ライフサイエンスコーパス: pancreata

1 istologic examination of salivary glands and pancreata.

2 is is induced in postpartum FoxM1(Deltapanc) pancreata.

3 tained primary cilia in both human and mouse pancreata.

4 ding outpouches of ducts in murine and human pancreata.

5 the native insulin B:9-23 sequence in their pancreata.

6 +/- 3.0%) and obese diabetic (18.5 +/- 3.6%) pancreata.

7 tion of PGC-GdDTPA-F in diabetic and control pancreata.

8 P < 0.01) in obese diabetic (0.49 +/- 0.17%) pancreata.

9 rine embryonic stem cells to early endocrine pancreata.

10 man islets were obtained from research-grade pancreata.

11 ic islets of Langerhans of adult human donor pancreata.

12 ation is an insufficient supply of cadaveric pancreata.

13 target, was also activated in the Ucp2(-/-) pancreata.

14 fected pancreata but not in CVB3/GA-infected pancreata.

15 ion-specific PCR but not in any of 15 normal pancreata.

16 glucagon was similar to that from wild-type pancreata.

17 not stain for MGMT in histologically normal pancreata.

18 n Ilotropin but not in extracts from control pancreata.

19 th day and was absent from untreated control pancreata.

20 mes of VXM after transplantation of imported pancreata.

21 let development in Neurog3-null mutant mouse pancreata.

22 ext, we analyzed the oxidative stress in the pancreata.

23 ing of embryonic day (e) 13.5 and 15.5 mouse pancreata.

24 al neoplasias and PDAs compared with healthy pancreata.

25 yses of the IkappaBalpha- and RelA-deficient pancreata.

26 neutrophil recruitment compared with normal pancreata.

27 alpha-cells in Gcgr(-/-) and Gcgr(Hep)(-/-) pancreata.

28 rgans included 1,779 kidneys, 395 livers, 54 pancreata, 2 lungs, and 1 heart.

29 MINT2) harboring methylation in some normal pancreata (36, 21, and 14%, respectively).

30 A total of 188 PanINs were identified in 40 pancreata, 38 (95%) of which also contained an infiltrat

31 Imported pancreata accumulate cold ischemia time (CIT), limiting

32 tic acinar tissue and from fibrous stroma in pancreata affected by chronic pancreatitis.

33 d on studies of human, mouse, and guinea pig pancreata, alcohol disrupts expression and localization

34 long-term high fat diet (HFD), M4K4 iKO mice pancreata also displayed reduced beta cell mass, fewer p

35 The ductal system was analyzed in normal pancreata and chronic pancreatitis in humans and mice.

36 Mouse pancreata and clonal beta-cells were examined for expres

37 ad high levels of viral replication in their pancreata and comparable tissue pathology following vira

38 acceptance criteria for deceased donor organ pancreata and critical raw materials, PHPI product speci

39 ation with infusions from two to three donor pancreata and Edmonton immunosuppression consistently ac

40 xpression was comparable with liver in mouse pancreata and in rat and human islets.

41 ple experimental systems, including perfused pancreata and isolated islets of rodent or human origin.

42 Pancreata and liver tissues were collected and analyzed

43 Pancreata and lungs were harvested, and histologic secti

44 ssfully and consistently produced from human pancreata and maintain their innate molecular and spatia

45 We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bc

46 Numerous studies of isolated pancreata and pancreatic islets support the hypothesis t

47 Pancreata and primary acinar cells were isolated; acinar

48 om three independent hPSC lines, human fetal pancreata, and adult human islets points to two major co

49 s on patient safety and care, prudent use of pancreata, and consolidates PII expertise and experience

50 As were cloned and sequenced from developing pancreata, and expression of a subset of these genes was

51 pproaches, organotypic cultures of embryonic pancreata, and genomics, we found that sphingosine-1-pho

52 as greatly accelerated in Mist1KO/KrasG12D/+ pancreata, and in vitro assays revealed that Mist1KO aci

53 ot used are smaller than numbers of kidneys, pancreata, and livers because intestines, hearts, and lu

54 -fixed paraffin-embedded surgically resected pancreata, and were analyzed by methylation-specific pol

55 crine congenital defects of Prox1(DeltaPanc) pancreata appeared to initiate a gradual process of dete

56 ons at low frequency, and in most cases, the pancreata are histologically normal.

57 ween 3.5 and 6.2 in otherwise transplantable pancreata are not associated with different short-term o

58 ese data also suggest that many good quality pancreata are not procured, emphasizing the need for imp

59 After donor cross-clamp in Houston, donor pancreata arrived at DRI and the isolation process began

60 ing was performed on wild-type and MafB(-/-) pancreata at embryonic day 18.5, with candidates evaluat

61 In contrast, the PKC pancreata bearing a Grp78(f/+) allele (PKC78(f/+) mice)

62 The PKC pancreata bearing wild-type Grp78 showed detectable PDAC

63 extend the acceptable preservation period of pancreata before islet isolation and increase islet yiel

64 pothesis that such changes are present in CF pancreata before the development of lipofibrosis.

65 nick end labeling) assay in CVB3/M-infected pancreata but not in CVB3/GA-infected pancreata.

66 both mouse embryonic and adult regenerating pancreata but was absent in normal adult islets.

67 cells are specified normally in Hox6 mutant pancreata, but fail to mature into hormone-producing cel

68 , and delta-cells from human fetal and adult pancreata by intracellular staining for the cell-specifi

69 TGF-beta signaling was inactivated in mouse pancreata by overexpressing a dominant-negative mutant f

70 We have previously shown that rat pancreata can be created from rat pluripotent stem cells

71 lotropin, a protein extract isolated from CW pancreata, causes recapitulation of normal islet ontogen

72 CPV/49 replicates in murine hearts and pancreata, causing no disease in hearts and a minor panc

73 HEV in wild-type LN and in RIPLT alpha beta pancreata, coincident with HEC-6ST.

74 ient rat blastocysts, we generated rat-sized pancreata composed of mouse-PSC-derived cells.

75 alginate hydrogel matrix.Collagenase treated pancreata, cultured for 4 days, formed NPCCs that were e

76 Pancreata developing without beta-catenin are hypoplasti

77 le Gata4/Gata6 mutant mice failed to develop pancreata, died shortly after birth, and displayed hyper

78 histologically similar to WT, whereas K8/K18 pancreata displayed age-enhanced vacuolization and atrop

79 ss was normal in postpartum FoxM1(Deltapanc) pancreata due to a combination of increased beta-cell si

80 ir and resuscitate warm ischemically injured pancreata during preservation, improve pancreas graft su

81 te endocrine progenitor cells from embryonic pancreata (embryonic day [E]13.5 through E17.5).

82 F-alpha, MIP-1alpha, IL-12, and IFN-gamma in pancreata, endotoxin, or anti-CD3-stimulated splenic cel

83 CFRD pancreata exhibit reduced islet density and altered cell

84 CFRD pancreata exhibited greater islet injury with further re

85 RIPLT alpha beta pancreata exhibited massive intra-islet mononuclear infi

86 Pancreata exposed to long CIT yielded lower islet number

87 PDGs and PanIN lesions in rodent and human pancreata express the GLP-1 receptor.

88 udied 45 pancreatic carcinomas and 14 normal pancreata for aberrant DNA methylation of CpG islands of

89 valent to UW solution in the preservation of pancreata for islet isolation.

90 on and could provide a significant source of pancreata for islet transplantation.

91 Pancreata from 1- to 3-day-old pigs were collagenase dig

92 ct lesions." Duct lesions were identified in pancreata from 33 pancreaticoduodenectomies performed fo

93 Examination of pancreata from age-matched organ donors with type 2 diab

94 Furthermore, pancreata from animals treated with 10 mg/kg BRD3308 exh

95 In contrast, pancreata from animals treated with GW1929 showed a firs

96 Pancreata from ATG5-deficient mice had signs of inflamma

97 chronic pancreatitis (CP) and compared with pancreata from ATG5-deficient mice.

98 3) Do recipients of whole pancreata from cadaveric donors have twice the amount of

99 Levels of BCL3 were higher in pancreata from control mice given cerulein than from mic

100 es, and the histopathological examination of pancreata from diabetic organ donors with the goal of pr

101 A substantial nationwide underutilization of pancreata from donor procurements is demonstrated in the

102 adopted a new allocation algorithm in which pancreata from donors >30 kg/m or >50 years of age are,

103 ficity for type 2 diabetes, we also examined pancreata from eight cases of type 1 diabetes.

104 Pancreata from extended criteria donors were flushed and

105 Furthermore, pancreata from MafB deficient (kr(ENU)/kr(ENU)) mice exh

106 Pancreata from mice exposed to radiation had fewer CD8(+

107 xpression of hepatic markers was examined in pancreata from mice genetically modified to secrete elev

108 Pancreata from mice, rats, and nonhuman primates were ex

109 These data support that pancreata from mildly obese donors (BMI, 30-35 kg/m) can

110 onist enhanced insulin secretion in perfused pancreata from neonatal streptozotocin-induced diabetic

111 abetes resistance, histologic examination of pancreata from NOD BCIID mice revealed foci of noninvasi

112 Here, we demonstrate that pancreata from NOD mice with islet infiltration have enh

113 Pancreata from NOD-gld/+ mice contained B cells that exp

114 f preneoplastic proliferative lesions in the pancreata from nonhuman primates was performed.

115 pproach indeed delayed rejection of neonatal pancreata from nontransgenic mice by >1 wk.

116 Consideration of pancreata from obese donors may decrease the pancreas di

117 Pancreata from older and more obese donors were used mor

118 udies in human acini isolated from cadaveric pancreata from organ donors.

119 Finally, examination of human pancreata from patients with T1D revealed that VEGFR-2 w

120 lopment of beta-cells, we analyzed embryonic pancreata from Pax6- and MafB-deficient mice.

121 In contrast, pancreata from pdx-1(-/-) mice expressing the mutant PDX

122 Pancreata from Ptf1a-Cre(ERTM);LSL-Kras(G12D) mice conta

123 Pancreata from Ptf1a-Cre(ERTM);LSL-Kras(G12D);Klf5(fl/fl

124 Since recent studies on human pancreata from T1D patients have indicated that both lig

125 recise tissue distribution of CD8 T cells in pancreata from T1D, T2D, autoantibody-positive, and heal

126 roximately 30% decrease in beta cell mass in pancreata from Tcfl2(fl/fl)::Ins1Cre mice.

127 in or sodium taurocholate than control mice; pancreata from the Bcl3(-/-) mice with AP had greater nu

128 Pancreata from these mice had reduced autophagy, increas

129 ent of 30 kidneys, 12 hearts, 7 lungs, and 9 pancreata from these same donors.

130 Pancreata from transgenic mice display early-onset acina

131 prevent allograft rejection, we transplanted pancreata from transgenic neonatal mice and their nontra

132 ormed at the end of the study confirmed that pancreata from vehicle-treated rats showed no increase i

133 Thus, in exocrine pancreata, Grp78 heterozygosity regulates ER chaperone b

134 ntitative RT-PCR showed that the Pax6(PE/PE) pancreata had a significant decrease in Pax6, glucagon,

135 More than 50% of recovered pancreata had at least one injury, most commonly a short

136 Ninety-seven percent of pancreata had three lobes: duodenal lobe (DL), connectin

137 lpha-specific gene expression, and Grg3(+/-) pancreata have more alpha-cells and more polyhormonal ce

138 -term functional graft survival data for DCD pancreata have not been reported.

139 Numerous pancreata have not been used because of long ischemia ti

140 p16 mutations were not found in PILs of pancreata having wild-type p16 in the carcinoma, nor wer

141 itative confocal immunofluorescence in fetal pancreata identified the highest levels of Ep-CAM expres

142 elded significantly more islets than control pancreata (IEQ/g: 2134+/-297 vs. 1477+/-145 IEQ/g or 65,

143 For pancreata imported from United Network of Organ Sharing

144 Pancreata in DM treated with incretin therapy were notab

145 turation and might be used to repair damaged pancreata in patients with pancreatic disorders.

146 e disposition and outcomes of deceased donor pancreata in the United States between January 1, 2000 a

147 The pancreata in wild-type (WT) mice (n = 64) were scanned a

148 , insulin-producing cell lines, and perfused pancreata indicated xenin-25 does not enhance GIP-mediat

149 ed with NKX6-1 and PTF1A in human developing pancreata, indicating that it marks the multipotent panc

150 ic ghrelin-producing cells are maintained in pancreata lacking the essential endocrine lineage regula

151 ficiency in both the PKC78(f/+) and c78(f/+) pancreata leads to reduction of epidermal growth factor

152 proach are an inadequate supply of cadaveric pancreata, lifelong immunosuppression, and chronic graft

153 p38IH treatment of human pancreata may improve islet yield for use in clinical tr

154 dichotomy raises the hypothesis that K8-null pancreata may undergo compensatory cytoprotective gene e

155 ceased donor (n=30) and chronic pancreatitis pancreata (n=30).

156 ived cells were observed in the nonendocrine pancreata, no pancreatic beta-cells were identified that

157 We addressed this in 31 human pancreata obtained at autopsy from hematopoietic stem ce

158 diabetic, and 14 obese type 2 diabetic human pancreata obtained at autopsy.

159 Concerns exist regarding the utilization of pancreata obtained from DCD donors.

160 we observed no abnormal pathology within the pancreata of 23 Pdx1-Cre;Smad4(lox/lox) animals that wer

161 Islet size and insulin content in pancreata of A2AAR-deficient mice were decreased compare

162 inoma cell line (HPAC) was injected into the pancreata of BALB/c nu/nu mice.

163 Pancreata of Bmi1(-/-) mice were hypoplastic, and the ex

164 f the CCR2-ligand (CCL2) was observed in the pancreata of cadaveric donors, suggesting that beta-cell

165 In contrast, the pancreata of CD1d-null mice harbored significantly highe

166 y qRT-PCR using RNA derived from spleens and pancreata of cured mice validated the suppression of mos

167 peri-insulitic infiltrate were found in the pancreata of cured NOD mice.

168 greater accumulation of PGC-GdDTPA-F in the pancreata of diabetic animals compared with controls.

169 Previously, pancreata of dying alcoholics and pancreatic necrosis in

170 Pancreata of elastase sshIL-1beta mice were analyzed for

171 rx(+) cells was significantly reduced in the pancreata of embryos deficient for the Islet-1 (Isl-1) t

172 diated insulin release from in situ perfused pancreata of GIP/DT mice.

173 re significantly decreased in the developing pancreata of Glis3(zf/zf) mutant mice.

174 Pancreata of KC mice exposed to radiation had a higher f

175 i, we electroporated oncogenic plasmids into pancreata of LSL-KrasG12D x p53fl/fl mice; mutant Kras w

176 We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and

177 NETs form in the pancreata of mice during the development of AP, and NET

178 Loss of ACVR1B from pancreata of mice increased the proliferation of pancrea

179 verse relaxation time (T2) shortening in the pancreata of mice injected with the MN-Ex10-Cy5.5 probe

180 n of an activated form of KRAS (KrasG12D) in pancreata of mice is sufficient to induce formation of p

181 gnificant up-regulation of the Hh pathway in pancreata of mice overexpressing GLI2.

182 plex II(+)CD11c(+) DCs increased 100-fold in pancreata of mice with acute pancreatitis to account for

183 Pancreata of mice with Sbds mutations had decreased mass

184 Defects developed specifically in the pancreata of mice, reducing growth of mice and productio

185 contrast-induced activation of NF-kappaB in pancreata of mice, this was observed by live imaging of

186 alpha (eIF-2 alpha[P]) levels in nonstressed pancreata of mice.

187 Although the pancreata of Mist1(KrasG12D/+) mutant mice predictably e

188 imulated insulin secretion from the perfused pancreata of MKR mice and reduced the beta-cell mass.

189 The pancreata of Mmp9(-/-) mice did not differ from wild typ

190 leakage, as an indicator of inflammation, in pancreata of mouse models of type 1 diabetes ex vivo or

191 Here we show that beta cells from the pancreata of newly diagnosed insulin-dependent diabetes

192 educed immune infiltration and activation in pancreata of NOD mice as well as humanized NOD Scid IL2

193 scaffolds that were also expanded within the pancreata of NOD mice.

194 4 and IL-10 were significantly higher in the pancreata of OGG-1(-/-) mice as compared with the levels

195 Pancreata of Pdx-Shh mice (in which Shh is misexpressed

196 In the pancreata of Pdx1-Cre; LSL-Kras(G12D) mice, exendin-4 le

197 Pancreata of Perk(-/-) mice are morphologically and func

198 ouse homologues of HIP/PAP was determined in pancreata of prediabetic and diabetic NOD mice.

199 Furthermore, DeltaT2 of the pancreata of prediabetic NOD mice was significantly high

200 Exocrine pancreata of RD-fed Grp78(+/-) mice in an outbred C57BL/

201 e mainly found in pancreatic lymph nodes and pancreata of recipients, indicating that the transferred

202 ation of effector cells that migrated to the pancreata of RIP-mOVA recipients but did not cause diabe

203 eased islet cell number and proliferation in pancreata of rPdx1-treated mice.

204 entage of polyhormonal cells in the neonatal pancreata of Snord116p-/m+ mice, due primarily to an inc

205 Histological examination of the pancreata of the control mice revealed a severe and dest

206 ed PDX1 rescues the Pdx1-null phenotype; the pancreata of these mice develop and function normally.

207 oliferation of intra-islet duct cells in the pancreata of these mice evidently stemmed directly from

208 t intra-islet duct cell proliferation in the pancreata of transgenic KGF mice was observed.

209 In pancreata of transgenic mice, marked hyperplasia of cell

210 c periductal lymphocytic infiltration in the pancreata of transgenic mice, predominantly CD4+ T lymph

211 as IFN-gamma production was increased in the pancreata of treated animals, insulin expression was str

212 The pancreata of treated mice showed significantly lower lev

213 c patients directly, we isolated islets from pancreata of type 2 diabetic cadaveric donors (n = 14) a

214 esions and more foci of invasive cancer than pancreata of unexposed mice (controls); radiation reduce

215 by comparing the gene expression profile in pancreata of wild-type and K8-null mice.

216 ransgenic mice compared with normal, control pancreata of WT mice (mean intensity, 0.25 lau +/- 0.25)

217 - and beta-cell subsets from fetal and adult pancreata offers clear implications for strategies that

218 ed at any of the 15 CpG islands in 15 normal pancreata or in an immortalized normal pancreatic duct e

219 number of islets of Langerhans (two to four pancreata per recipient) into patients with type I diabe

220 8.8%) kidneys, 3/5(60%) livers and 1/2 (50%) pancreata performed.

221 In type 1 diabetic pancreata, perinuclear CHOP was rare (2.5 +/- 2.3%) and

222 lls detected in heterozygous and hypomorphic pancreata, possibly those that express low levels of Neu

223 Pancreata preserved in the TLM are oxygenated through th

224 ess-than-ideal donors, the ratio of liver to pancreata procured can be reduced to 1.25:1.

225 Islets were isolated from pancreata procured from 12 cadaveric organ donors and cu

226 All pancreatic islets were isolated from pancreata procured in Houston and subsequently transport

227 scard rate in 2011 was 27.7%, and higher for pancreata recovered from older donors.

228 btypes, and beta-cell and alpha-cell mass in pancreata recovered from organ donors with type 1 diabet

229 Pancreata removed from Beagle dogs were infused with Uni

230 cent analyses of transgenic rodent and human pancreata reveal a number of novel heterogeneity markers

231 Histologic analyses of RARdn-expressing pancreata revealed a decrease in beta-cell mass and insu

232 We found that perfused Sur1 null pancreata secreted insulin in response to the cholinergi

233 peri-islet cell accumulations in RIPLT alpha pancreata: separation into T and B cell areas was more d

234 Adult DKO pancreata showed no histological abnormalities, and immu

235 Compared with PKC, the PKC78(f/+) pancreata showed substantial reduction of ADM as well as

236 observations, immunohistological analysis of pancreata showed that CD105(+) cells are restricted to t

237 This allows pancreata stored in the TLM to generate adenosine tripho

238 techniques for isolating islets require that pancreata stored with University of Wisconsin solution (

239 negative constructs and isolated human fetal pancreata suggest that c-Src is at least partially respo

240 /progenitor cells, prepared from human adult pancreata survive engraftment and produce tissue chimeri

241 Vessel density was less in IUGR pancreata than in controls.

242 Because donor pancreata that are unsuitable for WOP can often be used

243 Of whole organ pancreata that were transplanted, 90% were from donors w

244 y distinct from normal ducts; even in normal pancreata they display PanIN and metaplastic features, s

245 t isolation and reduce the need for multiple pancreata to achieve insulin independence in the recipie

246 ith placental defects, so we explanted E12.5 pancreata to allow endocrine differentiation to occur in

247 ison with UW organ preservation, exposure of pancreata to the TLM result in greater islet yields and

248 We analyzed the ratio of livers to pancreata transplanted at our center and compared this t

249 e accomplished into all cell types of murine pancreata using a plasmid/ liposome vector.

250 ignaling was inhibited in cultured embryonic pancreata using morpholine-ring antisense against GIP li

251 Collagenase digestion of pancreata was carried out using standard procedures.

252 ration index of acinar cells from Mist1 null pancreata was evaluated by immunohistochemistry.

253 al recovered islet mass from type 2 diabetic pancreata was significantly less than that from nondiabe

254 tablish the functional role of PERK in adult pancreata, we generated mice harboring a conditional PER

255 s of thousands of cells in human organ donor pancreata, we show that quantitative graph characteristi

256 Zymogen granules in K8/K18 pancreata were 50% smaller and more dispersed than their

257 ross and histologic findings in the resected pancreata were also assessed.

258 Pancreata were analyzed by terminal deoxynucleotide tran

259 Pancreata were analyzed for edema and TNF-alpha mRNA and

260 Morphological defects in Gata4/Gata6 mutant pancreata were apparent during embryonic development, an

261 Pancreata were collected and analyzed by immunohistochem

262 Pancreata were collected and extracellular DNA was detec

263 Pancreata were collected and histologically analyzed for

264 Pancreata were collected and histology, immunohistochemi

265 Pancreata were collected from mice and analyzed for Kras

266 Pancreata were collected when mice were 28 weeks to 14.5

267 To achieve our goal, human pancreata were decellularized with Triton-based solution

268 A total of 53 pancreata were divided into two groups: group 1 (n=23),

269 or resveratrol (HFS+Resv) for 24 months, and pancreata were examined before overt dysglycemia occurre

270 Pancreata were exposed to doses of radiation ranging fro

271 Islets obtained from long-CIT pancreata were functionally impaired after transplantati

272 beta1 Integrin-null pancreata were highly susceptible to cerulein-induced ac

273 K8- and K18-overexpressing pancreata were histologically similar to WT, whereas K8/

274 Four pancreata were maintained as a control group in UW alone

275 In the second experimental set, six pancreata were maintained for an average of 6.4+/-1.8 ho

276 In the first experimental set, eight pancreata were maintained for an average of 8.3+/-1.2 ho

277 Degenerating beta1 integrin-null pancreata were marked by disruption of acinar cell polar

278 composed of rat-derived cells, the resulting pancreata were of mouse size, rendering them insufficien

279 Then samples of cells or pancreata were probed for IP3 receptor content and distr

280 tween January 16, 2002 and June 30, 2003, 39 pancreata were procured and processed for PIT at a dista

281 All pancreata were procured by a single surgeon, and special

282 Pancreata were procured from cadaveric organ donors, and

283 Twelve hundred ninety-six pancreata were procured from donation after brain death

284 Pancreata were removed by en bloc viscerectomy from 65 f

285 Rat pancreata were stored in cold University of Wisconsin pr

286 ntly prepared from these mouse-rat chimaeric pancreata were transplanted into mice with streptozotoci

287 When pancreata were transplanted under the kidney capsules of

288 15 patients with PDAC; histologically normal pancreata were used as controls (n = 18).

289 6,000 organ donors, only approximately 1,500 pancreata were used for clinical transplantation.

290 ntial donors during this period, 6,140 donor pancreata were used for whole organ transplant.

291 insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta

292 This damage may be prevented by treating pancreata with a p38MAPK inhibitor (p38IH) before cold p

293 raft loss was significantly more frequent in pancreata with arterial damage (p = 0.04) and in those w

294 underwent single-pass perfusion of isolated pancreata with low and high glucose concentration (n = 4

295 eptor (OB-Rb) in ZDF islets by perfusing ZDF pancreata with recombinant adenovirus containing the cDN

296 Infusion of pancreata with University of Wisconsin solution containi

297 -16 mice developed dedifferentiated exocrine pancreata within 2 months of age and became malnourished

298 All but one of the PanINs from the 14 pancreata without pancreatic carcinoma was unmethylated

299 Twenty-six of 39 (67%) procured pancreata yielded more tha 5,000 islet equivalents (IEQ)

300 p38IH-treated pancreata yielded significantly more islets than control