ライフサイエンスコーパス: pancreatic acinar cell

1 or agonist-induced zymogen activation in the pancreatic acinar cell.

2 rn the differentiated phenotype of the adult pancreatic acinar cell.

3 rt and exocytosis of zymogen granules in the pancreatic acinar cell.

4 ase relevant to the secretory process in the pancreatic acinar cell.

5 the aberrant signaling of Ca(2+) within the pancreatic acinar cell.

6 of active trypsin determines its effects on pancreatic acinar cells.

7 we analyzed the Bmi1-labeled cell lineage of pancreatic acinar cells.

8 es that may maintain the stable phenotype of pancreatic acinar cells.

9 ng digestive enzyme and fluid secretion from pancreatic acinar cells.

10 P(3)-induced Ca(2+) release (IICR) to ATP in pancreatic acinar cells.

11 uated agonist-induced Ca(2+) signaling in WT pancreatic acinar cells.

12 ach to determine the plasticity potential of pancreatic acinar cells.

13 nges of NO concentration in acutely isolated pancreatic acinar cells.

14 reactive oxygen species generation in mouse pancreatic acinar cells.

15 focal microscopy of isolated perfused murine pancreatic acinar cells.

16 the pathologic activation of zymogens within pancreatic acinar cells.

17 exocytosis are highly polarized functions of pancreatic acinar cells.

18 s and the underlying signaling mechanisms in pancreatic acinar cells.

19 uring zymogen granule exocytosis in exocrine pancreatic acinar cells.

20 mechanism for mesotrypsinogen activation in pancreatic acinar cells.

21 on with membrane-bound secretory vesicles in pancreatic acinar cells.

22 Kras transgene, which targets expression to pancreatic acinar cells.

23 ns of [Ca(2+)](c) oscillations are shaped in pancreatic acinar cells.

24 ing protein we find prominently expressed in pancreatic acinar cells.

25 nts also may lead to NF-kappaB activation in pancreatic acinar cells.

26 g cascade of terminally differentiated mouse pancreatic acinar cells.

27 in regulating digestive enzyme secretion in pancreatic acinar cells.

28 nucleotide phosphate (NAADP) release Ca2+ in pancreatic acinar cells.

29 is selectively transcribed to high levels in pancreatic acinar cells.

30 toimmunity or in preserving the integrity of pancreatic acinar cells.

31 s and matrix metalloproteinase expression in pancreatic acinar cells.

32 fic phosphoregulation of Ca(2+) signaling in pancreatic acinar cells.

33 the exocyst in polarized Ca(2+) signaling in pancreatic acinar cells.

34 d for taurocholate-induced necrosis in mouse pancreatic acinar cells.

35 modification in secretagogue-stimulated rat pancreatic acinar cells.

36 published values for the volume of the ER in pancreatic acinar cells.

37 by Ins(1,4,5)P3, as originally discovered in pancreatic acinar cells.

38 R and CCK to induce cytosolic Ca2+ spikes in pancreatic acinar cells.

39 mice that over-express Rab3D specifically in pancreatic acinar cells.

40 , intestinal and bronchiolar epithelial, and pancreatic acinar cells.

41 cium concentration ([Ca2+]i) in isolated rat pancreatic acinar cells.

42 ores of submandibular salivary gland but not pancreatic acinar cells.

43 f almost all islet beta cells and subsets of pancreatic acinar cells.

44 nohistochemistry showed TNFalpha presence in pancreatic acinar cells.

45 after stimulation of secretion from isolated pancreatic acinar cells.

46 led that CB2R protein was expressed in mouse pancreatic acinar cells.

47 ccurs at the site of Ca2+ wave initiation in pancreatic acinar cells.

48 Ca(2+) ([Ca(2+)]i) overload and necrosis of pancreatic acinar cells.

49 e pancreatic duct and subsequent exposure to pancreatic acinar cells.

50 ressed with KIAA1967 in the nuclei of normal pancreatic acinar cells.

51 rticipate in the regulation of exocytosis in pancreatic acinar cells.

52 uction of the neutrophil attractant CXCL1 in pancreatic acinar cells.

53 ed whether Bcl-2 affects Ca(2+) extrusion in pancreatic acinar cells.

54 d with atypical localization of claudin-2 in pancreatic acinar cells.

55 and carbachol-regulated Ca(2+) signaling in pancreatic acinar cells.

56 cohol and accelerates disorders of the ER in pancreatic acinar cells.

57 dramatically modifies autophagy in infected pancreatic acinar cells.

58 n of the effects of intracellular trypsin on pancreatic acinar cells.

59 associated with zymogen granule membranes in pancreatic acinar cells.

60 tor, thapsigargin, activated Ca2+ entry into pancreatic acinar cells, a process known as capacitative

61 In pancreatic acinar cells, acetylcholine and bombesin excl

62 In pancreatic acinar cells, acetylcholine evokes local Ca(2

63 Interestingly, in the pancreatic acinar cells, activation by cholecystokinin i

64 of intracellular Ca(2+) signals may protect pancreatic acinar cells against Ca(2+) overload, intrace

65 receptor (CCKR) in its native milieu in the pancreatic acinar cell and in a Chinese hamster ovary (C

66 roteolytic activation of zymogens within the pancreatic acinar cell and initiate acute pancreatitis.

67 serves a major intracellular role within the pancreatic acinar cell and may be functionally active af

68 tionship between the events occurring in the pancreatic acinar cell and the vascular, neural, and imm

69 x-loop-helix transcription factor complex of pancreatic acinar cells and critical to acinar cell fate

70 GRP inhibited protein synthesis in AR42J rat pancreatic acinar cells and HuTu 80 human duodenal adeno

71 g/kg) induced a wave of DNA synthesis in the pancreatic acinar cells and in the proximal tubular epit

72 present in a subpopulation of self-renewing pancreatic acinar cells and is expressed in response to

73 on inside the endoplasmic reticulum store of pancreatic acinar cells and monitored the cytoplasmic Ca

74 has been described in considerable detail in pancreatic acinar cells and oocytes.

75 pancreatic ductal cannulas, and in isolated pancreatic acinar cells and pancreatic lobules in vitro.

76 genic mice showed increased proliferation of pancreatic acinar cells and severely perturbed acinar di

77 presence of ARC channels in both parotid and pancreatic acinar cells and shown that, again, they are

78 sitive palmitoyl-CoA-sensitive Ca2+ store in pancreatic acinar cells and suggest that palmitoyl-CoA m

79 e advanced understanding of the functions of pancreatic acinar cells and the mechanisms by which thes

80 Bcl-2 regulates PMCA function in pancreatic acinar cells and thereby influences cell fate

81 n to play a role in amylase secretion by rat pancreatic acinar cells and to specifically dephosphoryl

82 sease that causes progressive destruction of pancreatic acinar cells and, ultimately, loss of pancrea

83 erleukin-6, interleukin-1, and chemokines by pancreatic acinar cells and/or transmigrated leukocytes.

84 ractivation, IgG-type autoantibodies against pancreatic acinar cells, and IgM-type autoantibodies aga

85 tophagy gene Atg5 is specifically deleted in pancreatic acinar cells, and show that coxsackievirus B3

86 ogen granule transport and exocytosis in the pancreatic acinar cell are not well defined.

87 ts show that key pathologic responses of the pancreatic acinar cell are regulated by PI3K gamma and s

88 Pancreatic acinar cells are a classic model for the stud

89 Aberrant Ca(2+) signals within pancreatic acinar cells are an early and critical featur

90 Pancreatic acinar cells are commonly cotransplanted alon

91 Pancreatic acinar cells are involved in development of t

92 Pancreatic acinar cells are reprogrammed to a "ductal-li

93 nist-evoked cytosolic Ca(2+) spikes in mouse pancreatic acinar cells are specifically initiated in th

94 that adult intestinal cells, hepatocytes and pancreatic acinar cells are supplied physiologically fro

95 tant role in regulating protein secretion by pancreatic acinar cells, as does Rab3D.

96 inogen induced apoptosis of HEK293 cells and pancreatic acinar cells, as indicated by histology, DNA

97 duce Ca(2+) signals and necrosis in isolated pancreatic acinar cells but the effects of bile acids on

98 eak pathways in the endoplasmic reticulum of pancreatic acinar cells by directly measuring Ca(2+) in

99 1 mutant R122H (R122H_mPRSS1) is targeted to pancreatic acinar cells by fusion to the elastase promot

100 the regulation of potassium channels in rat pancreatic acinar cells by the cyclic AMP-mediated agoni

101 TP53(+/+) or TP53(f/f) specifically in adult pancreatic acinar cells by using a full-length pancreati

102 We investigated these processes in pancreatic acinar cells by using video-rate 2-photon mic

103 nduced cytosolic Ca2+ oscillations in single pancreatic acinar cells by whole-cell patch-clamp monito

104 One such factor is an excessive elevation in pancreatic acinar cell Ca(2+).

105 elevation of the Ca(2+) concentration inside pancreatic acinar cells ([Ca(2+)]i), due to excessive re

106 n conclusion, changes in intracellular pH in pancreatic acinar cells can profoundly alter cytosolic [

107 It has been suggested that pancreatic acinar cells can serve as progenitors for pan

108 In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal met

109 Pancreatic acinar cell carcinoma (ACC) is an aggressive

110 In parotid and pancreatic acinar cells, changes in [Ca(2+)](c) and acti

111 ethyl Urea (NMU) results in abnormal foci in pancreatic acinar cells characterized by increased level

112 e previously reported phosphorylation of the pancreatic acinar cell cholecystokinin (CCK) receptor an

113 In pancreatic acinar cells, cholecystokinin (CCK) stimulate

114 close binding proximity of PTF1 and MIST1 in pancreatic acinar cell chromatin implies extensive colla

115 In isolated mouse pancreatic acinar cells, CRAC channels were activated by

116 Early events in the pancreatic acinar cell critical for development of pancr

117 TGF-beta isoforms in primary hepatocyte and pancreatic acinar cell cultures generated from transgeni

118 We show that in pancreatic acinar cells, CVB3 induces the formation of a

119 human SPINK1, die perinatally due to massive pancreatic acinar cell death, precluding investigation o

120 et effect of which is induction of apoptotic pancreatic acinar cell death.

121 rming growth factor alpha (TGF-alpha) in the pancreatic acinar cells develop tubular metaplasia, a po

122 k that is required to establish and maintain pancreatic acinar cell differentiation.

123 erved by fluorescence microscopy in isolated pancreatic acinar cells, dissociated hepatocytes, rod ph

124 Terminally differentiated pancreatic acinar cells do not have the innate capacity

125 These data indicate that human pancreatic acinar cells do not respond to CCK receptor a

126 dings include those demonstrating that human pancreatic acinar cells do not respond to cholecystokini

127 his study to measure total calcium loss from pancreatic acinar cells due to calcium extrusion.

128 ments of TNFalpha indicated its release from pancreatic acinar cells during incubation in primary cul

129 nvestigated by monitoring Ca(2+) dynamics in pancreatic acinar cells evoked by the flash photolysis o

130 gate the kinetics of ACh-evoked secretion in pancreatic acinar cells, exocytosis of zymogen granules

131 Zymogen secretory granules in pancreatic acinar cells express two vesicle-associated m

132 Differentiated pancreatic acinar cells expressing endogenous levels of

133 mice, substance P levels in the pancreas and pancreatic acinar cell expression of NK1R are both incre

134 nd the Gbetagamma subunit of G proteins from pancreatic acinar cell extracts.

135 riptional network continuously maintains the pancreatic acinar cell fate.

136 hat ANO1/TMEM16A is a significant pathway in pancreatic acinar cells for HCO3 (-) secretion into the

137 ies of human pancreatitis, directly protects pancreatic acinar cells from oxidant-induced cytosolic C

138 nger RNA population and PTF1 target genes in pancreatic acinar cells from these and wild-type mice.

139 Pancreatic acinar cells from various species express cho

140 f epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for th

141 The intracellular mechanisms regulating pancreatic acinar cell function are more complex than pr

142 eing made in understanding the regulation of pancreatic acinar cell function by receptor-activated in

143 Recent investigations into the regulation of pancreatic acinar cell function have led to a more detai

144 Recent studies on pancreatic acinar cell function have led to a more detai

145 Understanding the mechanisms that regulate pancreatic acinar cell function is contributing to knowl

146 Understanding the mechanisms that regulate pancreatic acinar cell function is contributing to our k

147 Understanding the mechanisms that regulate pancreatic acinar cell function is contributing to our k

148 ding of molecular and cellular regulation of pancreatic acinar cell function.

149 rocess of acinar-to-ductal metaplasia (ADM), pancreatic acinar cells give rise to pancreatic intraepi

150 3-sulfate (TLC-S), on calcium signalling in pancreatic acinar cells has been investigated.

151 d cytosolic Ca(2+) ([Ca(2+)](i)) overload in pancreatic acinar cells have been implicated as the card

152 of the brain-gut peptide cholecystokinin on pancreatic acinar cells have indicated that NAADP and cA

153 ylene diamine (TPEN), we demonstrate that in pancreatic acinar cells, hepatocytes, and a variety of m

154 TG16L2, plays a critical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation

155 hondrial alterations also occur in untreated pancreatic acinar cells; however, the underlying mechani

156 astase-Kras founder mice displayed perinatal pancreatic acinar cell hyperplasia and dysplasia.

157 1A on the specialized phenotype of the adult pancreatic acinar cell in vivo Transcriptome sequencing

158 at SEC23B is required for normal function of pancreatic acinar cells in adult mice.

159 based upon experiments with intact mice and pancreatic acinar cells in culture, that ZnT2 participat

160 cells of transgenic mice and in transfected pancreatic acinar cells in culture.

161 The role of pancreatic acinar cells in initiating fibrogenic respons

162 Rat PSTI-I expression was targeted to pancreatic acinar cells in transgenic mice by creating a

163 poptosis and death signaling pathways in rat pancreatic acinar cells, including caspase activation, c

164 We measured DeltaPsim in mouse pancreatic acinar cells incubated with ethanol alone and

165 ively inactivated CCK-evoked Ca2+ signals in pancreatic acinar cells, indicating that NAADP may funct

166 irst evidence that insulin directly protects pancreatic acinar cell injury induced by bona fide pancr

167 Bile acid exposure causes pancreatic acinar cell injury through a sustained rise i

168 In pancreatic acinar cells, inositol 1,4,5-trisphosphate (I

169 Protease activation within the pancreatic acinar cell is a key early event in acute pan

170 The pancreatic acinar cell is a valuable cell model for unde

171 The mature pancreatic acinar cell is dedicated to the production of

172 The pancreatic acinar cell is known to regulate exocytosis,

173 dings indicate that signaling specificity in pancreatic acinar cells is aided by polarized expression

174 endocytosis at the apical plasma membrane in pancreatic acinar cells is coupled to ductal bicarbonate

175 2Rs modulate intracellular Ca(2+) signals in pancreatic acinar cells is largely unknown.

176 ed that cholecystokinin stimulation of human pancreatic acinar cells is likely regulated by an indire

177 s of nicotine were also evaluated in primary pancreatic acinar cells isolated from wild-type, nAChR7a

178 A but not wild-type K18-overexpressing mice, pancreatic acinar cell keratin filaments retracted from

179 own to activate signaling kinase cascades in pancreatic acinar cells, leading to the activation of ex

180 Overexpression of Bcl-2 in the pancreatic acinar cell line AR42J decreased Ca(2+) extru

181 Despite its presence within a pancreatic acinar cell line, reg I gene expression is no

182 d gastrin (Gly-G) stimulates growth of a rat pancreatic acinar cell line; however, the effect of Gly-

183 inct groups of mitochondria in normal living pancreatic acinar cells, located (i) in the peripheral b

184 In pancreatic acinar cells, low concentrations of acetylcho

185 Secretory pancreatic acinar cells mature postnatally to synthesize

186 eurotransmitter cholecystokinin (CCK) in rat pancreatic acinar cells may be an important signaling ca

187 with cholecystokinin were noted in a primary pancreatic acinar cell model.

188 eutrophil sequestration in the pancreas, and pancreatic acinar cell necrosis were significantly reduc

189 However, in pancreatic acinar cells, neither messenger can explain t

190 Pancreatic acinar cells normally do not express K19, but

191 PKD phosphorylation in pancreatic acinar cells occurs viaaCa2+-independent, dia

192 Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreas

193 or the inhibitor of kappaB kinase (IKK)2 in pancreatic acinar cells of mice.

194 Pancreatic acinar cells of patients with CP have increas

195 enhancer drives high level transcription to pancreatic acinar cells of transgenic mice and in transf

196 Ca(2+) release-activated Ca(2+) currents in pancreatic acinar cells offers remarkable protection aga

197 nd 19 were tested in freshly isolated murine pancreatic acinar cells (PACs) to determine inhibition o

198 Epithelial pancreatic acinar cells perform crucial functions in foo

199 Within isolated mouse pancreatic acinar cells, PKD3 undergoes rapid membrane t

200 alpha- and beta-cells but is abundant in the pancreatic acinar cell plasma membrane.

201 Pancreatic acinar cells possess very high protein synthe

202 perimental approaches with acute dissociated pancreatic acinar cells prepared from wild type, CB1R-kn

203 The results indicate that pancreatic acinar cells produce, release, and respond to

204 The effects of aging on pancreatic acinar cell proliferation have not been clear

205 the critical role of the PI3K/Akt pathway in pancreatic acinar cell proliferation, IGF-1-mediated cel

206 I and PNA appear to be excellent lectins for pancreatic acinar cell purification.

207 To study the role of palmitoyl-CoA in the pancreatic acinar cell, rat pancreatic acini were isolat

208 aracterized the pH-dependent interactions of pancreatic acinar cell-regulated secretory proteins (zym

209 ressed in the exocrine pancreas, and whether pancreatic acinar cells release and respond to TNFalpha.

210 ent with high levels of IL-22RA1 expression, pancreatic acinar cells responded to IL-22 signaling via

211 tor kappaB transcriptional program in normal pancreatic acinar cells, resulting in acinar-ductal meta

212 Functional mapping of Ca2+ signaling in pancreatic acinar cells revealed that the M3, cholecysto

213 Pancreatic acinar cells secreted physiological concentra

214 in 2 (VAMP 2) and VAMP 8 in Ca(2+)-regulated pancreatic acinar cell secretion, however, their coordin

215 stress has not been studied in CP, although pancreatic acinar cells seem to be especially vulnerable

216 We generated mice with tamoxifen-inducible, pancreatic acinar cell-specific Sec23b deletion.

217 Perturbation of pancreatic acinar cell state can lead to acinar-to-ducta

218 nals and NADH responses were investigated in pancreatic acinar cells stimulated with calcium-releasin

219 and intracellular chymotrypsin activation in pancreatic acinar cells, suggesting that the modulation

220 ults provide insights into the mechanisms in pancreatic acinar cells that link tumor necrosis factor

221 induced by muscarinic receptor activation of pancreatic acinar cells that reside within intact pancre

222 Menadione caused apoptosis of pancreatic acinar cells that was significantly potentiat

223 ool of heavy metal ions (> or = 12 microM in pancreatic acinar cells) that does not rapidly exchange

224 In pancreatic acinar cells the activity of the B element re

225 In pancreatic acinar cells the fusion pore remains open muc

226 In pancreatic acinar cells, the HOX-like factor PDX1 acts a

227 Thus, infusion of purified Gbetagamma into pancreatic acinar cells through a patch pipette evokes [

228 s suggest that acid challenge sensitizes the pancreatic acinar cell to secretagogue-induced zymogen a

229 The transdifferentiation of pancreatic acinar cells to a ductal phenotype (acinar-to

230 s, Ngn3, Mafa, and Pdx1, directly reprograms pancreatic acinar cells to beta-cells.

231 th the CHO-CCKR cells and agonist-stimulated pancreatic acinar cells to provide direct evidence for t

232 r level acute alcohol exposure can sensitize pancreatic acinar cells to secretagogue stimulation, res

233 tic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechan

234 method for in vivo conversion of adult mouse pancreatic acinar cells toward beta cells, we show that

235 e transgenes is activated by doxycycline the pancreatic acinar cells turn into duct-like cells.

236 resent study describes a novel phenomenon in pancreatic acinar cells undergoing regulated exocytosis.

237 Phosphorylation of rpS6 was increased in pancreatic acinar cells upon implantation of the chemica

238 R sensitivity of different regions of intact pancreatic acinar cells using local uncaging of caged Ca

239 W) in agonist-induced Ca(2+) oscillations in pancreatic acinar cells using multiple experimental appr

240 small fluorescent probes in the ER lumen of pancreatic acinar cells, using confocal microscopy, loca

241 in InsP3-evoked Ca2+ release in single mouse pancreatic acinar cells, using high-speed (approximately

242 Marked apoptosis of pancreatic acinar cells was observed during embryogenesi

243 rise in the cytosolic Ca2+ concentration of pancreatic acinar cells was triggered by stimulation wit

244 In pancreatic acinar cells we have therefore found a differ

245 Since CEL is expressed mainly in pancreatic acinar cells, we asked whether we could find

246 oreover, using 3D explant culture of primary pancreatic acinar cells, we show that PKD1 acts downstre

247 Pancreatic acinar cells were able to generate fast calci

248 Isolated rat pancreatic acinar cells were exposed to cholecystokinin

249 Finally, NAADP-evoked Ca(2+) oscillations in pancreatic acinar cells were identical in wild-type and

250 Rat pancreatic acinar cells were isolated by collagenase dig

251 Mouse pancreatic acinar cells were whole-cell patch clamped to

252 In pancreatic acinar cells where intracellular infusion of

253 microsomes [5] and triggers Ca2+ signals in pancreatic acinar cells, where it is proposed to mediate

254 This is in marked contrast to the related pancreatic acinar cells, where the distribution of mitoc

255 fication had no effect on [Ca2+]i in resting pancreatic acinar cells, whereas cytosolic alkalinizatio

256 e primary receptors for basement membrane in pancreatic acinar cells, which function to synthesize an

257 ced enhancement of Ca(2+) signaling in mouse pancreatic acinar cells, which suggests a potential cell

258 Stimulation of pancreatic acinar cells with acetylcholine (ACh) and cho

259 te pancreatitis: supramaximal stimulation of pancreatic acinar cells with cholecystokinin.

260 calcium dependence of calcium extrusion from pancreatic acinar cells with preserved intracellular env

261 rincipal component of the UPR) in most adult pancreatic acinar cells (Xbp1fl/fl).

262 re-lox recombination strategy in adult mouse pancreatic acinar cells (Yap1fl/fl;Tazfl/fl;Ela1-CreERT2

263 A key event leading to exocytosis of pancreatic acinar cell zymogen granules is the inositol