ライフサイエンスコーパス: pancreatic beta cell

1 ent in the insulin secretory granules of the pancreatic beta cell.

2 ning the terminally differentiated status of pancreatic beta cells.

3 tal factors, resulting in the destruction of pancreatic beta cells.

4 insulin secretion, which is the function of pancreatic beta cells.

5 es cell cycle entry of quiescent adult human pancreatic beta cells.

6 aracterized by the autoimmune destruction of pancreatic beta cells.

7 insulin storage in the secretory granules of pancreatic beta cells.

8 CKD is caused by a direct effect of urea on pancreatic beta cells.

9 stimulus-secretion coupling in primary mouse pancreatic beta cells.

10 types of cells, including cardiomyocytes and pancreatic beta cells.

11 ical regulator of autophagosome formation in pancreatic beta cells.

12 tory subunit is expressed in human and mouse pancreatic beta cells.

13 acting/modulator protein in rodent and human pancreatic beta cells.

14 mice displayed lower ATG5 and LC3 levels in pancreatic beta cells.

15 utoimmune disease that causes severe loss of pancreatic beta cells.

16 functioning of cells, such as adipocytes and pancreatic beta cells.

17 lded protein response (UPR) and ER stress in pancreatic beta cells.

18 and contribute to autoimmune destruction of pancreatic beta cells.

19 ults in part from a deficiency of functional pancreatic beta cells.

20 leading to deleterious downstream effects in pancreatic beta-cells.

21 Diabetes is linked to loss of pancreatic beta-cells.

22 on insulin secretion is mediated by GHS-R in pancreatic beta-cells.

23 ator of glucose-induced insulin secretion by pancreatic beta-cells.

24 ing in the failure of insulin secretion from pancreatic beta-cells.

25 ng from the destruction of insulin-producing pancreatic beta-cells.

26 ndrome, to the production and maintenance of pancreatic beta-cells.

27 s but relatively silenced, or disallowed, in pancreatic beta-cells.

28 een SCHAD and glutamate dehydrogenase in the pancreatic beta-cells.

29 ucose-stimulated insulin secretion (GSIS) in pancreatic beta-cells.

30 ctions including the release of insulin from pancreatic beta-cells.

31 rs, and the postnatal growth and function of pancreatic beta-cells.

32 s to Ca(2+) homeostasis in insulin-secreting pancreatic beta-cells.

33 emopoietic stem cells, and insulin-releasing pancreatic beta-cells.

34 gnaling pathways coupled to proliferation in pancreatic beta-cells.

35 e found that the Klotho gene is expressed in pancreatic beta-cells.

36 iabetes of the young, regulates mitophagy in pancreatic beta-cells.

37 ce glucose-stimulated insulin secretion from pancreatic beta-cells.

38 ) channel located in both cardiomyocytes and pancreatic beta-cells.

39 lf-reactive T cells attack insulin-secreting pancreatic beta-cells.

40 secretion in C2C12 myotubes and INS-1 832/13 pancreatic beta-cells.

41 developing novel approaches to regenerating pancreatic beta-cells.

42 d fibrils as well as the loss of neuronal or pancreatic beta-cells.

43 ein, plays key roles in insulin secretion in pancreatic beta-cells.

44 xpressed in type II taste receptor cells and pancreatic beta-cells.

45 ocytes and glucose-dependent ATP increase in pancreatic beta-cells.

46 GLP-1R potentiation of insulin secretion in pancreatic beta-cells.

47 ate progression to autoimmune destruction of pancreatic beta-cells.

48 or self-antigen found in insulin granules of pancreatic beta-cells.

49 DM patients with hypomagnesemia have reduced pancreatic beta-cell activity and are more insulin resis

50 hat Glu-OCN-controlled production of DLK1 by pancreatic beta-cells acts as a negative feedback mechan

51 juvant for modulating the T-cell response to pancreatic beta-cell-Ag and reversing early-stage hyperg

52 nd we found that deglycosylation in cultured pancreatic beta cells altered insulin secretion.

53 In response to fasting or hyperglycemia, the pancreatic beta-cell alters its output of secreted insul

54 membrane domain receptor (7TMR) expressed in pancreatic beta cells and activated by FFAs.

55 t the proliferation of the insulin-producing pancreatic beta cells and especially their expansion dur

56 ound that the predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islet

57 exocytosis of insulin-containing granules in pancreatic beta cells and is required for the postprandi

58 Finally, db/db-PI3Kgamma(-/-) mice have more pancreatic beta cells and larger islets than db/db mice,

59 ution in Zn homeostasis in insulin producing pancreatic beta cells and the development of type 2 diab

60 (VA) is required both for the maintenance of pancreatic beta-cell and alpha-cell mass and for glucose

61 ved from prediabetes BB rats with destructed pancreatic beta-cells and controls than pancreas derived

62 43RFa and 26RFa on survival and apoptosis of pancreatic beta-cells and human pancreatic islets.

63 ism of the prostaglandin I2 (IP) receptor in pancreatic beta-cells and in glomerular podocytes.

64 ects a range of different tissues, including pancreatic beta-cells and liver.

65 previously reported that ARC is abundant in pancreatic beta-cells and modulates survival of these ce

66 A therapy capable of immunoisolating pancreatic beta-cells and providing normoglycaemia is an

67 an unrealized dynamic adaptive plasticity of pancreatic beta-cells and underscore the rationale for t

68 ng degree of transcriptional similarity with pancreatic beta cells, and expression of beta cell repro

69 in glucose metabolism through actions beyond pancreatic beta cells, and further points to functionall

70 and interferon (IFN)-gamma in rat and human pancreatic beta cells, and it is also up-regulated in be

71 ) controls the rate of glucose metabolism in pancreatic beta cells, and its activity is rate-limiting

72 -GPCRs acutely regulate insulin release from pancreatic beta cells, and variants in genes encoding se

73 GLP1R is highly expressed on pancreatic beta-cells, and activation by endogenous incr

74 abetes is associated with loss of functional pancreatic beta-cells, and restoration of beta-cells is

75 tor is found on gut enteroendocrine L-cells, pancreatic beta-cells, and sympathetic neurons, and is i

76 GLP-1 exerts a trophic effect on pancreatic beta-cells, and we report an increase of the

77 Pro-inflammatory cytokines contribute to pancreatic beta cell apoptosis in type 1 diabetes at lea

78 ion destroys the BiP binding site and causes pancreatic beta-cell apoptosis and diabetes in mice.

79 evaluated whether TYK2 plays a role in human pancreatic beta-cell apoptosis and production of proinfl

80 Pancreatic beta-cell apoptosis and proliferation were al

81 mall-molecule BRD0476, a novel suppressor of pancreatic beta-cell apoptosis, inhibits interferon-gamm

82 duced by inflammatory stress, but it induced pancreatic beta-cell apoptosis, reduced pancreatic beta-

83 ACH2 may also play a role in immune-mediated pancreatic beta-cell apoptosis.

84 but improves insulin sensitivity and reduces pancreatic beta-cell apoptosis.

85 s (T1D) manifests when the insulin-producing pancreatic beta cells are destroyed as a consequence of

86 Pancreatic beta cells are electrically excitable and res

87 Pancreatic beta cells are functionally programmed to rel

88 Pancreatic beta cells are of great interest for biomedic

89 Adult human pancreatic beta cells are refractory to current therapeu

90 Pancreatic beta cells are responsible for maintaining gl

91 Pancreatic beta-cells are destroyed by an autoimmune att

92 ugh we induced VAD in the entire animal, the pancreatic beta-cells are exquisitely sensitive to VAD-a

93 ich glucose regulates insulin secretion from pancreatic beta-cells are now well described, the way gl

94 on (GSIS) and its modulation by incretins in pancreatic beta-cells are only partly understood.

95 Tyk2-mutant pancreatic beta-cells are unresponsive even to high dose

96 and its receptor GPR103 are present in human pancreatic beta-cells as well as in the gut.

97 suppress the DDR appears to be selective for pancreatic beta cells, as nitric oxide fails to inhibit

98 atty acid-induced apoptosis in human and rat pancreatic beta-cells, as well as in human and murine pa

99 for Hnf1alpha are hyperglycemic, with their pancreatic beta-cells being defective in glucose-sensing

100 Cre driver lines are critical for exploring pancreatic beta cell biology with the Cre/LoxP approach.

101 inase B1 (LKB1) is an important regulator of pancreatic beta cell biology.

102 NAs and proapoptotic Bcl-2 proteins in human pancreatic beta-cells, broadening our understanding of c

103 e not only increased in palmitate-stimulated pancreatic beta-cells but also regulate beta-cell homeos

104 These differences may explain why pancreatic beta cells, but not alpha cells, are targeted

105 1 diabetes (T1D) results from destruction of pancreatic beta cells by autoreactive effector T cells.

106 previously showed that activation of TGR5 in pancreatic beta cells by bile acids induces insulin secr

107 rst-in-class surrogate imaging biomarker for pancreatic beta-cells by targeting the protein GPR44.

108 disease that results from the destruction of pancreatic beta-cells by the immune system that involves

109 The expression and function of NMDARs in pancreatic beta-cells, by contrast, are poorly understoo

110 cose-signal amplifier and calcein-AM-stained pancreatic beta-cell capsules, is developed by Z. Gu and

111 In pancreatic beta-cells, channels formed by SUR1 and Kir6.

112 Elevated pancreatic beta-cell cholesterol levels impair insulin s

113 diabetes, and have reduced immunity against pancreatic beta cells compared with control NOD mice.

114 confers resistance against cytokine-induced pancreatic beta cell death.

115 Islet amyloidosis by IAPP contributes to pancreatic beta-cell death in diabetes, but the nature o

116 (miR375) has been reported as a biomarker of pancreatic beta-cell death in small animal models.

117 s one of the molecular mechanisms underlying pancreatic beta-cell demise in type 1 diabetes.

118 erstanding the functional roles of TCF7L2 in pancreatic beta cells, despite evidence of TCF7L2 expres

119 ction following CB3 infection may exacerbate pancreatic beta cell destruction in T1D by influencing p

120 highlight a role for the microbiota in early pancreatic beta cell development and suggest a possible

121 a haploinsufficient requirement for PDX1 in pancreatic beta cell differentiation, and a potentially

122 Pancreatic beta-cell DNA was identified in the circulati

123 e elevated O-GlcNAc-modified proteins within pancreatic beta cells due to chronic hyperglycemia-induc

124 Thus, reduced Tyk2 gene expression in pancreatic beta-cells due to natural mutation is respons

125 fusion of ISG to the plasma membrane in the pancreatic beta cell during insulin exocytosis.

126 pathway may act as a protective mechanism in pancreatic beta cells during a high-calorie diet.

127 nescence effector p16(Ink4a) is expressed in pancreatic beta cells during aging and limits their prol

128 exocytosis and endocytosis are paramount to pancreatic beta cell dysfunction in diabetes mellitus.

129 and is implicated in insulin resistance and pancreatic beta cell dysfunction in the metabolic syndro

130 Pancreatic beta-cell dysfunction contributes to onset an

131 tified as a key player in the progression of pancreatic beta-cell dysfunction contributing to insulin

132 NDM-linked activating mutation in STAT3 and pancreatic beta-cell dysfunction.

133 /-) mice exhibit glycemic dysregulations and pancreatic beta-cell dysfunctions, we evaluated islet fu

134 sgenic mice that overexpress, selectively in pancreatic beta-cells, either wild-type (WT) or a mutate

135 In pancreatic beta cells exposed to endoplasmic reticulum (

136 Pancreatic beta cell failure is the central event leadin

137 Progressive pancreatic beta cell failure underlies the transition of

138 Interestingly, deletion of ERj6 causes pancreatic beta-cell failure and diabetes in mice and hu

139 actor 2alpha (eIF2alpha) are associated with pancreatic beta-cell failure and diabetes.

140 into how mitochondrial dysfunction may cause pancreatic beta-cell failure.

141 However, the presence of FFA2 and FFA3 on pancreatic beta-cells, FFA3 on neurons, and FFA2 on leuk

142 esults from a T cell-mediated destruction of pancreatic beta-cells following the infiltration of leuk

143 ke cells.Our incomplete understanding of how pancreatic beta cells form limits the generation of beta

144 Interleukin 6 protects pancreatic beta cells from apoptosis by stimulation of a

145 uppresses blood glucose levels by protecting pancreatic beta cells from oxidative stress and improvin

146 cretion by dopamine, which is synthesized in pancreatic beta-cells from circulating L-dopa.

147 Using mouse pancreatic beta-cells from wild-type and oestrogen recep

148 ctivates signaling pathways known to support pancreatic beta cell function and survival by modulating

149 Inadequate pancreatic beta cell function underlies type 1 and type

150 plays an essential role in the regulation of pancreatic beta cell function, affecting important proce

151 y the impact of the cell-autonomous clock on pancreatic beta cell function, we examined pancreatic is

152 DNA methylation to direct the acquisition of pancreatic beta cell function.

153 tows light sensitivity upon rodent and human pancreatic beta cell function.

154 : during the biological evening by decreased pancreatic beta-cell function (27% lower early-phase ins

155 el proteins concerned with the modulation of pancreatic beta-cell function (adipsin p=0.0056) and hae

156 hat highlights (a) the importance of iron in pancreatic beta-cell function and dysfunction in diabete

157 scovery of common pathways that mediate both pancreatic beta-cell function and end-organ function off

158 inked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis.

159 uced pancreatic beta-cell apoptosis, reduced pancreatic beta-cell function and enhanced hepatic gluco

160 xposure has been shown to be deleterious for pancreatic beta-cell function and insulin release.

161 t evidence for the action of sex hormones on pancreatic beta-cell function and the vasculature that a

162 in vivo expression of Klotho would preserve pancreatic beta-cell function in db/db mice.

163 ements in liver function, glucose uptake and pancreatic beta-cell function independent of weight loss

164 tients who are predisposed to the failure of pancreatic beta-cell function is a major concern for the

165 However, its role in regulation of pancreatic beta-cell function is not known.

166 Reduced pancreatic beta-cell function or mass is the critical pr

167 e and cell survival are necessary for normal pancreatic beta-cell function, glucose homeostasis, and

168 abetes pathogenesis through direct impact on pancreatic beta-cell function, senescence-associated sec

169 While mitophagy is critical to pancreatic beta-cell function, the posttranslational sig

170 to a new therapeutic approach for improving pancreatic beta-cell function.

171 wn to regulate cytokine-induced apoptosis in pancreatic beta cells (genes from the apoptotic machiner

172 ucose-stimulated insulin secretion (GSIS) in pancreatic beta cells has been extensively explored.

173 Elevated cholesterol content within pancreatic beta-cells has been shown to reduce beta-cell

174 Pancreatic beta cells have one of the highest protein se

175 e, it stimulates insulin secretion and keeps pancreatic beta-cells healthy and proliferating.

176 sfunction in rats expressing human amylin in pancreatic beta-cells (HIP rats).

177 Autophagy is a major regulator of pancreatic beta cell homeostasis.

178 ed in an asymmetric pattern of organ growth, pancreatic beta cell hyperplasia, and elevated plasma in

179 the production of vast amounts of insulin by pancreatic beta cells in response to glucose stimulation

180 Nitric oxide, produced in pancreatic beta cells in response to proinflammatory cyt

181 omplex to suppress TXNIP, thereby protecting pancreatic beta cells in the diabetic setting by inhibit

182 ed that expression of the chemokine CCL22 in pancreatic beta cells in the NOD mouse prevents autoimmu

183 n D3 is targeted by the autoimmune attack on pancreatic beta cells in vivo.

184 e 2 diabetes have revealed the importance of pancreatic beta-cells in genetic susceptibility to diabe

185 d by calcineurin-dependent NFAT signaling in pancreatic beta-cells in response to oxidative or inflam

186 ired for glucose-stimulated proliferation of pancreatic beta-cells in rodents and humans.

187 Here we show that the pancreatic beta-cells in zebrafish exhibit different gro

188 Systemically, KIRA6 preserves pancreatic beta cells, increases insulin, and reduces hy

189 gnificantly altered cytosolic zinc influx in pancreatic beta cells, indicating an important role for

190 results in part from a deficiency of normal pancreatic beta cells, inducing human beta cells to rege

191 , which is co-secreted with insulin from the pancreatic beta-cells, inhibit the activities of insulin

192 ung AnkbR1788W/R1788W mice displayed primary pancreatic beta cell insufficiency that was characterize

193 n a metabolic syndrome that combines primary pancreatic beta cell insufficiency with peripheral insul

194 Pancreatic beta-cell insulin production is orchestrated

195 om increasing insulin resistance and reduced pancreatic beta-cell insulin secretion.

196 nger molecule involved in cell signaling and pancreatic beta-cell insulin secretion.

197 undercarboxylated osteocalcin (Glu-OCN) and pancreatic beta-cell insulin; in turn, insulin favors os

198 Glucose stimulation of insulin secretion in pancreatic beta cells involves cell depolarization and s

199 The developing pancreatic beta cell is therefore sensitive to thyroid h

200 g by the integrated stress response (ISR) in pancreatic beta cells is coupled to metabolic alternatio

201 es have indicated that PI3Kgamma activity in pancreatic beta cells is required for normal insulin sec

202 rotein secretion system of insulin-producing pancreatic beta cells is stressed, leading to increased

203 Insulin production by the pancreatic beta-cell is required for normal glucose home

204 Metabolic deceleration in pancreatic beta-cells is associated with inhibition of g

205 Insulin secretion from pancreatic beta-cells is impaired in all forms of diabet

206 ellular chloride concentration ([Cl(-)]i) in pancreatic beta-cells is kept above electrochemical equi

207 ation of islet amyloid polypeptide (IAPP) in pancreatic beta cells-is limited.

208 active T-cells that attack insulin-secreting pancreatic beta-cells, it has been suggested that diseas

209 Our results show that in pancreatic beta-cells Kirrel2 localizes to adherens junc

210 dy, we demonstrate that inhibition of CK2 in pancreatic beta-cells, knockdown of CK2alpha expression,

211 that hIAPP fibrils are cytotoxic to cultured pancreatic beta-cells, leading us to determine the struc

212 mutations have not been characterized at the pancreatic beta-cell level.

213 that Pg LPS stimulates insulin secretion by pancreatic beta cell line MIN cells.

214 To test this hypothesis, pancreatic beta cell line MIN6 cells were used to determ

215 hase arrest in COS-1 and CHO cells, and in a pancreatic beta cell line that express endogenous Kv2.1.

216 roliferation and biological functions of rat pancreatic beta-cell line (INS-1) and islets.

217 e previously developed and described 2 human pancreatic beta cell lines (EndoC-betaH1 and EndoC-betaH

218 In pancreatic beta-cells, liver hepatocytes, and cardiomyoc

219 into fibrils and plaques is associated with pancreatic beta-cell loss in type 2 diabetes (T2D).

220 Pancreatic beta-cell loss through apoptosis is an import

221 fetal sheep is associated with reductions in pancreatic beta cell mass and circulating insulin concen

222 nd caused asymmetric organ growth, increased pancreatic beta cell mass and proliferation, and was ass

223 ABSTRACT: Development of pancreatic beta cell mass before birth is essential for

224 The regulation of pancreatic beta cell mass is a critical factor to help m

225 e mediated by insulin and the development of pancreatic beta cell mass is unknown.

226 ceptors are important biomarkers for imaging pancreatic beta-cell mass and detection of benign insuli

227 d for the preservation and/or restoration of pancreatic beta-cell mass and function in individuals wi

228 Pancreatic beta-cell mass is a critical determinant of t

229 Insufficient pancreatic beta-cell mass or function results in diabete

230 Insulin receptor antagonism increased pancreatic beta-cell mass threefold.

231 d, but then eventually surpassed, the normal pancreatic beta-cell mass, leading to islet hyperplasia

232 e in target cells followed by a reduction of pancreatic beta-cell mass.

233 In pancreatic beta cells, miRNAs have been largely unstudie

234 In pancreatic beta-cells, mitochondrial bioenergetics contr

235 Pancreatic beta-cells modulate insulin secretion through

236 In pancreatic beta cells, muscarinic cholinergic receptor M

237 Pancreatic beta-cell Na(+) channels control global Ca(2+

238 Pancreatic beta-cells normally produce adequate insulin

239 pite lacking identifiable stem cells, murine pancreatic beta cell number expands in response to an in

240 Elevated ER stress in pancreatic beta cells of ERdj4(GT/GT) mice was associate

241 all-trans-retinoic acid (atRA) signaling in pancreatic beta-cells of adult mice.

242 also identified novel CAMP expression in the pancreatic beta-cells of rats, mice, and humans.

243 Isolated CD1 mouse islets, INS-1 pancreatic beta-cells, or C2C12 mouse myotubes were incu

244 Thus, electrical activity of pancreatic beta cells plays a central role in GSIS.

245 Collectively, TFG in pancreatic beta-cells plays a vital role in maintaining

246 discovered that the normal expansion of the pancreatic beta cell population during early larval deve

247 KATP channels, and L-type Ca(2+) channels in pancreatic beta-cells, preceding insulin secretion.

248 nsulin-resistant conditions such as obesity, pancreatic beta-cells proliferate to prevent blood gluco

249 INT-777 also increased pancreatic beta cell proliferation and insulin synthesis

250 Pancreatic beta cell proliferation is high at birth and

251 entified DISC1 as a major player controlling pancreatic beta-cell proliferation and insulin secretion

252 uniquely unmethylated in insulin-expressing pancreatic beta-cells, providing a classic example of th

253 program underlying infrequent replication of pancreatic beta-cells remains largely inaccessible.

254 at increased the number of insulin-producing pancreatic beta cells represent potential new therapeuti

255 e showed that DUT silencing in human and rat pancreatic beta-cells results in apoptosis via the intri

256 s study explored the role of irisin as a new pancreatic beta-cell secretagogue and survival factor an

257 Pancreatic beta cells secrete insulin in response to pos

258 in neurons, is also the major Syt in rodent pancreatic beta-cells shown to mediate glucose-stimulate

259 gulatory T-cell (Treg) responses against the pancreatic beta-cell-specific antigen (Ag).

260 Pancreatic beta cells support glucose homeostasis with g

261 The pathways regulating pancreatic beta cell survival in diabetes are poorly und

262 ber of the transcriptional network governing pancreatic beta-cell survival during stress.

263 Pancreatic beta cells synthesize and secrete insulin to

264 s the activation of this proapoptotic UPR in pancreatic beta-cells that has been implicated in the on

265 R fetus produce developmental adaptations in pancreatic beta-cells that impair fetal insulin secretio

266 nsulin secretion is an essential function of pancreatic beta-cells that is partially lost in individu

267 on and inflammatory hyperalgesia, whereas in pancreatic beta-cells the channel has been linked to glu

268 mpensated by increased insulin production of pancreatic beta-cells, thereby maintaining normoglycemia

269 nstrated a potential in molecular imaging of pancreatic beta-cells; this may be useful in early detec

270 -associated locus involved in maintenance of pancreatic beta cells through a fine-tuned regulation of

271 atopoietic stem cells, and insulin-releasing pancreatic beta cells through a signaling pathway involv

272 Replacement of pancreatic beta-cells through deceased donor islet trans

273 7-amino acid residue peptide, is produced in pancreatic beta-cells through proteolytic cleavage of it

274 of signals finely tune insulin secretion by pancreatic beta cells to prevent both hyper-and hypoglyc

275 is secreted in conjunction with insulin from pancreatic beta cells to regulate glucose metabolism.

276 elivery of insulin mimicking the function of pancreatic beta-cells to achieve meticulous control of b

277 Although treatment with the pancreatic beta-cell toxin streptozotocin induced hyperg

278 The pancreatic beta-cell transcriptome is highly sensitive t

279 he communication between skeletal muscle and pancreatic beta-cells under lipotoxic conditions.

280 Dysfunction or death of pancreatic beta cells underlies both types of diabetes.

281 Pancreatic beta cells, unique cells that secrete insulin

282 ) is an autoimmune disease caused by loss of pancreatic beta cells via apoptosis while neighboring al

283 Direct interactions among pancreatic beta-cells via cell surface proteins inhibit

284 es apoptotic and proinflammatory pathways in pancreatic beta-cells via modulation of IFNalpha signali

285 in live neuroendocrine chromaffin cells and pancreatic beta-cells, visualized using confocal and sup

286 In pancreatic beta-cells, voltage-gated potassium 2.1 (Kv2.

287 ppression of the autoimmune reaction against pancreatic beta cells was evidenced by a reduction in th

288 erties of cAMP and metabolic oscillations in pancreatic beta cells, we propose here that in addition

289 Because DLK1 is colocalized with insulin in pancreatic beta-cells, we examined the role of DLK1 in i

290 and dopamine, in insulin storage granules in pancreatic beta-cells, we probed by molecular dynamics (

291 For these studies, pancreatic beta-cells were chemically destroyed by strep

292 immune assault against the insulin-producing pancreatic beta-cells, where chronic local inflammation

293 T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D

294 ate the cytoprotective mechanisms in CD31(-) pancreatic beta cells, which become resistant to immune-

295 endotoxemia upregulates miR-155-5p in murine pancreatic beta-cells, which improved glucose metabolism

296 overexpression promotes insulin secretion in pancreatic beta cells, while C193S-hSCGN inhibits it.

297 Glucose-stimulated insulin secretion from pancreatic beta-cells within islets of Langerhans plays

298 lipid composition of ISG and mitochondria in pancreatic beta cells without and with glucose stimulati

299 played robust Cre expression and activity in pancreatic beta cells without significant alterations in

300 tion of the insulin secretion from exogenous pancreatic beta-cells without implantation.