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1  to characterize GATA6 function during human pancreas development.
2 sked if PAK4 might have a functional role in pancreas development.
3 nes involved in islet beta cell function and pancreas development.
4  of Hedgehog activity is critical for proper pancreas development.
5 lleviated the effect of knocking out UCP2 on pancreas development.
6  and maturation of islet progenitor cells in pancreas development.
7 aturation of islet progenitor cells in mouse pancreas development.
8 are common for initiating dorsal and ventral pancreas development.
9 ial role in eye, central nervous system, and pancreas development.
10 has to be regulated tightly to ensure proper pancreas development.
11 described during mammalian liver and ventral pancreas development.
12 signaling pathways that are also used during pancreas development.
13  a requirement for hedgehog signaling during pancreas development.
14 xpression patterns provide new insights into pancreas development.
15 he specificity of expression required during pancreas development.
16 upstream regulators of the BETA2 gene during pancreas development.
17 amily of signaling molecules that antagonize pancreas development.
18  identify genes expressed at early stages of pancreas development.
19 indicate that some of the genes could govern pancreas development.
20  been investigated in vivo in the context of pancreas development.
21 and provides a means for expanding embryonic pancreas development.
22 scription factor involved in eye, brain, and pancreas development.
23 ther NEUROG3 is required for human endocrine pancreas development.
24  suggests that PAK4 is dispensable for mouse pancreas development.
25 strate an essential role for p120 catenin in pancreas development.
26 man embryonic stem cells in a model of human pancreas development.
27 iation and morphogenetic events during human pancreas development.
28 SPR/Cas9 targeting PDX1, a critical gene for pancreas development.
29 cription factor for lens, lacrimal gland and pancreas development.
30 ity produces distinct cellular states during pancreas development.
31 sis is a human disorder caused by defects in pancreas development.
32  for ribosomal biogenesis genes in zebrafish pancreas development.
33  important role for Cdk4 in regulating early pancreas development.
34 d acinar cell neogenesis required for normal pancreas development.
35 ry transcription factor network during early pancreas development.
36 eration, cell survival, and cell size during pancreas development.
37  have investigated the role of Jarid2 during pancreas development.
38 inositol-3-OH kinase (PI3K) pathway controls pancreas development.
39 n the canonical Wnt pathway is essential for pancreas development.
40 f the mammalian pygopus ortholog, mPygo2, in pancreas development.
41 rther reveal specific functions for Hdac1 in pancreas development.
42 thways that regulate vhnf1 expression during pancreas development.
43  act genetically upstream of RA in directing pancreas development.
44 ignals have been implicated as regulators of pancreas development.
45 regut markers and is essential for liver and pancreas development.
46 tain foregut identity and to allow liver and pancreas development.
47 ate the gene expression cascades involved in pancreas development.
48  the miRNA processing enzyme Dicer1 early in pancreas development.
49 a transcription factor complex essential for pancreas development.
50 acinar and endocrine progenitor cells during pancreas development.
51 ial role in endoderm patterning and promotes pancreas development.
52 tors (FGFRs) are key signaling molecules for pancreas development.
53 ox-1 (Pdx-1) that is essential for embryonic pancreas development and adult beta-cell function.
54 of the transcriptional mechanisms regulating pancreas development and beta cell function.
55 owever, requires a thorough understanding of pancreas development and beta-cell formation.
56 at Foxa2 is the major regulator in promoting pancreas development and cell differentiation.
57  are likely to control critical decisions in pancreas development and disease.
58 omic-scale genetic and epigenetic studies of pancreas development and diseases such as diabetes and p
59         Neurogenin-3 (Ngn-3) is required for pancreas development and ductal cell neogenesis.
60 xpressed in the pancreas and is required for pancreas development and endocrine cell differentiation.
61 in that is a critical requirement for normal pancreas development and for proper differentiation of t
62 to the pancreas and foregut, is required for pancreas development and for the expression of genes con
63 n transcription factor IDX-1 is critical for pancreas development and for the regulation of islet cel
64 n adult human pancreas, although its role in pancreas development and function is unknown.
65 al nervous system independent of its role on pancreas development and function.
66                 Thus, Hlxb9 is key to normal pancreas development and function.
67 identify multiple sequential roles for Hh in pancreas development and highlight an unexpected antagon
68 iption factor IDX-1, a critical regulator of pancreas development and insulin gene transcription, con
69 ineate the role of Hh in zebrafish endocrine pancreas development and investigate its relationship wi
70  gene is expressed in endocrine cells during pancreas development and is essential for proper islet m
71        Ptf1a is a gene required for exocrine pancreas development and is first expressed as the ventr
72  unique profile of miRNAs is required during pancreas development and is necessary for beta-cell form
73 es for transcription factors associated with pancreas development and islet cell function, we analyze
74   Expression of PDX, a critical regulator of pancreas development and islet differentiation, is resto
75 ssion of multiple genes related to endocrine pancreas development and islet function in these liver c
76  Pdx1 is a transcription factor required for pancreas development and lineage specification; however,
77 which is altered in MODY-4) is essential for pancreas development and mature beta-cell function.
78 s and colonies, should also advance study of pancreas development and pancreatic progenitor cells.
79  Nkx6.1 paralog, Nkx6.2, is expressed during pancreas development and partially compensates for NKX6.
80 mbined requirements for Hhip and Ptch during pancreas development and point to a dose-dependent respo
81  duct, while Sox17 overexpression suppresses pancreas development and promotes ectopic biliary-like t
82 s underlying GATA4 and GATA6 function during pancreas development and provide a new mouse model to ch
83 that Hippo signaling plays a crucial role in pancreas development and provide novel routes to a bette
84  accurately recapitulates key steps of human pancreas development and provides a fast and reproducibl
85 that CTGF acts in an autocrine manner during pancreas development and suggest that CTGF has the poten
86 omeobox 1 (PDX-1) is absolutely required for pancreas development and the maintenance of islet beta-c
87 nscription factor IDX-1 that is critical for pancreas development and the transcriptional regulation
88 o some ambiguity as to the role of Hh during pancreas development and whether its function has comple
89  histone deacetylases (HDACs), HDACs mediate pancreas development, and aspects of pancreas developmen
90 mplicate new signaling pathways in endocrine pancreas development, and identified sets of known and n
91 ic hedgehog also affects zebrafish liver and pancreas development, and these effects occur in a recip
92         To analyze whether other features of pancreas development are conserved and investigate the i
93 mediate pancreas development, and aspects of pancreas development are recapitulated during recovery o
94  in maturing hormone-expressing cells during pancreas development as well as in adult islet cells.
95                                              Pancreas development begins with the formation of buds a
96                                       During pancreas development, both the exocrine and endocrine li
97 ing is not restricted to patterning in early pancreas development but also continues to signal in dif
98            Sox9 plays important roles during pancreas development but does not have a described role
99  have identified factors required for dorsal pancreas development, but factors that initiate the vent
100  has been shown to regulate early aspects of pancreas development, but its role in endocrine, and esp
101 in, a TGF(beta+) signaling molecule, permits pancreas development by repressing expression of Sonic h
102 orm of beta-catenin at a later time point in pancreas development causes enhanced proliferation that
103 nitor-specific ablation of Sox9 during early pancreas development causes pancreas-to-liver cell fate
104                                       During pancreas development, endocrine precursors and their pro
105 biologically significant stages of endocrine pancreas development: endoderm before pancreas specifica
106 , we have compiled reference GRNs underlying pancreas development from data mining that integrates mu
107               A critical gene that initiates pancreas development has been identified, as well as a n
108 vation of Hedgehog signaling at the onset of pancreas development has been shown to inhibit organ mor
109 larify the function of Hedgehog signaling in pancreas development, identify an unexpected cellular so
110 as an inhibitory role during later stages of pancreas development in amniotes.
111 lude that NEUROG3 is essential for endocrine pancreas development in humans and that as little as 10%
112 , IPF1 appears to be a critical regulator of pancreas development in humans as well as mice.
113 h of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and oth
114 both Gata4 and Gata6 is necessary to disrupt pancreas development in mice.
115 of Nkx2.2 that is greatly upregulated during pancreas development in Nkx2.2(-/-) mice.
116 rams regulate pharynx, esophagus, liver, and pancreas development in teleosts and mammals.
117                                 The onset of pancreas development in the foregut endoderm is marked b
118     Here, we characterize zebrafish exocrine pancreas development in wild type and mutant larvae usin
119 ing pathways of RA, Bmp, and Fgf to regulate pancreas development in zebrafish.
120 1), a transcription factor indispensable for pancreas development, in the progression from normal exo
121  of critical embryonic signaling pathways in pancreas development including beta-cell expansion.
122  Here we describe systems for reconstructing pancreas development, including islet beta-cell and alph
123 in transcription factor Pdx1 is required for pancreas development, including the differentiation and
124 othelial growth factor (VEGF) is crucial for pancreas development, insulin gene expression/secretion,
125                                              Pancreas development is coordinated by a complex interpl
126 elucidation of the key regulatory factors in pancreas development is critical for understanding the p
127            Proper lumen morphogenesis during pancreas development is critical to endocrine and exocri
128 rine pancreas, whereas hepatocyte and acinar pancreas development is not affected.
129 main transcription factor PDX1, required for pancreas development, is expressed broadly in the poster
130 al homeobox factor-1, PDX-1, is required for pancreas development, islet cell differentiation, and th
131          Given the essential role of IPF1 in pancreas development, it is likely that this autosomal r
132 in contact with the posterior bud throughout pancreas development, its absence in cloche mutant embry
133 d receptor (GPCR) S1pr2, plays a key role in pancreas development linking lineage allocation and spec
134    Previous studies have shown that exocrine pancreas development may be modeled in zebrafish.
135 pressed broadly in the posterior foregut but pancreas development normally initiates only in a restri
136 sed Ig domain protein and may be involved in pancreas development or beta cell function.
137 eam transcription factor E2f1 regulate mouse pancreas development prior to and during the secondary t
138                   Previously associated with pancreas development, Sox4 mutations in the adult mouse
139 ent for native genetic regulators of in vivo pancreas development, such as Ngn3, Arx, and Pax4, revea
140      We identified several genes involved in pancreas development that also harbor NRSE-like motifs,
141 tify Cdk4 as an important regulator of early pancreas development that modulates the proliferation po
142 r, these data demonstrate that UCP2 controls pancreas development through the ROS-AKT signaling pathw
143  Fgf signaling participates in regulation of pancreas development through the vhnf1 pathway.
144                           Knowledge of human pancreas development underpins our interpretation and ex
145 question, we first evaluated FoxO1's role in pancreas development using gain- and loss-of-function al
146 we examine the specific role of Hnf1b during pancreas development, using constitutive and inducible c
147 activate the Hedgehog pathway midway through pancreas development via expression of either Sonic (Shh
148 to understand the biology of p120 catenin in pancreas development, we ablated p120 catenin in mouse p
149 lished data from mouse embryos, during human pancreas development, we detected only a single-phase of
150 sequences of epithelial Hh activation during pancreas development, we employed a transgenic mouse mod
151 gate the influence of surrounding tissues on pancreas development, we examined the role of the vascul
152  pathway is functionally required for normal pancreas development, we have specifically deleted the b
153               To gain insight into liver and pancreas development, we investigated the target of 2F11
154 derstanding of transcriptional regulation in pancreas development, we know relatively little about th
155              Using models of mouse and human pancreas development, we show that lengthening of the G1
156                       Glucose metabolism and pancreas development were investigated in the Smn(2B/-)
157 Discovering the function of genes regulating pancreas development with our system should enrich strat
158                  MicroRNAs (miRNAs) regulate pancreas development, yet little is known about their co

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