ライフサイエンスコーパス: pancreatic islet cell

1 1000 cDNA libraries, each from an individual pancreatic islet cell.

2 apparatus which directs STF-1 expression to pancreatic islet cells.

3 rly endoderm stage cells (CXCR4+ cells), and pancreatic islet cells.

4 Here we explored whether Hes3 also regulates pancreatic islet cells.

5 of adenovirus as a gene delivery vehicle for pancreatic islet cells.

6 regulatory models for the differentiation of pancreatic islet cells.

7 CD40L-induced upregulation of CD40 in human pancreatic islet cells.

8 tocin injection were transplanted with human pancreatic islet cells.

9 d mechanisms that stimulate proliferation of pancreatic islet cells.

10 which is required for the differentiation of pancreatic islet cells.

11 ed insulin action and abnormalities in their pancreatic islet cells.

12 ic acid (GABA) is stored in microvesicles in pancreatic islet cells.

13 platform for RNA sequencing of single mouse pancreatic islet cells.

14 by mammalian promoters into human and mouse pancreatic islet cells.

15 , no aP2 expression was detected in isolated pancreatic islet cells.

16 y was predominantly detected in pancreas and pancreatic islet cells.

17 demonstrates the presence of Kv1.7 in mouse pancreatic islet cells.

18 owed that this protein is expressed in human pancreatic islet cells.

19 This postulate was tested in a murine pancreatic islet cell allograft model in which a novel m

20 ed in significantly longer survival of DBA/2 pancreatic islet cell allografts in the B6AFl recipient

21 ue sites throughout the rat genome in normal pancreatic islet cells, allowing us to identify the chan

22 re expressed selectively in beta cell lines, pancreatic islet cells and brain.

23 Pancreatic islet cells and neurons share common function

24 tion of whole organs or free tissues such as pancreatic islet cells and should facilitate studies of

25 endent protein kinase (PKR) are expressed by pancreatic islet cells and that IFNs (IFN-alpha and IFN-

26 There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells (E

27 matopoietic and parenchymal cells, including pancreatic islet cells; and PD-L2, which is restricted t

28 isease mediated by T lymphocytes recognizing pancreatic islet cell antigens.

29 of insulin receptor mRNA was examined in rat pancreatic islet cells by single-cell reverse transcript

30 inium chelates (GG) were coencapsulated with pancreatic islet cells by using protamine sulfate as a c

31 tively, these data indicate that adult human pancreatic islet cells can be expanded by three serial p

32 In a transgenic mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), an ang

33 hepsins are up-regulated in a mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), and tu

34 By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine c

35 with ovarian cancer (5.0 mg/kg) and one with pancreatic islet cell carcinoma (15.0 mg/kg), achieved a

36 These mice reproducibly develop pancreatic islet cell carcinoma and squamous cell carcin

37 g transgenic model of angiogenesis-dependent pancreatic islet cell carcinoma and the 4T1 model of met

38 ns in genetically engineered mouse models of pancreatic islet cell carcinoma, in which oncogenic tran

39 pression and glycogenolysis that result from pancreatic islet cell defects.

40 It is currently thought that pancreatic islet cells develop from undifferentiated pro

41 probed the role of activin signaling during pancreatic islet cell development and regeneration.

42 n factors in the gene network that regulates pancreatic islet cell development.

43 sional islet cell-like clusters that express pancreatic islet cell differentiation-related transcript

44 Thus, mammalian pancreatic islet cells display cell-type-specific epigen

45 As early as 7 days following Men1 excision, pancreatic islet cells display increased proliferation,

46 that Nkx2.2 and NeuroD1 interact to regulate pancreatic islet cell fates, and this epistatic relation

47 ular regulatory program to correctly specify pancreatic islet cell fates.

48 proach may provide a potential new source of pancreatic islet cells for transplantation.

49 s using streptozotocin (STZ)-treated primary pancreatic islet cells from ICR mice to unravel the prot

50 Allogeneic pancreatic islet cells from unrelated donors were subseq

51 glucagon secretion resulting from changes in pancreatic islet cell function and/or mass.

52 We found a decrease in pancreatic islet cell hyperplasia, fat accumulation in t

53 expressing the PEPCK-TAg transgene developed pancreatic islet cell hyperplasias and carcinomas, with

54 Immunocytochemistry revealed that, although pancreatic islet cells in the STZ-treated rats were spar

55 (-/-) background into mice expressing OVA in pancreatic islet cells induces acute insulitis and diabe

56 ed EPCs could play a role in the response to pancreatic islet cell injury.

57 The pancreatic islet cells invariably stained for growth hor

58 f human islet amyloid polypeptide (hIAPP) in pancreatic islet cells is implicated in the pathogenesis

59 cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplant

60 -phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fastin

61 PGE2 We tested the hypothesis that enriching pancreatic islet cell membranes with EPA, thereby reduci

62 associated with loss of tolerance to several pancreatic islet cell molecules, including insulin, glut

63 In the exercising MC4R knockout mice, the pancreatic islet cell morphology and other physiological

64 Rabbits were treated with alloxan to destroy pancreatic islet cells, or mock-treated with vehicle, an

65 1 x 10(-4)), 67 SNPs for type 2 diabetes in pancreatic islet cells (P = 0.003) and the liver (P = 0.

66 Organ growth and pancreatic islet cell proliferation and mass were examin

67 med at evaluating the effect of rapamycin on pancreatic islet cell proliferation in vivo.

68 nd whether mutation of Men1 acutely promotes pancreatic islet cell proliferation in vivo.

69 s to the full spectrum of fractionated human pancreatic islet cell proteins to determine whether nume

70 Pancreatic islet cells provide the major source of count

71 pite their origins in different germ layers, pancreatic islet cells share many common developmental f

72 rotein Nkx2.2 (Nkx2-2) is a key regulator of pancreatic islet cell specification in mice; Nkx2.2 is e

73 ontaining transcription factor essential for pancreatic islet cell specification.

74 Applying the method to mouse pancreatic islet-cell subsets, we detected both expected

75 icates that the plasticity of differentiated pancreatic islet cells, suggested by earlier static and

76 tion and characterization of a cDNA from rat pancreatic islet cells that encodes a new related kinase

77 d applicability to sophisticated analyses of pancreatic islet cells that reveal new biological insigh

78 mising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered b

79 The optimal site for pancreatic islet cell transplantation is presently uncle

80 er SOCS proteins can prevent the destruction pancreatic islet cells transplanted beneath the kidney c

81 We also show that for encapsulated rat pancreatic islet cells transplanted into streptozotocin-

82 ession in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis.

83 evelopment of renal cell carcinoma (RCC) and pancreatic islet cell tumors (PICT).

84 s after initial screening, she developed two pancreatic islet cell tumors and a premalignant renal cy

85 e reviews the current clinical management of pancreatic islet cell tumors and describes the molecular

86 ly history that describes the development of pancreatic islet cell tumors in four of five female sibl

87 rmore, we conclude that the preponderance of pancreatic islet cell tumors in this family cannot be ex

88 ma are common lesions; pheochromocytomas and pancreatic islet cell tumors occur less frequently but a

89 Angiogenesis was examined in pancreatic islet cell tumors of RIP-Tag2 transgenic mice

90 e molecular events underlying the biology of pancreatic islet cell tumors will aid the development of

91 e endocrine pancreas, commonly referenced as pancreatic islet cell tumors, are rare, often well diffe

92 VHL gene in the four affected siblings with pancreatic islet cell tumors.

93 cts of RCA I on blood vessels of spontaneous pancreatic islet-cell tumors in RIP-Tag2 transgenic mice

94 the Pax6 gene in mice leads to loss of most pancreatic islet cell types, the functional consequences

95 for the development of beta-cells and other pancreatic islet cell types, we considered it a candidat

96 roD1 are vital for proper differentiation of pancreatic islet cell types.

97 e enhancer which directs STF-1 expression to pancreatic islet cells via two functional elements that

98 cose and gut hormones during feeding promote pancreatic islet cell viability in part via the calcium-

99 rmeability coefficient of the golden hamster pancreatic islet cells was determined to be 0.27 microns

100 r permeability coefficient of golden hamster pancreatic islet cells were determined.

101 To validate the approach, single rat pancreatic islet cells were rapidly analyzed with optica

102 ltage-gated potassium (Kv) currents of human pancreatic islet cells were studied by whole-cell patch

103 at amphioxus may have homologs of vertebrate pancreatic islet cells, which express neurogenin3.

104 RIP-mOVA mice expressing chicken OVA in the pancreatic islet cells, which received naive OVA-specifi

105 effectively transduces both human and murine pancreatic islet cells with reporter genes as well as po