ライフサイエンスコーパス: pancreas

1 bout 209 mg of collagenase to digest a 100-g pancreas).

2 ginine-ureahydrolase, is highly expressed in pancreas.

3 raft appears congruent to that of the native pancreas.

4 were altered in Irf6-null salivary gland and pancreas.

5 en previously reported to exist in the adult pancreas.

6 o suppress proliferation of Th1 cells in the pancreas.

7 udy the intrinsic heterogeneity of the human pancreas.

8 ubsequent high-risk neoplasms in the remnant pancreas.

9 evelopment of the CNS, olfactory system, and pancreas.

10 lycaemic management with a bihormonal bionic pancreas.

11 their migration and eventual function in the pancreas.

12 l development without known functions in the pancreas.

13 trasonography for strain elastography of the pancreas.

14 roximating aspects of a normally functioning pancreas.

15 n regulating the release of insulin from the pancreas.

16 ld higher collagen level compared to healthy pancreas.

17 oss of CELA1 digestive activity in the human pancreas.

18 ssess the functional status of the endocrine pancreas.

19 n addition to a moderate signal from healthy pancreas.

20 io, volume and number of islets in the whole pancreas.

21 ough the control of insulin release from the pancreas.

22 ural tube, third ventricle, diencephalon and pancreas.

23 coexpressing both CRFRs and in vivo in mouse pancreas.

24 highest uptake on images were the spleen and pancreas.

25 mice following delivery of blue light to the pancreas.

26 ght promote the inflammatory response in the pancreas.

27 stasis, including adipose tissue, liver, and pancreas.

28 e in [(11)C]5-HTP tracer accumulation in the pancreas.

29 l types in the complex islet environment and pancreas.

30 (NCEM) dose commonly used to digest a 100-g pancreas.

31 ine cell type to be formed in the developing pancreas.

32 cesses in the brain as well as the endocrine pancreas.

33 fects of pri-miR-9-BMSCs and protect injured pancreas.

34 activation and tissue injury of the exocrine pancreas.

35 istal common bile duct (CBD), or head of the pancreas.

36 ctivation resulted in animals with an intact pancreas.

37 le, adipose tissue, brain, and the endocrine pancreas.

38 erated artificial organs, such as artificial pancreas.

39 regnancy for normal development of the fetal pancreas.

40 and impaired autophagy, compared with normal pancreas.

41 ed by loss of PAK4 protein expression in the pancreas.

42 etabolism do not regulate alpha-cells in the pancreas.

43 ich Gata6 is specifically inactivated in the pancreas.

44 ction of insulin-producing beta-cells in the pancreas.

45 HGD or an invasive carcinoma in the remnant pancreas.

46 antable artificial organs such as artificial pancreas.

47 underlying local progression in the remnant pancreas: (1) residual microscopic disease at the resect

48 .5%) in the adrenal glands, 38 (2.3%) in the pancreas, 109 (6.7%) in the spleen, and 305 (18.8%) with

49 in the absorbed dose to the tumor versus the pancreas (200 pmol, 570 vs. 265 mGy/MBq; 10 pmol, 435 vs

50 11; colorectal, 11; prostate, 7; breast, 5; pancreas, 5; ovarian/endometrial/vulvar cancers, 3; and

51 and pancreas, pancreas transplant alone, and pancreas after kidney between 1994 and 2015 were reviewe

52 of 1022 simultaneous pancreas and kidney or pancreas after kidney recipients, 246 satisfied these cr

53 ents of simultaneous pancreas and kidney and pancreas after kidney transplants between January 1994 a

54 tary pancreas (pancreas transplant alone and pancreas after kidney) transplants between 2000 and 2013

55 g/m was associated with significantly higher pancreas allograft [adjusted hazard ratio [aHR], 1.37; 9

56 versus severe obesity (D-BMI, >/=35 kg/m) on pancreas allograft outcomes.

57 increased risk of technical failure and poor pancreas allograft outcomes.

58 The impact of transplant center volume on pancreas allograft survival remains unclear.

59 Patients with functional kidney but failed pancreas allografts after 90 days were included.

60 ding 182 simultaneous kidney-pancreas and 84 pancreas alone transplants were reviewed for the study.

61 t patients including 182 simultaneous kidney-pancreas and 84 pancreas alone transplants were reviewed

62 e of unilocular or multilocular cysts of the pancreas and a non-dilated main pancreatic duct (<5 mm).

63 d as highly beta-cell selective in the human pancreas and constitutes a tentative surrogate imaging b

64 and low-affinity Tregs were recruited to the pancreas and contributed to protection from autoimmune d

65 composition differ between EVs from healthy pancreas and EVs from T2D pancreas and serum.

66 We evaluated pancreas and islet morphology in tissues from very young

67 glycemia achieved by successful simultaneous pancreas and kidney (SPK) transplantation could benefici

68 Associations of D-BMI with pancreas and kidney allograft failure were assessed by m

69 We analyzed recipients of simultaneous pancreas and kidney and pancreas after kidney transplant

70 Out of 1022 simultaneous pancreas and kidney or pancreas after kidney recipients,

71 Normal intense (11)C-MET uptake in the pancreas and liver reduced sensitivity for disease detec

72 Mechanismly, GMSCs could migrate to pancreas and local lymph node and function through CD39/

73 Optical projection tomography of the pancreas and longitudinal in vivo confocal microscopy of

74 (18)F-FETrp showed prominent uptake in the pancreas and no bone uptake, whereas (11)C-AMT showed hi

75 n of epithelial fluid transport in the lung, pancreas and other organs in cystic fibrosis (CF).

76 This PDX1(-/-) fetus lacked a pancreas and provides the basis for the production of ge

77 in maintaining immune homeostasis in the gut/pancreas and reveals a conversation between the nervous

78 n EVs from healthy pancreas and EVs from T2D pancreas and serum.

79 ross-talk between the liver, adipose tissue, pancreas and skeletal muscle.

80 )C]AZ12204657 bound specifically to GPR44 in pancreas and spleen and could be competed away dose-depe

81 in sigma-1 receptor-dense organs such as the pancreas and spleen, moderate uptake in the brain and my

82 h sexes, and led to iron accumulation in the pancreas and the heart of females.

83 , we discuss the major cystic lesions of the pancreas and their underlying molecular pathology, curre

84 ndex (SI) values at various locations in the pancreas and to investigate the relationship between age

85 combination with heart, lung, intestine, or pancreas) and then on a national basis where allocation

86 lculated for the head, body, and tail of the pancreas, and a mean value was obtained.

87 ng a meal, including amylin, secreted by the pancreas, and cholecystokinin (CCK), secreted by the sma

88 cell carcinoma, cancers of the small bowel, pancreas, and colorectum show the highest rates among bl

89 betes onset, ameliorated pathology scores in pancreas, and down-regulated production of IL-17 and IFN

90 redict patient dosimetry, we found a kidney, pancreas, and liver exposure of 0.10, 0.65, and 0.06 mGy

91 phagus, stomach, small and large intestines, pancreas, and liver.

92 omatic cells to initiate tumors in the lung, pancreas, and muscle.

93 cells in the pancreas-draining lymph nodes, pancreas, and peripheral blood of all treated mice, inde

94 blunted antiviral gene signature within the pancreas, and reduced proinflammatory M1 macrophage resp

95 al subcutaneous, liver, pericardial, muscle, pancreas, and renal sinus) by magnetic resonance imaging

96 wth of cancers of the brain, skin, prostate, pancreas, and stomach.

97 ng IPF; scleroderma; myelofibrosis; kidney-, pancreas-, and heart-fibrosis; and nonalcoholic steatohe

98 on of insulin in its storage granules in the pancreas are not known.

99 e persistence of CD206(+) macrophages in the pancreas as both types of cells confer resistance to T1D

100 was the [(11)C]5-HTP uptake and retention in pancreas, as a surrogate marker for the endogenous islet

101 of acinar cell clusters isolated from mouse pancreas bearing targeted heterozygous knockout of Grp78

102 A genuine understanding of human exocrine pancreas biology and pathobiology has been hampered by a

103 ressed in tumor tissue compared with healthy pancreas, but its receptors LIFR and gp130 were expresse

104 t was associated with an infiltration of the pancreas by gut-derived lymphocytes that manifested as a

105 ild-type endoderm cells within the liver and pancreas can rescue Notch activity and duct lineage spec

106 ; Moffitt Lung Cancer Cohort (n=60); Moffitt Pancreas Cancer Cohort (n=40); and The Cancer Genome Atl

107 es experimental opportunities to investigate pancreas cancer development, progression and early-stage

108 skin cancer, breast cancer, lung cancer and pancreas cancer.

109 e-cell transcriptome analysis of 2,544 human pancreas cells from eight donors spanning six decades of

110 Head and neck, non-small lung and pancreas cells were exposed to 2, 4 and 6 Gy IR doses an

111 um (ER) stress in both KRAS wild-type normal pancreas cells, as well as in KRAS mutated pancreatic ca

112 dergoing DP for all causes at 14 high-volume pancreas centers were preoperatively randomized to place

113 SI values of pancreas change with age, body weight, height, and BMI i

114 evealed a large influx of macrophages in the pancreas colocalizing with the retained fluorescent prob

115 menon in epithelial cancers such as bladder, pancreas, colon, and prostate-appears rooted in stromal

116 ally advanced or metastatic carcinoma of the pancreas confirmed by cytology or histology.

117 CNs at the 8 academic centers of the Central Pancreas Consortium from January 1, 2000, through Decemb

118 Cystic lesions of the transplant pancreas developed in 22 patients (1.8%): 12 pseudocysts

119 es for transcription factors associated with pancreas development and islet cell function, we analyze

120 Proper lumen morphogenesis during pancreas development is critical to endocrine and exocri

121 rine pancreas, whereas hepatocyte and acinar pancreas development is not affected.

122 d receptor (GPCR) S1pr2, plays a key role in pancreas development linking lineage allocation and spec

123 r, these data demonstrate that UCP2 controls pancreas development through the ROS-AKT signaling pathw

124 Using models of mouse and human pancreas development, we show that lengthening of the G1

125 to characterize GATA6 function during human pancreas development.

126 have investigated the role of Jarid2 during pancreas development.

127 sked if PAK4 might have a functional role in pancreas development.

128 lleviated the effect of knocking out UCP2 on pancreas development.

129 suggests that PAK4 is dispensable for mouse pancreas development.

130 SPR/Cas9 targeting PDX1, a critical gene for pancreas development.

131 ation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune

132 pancreata from obese donors may decrease the pancreas discard rate.

133 atitis (n = 6), idiopathic pancreatitis with pancreas divisum (n = 3), and alcohol abuse (n = 2).

134 The human pancreas does not express CELA1 but secretes two CELA3 i

135 Diabetes is more common after living pancreas donation than after living kidney donation, sup

136 This potential benefit of DCD pancreas donation warrants further study.

137 Pancreas donor risk index (PDRI) was highest in high vol

138 survival rates across all categories of the Pancreas Donor Risk Index.

139 ported, long-term medical outcomes in living pancreas donors are not known.

140 ion follow-up period of 16.3 years, 26.7% of pancreas donors filled prescriptions for diabetes treatm

141 Among 73 pancreas donors in the study period, 45 were identified

142 with baseline good health, we matched living pancreas donors to living kidney donors (1:3) by demogra

143 l, 2.09-9.68; P = 0.0001) was also higher in pancreas donors.

144 frequencies of CD4(+)Foxp3(+) T cells in the pancreas-draining lymph nodes, pancreas, and peripheral

145 Primary human pancreas duct cells harbouring oncogenic KRAS and induce

146 t the dynamics of lymphocyte movement in the pancreas during disease progression.

147 with ALDH activity are abundant in the mouse pancreas during early postnatal growth, pregnancy, and i

148 th ALDH activity in the adult mouse or human pancreas during physiological conditions or injury.

149 In fact, the frequency and spleen-to-pancreas dynamics of both Th1 and Th17 cells were affect

150 Jarid2-deficient pancreases exhibit impaired deposition of RNAPII-Ser5P,

151 result from beta-cell injury due in part to pancreas exocrine damage and lipofibrosis.

152 5-induced cell death and inflammation in the pancreas facilitate progression to autoimmune destructio

153 volume were associated with higher risk for pancreas failure.

154 ed the study: 20 who were assigned to bionic pancreas first and 19 who were assigned to the comparato

155 ression of neoplastic disease in the remnant pancreas following resection of IPMN may include develop

156 developed disease progression in the remnant pancreas following resection of IPMN; and (2) 10 patient

157 ld become a central element in an artificial pancreas for an improved treatment of patients with type

158 quires the use of >20 Wunsch units (WU)/g of pancreas for digestion.

159 ATA6 play essential, but redundant, roles in pancreas formation in mice, and GATA6 mutations cause pa

160 ient for definitive endoderm development and pancreas formation, but it is inadequate for functional

161 e-control study to assess UCP2 expression in pancreas from BD donors (cases) and subjects who underwe

162 UCP2 gene expression was higher in pancreas from BD donors compared with controls (1.73 +/-

163 expression of uncoupling protein-2 (UCP2) in pancreas from rats with BD as compared with controls.

164 management of IPMN and adenocarcinoma in the pancreas graft appears congruent to that of the native p

165 bA1c) levels are often obtained in potential pancreas graft donors to assess the overall long-term fu

166 were associated with a higher risk of early pancreas graft failure at 3 months.

167 (HR, 1.04; P = 0.024) were risk factors for pancreas graft failure.

168 easured, the impact of donor HbA1c levels on pancreas graft outcomes has not been reported.

169 Pancreas graft survival at 1 year did not differ signifi

170 between donor HbA1c levels and postoperative pancreas graft survival.

171 C]5-HTP) positron emission tomography of the pancreas has been shown to be a surrogate imaging biomar

172 -)/Ecad(-) cells residing in the adult mouse pancreas have the ability to initiate Pancreatic and duo

173 n reported in cases of kidney, liver, bowel, pancreas, heart, lung, and stem-cell transplant, and blo

174 al analysis in the founder population of the pancreas here we reveal highly heterogeneous contributio

175 In WAT and the pancreas, HFD also impacted the levels of histone acetyl

176 pressing amyloidogenic (human) amylin in the pancreas (HIP rats) and amylin knockout (AKO) rats intra

177 imaging findings in a case of portal annular pancreas in a 45-year-old male patient.

178 ss index (BMI), and elasticity values of the pancreas in healthy children.

179 y determined normal elasticity values of the pancreas in healthy children.

180 We found an increased size of the pancreas in Ucp2(-/-) fetuses at embryonic day 16.5, ass

181 ression caused histological abnormalities of pancreas, including increased immune cell infiltration,

182 We aimed to assess whether bihormonal bionic pancreas initialised only with body mass can safely redu

183 insulin pump therapy, the bihormonal bionic pancreas, initialised only with participant weight, was

184 ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cell

185 Portal annular pancreas is a rare and often neglected pancreatic anomal

186 p insulin delivery (the so-called artificial pancreas) is safe and effective compared with standard s

187 When the primary tumour is located in the pancreas, it is associated with a risk of cerebral metas

188 ey used in kidney-alone (Ki) or simultaneous pancreas kidney (SPK) transplants.

189 antation Network data on 11 568 simultaneous pancreas-kidney (SPK) and 4308 solitary pancreas (pancre

190 twork database records for 9916 simultaneous pancreas-kidney transplants (SPKT) performed between 200

191 (<1 mm) micrometastases in the liver, lung, pancreas, kidneys, and bone, that have disseminated from

192 rance was observed with stable uptake in the pancreas, kidneys, liver, heart, and salivary gland.

193 is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction.

194 nc18c-depleted mice (Munc18c(+/-)) and human pancreas (lenti-Munc18c-shRNA-treated) exhibit normal ap

195 Several transcription factors regulating pancreas lineage specification have been identified, and

196 pment and adult homeostasis of the endocrine pancreas, little is known about what regulates early pos

197 submandibular and sublingual gland, spleen, pancreas, liver, and gallbladder was observed.

198 A in the developing hypothalamus, pituitary, pancreas, lungs and oesophagus of mouse embryos using in

199 al gut hormone secretions, glycemic control, pancreas morphology, and micronutrient and mineral absor

200 A liver-brain-pancreas neuronal relay plays an important role in this

201 preparation of the normal portions of human pancreas obtained from cancer resections.

202 nt of the autoinflammatory milieu within the pancreas of patients with T1D.

203 endent antiviral response is specific to the pancreas of rotavirus-infected mice, similar to the auto

204 ified developmental changes in the endocrine pancreas of Snord116p-/m+ animals that persist into adul

205 2b induce duct cell lineage in the liver and pancreas of the zebrafish.

206 ucose metabolism in islets isolated from the pancreases of children with KATPHI who required pancreat

207 are expounded, and future prospects, such as pancreas-on-a-chip, are also presented.

208 a stomach hormone typically expressed in the pancreas only during embryogenesis, is expressed in isle

209 gate that BMSCs deliver miR-9 to the injured pancreas or peripheral blood mononuclear cell (PBMC), wh

210 lycaemic regulation with a bihormonal bionic pancreas or usual care (conventional or sensor-augmented

211 rom that of controls in breast, endometrial, pancreas, or colorectal adenocarcinomas.

212 set of weaning), with only a small effect on pancreas organogenesis and no deficiencies in their fema

213 measured in the head, trunk, and tail of the pancreas (p=0.594).

214 eous pancreas-kidney (SPK) and 4308 solitary pancreas (pancreas transplant alone and pancreas after k

215 onors that underwent simultaneous kidney and pancreas, pancreas transplant alone, and pancreas after

216 cifically in the ligated tail portion of the pancreas (PDL-tail).

217 e (score 0-10) was greater during the bionic pancreas period (0.52 [SD 0.83]) than in the comparator

218 s or unexpected adverse events in the bionic pancreas period of the study.

219 than 3.3 mmol/L was 0.6% (0.6) in the bionic pancreas period versus 1.9% (1.7) in the comparator peri

220 ration was 7.8 mmol/L (SD 0.6) in the bionic pancreas period versus 9.0 mmol/L (1.6) in the comparato

221 In the fetal pancreas, peripheral mesenchymal cells expressed Sema3a,

222 of ER stress and increased apoptosis in the pancreas, potentially explaining the loss of pancreatic

223 comprehensive information out of individual pancreas providing multifaceted parameters to study the

224 c resection for ductal adenocarcinoma of the pancreas (R0 or R1 resection).

225 arrow) and enhanced regeneration of damaged pancreas (Reg4 upward arrow, PTF1 upward arrow, and PDX1

226 We reported that in the pancreas remarkable up-regulation of angiogenesis as dow

227 ated to reduce the incidence of PF following pancreas resection; however, the drug cost is significan

228 Unexpectedly, significant portions of pancreas-resident macrophages originated from embryonic

229 ers of the duodenum, ampulla, distal CBD, or pancreas, respectively (P = .01), indicating a significa

230 idneys, stomach, colon, small intestine, and pancreas, respectively.

231 is reduces enzyme production by the exocrine pancreas, resulting in digestive insufficiencies.

232 rcoded Kras (HDR) alleles from bulk lung and pancreas reveals surprising diversity in Kras variant on

233 diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic

234 KEY POINTS: The ductal system of the pancreas secretes large volumes of alkaline fluid contai

235 we show, for the first time in situ, that in pancreas sections from autoantibody-positive (Ab+) donor

236 chemotaxis as well as a diminished exocrine pancreas size in a SRP54-knockdown zebrafish model faith

237 oach, rAAV efficiently transduces the liver, pancreas, skeletal muscle, heart and diaphragm without c

238 rather than acting on the nerves within the pancreas slice, CCK cellular actions directly affected h

239 Human pancreas slices represent excellent preparations to exam

240 ly stimulated secretory responses from human pancreas slices similar to those previously observed in

241 ), using mice with a complete (CTSD(-/-)) or pancreas-specific conditional CTSD knockout (KO) (CTSD(f

242 trypsinogen in vitro During pancreatitis in pancreas-specific CTSD(f/f)/p48(Cre/+) animals, markers

243 PDAC mice with pancreas-specific CXCL12 depletion exhibited diminished

244 Mice with pancreas-specific deletion of Cdk2 are glucose-intoleran

245 Pancreas-specific knockout of Yap or antibody-mediated d

246 ort that Bacteroides share an epitope with a pancreas-specific peptide that induces protective CD8+ T

247 , H5N1 virus induced cytokines in the heart, pancreas, spleen, liver, and jejunum.

248 ansplanted at high-volume centers had better pancreas survival rates across all categories of the Pan

249 glucose monitors, closed-loop and artificial pancreas systems) have been the subject of frequent syst

250 performed at 106 centers in 2014, using the pancreas-targeted American College of Surgeons' National

251 orbidities, pathology, pancreatic duct size, pancreas texture, or operative technique.

252 ultipotent non-epithelial cells in the adult pancreas that can commit to the pancreatic lineage follo

253 ulates a robust increase in lysosomes in the pancreas that is restricted to the islet.

254 is is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a major susc

255 onors with T1D that have examined T cells in pancreas, the diabetogenic insulitis lesion, and lymphoi

256 bolic tissues (e.g., liver, skeletal muscle, pancreas) through lipotoxicity and inflammatory signalin

257 me-based transcriptome and AS profiles of 43 pancreas tissues using Affymetrix exon array.

258 oprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1

259 rimary tumor migrates from its origin in the pancreas to colonize distant metastatic sites.

260 ER stress in acinar cells and sensitized the pancreas to LPS-induced pathology.

261 -dose RCEM was efficient in digesting entire pancreases to obtain higher yield (5535 +/- 830 and 2582

262 eas-kidney (SPK) and 4308 solitary pancreas (pancreas transplant alone and pancreas after kidney) tra

263 underwent simultaneous kidney and pancreas, pancreas transplant alone, and pancreas after kidney bet

264 Living donor pancreas transplant is a potential treatment for diabeti

265 Data from 266 pancreas transplant patients including 182 simultaneous

266 Patient and graft survival after pancreas transplantation are superior in higher volume c

267 rocesses that support optimal outcomes after pancreas transplantation irrespective of center volume.

268 Pancreas transplantation remains the gold standard for t

269 Successful pancreas transplantation requires surgical expertise and

270 D-BMI of 30 kg/m to decline donor offers for pancreas transplantation.

271 lso be the case in a highly complex field as pancreas transplantation.

272 All consecutive pancreas transplantations from January 2008 until Decemb

273 In the study period, 1276 pancreas transplantations were included.

274 erature on the behavior of cystic lesions in pancreas transplants is scarce, and hence a better under

275 des improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesi

276 1518), and 11 to 33 (n = 1377) for solitary pancreas transplants.

277 CI, 0.62-2.78; P = 0.47) between DCD and DBD pancreas transplants.

278 15, for studies reporting the outcome of DCD pancreas transplants.

279 Comparison of isogenic lung and pancreas tumor models suggests that use of some metaboli

280 findings show that RET is upregulated during pancreas tumorigenesis and its activation induces cancer

281 enously delivered into orthotopic breast and pancreas tumors in mice by using the tumor-penetrating i

282 data obtained from isolated ducts and intact pancreas under a range of experimental conditions.

283 ttempts to reduce this dose have resulted in pancreas underdigestion and poor islet recovery but impr

284 pmol (68)Ga-NeoBOMB1 resulted in a tumor and pancreas uptake of 12.4 +/- 2.3 and 22.7 +/- 3.3 percent

285 Strain ratios were obtained for the pancreas using ultrasound strain elastography (Toshiba A

286 Histopathology of the pancreas varied widely with graft thrombosis as the most

287 r barrier to oncogenic transformation in the pancreas via maintaining genomic stability.

288 ed type 1 diabetes, (52)Mn(2+) uptake in the pancreas was distinguished from healthy controls in para

289 The bionic pancreas was initialised with only the participant's bod

290 ate the role of GATA6 in the adult endocrine pancreas, we generated mice in which Gata6 is specifical

291 n-diabetic male subjects in relation to BMI, pancreas weight, and the percent ratio, volume and numbe

292 between beta-cell/islet mass and age, BMI or pancreas weight, with large differences in beta-cell/isl

293 nts of SM, heart, liver, kidney, spleen, and pancreas were acquired.

294 Pancreas were collected and analyzed for inflammation, p

295 ge I or II adenocarcinoma of the head of the pancreas were identified in the National Cancer Database

296 mon causes being carcinoma of the stomach or pancreas, whereas diseases of the sternum presenting as

297 and duct cells within the liver and exocrine pancreas, whereas hepatocyte and acinar pancreas develop

298 ch as nitrite, are generated in precancerous pancreases, which induce massive DNA damage, including D

299 PAK3 caused functional deficits in the mouse pancreas, while gene depletion of PAK5 or PAK6 did not,

300 lineage allocation and specification in the pancreas will shed light in the origins of pancreatic di