ライフサイエンスコーパス: palmitoyltransferase

1 oxidation (acetylCoA carboxylase; carnitine-palmitoyltransferase).

2 like myriocin FTY720 does not inhibit serine palmitoyltransferase.

3 des a posttranslational modification enzyme, palmitoyltransferase.

4 a functional human ortholog of the yeast Ras palmitoyltransferase.

5 HHC8, which encodes a putative transmembrane palmitoyltransferase.

6 ivities of both ceramide synthase and serine palmitoyltransferase.

7 srupted genes is ZDHHC8, which encodes for a palmitoyltransferase.

8 was corrected by transformation with serine palmitoyltransferase.

9 activities for arylsulfatase A and carnitine palmitoyltransferase.

10 f complex sphingolipids downstream of serine palmitoyltransferase.

11 enzyme in sphingolipid biosynthesis, serine palmitoyltransferase.

12 roteins shown recently in yeast to represent palmitoyltransferases.

13 esidues are replaced by glycine in carnitine palmitoyltransferases.

14 was associated with a decrease in carnitine palmitoyltransferase 1 (cPT1) and cPT2 levels.

15 The enzyme carnitine palmitoyltransferase 1 (CPT1), which is anchored in the

16 centrations are known to derepress carnitine palmitoyltransferase 1 (CPT1).

17 antigen) and the suppression of carnitine O-palmitoyltransferase 1 (Cpt1a) and acyl-CoA synthetase l

18 changes in ACSL1 (R(2) = 0.39) and carnitine palmitoyltransferase 1 (R(2) = 0.30) expressions (P < 0.

19 etyl coenzyme A carboxylase 2, and carnitine palmitoyltransferase 1 alpha) in both WT and ATGL KO mic

20 xidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA.

21 acetyl-coenzyme A carboxylase and carnitine palmitoyltransferase 1 in the liver.

22 pogenic pool but diminution of the carnitine palmitoyltransferase 1 inhibitory pool under cold condit

23 o the PPAR response element on the carnitine palmitoyltransferase 1 promoter.

24 tor alpha and induction of hepatic carnitine palmitoyltransferase 1, suggesting increased energy meta

25 rough its allosteric inhibition of carnitine palmitoyltransferase 1, the enzyme that normally exerts

26 ochondria-specific protein and the carnitine palmitoyltransferase 1.

27 ion by stimulating the activity of carnitine palmitoyltransferase-1 (CPT-1) and inhibiting that of ac

28 In addition, carnitine palmitoyltransferase-1 (CPT-1) inhibitor up-regulated th

29 (LCFAs) into the mitochondria via carnitine palmitoyltransferase-1 (CPT-1) is inhibited by increased

30 Remarkably, 30 does not activate carnitine palmitoyltransferase-1 (CPT-1) nor induces in mice weigh

31 am effects including inhibition of carnitine palmitoyltransferase-1 (CPT-1) with resultant inhibition

32 hibits FAS activity and stimulates carnitine palmitoyltransferase-1 (CPT-1), consistent with its effe

33 Etomoxir, an inhibitor of carnitine O-palmitoyltransferase-1 (CPT-1), reversed the increased e

34 Carnitine palmitoyltransferase-1 (CPT1) is a rate-limiting step of

35 The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty

36 CoA is an established inhibitor of carnitine palmitoyltransferase-1 (CPT1), an outer mitochondrial me

37 , we targeted the liver isoform of carnitine palmitoyltransferase-1 (encoded by the CPT1A gene) by in

38 d receptor alpha protein and liver-carnitine palmitoyltransferase-1 (l-CPT-1) mRNA increased in liver

39 is and decrease in the activity of carnitine palmitoyltransferase-1 and total energy expenditure were

40 tment of mice for 4 weeks with the carnitine palmitoyltransferase-1 inhibitor, oxfenicine (150 mg/kg

41 umed diets containing 0.01% of the carnitine palmitoyltransferase-1 inhibitor, R-etomoxir, which prod

42 Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO model, we show that prolonged

43 Similarly, carnitine palmitoyltransferase-1 was inhibited after repetitive hy

44 atty acid oxidation such as Cpt-1 (carnitine palmitoyltransferase-1) as well as Pgc-1alpha are induce

45 Activity of carnitine palmitoyltransferase-1, a key enzyme controlling fatty a

46 potent inhibitor of mitochondrial carnitine palmitoyltransferase-1, a key enzyme involved in the mit

47 metabolic bottleneck downstream of carnitine palmitoyltransferase-1, a mitochondrial enzyme that cata

48 uced liver injury due to increased carnitine palmitoyltransferase-1, phosphorylated 5'AMP-activated p

49 In addition, a missense SNP in the carnitine palmitoyltransferase 1A (CPT1A) gene was associated with

50 98, and cg09737197) in intron 1 of carnitine palmitoyltransferase 1A (CPT1A) were strongly associated

51 itochondrial fatty acid transport, carnitine palmitoyltransferase 1A (CPT1A), as a direct HIF target

52 yl-CoA levels and desinhibition of carnitine palmitoyltransferase 1A (CPT1A), which increases mitocho

53 resulted in reduced expression of carnitine palmitoyltransferase 1A (CPT1A), which is a key mitochon

54 ssion of the beta-oxidation enzyme carnitine palmitoyltransferase 1A (CPT1A).

55 down-regulated the mRNA levels of carnitine palmitoyltransferase 1A (in beta-oxidation) and mitochon

56 ransmembrane domain 2 (TM2) of rat carnitine palmitoyltransferase 1A (rCPT1A), to elucidate the role

57 genes acyl coenzyme A oxidase and carnitine palmitoyltransferase 1A in livers of alcohol-fed MCP-1KO

58 pyruvate carboxykinase and CPT-1a (carnitine palmitoyltransferase 1a) genes.

59 CPT1a (carnitine palmitoyltransferase 1a) in the liver mitochondrial oute

60 ng carnitine O-octaniltransferase, carnitine palmitoyltransferase 1A, hydroxyacyl-CoA-dehydrogenase,

61 ted receptor-gamma (PPARgamma) and carnitine palmitoyltransferase 1alpha (CPT1alpha).

62 1alpha, uncoupling protein 1, and carnitine palmitoyltransferase 1alpha, were increased by EPO but i

63 oA with simultaneous inhibition of carnitine palmitoyltransferase 1b and 2) catalyze the palmitoyl-Co

64 cids (BCAA) and fatty acids (e.g., carnitine palmitoyltransferase 1B).

65 effects, coupled with an increased carnitine palmitoyltransferase 1b, led to increased fatty acid oxi

66 r glucose oxidation and suppresses carnitine palmitoyltransferase-1B (CPT-1B), a key enzyme in fatty

67 Transcriptional regulation of carnitine palmitoyltransferase-1beta (CPT-1beta) is coordinated wi

68 The brain-specific isoform carnitine palmitoyltransferase 1C (CPT1C) has been implicated in t

69 nstituents of the AMPAR complex is carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isofor

70 l long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle and heart struc

71 nockdowns affecting either subunit of serine palmitoyltransferase, a key enzyme in ceramide and sphin

72 Inactivation of serine palmitoyltransferase, a key enzyme in generating endogen

73 ubstrate specificity of virus-encoded serine palmitoyltransferase, a key enzyme of sphingolipid biosy

74 olipids, apparently via modulation of serine palmitoyltransferase, a rate-limiting enzyme in de novo

75 otected from diet-induced increase in serine palmitoyltransferase, acid sphingomyelinase, and neutral

76 -beta-cyclodextrin resulted in inhibition of palmitoyltransferase activity and a redistribution of th

77 at associates with increased monocyte serine palmitoyltransferase activity and chemotaxis toward infl

78 This effect required palmitoyltransferase activity and was abolished if the p

79 e mutations are dominant and decrease serine palmitoyltransferase activity by 50% when the wild-type

80 The palmitoyltransferase activity demonstrates a modest pref

81 r ultraviolet B irradiation), whereas serine palmitoyltransferase activity did not change.

82 herefore of interest to determine if protein palmitoyltransferase activity is also present in these d

83 Palmitoyltransferase activity is high in plasma membrane

84 Palmitoyltransferase activity is membrane-associated and

85 We propose that control of palmitoyltransferase activity levels provides a fundamen

86 identification of a palmitoyl-CoA:protein S-palmitoyltransferase activity that acylates G-protein al

87 delays meiotic entry, while increasing Erf2 palmitoyltransferase activity triggers aberrant meiosis

88 In this study, protein palmitoyltransferase activity, assayed using G-protein a

89 Cycloserine, an inhibitor that blocks serine palmitoyltransferase activity, lowered both sphingosine

90 ine resulted in 50 and 93% loss in carnitine palmitoyltransferase activity, respectively.

91 elin) are reduced secondary to absent serine palmitoyltransferase activity.

92 ne of Saccharomyces cerevisiae reduce serine palmitoyltransferase activity.

93 oxoamine synthase family required for serine palmitoyltransferase activity.

94 c3 mutant cells have severely reduced serine palmitoyltransferase activity.

95 f Tyr(164) to Phe in SPTLC1 increased serine palmitoyltransferase activity.

96 ation, and analyses of the Toxoplasma serine palmitoyltransferase, an enzyme catalyzing the first and

97 ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial s

98 [(3)H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into C16-cer

99 f [3H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into C16-cer

100 , specific inhibitors of key enzymes (serine palmitoyltransferase and dihydroceramide synthase, respe

101 ctivity (over 2-fold, p = 0.01); both serine palmitoyltransferase and glucosylceramide synthase activ

102 in obese Zucker rat hearts, muscle carnitine palmitoyltransferase and medium-chain acyl-CoA dehydroge

103 ingosine bypasses the requirement for serine palmitoyltransferase and restores proteolysis.

104 se results suggest a novel mechanism whereby palmitoyltransferases and nuclear import receptors both

105 ion through the de novo pathway (e.g. serine palmitoyltransferase) and via the hydrolysis of sphingom

106 pid biosynthetic pathway (mediated by serine palmitoyltransferase), and at least regulated, de novo s

107 ell cortex, an effect partly mediated by the palmitoyltransferase Approximated under the control of F

108 These results implicate serine palmitoyltransferase as the enzyme controlling de novo c

109 n and highlight individual thioesterases and palmitoyltransferases as potential targets to modulate N

110 identified Approximated (App), a DHHC domain palmitoyltransferase, as a negative regulator of Fat sig

111 yltransferases, DHHC17 is the major ClipR-59 palmitoyltransferase, as evidenced by the fact that DHHC

112 ify Swf1, a member of the DHHC-CDR family of palmitoyltransferases, as the protein responsible for mo

113 ntracellular proteins is mediated by protein palmitoyltransferases belonging to the DHHC family, whic

114 es express two active but distinct carnitine palmitoyltransferases: carnitine palmitoyltransferase I

115 DHHC palmitoyltransferases catalyze the addition of the fatty

116 nown as the alpha-oxoamine synthases, serine palmitoyltransferase catalyzes the committed step of sph

117 Serine palmitoyltransferase catalyzes the first step of sphingo

118 oline octanoyltransferase (ChOT) and choline palmitoyltransferase (ChPT).

119 membrane, and this localization requires the palmitoyltransferase complex Erf2-Erf4.

120 s for mitochondrial outer-membrane carnitine palmitoyltransferase (CPT I) over hepatic ketogenesis be

121 Carnitine palmitoyltransferase (CPT) 1A adopts a polytopic conform

122 Carnitine palmitoyltransferase (CPT) I catalyzes the conversion of

123 atty acids in the early 1960s, the carnitine palmitoyltransferase (CPT) system has since come to be r

124 component(s) of the mitochondrial carnitine palmitoyltransferase (CPT) system.

125 o determine if the cDNA encoding a carnitine palmitoyltransferase (CPT)-like protein recently isolate

126 malonyl-coenzyme A (CoA)-sensitive carnitine palmitoyltransferase (CPT-I) is localized on the outer m

127 increased expression of the muscle carnitine palmitoyltransferase (CPT-I) isoform as measured by Nort

128 altered lipid metabolism and that carnitine palmitoyltransferases (CPT) have a major role in transpo

129 lic channeling of acyl-CoA through carnitine palmitoyltransferases (CPT-1/2) and attenuated the palmi

130 hibited hypothalamic expression of carnitine palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehy

131 the T(3) induction of the Pdk4 and carnitine palmitoyltransferase (Cpt1a) genes.

132 ported that T(3) induces genes for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kin

133 Additionally, cancer mutations in palmitoyltransferases decrease MCAM palmitoylation and h

134 rine, and 4-HPR transiently activated serine palmitoyltransferase, demonstrating that 4-HPR induced d

135 We found that, among 23 mammalian DHHC palmitoyltransferases, DHHC17 is the major ClipR-59 palm

136 ic, signal-regulated palmitate turnover; the palmitoyltransferase DHHC2 mediates de novo and turnover

137 ivity was enhanced by co-expression with the palmitoyltransferase DHHC2 that also co-immunoprecipitat

138 In this study, we show that the protein palmitoyltransferase DHHC3 is upregulated in malignant a

139 we identify a functional network connecting palmitoyltransferases DHHC5/8 with ankyrin-G, ankyrin-G

140 palmitoylating enzyme by screening all known palmitoyltransferases (DHHCs).

141 roduction of the enzymatically active ZDHHC8 palmitoyltransferase encoded by a gene in the 22q11.2 lo

142 d N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 gen

143 s deleted for the PhoPQ-regulated OM lipid A palmitoyltransferase enzyme, PagP.

144 demonstrates that one subunit of the serine palmitoyltransferase enzyme, SPTLC1, but not subunit 2 (

145 Indeed, co-expression of palmitoyltransferase enzymes promoted the aggregation of

146 Although changes in palmitoyltransferase expression are associated with vari

147 ogenic responses in mice with reduced serine palmitoyltransferase expression.

148 Thus, palmitoyltransferase facilitates the enrichment of fatty

149 Knowledge about the DHHC palmitoyltransferase family is still limited.

150 ipid modification mediated by members of the palmitoyltransferase family, serves as an important memb

151 are the first genes identified that encode a palmitoyltransferase for a Ras GTPase.

152 L-serine, the mutant HSAN1-associated serine palmitoyltransferase generates deoxysphingolipids, which

153 e the putative homologues of giardial serine palmitoyltransferase (gSPT) subunit genes (gspt-1 and -2

154 oforms of the small subunits of human serine palmitoyltransferase (hssSPTs) that activate the catalyt

155 nsduced with adenoviruses encoding carnitine palmitoyltransferase I (CPT I) isoforms or beta-galactos

156 bitor of the two known isoforms of carnitine palmitoyltransferase I (CPT I), which control mitochondr

157 Carnitine palmitoyltransferase I (CPT-I) catalyzes the rate-contro

158 Carnitine palmitoyltransferase I (CPT-I) catalyzes the rate-determ

159 Carnitine palmitoyltransferase I (CPT-I) catalyzes the transfer of

160 Carnitine palmitoyltransferase I (CPT-I) is a key enzyme involved

161 and mitochondrial differentiation [carnitine palmitoyltransferase I (CPT-I) isoforms] were measured.

162 uter mitochondrial membrane enzyme carnitine palmitoyltransferase I (CPTI) and inhibited by malonyl-C

163 Carnitine palmitoyltransferase I (CPTI) catalyzes the conversion o

164 t carnitine palmitoyltransferases: carnitine palmitoyltransferase I (CPTI), which is malonyl coA-sens

165 deletion mutants of rat liver-type carnitine palmitoyltransferase I (L-CPT I) expressed in Pichia pas

166 l amino acid residues of rat liver carnitine palmitoyltransferase I (L-CPTI) are essential for malony

167 l amino acid residues of rat liver carnitine palmitoyltransferase I (L-CPTI) on malonyl-CoA sensitivi

168 c activity in the liver isoform of carnitine palmitoyltransferase I (L-CPTI), we separately mutated f

169 lux, the expression of muscle-type carnitine palmitoyltransferase I (M-CPT I) was characterized in pr

170 ession of the gene encoding muscle carnitine palmitoyltransferase I (M-CPT I), an enzyme involved in

171 cumulation of mRNA encoding muscle carnitine palmitoyltransferase I (M-CPT I), an enzyme that catalyz

172 Heart/skeletal muscle carnitine palmitoyltransferase I (M-CPTI) is 30-100-fold more sens

173 eart, but the liver isoform (liver carnitine palmitoyltransferase I [L-CPT1]) is elevated in hearts w

174 he role of ACC-beta in controlling carnitine palmitoyltransferase I activity and fatty acid oxidation

175 ithout affecting the activities of carnitine palmitoyltransferase I and II.

176 ress the activity of mitochondrial carnitine palmitoyltransferase I and thus fatty acid oxidation in

177 Carnitine palmitoyltransferase I catalyzes the conversion of long-

178 Muscle carnitine palmitoyltransferase I is predominant in the heart, but

179 ward increased expression of the L-carnitine palmitoyltransferase I isoform.

180 fatty acids into mitochondria via carnitine palmitoyltransferase I relative to overall oxidative rat

181 lic acid cycle rates, flux through carnitine palmitoyltransferase I was 23% lower in hypertrophied (P

182 CPT1 infusion (P<0.05), but muscle carnitine palmitoyltransferase I was unaffected.

183 dium-chain acyl-CoA dehydrogenase, carnitine palmitoyltransferase I) and extramitochondrial (acyl-CoA

184 hout (-) etomoxir (an inhibitor of carnitine palmitoyltransferase I).

185 xidation through the inhibition of carnitine palmitoyltransferase I, a mitochondrial component of the

186 on of malonyl-CoA, an inhibitor of carnitine palmitoyltransferase I, have been linked to the regulati

187 CPT-IA and CPT-IB are isoforms of carnitine palmitoyltransferase I, of which CPT-IA is expressed in

188 receptor alpha target, muscle-type carnitine palmitoyltransferase I, providing a second mechanism by

189 ty acid oxidation in mitochondria, carnitine palmitoyltransferase I; and by reduction of superoxide l

190 Carnitine palmitoyltransferase-I (CPT-I) catalyzes the rate-contro

191 treatment of fasting rats with the carnitine palmitoyltransferase-I (CPT-I) inhibitor reduced the liv

192 enous, and allosteric inhibitor of carnitine palmitoyltransferase-I (CPT-I), a key enzyme for mitocho

193 coverage for the membrane proteins carnitine palmitoyltransferase-I (CPT-I), long-chain acyl-CoA synt

194 Hepatic carnitine palmitoyltransferase-I (CPT-IL) isolated from mitochondr

195 sponses to fasting are maintained; carnitine palmitoyltransferase-I induction and glucose levels are

196 sion of enzymes of fat catabolism (carnitine palmitoyltransferase-I, acyl-CoA oxidase, and uncoupling

197 Finally, knockdown of carnitine palmitoyltransferase IA in an AML patient-derived xenogr

198 of the 5'-flanking sequence of the carnitine palmitoyltransferase Ibeta (CPT-Ibeta) gene defines regu

199 utionarily related to the prokaryotic serine palmitoyltransferase, identified in the Sphingomonadacea

200 ensitive and detergent-labile; and carnitine palmitoyltransferase II (CPTII), which is malonyl coA-in

201 lated RAW264.7 cells (and mutation of serine palmitoyltransferase in CHO-LYB cells); furthermore, an

202 e novo sphingoid base biosynthesis by serine palmitoyltransferase in the transient G0/G1 arrest media

203 Recent reports of protein palmitoyltransferases in Saccharomyces cerevisiae and Dr

204 ase renders mutant cells sensitive to serine palmitoyltransferase inhibition due to impaired sphingoi

205 armacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly

206 The serine palmitoyltransferase inhibitor myriocin reversed these d

207 In all eukaryotes analyzed to date, serine palmitoyltransferase is a highly conserved heterodimeric

208 synthases are soluble homodimers, but serine palmitoyltransferase is a membrane-associated enzyme com

209 We also show that serine palmitoyltransferase is an Lcb1p small middle dotLcb2p h

210 Ser palmitoyltransferase is essential for plant viability.

211 Modeling studies suggest that serine palmitoyltransferase is likely to have a single active s

212 e that the gene encoding a subunit of serine palmitoyltransferase is located within the HSN1 locus, e

213 itoylation of a cysteine residue by the Akr1 palmitoyltransferase is required both for the switch of

214 esult suggests that the activation of serine palmitoyltransferase is the event responsible for increa

215 which harbors a temperature-sensitive serine palmitoyltransferase, lacked increased de novo generated

216 logue to be a functional, homodimeric serine palmitoyltransferase localized to the endoplasmic reticu

217 ow Swf1p, a member of the DHHC-CRD family of palmitoyltransferases, localizes to actin cables and cor

218 ide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is required f

219 ed that the ER-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1), which is the

220 europathies are dominant mutations in serine palmitoyltransferase, long chain base subunit 1 (SPTLC1)

221 ne was identified as SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1.

222 crease in the message and activity of serine palmitoyltransferase (P < 0.05).

223 a lipid A 3-O-deacylase, PagL, and a lipid A palmitoyltransferase, PagP.

224 Palmitoyltransferase (PAT) catalyses protein S-palmitoyl

225 Protein palmitoyltransferases (PATs) represent an exciting new t

226 Protein S-acyltransferases, also known as palmitoyltransferases (PATs), are characterized by the p

227 Overexpression of the palmitoyltransferase Pfa4 DHHA or DHHR mutants also resu

228 re we show that the Saccharomyces cerevisiae palmitoyltransferase Pfa4 enhanced heterochromatin forma

229 the FWC signature, which is palmitoylated by palmitoyltransferase Pfa4.

230 Study describes how a palmitoyltransferase regulates the Hippo pathway in flie

231 istidine-cysteine 5/8 (DHHC5/8) as ankyrin-G palmitoyltransferases required for ankyrin-G lateral mem

232 interaction between Orm1 and Orm2 and serine palmitoyltransferase, responsible for the first committe

233 n ZDHHC8 knockout mice deficient in a PSD-95 palmitoyltransferase, results in increased PSD-95 nitros

234 , and ISP-1, myriocin an inhibitor of serine palmitoyltransferase, significantly attenuated the ultra

235 The relationship between serine palmitoyltransferase (SPT) activity and ORMDL regulation

236 Serine palmitoyltransferase (SPT) catalyzes the first committed

237 Serine palmitoyltransferase (SPT) catalyzes the first step in s

238 Serine palmitoyltransferase (SPT) catalyzes the first step in s

239 Serine palmitoyltransferase (SPT) catalyzes the first step of s

240 The enzyme serine palmitoyltransferase (SPT) catalyzes the formation of th

241 Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT) cause an adult-onset, heredit

242 ry neuropathy due to mutations in the serine palmitoyltransferase (SPT) enzyme.

243 Serine palmitoyltransferase (SPT) is a key enzyme in the first

244 Serine palmitoyltransferase (SPT) is the first and rate-limitin

245 Serine palmitoyltransferase (SPT) is the first rate-limiting en

246 Serine palmitoyltransferase (SPT) is the key enzyme in SM biosy

247 The LCB chain length is determined by serine palmitoyltransferase (SPT) isoenzymes, which are trimeri

248 we utilized two models: heterozygous serine palmitoyltransferase (SPT) subunit 2 (Sptlc2) gene knock

249 l-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) which is a promising therapeu

250 ion of alanine with palmitoyl-CoA via serine palmitoyltransferase (SPT), as indicated by incorporatio

251 1 gene, encoding the Lcb1p subunit of serine palmitoyltransferase (SPT), cause hereditary sensory neu

252 Serine palmitoyltransferase (SPT), composed of LCB1 and LCB2 su

253 either L-cycloserine, an inhibitor of serine palmitoyltransferase (SPT), or fumonisin B(1), an inhibi

254 eled with [14C]serine, a substrate of serine palmitoyltransferase (SPT), the enzyme catalyzing the in

255 base 1 (LCB1), one of two subunits of serine palmitoyltransferase (SPT), the enzyme catalyzing the in

256 rectly alter the in vitro activity of serine palmitoyltransferase (SPT), the enzyme responsible for i

257 the ehv050 gene predicted to encode a serine palmitoyltransferase (SPT), the first and rate-limiting

258 crease in LCB levels, indicating that serine palmitoyltransferase (SPT), the first and rate-limiting

259 ciated with changes in mRNA levels of serine palmitoyltransferase (SPT), the rate-limiting enzyme in

260 SPTLC1 encodes one subunit of serine palmitoyltransferase (SPT), the rate-limiting enzyme in

261 sis in Leishmania, we have focused on serine palmitoyltransferase (SPT), which catalyses the first, r

262 We therefore semiquantified mRNA of serine palmitoyltransferase (SPT), which catalyzes the first st

263 ing 2 of the 3 subunits of the enzyme serine palmitoyltransferase (SPT).

264 from mutations in the LCB1 subunit of serine palmitoyltransferase (SPT).

265 catalyzed by the PLP-dependent enzyme serine palmitoyltransferase (SPT).

266 nthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT).

267 s are claimed to be inhibitors of the serine palmitoyltransferase (SPT).

268 lipids are 2-amino, 1,3-diols made by serine palmitoyltransferase (SPT).

269 sphingolipids that are formed by the serine-palmitoyltransferase (SPT).

270 phingolipid synthesis is catalyzed by serine palmitoyltransferase (SPT).

271 mitted biosynthetic step catalyzed by serine palmitoyltransferase (SPT, EC 2.3.1.50).

272 catalysed by the PLP-dependent enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which is a memb

273 Lcb1p subunit of yeast and mammalian serine palmitoyltransferases (SPT) were investigated.

274 osomatid protozoan Leishmania lacking serine palmitoyltransferase (spt2-) and SLs grow well, although

275 f the key de novo biosynthetic enzyme serine palmitoyltransferase subunit 2 (SPT2).

276 To determine which palmitoyltransferases (termed DHHCs) regulate the channe

277 s recently been shown to be an ER-associated palmitoyltransferase that can palmitoylate Cys-318 of Ra

278 ZDHHC9 is a palmitoyltransferase that catalyzes the posttranslationa

279 Furthermore, now that the first palmitoyltransferase that causes mental retardation has

280 We suggest that DHHC17 is a ClipR-59 palmitoyltransferase that modulates ClipR-59 plasma memb

281 Furthermore, we identify several zDHHC palmitoyltransferases that influence NMNAT2 palmitoylati

282 ocin (50 nm), a specific inhibitor of serine palmitoyltransferase (the first step in de novo synthesi

283 tlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enzyme responsible for the fir

284 is that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme

285 reduced by myriocin, an inhibitor of serine palmitoyltransferase, the first committed step in de nov

286 rease the activity and mRNA levels of serine palmitoyltransferase, the first committed step in sphing

287 We therefore inactivated serine palmitoyltransferase, the first enzyme in the sphingolip

288 with myriocin, a potent inhibitor of serine palmitoyltransferase, the rate-limiting enzyme in SM bio

289 igation using a labeled substrate for serine palmitoyltransferase, the rate-limiting enzyme in the pa

290 Nogo-B inhibits serine palmitoyltransferase, the rate-limiting enzyme of the de

291 se, but not by ISP-1, an inhibitor of serine palmitoyltransferase, the rate-limiting step in the de n

292 golipids are produced when the enzyme serine palmitoyltransferase uses l-alanine instead of l-serine

293 multiple cognate substrates of a single Erf2 palmitoyltransferase, we demonstrate that control of Erf

294 deletion mutant of BF2461, a putative serine palmitoyltransferase whose yeast homolog catalyzes the c

295 AT2 receptor activated serine palmitoyltransferase with a maximum time of 24 h after a

296 Nogo-B, pharmacological inhibition of serine palmitoyltransferase with myriocin reinstates endothelia

297 n, we have examined all known mammalian DHHC palmitoyltransferases with respect to their ability to p

298 S. pombe erf2 (sp-erf2), encoding sp-Erf2, a palmitoyltransferase, with various activities.

299 smic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmi

300 diated by zinc finger DHHC domain-containing palmitoyltransferases (ZDHHCs), but which members of thi