ライフサイエンスコーパス: pancreatic islet

1 n, regenerating the form and function of the pancreatic islet.

2 or some slower turnover tissues, such as the pancreatic islet.

3 both vascularization and innervation of the pancreatic islet.

4 al and peripheral metabolic signals into the pancreatic islet.

5 hormone, is released from alpha-cells of the pancreatic islet.

6 expression profiling of CVB5-infected human pancreatic islets.

7 iRNAs that are modulated by glucose in mouse pancreatic islets.

8 show little evidence of autoimmunity in the pancreatic islets.

9 roduction of GLP1 and insulin secretion from pancreatic islets.

10 protocol for extrahepatic transplantation of pancreatic islets.

11 and alters expression of metabolic genes in pancreatic islets.

12 TRMs formed a protective barrier surrounding pancreatic islets.

13 mmation- and autoimmunity-mediated damage of pancreatic islets.

14 marker for endoplasmic reticulum stress) in pancreatic islets.

15 r GLP-1 directly drives insulin secretion in pancreatic islets.

16 of bystander CD4+ and CD8+ T cells, but not pancreatic islets.

17 eatic islets and direct cytotoxic effects on pancreatic islets.

18 ulin release in pure beta cells and in human pancreatic islets.

19 ction of the insulin-producing beta-cells of pancreatic islets.

20 ceptor interaction, and visualization of the pancreatic islets.

21 moter activity and ARAP1 expression in human pancreatic islets.

22 8067 overlaps a predicted enhancer region in pancreatic islets.

23 apoptosis of pancreatic beta-cells and human pancreatic islets.

24 appearance of circulating autoantibodies to pancreatic islets.

25 one that is cosecreted with insulin from the pancreatic islets.

26 an effect on beta cell replication in human pancreatic islets.

27 us tissues, including isolation of the human pancreatic islets.

28 ction of the insulin-producing beta cells in pancreatic islets.

29 and pituitary, and at more modest levels in pancreatic islets.

30 d that Hes3 is expressed in human and rodent pancreatic islets.

31 ect on insulin secretion in rodent and human pancreatic islets.

32 emain competent to internalize Ag and invade pancreatic islets.

33 ized bed that enables the transplantation of pancreatic islets.

34 ction of insulin-producing beta-cells within pancreatic islets.

35 ing the hallmark morphogenetic properties of pancreatic islets.

36 matory signaling in macrophages infiltrating pancreatic islets.

37 ion of at least four cell types constituting pancreatic islets.

38 te to the development and proper function of pancreatic islets.

39 s and induction of an interferon response in pancreatic islets.

40 e seen in nondiabetic deceased donor control pancreatic islets.

41 ts of maternal bisphenol A exposure on mouse pancreatic islets.

42 4 miRNAs was examined in CVB5-infected human pancreatic islets.

43 in autoreactive B-lymphocytes infiltrate NOD pancreatic islets, acquire an activated proliferative ph

44 catalog of gene expression changes in human pancreatic islets after exposure to glucose.

45 that IL-7R blockade alone induced indefinite pancreatic islet allograft survival if anti-IL-7R treatm

46 Permanent acceptance of pancreatic islet allografts was achieved in mice treated

47 ded MALDI MS was used to identify individual pancreatic islet alpha and beta cells, which were then t

48 y (insulin sensitivity in peripheral tissue, pancreatic islet and beta cell function, adipocyte diffe

49 To do so, we quantified pancreatic islet and exocrine sympathetic nerve fiber ar

50 tion in real time from as few as five murine pancreatic islets and (2) standard addition experiments

51 data reveal novel direct neuronal effects on pancreatic islets and also render a functional validatio

52 e homeostasis, and an in-depth evaluation of pancreatic islets and beta cells from these animals reve

53 activate protein kinase C zeta (PKCzeta) in pancreatic islets and beta-cells.

54 o the complexity of gene regulation in human pancreatic islets and better understanding of how geneti

55 vitro experiments were performed with mouse pancreatic islets and cultured pancreatic alpha TC 1 clo

56 In mouse pancreatic islets and cultured pancreatic alphaTC1c9 cel

57 mice express B7.1 costimulatory molecules in pancreatic islets and develop diabetes after treatment w

58 es, which induce CCL5 expression in adjacent pancreatic islets and direct cytotoxic effects on pancre

59 ed glucose-stimulated insulin secretion from pancreatic islets and enhanced systemic glucose toleranc

60 Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh-frozen whole pancreatic

61 d insulin secretion both in human and murine pancreatic islets and in clonal beta cells in a dose- an

62 h significantly reduced apoptosis of murine pancreatic islets and insulin-secreting INS-1E cells, re

63 Our results confirm SP-D expression in pancreatic islets and intercalated ducts and are the fir

64 xpressed in insulin-producing cells of mouse pancreatic islets and investigated its role in beta cell

65 We obtained samples of human pancreatic islets and isolated islets from mice; human a

66 fluorescent ATP biosensor Perceval in mouse pancreatic islets and loaded them with a Ca(2+) indicato

67 We have evaluated whether pancreatic islets and lymphoid tissues of T1D and nondia

68 ell-autoreactive T cells to traffic into the pancreatic islets and may represent a new target for pha

69 (Men1(+/-)) develop tumors in the pituitary, pancreatic islets and other neuroendocrine tissues, whic

70 of the global Ca(2+) response to glucose in pancreatic islets and significantly reduces insulin rele

71 he importance of epigenetic dysregulation in pancreatic islets and T2D pathogenesis.

72 Finally, we show that the number of pancreatic islets and the area of insulin-positive cells

73 nduce free cholesterol accumulation in human pancreatic islets and the INS-1 insulinoma cell line.

74 little is known about the role of NMDARs in pancreatic islets and the insulin-secreting beta cells w

75 o augment insulin secretion in primary mouse pancreatic islets, and (S)-9b alone was effective in pot

76 uses amylin deposition and proteotoxicity in pancreatic islets, and contributes to the development of

77 ber of beta-cells, insulin storage levels in pancreatic islets, and glucose-stimulated insulin secret

78 sufficient to mitigate local lipotoxicity in pancreatic islets, and it promotes reconstitution of bet

79 The expression of cd93 was observed in pancreatic islets, and leaky vessels were apparent in cd

80 most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated

81 e beta cell proliferation in the fetal ovine pancreatic islets, and that growth retardation in hypoth

82 In type 1 diabetes, the pancreatic islets are an important site for therapeutic

83 The pancreatic islets are central to the maintenance of gluc

84 PRV) retrograde tracing, indicating that the pancreatic islets are innervated by efferent circuits th

85 ade of autoimmune attack and regeneration of pancreatic islets are ultimate goals for the complete cu

86 estimates for the rate of glucose cycling in pancreatic islets, as assessed using radioisotopes.

87 lmark of type 2 diabetes is the reduction of pancreatic islet beta cell mass through induction of apo

88 Insulinomas (pancreatic islet beta cell tumors) are the most common t

89 Insulin secretion by pancreatic islet beta cells is critical for glucose home

90 zinc transporter ZnT8 largely restricted to pancreatic islet beta- and alpha-cells, and responsible

91 d amyloid protein intimately associated with pancreatic islet beta-cell dysfunction and death in type

92 There is also the potential for pancreatic islet beta-cell expansion through c-MET regul

93 nylurea receptor (SUR) 1 critically regulate pancreatic islet beta-cell membrane potential, calcium i

94 lipid synthesis, and fatty acid oxidation in pancreatic islet beta-cells and hepatocytes, and that gl

95 Pancreatic islet beta-cells are particularly susceptible

96 Destruction of pancreatic islet beta-cells in type 1 diabetes (T1D) is

97 Loss of insulin-producing pancreatic islet beta-cells is a hallmark of type 1 diab

98 The failure of pancreatic islet beta-cells is a major contributor to th

99 The secretion of insulin from pancreatic islet beta-cells is critical for glucose home

100 Pancreatic islet beta-cells that lack the MEN1-encoded p

101 ls play a central role in the destruction of pancreatic islet beta-cells that leads to type 1 diabete

102 pecific" KCC2 co-transporter is expressed in pancreatic islet beta-cells where it modulates Ca(2+)-de

103 , when relieved, could promote exocytosis in pancreatic islet beta-cells.

104 id receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous

105 Using isolated pancreatic islets, BETP potentiated insulin secretion in

106 (4C) to identify a physical contact in human pancreatic islets between the region near the insulin (I

107 However, our comprehensive analysis of pancreatic islet bioenergetics reveals that Drp1 does no

108 lts show that in INS-1E beta-cells and human pancreatic islets both 43RFa and 26RFa prevented cell de

109 matrix glycosaminoglycan that is present in pancreatic islets, but little is known about its involve

110 etic mouse stems from an infiltration of the pancreatic islets by a mixed population of immunocytes,

111 d examined for the number and cellularity of pancreatic islets by immunofluorescence and FACS.

112 ular regulatory program to correctly specify pancreatic islet cell fates.

113 glucagon secretion resulting from changes in pancreatic islet cell function and/or mass.

114 PGE2 We tested the hypothesis that enriching pancreatic islet cell membranes with EPA, thereby reduci

115 Organ growth and pancreatic islet cell proliferation and mass were examin

116 the Pax6 gene in mice leads to loss of most pancreatic islet cell types, the functional consequences

117 1000 cDNA libraries, each from an individual pancreatic islet cell.

118 f human islet amyloid polypeptide (hIAPP) in pancreatic islet cells is implicated in the pathogenesis

119 d applicability to sophisticated analyses of pancreatic islet cells that reveal new biological insigh

120 We also show that for encapsulated rat pancreatic islet cells transplanted into streptozotocin-

121 To validate the approach, single rat pancreatic islet cells were rapidly analyzed with optica

122 Rabbits were treated with alloxan to destroy pancreatic islet cells, or mock-treated with vehicle, an

123 rly endoderm stage cells (CXCR4+ cells), and pancreatic islet cells.

124 Here we explored whether Hes3 also regulates pancreatic islet cells.

125 platform for RNA sequencing of single mouse pancreatic islet cells.

126 A new study mapping the human pancreatic islet cistrome provides a roadmap for explori

127 Human pancreatic islets consist of multiple endocrine cell typ

128 The pancreatic islets contain three major hormone-secreting

129 hat a low-grade enteroviral infection in the pancreatic islets contributes to disease progression in

130 studies, we showed that isolated autologous pancreatic islets could be labeled with iron oxide nanop

131 An iron overload may induce pancreatic islet damage and increase risk of diabetes.

132 s, bone marrow transplantation, and cultured pancreatic islets demonstrated that stabilization of IFN

133 owth factors are highly integrated in normal pancreatic islet development, and this regulation is dec

134 Using gene expression profiles of 66 human pancreatic islets donors', we also show that the identif

135 ice) exhibit hypoplasia in the pituitary and pancreatic islet due to primary postnatal defects in pro

136 s fundamental cell-type-specific features of pancreatic islet (dys)function and provides a critical r

137 Pancreatic islet dysfunction and beta cell failure are h

138 Pancreatic islet dysfunction is central in type 2 diabet

139 AnkB-KO mice develop obesity and progressive pancreatic islet dysfunction with age or high-fat diet (

140 ated variants to exert their effects through pancreatic islet dysfunction.

141 anonical NF-kappaB pathway in the context of pancreatic islet dysfunction.

142 hormones that mediate communication between pancreatic islet endothelial cells (ECs) and beta-cells.

143 ific enrichment of regulatory annotations in pancreatic islet enhancers for loci influencing insulin

144 ate with cell-specific chromatin domains and pancreatic islet enhancers.

145 Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be us

146 In sum, increasing pancreatic islet EPA abundance improves diabetic beta-ce

147 stration of high rates of glucose cycling in pancreatic islets explains why G6pc2 deletion enhances G

148 In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTO

149 a versus beta cells generated from dispersed pancreatic islets, followed by the construction of frequ

150 The transplantation of pancreatic islets, following the Edmonton Protocol, is a

151 Transplantation of pancreatic islets for treating type 1 diabetes is restri

152 ids to cell proliferation and sorting during pancreatic islet formation, as well as to life-long prog

153 potential of DNA and RNA sequencing in human pancreatic islets from 89 deceased donors to identify ge

154 However, the yield of pancreatic islets from brain-dead donors is negatively a

155 ARA 290 protected pancreatic islets from cytokine-induced damage and apopt

156 genome at a single nucleotide resolution, in pancreatic islets from donors with T2D and control subje

157 GSIS in rat insulinoma cells (INS-1) and in pancreatic islets from ghrelin (-/-) mice.

158 In studies of pancreatic islets from human beings and mice, we found t

159 n pancreatic beta cell function, we examined pancreatic islets from mice with either intact or disrup

160 nsmitters as paracrine signals that regulate pancreatic islet function.

161 nchanged insulin tolerance suggested altered pancreatic islet function.

162 These data suggest roles of Hes3 in pancreatic islet function.

163 t organ, as both alpha and beta cells within pancreatic islets gradually lose their VTCN1 protein dur

164 tion regarding the longevity of transplanted pancreatic islet grafts could provide valuable informati

165 of T cell-mediated damage and protection of pancreatic islet grafts.

166 MSCs support pancreatic islet growth by direct differentiation into i

167 vation of ionic signaling dynamics in intact pancreatic islets has contributed greatly to our underst

168 Yet, the neuronal network linking to pancreatic islets has never been fully mapped.

169 Single-cell RNA-seq (scRNA-seq) of pancreatic islets have reported on alpha- and beta-cell

170 rome MENX, caused by a p27 mutation, develop pancreatic islet hyperplasia containing elevated numbers

171 lipid accumulation in liver and muscle, and pancreatic islet hyperplasia.

172 ted syndrome that includes susceptibility to pancreatic islet hyperplasia.

173 Within the pancreatic islet, IL-6 stimulates secretion of the prosu

174 in, we report the discovery of first TP live pancreatic islet imaging probe; TP-alpha (Two Photon-alp

175 re several OP fluorescence probes in use for pancreatic islet imaging, TP imaging of selective cells

176 ike-lectins (siglecs) are expressed in human pancreatic islets in a cell-type specific manner.

177 ulated ciliary/basal body gene expression in pancreatic islets in a diabetic rat model.

178 ry nerve terminals and insulin from isolated pancreatic islets in a TRPM3-dependent manner.

179 eration), and LC3 (a marker of autophagy) in pancreatic islets in db/db mice.

180 due to attenuation of T-cell infiltration in pancreatic islets in NOD mice.

181 f an antiaging gene, Klotho, was depleted in pancreatic islets in patients with type 2 diabetes melli

182 Pancreatic islets in patients with type 2 diabetes melli

183 asculature over time within extracted murine pancreatic islets in static culture, which may have impl

184 AD, and islet amyloid polypeptide (IAPP) in pancreatic islets in T2D.

185 ates were determined in isolated fetal ovine pancreatic islets in vitro.

186 Furthermore, we report that pancreatic islets in whole-body Nck1-knockout mice conta

187 coordinated neurovascular development within pancreatic islets, in which endocrine cell-derived VEGF

188 en discovered to play important roles in the pancreatic islet, including beta-cell function, prolifer

189 expressed in several endocrine cells of the pancreatic islet, including glucagon secreting alpha-cel

190 restricted to the hepatopancreatic ducts and pancreatic islets, including the insulin producing ss-ce

191 iption factor NK6 homeobox 1 (Nkx6.1) in rat pancreatic islets induces beta-cell proliferation and en

192 bitors as a therapeutic approach to suppress pancreatic islet infiltration and prevent beta-cell deat

193 lases (HDACs), has been reported to suppress pancreatic islet inflammation and beta-cell apoptosis in

194 ecreased in IUGR fetuses, resulting in lower pancreatic islet insulin concentrations and insulin secr

195 ws, for the first time, visual assessment of pancreatic islet insulin content, and we demonstrate tha

196 hat local apoCIII production is connected to pancreatic islet insulin resistance and beta-cell failur

197 In pancreatic islets, insulin secretion occurs via synchron

198 , CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis).

199 We hypothesized that 12-LO in the pancreatic islet is sufficient to cause dysglycemia in t

200 The liver as transplantation site for human pancreatic islets is a harsh microenvironment for islets

201 Transplantation of pancreatic islets is a therapeutic option to preserve or

202 DATA: The liver as transplantation site for pancreatic islets is associated with significant loss of

203 We found that glucagon release in human pancreatic islets is mediated by the Nav1.3 isoform.

204 Xenocell therapy from neonate or adult pig pancreatic islets is one of the most promising alternati

205 NIK levels are elevated in pancreatic islets isolated from diet-induced obese (DIO)

206 n the circulation of Ghsr (-/-) mice, and in pancreatic islets isolated from Ghsr (-/-) mice.

207 In pancreatic islets isolated from intact fetal sheep, beta

208 LA2-deficient (GX KO) mice and ex vivo using pancreatic islets isolated from WT and GX KO mice.

209 In insulin-secreting beta-cells of pancreatic islets, K(ATP) channels play a key role in re

210 n hIAPP oligomer and amyloid accumulation in pancreatic islets, leading to increased death and decrea

211 the destruction of beta (beta) cells in the pancreatic islets, leading to loss of insulin production

212 Basal body/ciliary perturbation in murine pancreatic islets leads to impaired first phase insulin

213 months (the length of the experiment), form pancreatic islet-like structures and support normoglycem

214 n microfluidic two-organ-chip model to study pancreatic islet-liver cross-talk based on insulin and g

215 Pancreatic islets manage elevations in blood glucose lev

216 development with expected stratification of pancreatic islet mass were examined in relation to indiv

217 shown to be a surrogate imaging biomarker of pancreatic islet mass.

218 to test whether and how TH signaling affects pancreatic islet maturation, and consequently glucose ho

219 icate that increased local levels of IGF2 in pancreatic islets may predispose to the onset of diabete

220 ed damage of insulin-producing beta-cells of pancreatic islets, may involve viral infection.

221 ave established a robust co-culture of human pancreatic islet microtissues and liver spheroids mainta

222 enesis, with particular attention focused on pancreatic islet morphology including assessment for inf

223 ecretion, steatosis, metabolic inflammation, pancreatic islet morphometry, islet cellular composition

224 Pancreatic islet number and area, as well beta-cell area

225 Insulin-producing beta cells within the pancreatic islet of Langerhans are responsible for maint

226 D4(+) T-cell clones from within the residual pancreatic islets of a deceased organ donor who had T1D.

227 posure has dose- and sex-specific effects on pancreatic islets of adult F1 and F2 mice offspring.

228 ble decline in mitochondrial function in the pancreatic islets of aged mice (>/=24 months), the resul

229 The effects of ARA 290 on pancreatic islets of C57BL/6J (H-2) mice and on murine m

230 n vitro, we tested whether EVs isolated from pancreatic islets of healthy patients and patients with

231 The pancreatic islets of Langerhans are multicellular micro-

232 Pancreatic islets of Langerhans consist of endocrine cel

233 Human pancreatic islets of Langerhans contain five distinct en

234 Insulin secretion from beta cells of the pancreatic islets of Langerhans controls metabolic homeo

235 cose to stimulate insulin secretion from the pancreatic islets of Langerhans is enhanced by the intes

236 Pancreatic islets of Langerhans regulate blood glucose h

237 in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several

238 ons of cells from the rat pituitary, the rat pancreatic islets of Langerhans, and from the Aplysia ca

239 n insulin-secreting beta-cells, found in the pancreatic islets of Langerhans, are destroyed by infilt

240 A primary insult to the pancreatic islets of Langerhans, leading to the activati

241 PP) is responsible for cell depletion in the pancreatic islets of Langherans, and for multiple pathol

242 Upon exposing isolated pancreatic islets of obese mice to normal glucose concen

243 proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D.

244 major component of amyloid deposits found in pancreatic islets of patients with type 2 diabetes (T2D)

245 is found in vivo as amyloid deposits in the pancreatic islets of sufferers of type II diabetes melli

246 identified hundreds of T cells from inflamed pancreatic islets of three young organ donors with type

247 CD4 T cells from the residual pancreatic islets of two organ donors who had T1D also r

248 evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, which is

249 , induced the generation of approximately 80 pancreatic islets per animal, and ultimately led to incr

250 This was confirmed in vitro by pancreatic islet perifusion showing an amplified biphasi

251 the manufacture of allogeneic purified human pancreatic islet (PHPI) product evaluated in a phase 3 t

252 Pancreatic islets produce and secrete cytokines and chem

253 We found that rat and human pancreatic islets release the intracellular beta-cell au

254 patients undergoing bariatric surgery, from pancreatic islet research, from functional neuroimaging

255 in an insulin-secreting cell line and mouse pancreatic islets, respectively, uniquely attenuated the

256 Pancreatic islets respond to elevated blood glucose by s

257 delta-1, the dominant alpha2delta subunit in pancreatic islets, results in glucose intolerance and di

258 ment of allele-specific mRNA levels in human pancreatic islet samples heterozygous for rs11603334 sho

259 ed by a heightened antibody (Ab) response to pancreatic islet self-antigens, which is a biomarker of

260 r a central mode of action of PREP, isolated pancreatic islets showed no difference in glucose-induce

261 Transcriptome analysis of pancreatic islets showed that P2Y14 deficiency significa

262 In the VAD mice, the reductions in pancreatic islet sizes and the associated aberrant endoc

263 de CGRP from sensory endings innervating the pancreatic islets, subsequently promoting insulin secret

264 tor T cell responses evolve over time in the pancreatic islets targeted for destruction.

265 which PTP inactivation induces signaling in pancreatic islets that results in increased expression o

266 Within the pancreatic islet, the beta-cell represents the ultimate

267 small fraction of genomic CpG sites in human pancreatic islets, the tissue of primary pathogenic impo

268 ing the inflammatory and immune responses to pancreatic islets, thereby promoting inflammatory destru

269 t that exposure of beta-cell lines and human pancreatic islets to high levels of glucose and lipids b

270 reduction in beta-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in

271 enomic, and transcriptomic profiles in human pancreatic islets to understand the links between geneti

272 le-genome DNA methylation landscape in human pancreatic islets, to identify differentially methylated

273 GLP-1R is expressed in pancreatic islets together with the closely related gluc

274 Strikingly, the pancreatic islet transcriptome was greatly altered in he

275 The efficacy of pancreatic islet transplantation (PITx) is reduced due t

276 n patients with type 1 diabetes who received pancreatic islet transplantation and anti-CD25 mAb as in

277 -establishment of glycemic control following pancreatic islet transplantation in animal models is dis

278 Pancreatic islet transplantation is a promising clinical

279 Pancreatic islet transplantation is a promising potentia

280 Pancreatic islet transplantation offers a promising biot

281 iteria for adverse events in Trials of Adult Pancreatic Islet Transplantation." RESULTS: There were n

282 Insulinomas are pancreatic islet tumors that inappropriately secrete ins

283 the effects of the loss of MMP-9 function on pancreatic islets uncovers a deteriorated beta cell func

284 ication of both cAMP and insulin from single pancreatic islets undergoing a variety of treatments (gl

285 ve reassessed the rate of glucose cycling in pancreatic islets using a novel stable isotope method.

286 ling peptides extracted from mouse and human pancreatic islets using mass spectrometry (MS).

287 c beta-cells, as well as in human and murine pancreatic islets, via AKT/BCL2 signaling.

288 Accumulation of CXCR3(+) Treg cells within pancreatic islets was dependent on the transcription fac

289 Here the MLCL content of mouse pancreatic islets was found to rise with increasing iPLA

290 ance of CD4 T cells and dendritic cells into pancreatic islets was reduced, (ii) presentation of insu

291 pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.

292 ciple studies, iron oxide-labeled autologous pancreatic islets were transplanted under the renal caps

293 morigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 is dispensable for tumori

294 nd glucose-stimulated insulin secretion from pancreatic islets, which led to increased blood insulin

295 ylglycerol (2-AG) in mouse fetuses and human pancreatic islets, which primes the recruitment of beta

296 veloped serotonin system is localized to the pancreatic islets while being absent in exocrine pancrea

297 Treatment of mouse pancreatic islets with CX4945, a highly selective CK2 in

298 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading to insulin

299 Mice lacking Snord116 have smaller pancreatic islets; within the islet the percentage of de

300 to functional hepatocytes,cholangiocytes or pancreatic islets, yielding similar levels of secretion