ライフサイエンスコーパス: pancreatic duct

1 ated with local fibrosis and stenosis of the pancreatic duct.

2 coordinate fluid and HCO3- secretion by the pancreatic duct.

3 gnificant disruption or stenosis of the main pancreatic duct.

4 of endocrine cells usually present near the pancreatic duct.

5 uct, a stricture, or complete cut-off of the pancreatic duct.

6 roliferation in the epithelium of the common pancreatic duct.

7 or signs referrable to the biliary tract or pancreatic duct.

8 ells in the biliary tract but not the normal pancreatic duct.

9 ocus in the expected region of the accessory pancreatic duct.

10 sed mechanism is the reflux of bile into the pancreatic duct.

11 ccompanied by reverse-Z type meandering main pancreatic duct.

12 nfusion of TLCS or taurocholic acid into the pancreatic duct.

13 nd to a lesser extent in the gallbladder and pancreatic duct.

14 tions in cultured murine sealed intralobular pancreatic ducts.

15 on of beta-cells rather than neogenesis from pancreatic ducts.

16 e able to differentiate malignant and normal pancreatic ducts.

17 locations within the human biliary tree and pancreatic ducts.

18 with an initial expansion of the developing pancreatic ducts.

19 ression in a subset of cells embedded within pancreatic ducts.

20 c liver precursors reside within or close to pancreatic ducts.

21 new beta-cells (neogenesis) derived from the pancreatic ducts.

22 hyperplastic and remained very close to the pancreatic ducts.

23 and greater proportion of nondilated (<3 mm) pancreatic ducts.

24 thelial cells adjacent to, or emerging from, pancreatic ducts.

25 and cyst formation in maturing nephrons and pancreatic ducts.

26 elial neoplasms involving the main and large pancreatic ducts.

27 with a standard meal to 5 dogs with ligated pancreatic ducts.

28 oradic glp1r-fluorescent cells were found in pancreatic ducts.

29 e model to experimental data from guinea-pig pancreatic ducts.

30 and ducts, whereas AC7 was expressed only in pancreatic ducts.

31 d monocytes/macrophages, centered around the pancreatic ducts.

32 reatography, 160 for deep cannulation of the pancreatic duct, 120 for stone extraction, and 60 for st

33 to 0.60) and 164 patients with a nondilated pancreatic duct (15% vs. 27%; relative risk, 0.55; 95% C

34 as well as among 136 patients with a dilated pancreatic duct (2% vs. 15%; relative risk, 0.11; 95% CI

35 ively, who were all independent and blinded; pancreatic duct abnormalities were evaluated.

36 Pancreatic duct abnormalities were observed in 60.2% of

37 an secretin (RG1068)-stimulated MRCP detects pancreatic duct abnormalities with higher levels of sens

38 s include cystic kidney disease, biliary and pancreatic duct abnormalities, skeletal patterning defec

39 ubular epithelia, hepatic bile ductules, and pancreatic ducts, all sites of cystic changes in ADPKD,

40 pelvic pseudocyst associated with a dilated pancreatic duct and an elevated serum amylase level.

41 eatoscopy allows direct visualization of the pancreatic duct and bile duct.

42 shows promise for improved visibility of the pancreatic duct and biliary tree, compared with the conv

43 E images for image quality parameters in the pancreatic duct and common bile duct by using a five-poi

44 ue, while the anterior bud gives rise to the pancreatic duct and exocrine cells.

45 O(3)(-) secretion are vital functions of the pancreatic duct and other secretory epithelia.

46 oxide and Pefabloc) alone (n=7), through the pancreatic duct and preserved using the two-layer method

47 pancreatitis is the reflux of bile into the pancreatic duct and subsequent exposure to pancreatic ac

48 e overall visibility of the biliary tree and pancreatic duct and the number of ductal segments visual

49 nd distal (20 of 29 [69%] vs 13 of 29 [45%]) pancreatic duct and the proximal (25 of 28 [89%] vs 22 o

50 Pancreatic ducts and acini from control mice and early-s

51 ixed inflammatory infiltrate centered around pancreatic ducts and ductules, combined with obliterativ

52 Hi) regulation as well as HCO3- secretion by pancreatic ducts and HCO3- reabsorption by renal proxima

53 tin and collagen IV in the basal membrane of pancreatic ducts and of cell clusters budding from the d

54 Pancreatic ducts and pancreatic duct glands harbor commi

55 PAR-2 expression on dog pancreatic ducts and PDEC was verified by immunofluoresc

56 We investigated fluid secretion by sealed pancreatic ducts and the function of Slc26a6 and the cys

57 ancreatic ducts in humans and mice occluding pancreatic ducts and thereby driving pancreatic inflamma

58 Patients with normal pancreatic ducts and those with strictures but no commun

59 dual ductal segments of the biliary tree and pancreatic duct, and number of ductal segments visualize

60 Increased body mass index, small main pancreatic duct, and soft pancreatic texture are well-es

61 thickening of the wall, dilation of the main pancreatic duct, and tumor markers.

62 Normal bile duct, pancreatic duct, and tumor-associated metaplasias from t

63 ted molecule expressed in endothelial cells, pancreatic ducts, and embryonic beta cells that we previ

64 lizes to the lateral membrane in bile ducts, pancreatic ducts, and epididymis.

65 zed for appearances of pancreas, biliary and pancreatic ducts, and other findings, such as peripancre

66 Optical coherence tomography within the pancreatic duct appears to be able to differentiate mali

67 strated cell proliferation in the islets and pancreatic duct areas.

68 By contrast, the pancreatic duct arises from PDX1+ progenitors that are s

69 n reaction in total RNA from isolated common pancreatic ducts at levels 10% of those of isolated isle

70 on of secretin improves the visualization of pancreatic ducts at magnetic resonance (MR) cholangiopan

71 Ten percent (4/39) of nonneoplastic pancreatic ducts at the margins of MCN harbored mutation

72 ng WNK4 include sweat ducts, colonic crypts, pancreatic ducts, bile ducts, and epididymis.

73 unication was seen in 20 and 21 of 24 branch pancreatic duct (BPD) IPMNs with CT and MRCP, respective

74 readers for the proximal, middle, and distal pancreatic duct, but the difference was not statisticall

75 beta-cell formation from progenitors in the pancreatic ducts by selectively deleting Pdx1 from the d

76 Alternatively, 26 of 30 (86.7%) pancreatic duct CA were correctly categorized as inconsi

77 he diagnosis of PDP and differentiation from pancreatic duct CA.

78 vated receptor 2 activating peptide into the pancreatic duct can activate and sensitize pancreas-spec

79 Rats were prepared with pancreatic duct cannulation, pyloric ligation, and bile

80 Kras signaling has been shown to accelerate pancreatic duct carcinogenesis, it is unclear whether el

81 1 cases), malignant melanoma (5 of 5 cases), pancreatic duct carcinoma (4 of 4 cases), non-small cell

82 Pancreatic duct carcinoma remains a common disease with

83 eoplasms, grade 3; P: < 0.001) and in 55% of pancreatic duct carcinomas (P: < 0.0001).

84 duct epithelium in primary culture and a rat pancreatic duct cell line but had no effect on a hamster

85 has been investigated in the cystic fibrosis pancreatic duct cell line, CFPAC-1.

86 In the mPEC pancreatic duct cell line, where endogenous pNBC1 functi

87 o be expressed in the majority of neoplastic pancreatic duct cell lines and VIP stimulates growth of

88 Ngn3-dependent differentiation by infecting pancreatic duct cell lines with an Ngn3-expressing adeno

89 Immunohistochemistry, however, showed that pancreatic duct cell-specific differentiation (carbonic

90 udied two models of Ngn3 activation in adult pancreatic duct cells (low-dose alloxan treatment and pa

91 del of branching morphogenesis using primary pancreatic duct cells and identified a transient surge o

92 tion of bicarbonate and fluid secretion from pancreatic duct cells and suggested that cholecystokinin

93 idence that the bestrophins are expressed in pancreatic duct cells and, more specifically, that hBest

94 To test whether pancreatic duct cells are in vitro progenitors, they wer

95 decisions in the pancreas, and reveals adult pancreatic duct cells as a latent multipotent cell type.

96 The three actions of secretin on guinea-pig pancreatic duct cells described in this and the accompan

97 tely 75% of the HCO3- taken up by guinea-pig pancreatic duct cells during stimulation with secretin.

98 In knockdown experiments with pancreatic duct cells exposed to UV light, RNF43 appeare

99 Percentages of nonviable pancreatic duct cells in groups 1 to 5 were 3.8+/-2.7%,

100 CO(3)(-) exchanger at the apical membrane of pancreatic duct cells is now known to be SLC26A6.

101 dence as to whether Ngn3 activation in adult pancreatic duct cells may lead to duct-to-beta cell tran

102 r to normal columnar epithelial cells, these pancreatic duct cells secreted mucin constitutively and

103 tely 90% methylated in microdissected normal pancreatic duct cells using bisulfite-modified sequencin

104 port of HCO3- across the luminal membrane of pancreatic duct cells was studied by monitoring the lumi

105 BC3.To measure cotransporter activity, mouse pancreatic duct cells were grown to confluence on a poro

106 ficient mice were transplanted with cultured pancreatic duct cells, but no donor-derived hepatocytes

107 ce were transplanted with cells enriched for pancreatic duct cells, but only three of the 34 (9%) rec

108 ajor role in the secretion of bicarbonate by pancreatic duct cells, by transporting bicarbonate into

109 proproliferative signaling pathways in human pancreatic duct cells, cAMP-protein kinase A and mitogen

110 progenitor cells with similarities to mature pancreatic duct cells.

111 mitogen-activated protein kinase, and Src in pancreatic duct cells.

112 introns 2 and 18 in CFTR expression in some pancreatic duct cells.

113 hat pNBC1 is functionally expressed in mouse pancreatic duct cells.

114 We studied pNBC1 function in mouse pancreatic duct cells.

115 proliferation of epithelial cells as well as pancreatic duct cells.

116 nzyme of polyol metabolism, in Capan-1 human pancreatic duct cells.

117 FBR1-dependent ERK phosphorylation in benign pancreatic duct cells.

118 15 patients), "halo" (nine of 15 patients), pancreatic duct changes (15 of 15 patients), and distal

119 etion of p120 catenin displayed dilated main pancreatic ducts, chronic pancreatitis, acinar to ductal

120 planar reformations were generated along the pancreatic duct, common bile duct, and major mesenteric

121 sed a model of telomerase-immortalized human pancreatic duct-derived cells (E6/E7/st) to study mechan

122 The GSI inhibited the growth of premalignant pancreatic duct-derived cells in a Notch-dependent manne

123 IPMN type and main pancreatic duct diameter were significant predictors of

124 variables included pancreatic gland texture, pancreatic duct diameter, intraoperative blood loss, pat

125 f enhanced solid component (P = 0.014), main pancreatic duct dilatation of more than 5 mm (P < 0.001)

126 h-risk features on initial imaging (eg, main pancreatic duct dilatation, a solid component, or mural

127 ncreatic cancers and not expressed in normal pancreatic duct displayed a high prevalence of hypomethy

128 ts with diabetes or in those patients with a pancreatic duct disruption.

129 ning the lumen of the hepatic biliary ducts, pancreatic ducts, epididymis, sweat ducts, colonic crypt

130 ormal pancreata or in an immortalized normal pancreatic duct epithelial (HPDE) cell line.

131 Expression of P5P6 in immortalized human pancreatic duct epithelial (HPDE) cells activates downst

132 ined but was expressed in immortalized human pancreatic duct epithelial (HPDE) cells.

133 We have established a primary pancreatic duct epithelial cell culture (PDEC) system to

134 ms and mucin secretion via exocytosis in dog pancreatic duct epithelial cells (PDEC).

135 2, on well-differentiated nontransformed dog pancreatic duct epithelial cells (PDEC).

136 Pancreatic duct epithelial cells (PDECs) have been shown

137 We further show that Shh protects pancreatic duct epithelial cells from apoptosis through

138 We generated architectures of human pancreatic duct epithelial cells in a 3-dimensional base

139 y be expressed on the majority of neoplastic pancreatic duct epithelial cells in vivo.

140 nsequent decrease in Na,K-ATPase activity in pancreatic duct epithelial cells, and that this response

141 hat Shh expression enhances proliferation of pancreatic duct epithelial cells, potentially through th

142 atic cancer cells compared with normal human pancreatic duct epithelial cells.

143 nce between expansion and differentiation of pancreatic duct epithelial progenitors.

144 50>1,000 ng/mL) was observed in normal human pancreatic duct epithelium cells, fibroblasts, and human

145 The pancreatic duct epithelium is remarkable for its capacit

146 In many species the pancreatic duct epithelium secretes HCO3- ions at a conc

147 BSTRACT: A computational model of guinea-pig pancreatic duct epithelium was developed to determine th

148 re expressed in the SAGE libraries of normal pancreatic duct epithelium, and were excluded from furth

149 is the first report of AR regulation in the pancreatic duct epithelium.

150 at these early stages in the progenitors of pancreatic ducts, exocrine and endocrine cells, rather t

151 Pancreatic duct exteriorization abrogated T/HS-induced g

152 ested by diversion of pancreatic enzymes via pancreatic duct exteriorization whereas the role of the

153 Pancreatic duct glands (PDGs) are gland-like outpouches

154 Pancreatic duct glands (PDGs) have been hypothesized to

155 Pancreatic duct glands (PDGs) were recently described as

156 t that is gathered in gland-like outpouches (pancreatic duct glands [PDG]) of major ducts and charact

157 Pancreatic ducts and pancreatic duct glands harbor committed pancreatic proge

158 Ex vivo explants of mouse pancreatic ducts grew dense cultures that costained for

159 atients with chronic pancreatitis, a dilated pancreatic duct (>/=5 mm) and moderate pain and/or frequ

160 It remains controversial whether adult pancreatic ducts harbor facultative beta cell progenitor

161 nesis or the budding of new islet cells from pancreatic ducts has been reported, but the existence an

162 rent histologic specimens (comprising normal pancreatic ducts, hyperplasia, low-grade dysplasia, high

163 atively noninvasive technique of biliary and pancreatic duct imaging.

164 ducts in six, diffuse irregular narrowing of pancreatic duct in nine, and focal stricture of proximal

165 uct in nine, and focal stricture of proximal pancreatic duct in six.

166 ere we show that such aggregates form inside pancreatic ducts in humans and mice occluding pancreatic

167 nIN-2 or PanIN-3 lesions, whereas 40% of the pancreatic ducts in the control animals had PanIN-2 or P

168 Ten percent of all pancreatic ducts in the nimesulide-fed animals showed Pa

169 Infusion of Na-taurocholate into the pancreatic duct induced necrotizing pancreatitis in the

170 ced model and a model elicited by retrograde pancreatic duct infusion of sodium taurocholate).

171 , immunoreactivity was also strong in normal pancreatic ducts, intestinal smooth muscle, and several

172 septation, calcification, mural nodularity, pancreatic duct involvement, and presence of multiple cy

173 Collagenase infusion into the pancreatic duct is an essential step in human islet isol

174 This assessment is possible only when the pancreatic duct is visualized.

175 Expansion of pancreatic ducts is accompanied by apoptosis of neighbor

176 uctal papillary-mucinous tumor (IPMT) of the pancreatic ducts is increasingly recognized.

177 KRAS2 mutations were also detected in pancreatic duct juice from patients with pancreatic canc

178 These data support the hypothesis that pancreatic duct lesions are neoplastic and that they rep

179 of large numbers of morphologically defined pancreatic duct lesions.

180 arcinoma libraries but not in the two normal pancreatic duct libraries.

181 Here we used long-term partial pancreatic duct ligation (PDL) as a model to study CPRD.

182 In the adult, pancreatic duct ligation (PDL) caused facultative reacti

183 ing pancreatic macrophage infiltration after pancreatic duct ligation (PDL) completely inhibits beta-

184 Here, we demonstrate that pancreatic duct ligation (PDL) does not activate progeni

185 The effect of pancreatic duct ligation (PDL) on distant organ injury f

186 olization of the exocrine pancreas gland and pancreatic duct ligation in minipigs.

187 crosis, in models of pancreatitis induced by pancreatic duct ligation in the opossum and rat.

188 tion after severe pancreas injury by partial pancreatic duct ligation or partial pancreatectomy.

189 c duct cells (low-dose alloxan treatment and pancreatic duct ligation) and lineage-traced Ngn3-activa

190 ured pancreas, or as islet progenitors after pancreatic duct ligation.

191 cysts of the pancreas and a non-dilated main pancreatic duct (<5 mm).

192 Well-preserved pancreatic ducts maintained good distribution of collage

193 the pancreatic duct system and therefore the pancreatic duct may be difficult to visualize, represent

194 Patients with pancreas divisum and a dilated pancreatic duct may be ideally suited for this surgical

195 ist symptoms, cyst size >30 mm, dilated main pancreatic duct (MPD) >6 mm, mural nodule (MN) and "posi

196 tment in main-duct IPMN patients with a main pancreatic duct (MPD) diameter of >/=10 mm.

197 ed IPMNs) of the pancreatic system is a main pancreatic duct (MPD) diameter of 5.0 mm or greater on c

198 patients with chronic pancreatitis and main pancreatic duct (MPD) dilatation (>7 mm).

199 as-specific morbidity and injury to the main pancreatic duct (MPD) was noted.

200 tic phase; 2D curved reformations along main pancreatic duct (MPD) were generated.

201 high-risk of malignancy associated with main pancreatic duct (MPD)-involved intraductal papillary muc

202 eatic mass (84 cystic, 3 solid) or a dilated pancreatic duct (n = 5) by any of the imaging modalities

203 n these six patients included an interrupted pancreatic duct (n = 5), dilated biliary and pancreatic

204 pancreatic duct (n = 5), dilated biliary and pancreatic ducts (n = 1), atrophic distal pancreatic par

205 evealed histological involvement of the main pancreatic duct not evident in preoperative imaging.

206 head, intractable abdominal pain, and a main pancreatic duct obstruction or stricture resulting in ab

207 as present (n = 10), or evidence of complete pancreatic duct obstruction was found ar ERCP (n = 7).

208 basal levels of TG2 compared with the normal pancreatic ducts [odds ratio (OR), 2.439; P = 0.012].

209 by retrogradely infusing bile acids into the pancreatic duct of anesthetized mice.

210 havioral pain response when infused into the pancreatic duct of awake rats.

211 were not significantly different for common pancreatic ducts of Px, sham Px, and unoperated rats and

212 yl tri-oleate) or OAEE was injected into the pancreatic ducts of rats, and local and systemic severit

213 We infused the radiocontrast agent into the pancreatic ducts of wild-type mice (C57BL/6) to create a

214 retrograde infusion of taurocholate into the pancreatic ducts of wild-type, NFAT luciferase reporter

215 adiologists considered that depiction of the pancreatic duct on CT images was not sufficient to enabl

216 imens of 15 patients with IPMT (dilated main pancreatic duct or branch ducts with mucin overproductio

217 /6 mice by infusion of taurocholate into the pancreatic duct or by intraperitoneal administration of

218 r data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for

219 Thus, islet progenitor cells in adult pancreatic ducts or in isolated islets of Langerhans hav

220 most normal blood vessels or gain access to pancreatic ducts or intestinal smooth muscle.

221 eatic remnant (P = 0.41) nor ligation of the pancreatic duct (P > 0.05) affected the risk of clinical

222 veral methods can be used to help locate the pancreatic duct postendoscopic papillectomy (endoscopic

223 nvasive epithelial proliferations within the pancreatic ducts, referred to as pancreatic intraepithel

224 ed, mouse epithelial cell lines derived from pancreatic duct, renal collecting duct, salivary gland a

225 of the fluid content within the lumen of the pancreatic ducts, responsible of an increase of MR signa

226 HCO(3)(-) secretion into sealed intralobular pancreatic ducts revealed that deletion of slc26a6 enhan

227 Impaired pancreatic duct secretion is frequently observed in insu

228 Stenting of the pancreatic duct should be strongly considered after bili

229 proliferation, and/or observations in large pancreatic ducts similar to those described in the liter

230 best 2-predictor model (body mass index and pancreatic duct size) resulted in a c-index of 0.748.

231 mass index, RPV, SAT/VAT area, SM area, main pancreatic duct size, and pancreatic gland texture was d

232 s in demographics, comorbidities, pathology, pancreatic duct size, pancreas texture, baseline quality

233 s in demographics, comorbidities, pathology, pancreatic duct size, pancreas texture, or operative tec

234 l pancreatic endocrine neoplasms can produce pancreatic duct stenosis resulting in ductal dilatation

235 dvancements in endoscopic techniques such as pancreatic duct stenting and dye-free guidewire cannulat

236 Pancreatic duct stenting protects significantly against

237 Pancreatic duct stenting reduces the risk of developing

238 nist and clinically by use of diclofenac and pancreatic duct stenting.

239 hypertension were randomized to groups with pancreatic duct stents (n = 41) or no stents (n = 39) af

240 ous findings that neither the routine use of pancreatic duct stents decreases the rate of fistula for

241 d controlled trial has shown that the use of pancreatic duct stents is associated with less incidence

242 aving idiopathic pancreatitis complicated by pancreatic duct stones, we discuss the evaluation and tr

243 ncreatic endocrine neoplasms with associated pancreatic duct stricture had prominent stromal fibrosis

244 MRCP revealed pancreatic duct strictures in two and sclerosing cholang

245 phy (MRCP), because of an enlargement of the pancreatic duct system and an increase of the fluid cont

246 luid within the stomach may overlap with the pancreatic duct system and therefore the pancreatic duct

247 MRCP, which has the aim to depict the whole pancreatic duct system, the biliary tree, the major and

248 helial progression to full malignancy in the pancreatic duct system.

249 e gland-like outpouches budding off the main pancreatic ducts that function as a progenitor niche for

250 tic fistula include a soft pancreas, a small pancreatic duct, the underlying pancreatic pathology, th

251 In pancreatic ducts, the electrogenic sodium bicarbonate co

252 r, PDX-1 protein transduced into cultures of pancreatic ducts, thought to be islet progenitor cells,

253 1-mm diameter scope can be advanced into the pancreatic duct through a duodenoscope.

254 stinguish nonneoplastic from neoplastic main pancreatic duct tissue.

255 tic AFGPs enter the intestinal lumen via the pancreatic duct to prevent ingested ice from nucleating

256 ing to the type of resection and whether the pancreatic duct was dilated at the site of transection.

257 , because BrdU incorporation in cells of the pancreatic duct was not increased.

258 tation of the terminal portion of the dorsal pancreatic duct was observed unaccompanied by pancreas d

259 In cats, the main pancreatic duct was partially obstructed and the animals

260 Ligation of the pancreatic duct was performed in 22% of cases.

261 Nonneoplastic pancreatic ducts were also microdissected from tissues a

262 ditions used here, cells from isolated human pancreatic ducts were cultured under the same conditions

263 Epithelial cells, isolated from a normal dog pancreatic duct, were grown on collagen-coated culture i

264 BMI, perirenal fat thickness, pancreatic duct width on computed tomography and at oper

265 ative score [using body mass index (BMI) and pancreatic duct width] to predict POPF was tested upon a

266 secretin improves noninvasive imaging of the pancreatic duct with magnetic resonance cholangiopancrea

267 Preinfusion of the pancreatic duct with proteinase-activated receptor 2-spe

268 Jagged1-deficient mice displayed malformed pancreatic ducts with resulting acinar cell death, fatty

269 US, and diffuse irregular narrowing of main pancreatic duct, with associated multiple biliary strict