on SynDIG1 stability and localization.

217 Here, we show that JAM-C undergoes S-palmitoylation on two juxtamembrane cysteine residues, C

218 ations that display high phosphorylation-low palmitoylation or low phosphorylation-high palmitoylatio

219 ysosomal degradation of CD44, independent of palmitoylation or proteasome targeting.

220 cating that SERZ-beta does not contribute to palmitoylation or trafficking of GABAARs even in the abs

221 Together, the results show that palmitoylation plays a unique and critical role in contr

222 tions include N-myristoylation, S-acylation (palmitoylation), prenylation and GPI anchors but until r

223 MC1R palmitoylation, primarily mediated by the protein-acyl t

224 palmitoylated proteins have led to multiple palmitoylation proteomics studies but these datasets are

225 Consequently, we curated the data from 15 palmitoylation proteomics studies into one compendium co

226 ic domain results in a complete loss of HHAT palmitoylation, providing novel insights into how the pr

227 It has been proposed that the palmitoylation reaction occurs through a palmitoyl-PAT c

228 ale for the long-known effects of C-terminal palmitoylation reactions on G protein-coupled receptor s

229 ons that promote high phosphorylation or low palmitoylation reduce transport Vmax and enhance PKC-sti

230 ed mCCDcl1 cells with a general inhibitor of palmitoylation reduced ENaC-mediated Na(+) currents with

231 dominant-negative mutant and an inhibitor of palmitoylation reduced HSV-1 titers and altered the loca

232 iding new mechanistic insights into how UL20 palmitoylation regulates HSV-1 infectivity.IMPORTANCE HS

233 Palmitoylation regulates the localization and function o

234 , we show that pharmacological activation of palmitoylation rescues the defects of Mc1r RHC variants

235 The functional importance of palmitoylation results in part from a dramatic increase

236 ain) family of enzymes that catalyze protein palmitoylation revealed that one member, DHHC6, contains

237 Cysteine targets for S-palmitoylation, S-glutathionylation, and S-nitrosylation

238 ere unaltered, indicating that GODZ-mediated palmitoylation selectively controls the pool of receptor

239 immunomodulatory activity and indicates that palmitoylation serves as an additional level of regulato

240 These data indicate that palmitoylation, SH2- and SH3-mediated intermolecular int

241 (tdTomato) were fused at NH2-termini with a palmitoylation signal (PalmGFP, PalmtdTomato) for EV mem

242 the membrane due to a point mutation in the palmitoylation site (C451A), so called Nuclear-Only-ER (

243 rent N-terminal domains, possessing either a palmitoylation site (PSD95) or an L27 domain (SAP97).

244 for cholesterol binding adjacent to a native palmitoylation site and near to an interhelix crevice th

245 proteins however, methods for comprehensive palmitoylation site characterization are lacking.

246 We found that mutations disrupting Arl13b's palmitoylation site, cilia localization signal, or GTPas

247 e and either a polybasic cluster (in Src) or palmitoylation sites (e.g., Fyn).

248 wn palmitoylated proteins and 102 individual palmitoylation sites are known from the literature.

249 ssABE allows the global identification of palmitoylation sites as well as measurement of the activ

250 evealed that cornifelin, which contains five palmitoylation sites at cysteine residues (C58, C59, C60

251 ype ENaC and channels lacking beta and gamma palmitoylation sites co-immunoprecipitated with the five

252 54% of palmitoylation sites map to synaptic proteins including

253 me with TMT10-plex labelling, 400 (31%) of S-palmitoylation sites on 254 proteins were down-regulated

254 t allowed the identification of 906 putative palmitoylation sites on 641 proteins from mouse forebrai

255 Palmitoylation sites were identified on over half of the

256 ivation by DHHCs was lost when gamma subunit palmitoylation sites were mutated, whereas DHHCs 1, 2, a

257 ite specific mutagenesis of the three ZDHHC6 palmitoylation sites, experimental determination of kine

258 14 still activated ENaC lacking beta subunit palmitoylation sites.

259 , an effect lost in a Fyn mutant lacking the palmitoylation sites.

260 cysteine residues at positions 54 and 56 as palmitoylation sites.

261 are not normally palmitoylated, they became palmitoylation sites.

262 Modulation of the palmitoylation status of desmosomal cadherins can affect

263 s was validated by direct myristoylation and palmitoylation studies, which indicated that the residue

264 e identify four cysteines as possible Nav1.5 palmitoylation substrates.

265 In conclusion, DHHC3-mediated protein palmitoylation supports breast tumor growth by modulatin

266 onally within the cytoplasm of the parasite, palmitoylation takes place at membranes and is mediated

267 S-Palmitoylation targets 18 Cys within the N-terminal, cyt

268 Fatty acylation, such as myristoylation and palmitoylation, targets proteins to cilia and flagella.

269 velopmental changes in lipid composition and palmitoylation that facilitate the formation of postsyna

270 at catalyze S-acylation (commonly known as S-palmitoylation), the reversible posttranslational lipid

271 ly to cilia, multiple cilia proteins rely on palmitoylation, the post-translational attachment of a s

272 Protein palmitoylation, the reversible attachment of a 16 carbon

273 stigated the in vivo significance of BACE1 S-palmitoylation through the analysis of knock-in mice wit

274 ve site modification state of PATs, enabling palmitoylation to be studied at a systems level.

275 We mapped palmitoylation to Cys212 and Cys284, which are critical

276 For palmitoylation to occur, membrane association is a prere

277 e demonstrate that GobX exploits host cell S-palmitoylation to specifically localize to Golgi membran

278 lux, TMX1 requires its thioredoxin motif and palmitoylation to target to the MAM.

279 These mutations revealed palmitoylation, transmembrane domain length, and transme

280 Thus, NCX palmitoylation ubiquitously modulates Ca homeostasis and

281 not observe pronounced alteration of barttin palmitoylation upon increased salt and water intake or w

282 Blocking of palmitoylation using 2-bromopalmitate (2-BP) affected th

283 We measured NCX1 palmitoylation using resin-assisted capture, the subcell

284 beta subunit palmitoylation was increased by ENaC co-expression with

285 , dissection of the C terminus revealed that palmitoylation was not sufficient for complete fusogenic

286 Finally, gB palmitoylation was required for full fusogenic activity

287 urther insights into the regulation of Glut4 palmitoylation, we set out to identify the palmitoyl acy

288 egments (OS) presumably anchored to discs by palmitoylation, whereas ARL3 is an inner segment cytopla

289 ectopic expression of DHHC7 increased Glut4 palmitoylation, whereas DHHC7 knockdown in 3T3-L1 adipoc

290 lmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon palmitate to specifi

291 we identified that Zdhhc13-dependent Drp1 S-palmitoylation, which acting alone or in concert, enable

292 ion of ENaC cytoplasmic cysteine residues by palmitoylation, which enhance channel activity by alteri

293 hippocampal slice culture increases SynDIG1 palmitoylation, which is consistent with our prior demon

294 edgehog protein undergoes post-translational palmitoylation, which is critical for its signaling acti

295 roteins are modified post-translationally by palmitoylation, which is essential for their secretion,

296 ced beta2AR activation results in enhanced S-palmitoylation, which requires phosphorylation by the cA

297 three novel cellular and molecular roles of palmitoylation, which targets DLK to trafficking vesicle

298 on lipid, is shown to largely substitute for palmitoylation with regard to cilia localization of ARL1

299 the ZDHHCs were capable of increasing IFITM3 palmitoylation with ZDHHCs 3, 7, 15, and 20 having the g

300 e of Cys-739 in YFP-NCX1 did not affect NCX1 palmitoylation, with the exception of the rare human pol