ライフサイエンスコーパス: pandemic

1 ty has highlighted the threat of a potential pandemic.

2 ght have changed, increasing the threat of a pandemic.

3 za virus emerged in humans, causing a global pandemic.

4 in, where HIV-1 expanded early in the global pandemic.

5 ong people and cause a devastating worldwide pandemic.

6 nza pandemics, as in the 2009 H1N1 influenza pandemic.

7 l strains decades after the emergence of the pandemic.

8 milar to that described during the 2009 H1N1 pandemic.

9 phibian declines driven by a global wildlife pandemic.

10 ght after in order to stem the current HIV-1 pandemic.

11 xplain the frequent failure of AIV to become pandemic.

12 f the regions involved in the current global pandemic.

13 w of opportunity for vaccination in a future pandemic.

14 ndicate a correlation with the spread of the pandemic.

15 orefront of health promotion to address this pandemic.

16 dity and mortality during the 2009 influenza pandemic.

17 limited by neglected populations and the HIV pandemic.

18 d from human to human and cause an influenza pandemic.

19 acterium tuberculosis, remains a major human pandemic.

20 potentially influenced by the 2009 influenza pandemic.

21 e been able to establish and maintain global pandemics.

22 en causing seasonal epidemics and occasional pandemics.

23 ans due to seasonal epidemics and occasional pandemics.

24 for stopping the obesity and type 2 diabetes pandemics.

25 broadens our understanding of the history of pandemics.

26 ccounting for numerous AHC outbreaks and two pandemics.

27 imes and from Indonesia once to cause global pandemics.

28 catastrophic, strong and moderate influenza pandemics.

29 ulation in the strong and moderate influenza pandemics.

30 catastrophic, strong and moderate influenza pandemics.

31 rden through seasonal epidemics and sporadic pandemics.

32 H2N2, and H3N2 subtypes have caused previous pandemics.

33 and influenza A viruses intermittently cause pandemics.

34 idol in complex with influenza virus HA from pandemic 1968 H3N2 and recent 2013 H7N9 viruses.

35 s prior to the first historically documented pandemic [7].

36 ve predecessor and the oseltamivir-resistant pandemic A H1N1 strain that emerged and circulated in Ja

37 vestigating potential adverse effects of the pandemic A(H1N1) vaccine have supported that influenza A

38 ion of alpha-GalCer to piglets infected with pandemic A/California/04/2009 (CA04) H1N1 IAV ameliorate

39 Furthermore, using human immune sera from pandemic A/California/04/2009 immune subjects and mAbs s

40 The HIV-1 pandemic affecting over 37 million people worldwide cont

41 The HIV pandemic affects 36.9 million people worldwide, of whom

42 Over the last four decades the HIV pandemic and advances in medical treatments that also ca

43 a A group 1 viruses, including the 2009 H1N1 pandemic and avian H5N1 strains.

44 ence of mycoses is rising because of the HIV pandemic and because immunomodulatory drugs are increasi

45 f the world, and exacerbated by the HIV/AIDS pandemic and emergence of multidrug-resistant strains of

46 responses following challenge with H1N1 2009 pandemic and H3N2 viruses of mice that had been immunize

47 including the inferred ancestral viruses of pandemic and nonpandemic HIV-1 groups M (SIVcpzMB897) an

48 al and predictable, with the accuracy of pre-pandemic and real-time risk assessments hinging on relia

49 In the last few decades, the AIDS pandemic and the significant advances in the medical man

50 Influenza A virus causes pandemics and annual epidemics in the human population.

51 ical, especially with the prospect of future pandemics and for the effective development of a univers

52 widespread applications, from tracking virus pandemics and studying the macroevolutionary process of

53 subpopulation in the catastrophic influenza pandemic, and highest among the high-risk 0-19 years sub

54 accine to combat the hepatitis C virus (HCV) pandemic, and induction of broadly neutralizing monoclon

55 estral HIV-1 strains that founded the global pandemic, and very few complete genome sequences are ava

56 (IAV) causes annual epidemics and occasional pandemics, and is one of the best-characterized human RN

57 accounts for seasonal epidemics, infrequent pandemics, and zoonotic outbreaks.

58 In the event of a pandemic, antiviral agents are the mainstay for treatmen

59 s of the global burden of the 1957 influenza pandemic are lacking.

60 ected crises during their tenure, and global pandemics are among the most challenging.

61 e monitored for emerging IAVs.IMPORTANCE IAV pandemics are caused by the introduction of novel viruse

62 In addition, occasional pandemics are caused when IAVs circulating in other spec

63 ent of both seasonal influenza epidemics and pandemics are desirable.

64 This finding highlights how the 2009 pandemic arose from a region not considered a pandemic r

65 ealth Organization (WHO) to declare the ZIKV pandemic as a Public Health Emergency of International C

66 rains from the GII.4 genotype causing serial pandemics as the virus evolves new ligand binding and an

67 upplies are not unlikely in future influenza pandemics, as in the 2009 H1N1 influenza pandemic.

68 Zika virus (ZIKV) has recently emerged as a pandemic associated with severe neuropathology in newbor

69 cal infection, which is consistent with 2009 pandemic attack rates.

70 ent becomes the first line of defense during pandemics because there is insufficient time to produce

71 circulating T cell levels are reduced after pandemic, but not seasonal, IAV infection.

72 only the spring-summer timing of historical pandemics, but also early increases in pandemic severity

73 uenza A viruses can give rise to devastating pandemics, but currently it is impossible to predict the

74 Influenza pandemics can emerge unexpectedly and wreak global devas

75 health as both zoonotic agents and potential pandemic candidates.

76 r results consolidate historical accounts of pandemic cholera with data to show the importance of loc

77 USA300 is a pandemic clonal lineage of hypervirulent, community-acqu

78 s aureus (CA-MRSA) are the cause of a severe pandemic consisting primarily of skin and soft tissue in

79 The HIV pandemic continues to impose enormous morbidity, mortali

80 id substitution that has been adopted by all pandemic CV-A24v strains and we reveal that this adaptat

81 have occurred with increased frequency after pandemic declaration.

82 The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches tha

83 biotype is susceptible to CAMPs, but current pandemic El Tor biotype isolates gain CAMP resistance by

84 of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven line

85 cheap, safe and direct evidence relating to pandemic emergence, a field where indirect measurements

86 After a pandemic emergence, the virus has spread to much of Nort

87 an by the airborne route, a prerequisite for pandemic emergence.

88 y pose the greatest threats for zoonotic and pandemic emergence.IMPORTANCE Avian influenza viruses, s

89 tion are urgently needed to combat potential pandemics, emerging viruses, and constantly mutating str

90 In 2009, the global outbreak of an influenza pandemic emphasized the need for an effective vaccine ad

91 negatively correlated with that in the post-pandemic era (2010-2015) at the regional level.

92 B cases among the countries during the post-pandemic era (i.e. Week 1, 2010 to Week 40, 2015).

93 t increased after the influenza A(H1N1) 2009 pandemic from 72% in 2010-2011 to 89% in 2014-2015 (P <

94 vel of variability in the modelled number of pandemics from 2010-2110.

95 The emergence of pandemic GII.4 norovirus (NoV) strains has been proposed

96 979 and 2010 to block glycan binding of four pandemic GII.4 noroviruses isolated in the last 4 decade

97 ed for at least 6 years against 3 decades of pandemic GII.4 NoV.IMPORTANCE Human noroviruses (NoVs) a

98 The emergence of new pandemic GII.4 strains occurs at intervals of several ye

99 during natural coinfection of a patient with pandemic H1N1 (2009) and seasonal H1N1 influenza A virus

100 ) chains, a specificity shared with the 2009 pandemic H1N1 (Cal/04) hemagglutinin.

101 y coinfected with seasonal H1N1 (A/H1N1) and pandemic H1N1 (pdm/H1N1) during the Southern hemisphere

102 ssessed the public health risk of CIV-H3N2 x pandemic H1N1 (pdmH1N1) reassortants by characterizing t

103 luated the potential for viruses of the 2009 pandemic H1N1 (pH1N1) and seasonal H3N2 lineages to reas

104 Avian H9N2 and 2009 pandemic H1N1 (pH1N1) influenza viruses can infect pigs

105 sly shown that the NS1 protein from the 2009 pandemic H1N1 (pH1N1) virus is not able to inhibit gener

106 wn that the NS1 protein from this human 2009 pandemic H1N1 (pH1N1) virus was an effective interferon

107 th the PB2, NA, and M segments from the 2009 pandemic H1N1 (PH1N1) virus.In vitro and in vivo evaluat

108 d applies those tools to viruses of the 2009 pandemic H1N1 and seasonal H3N2 lineages, which currentl

109 st HAI response and protected mice against a pandemic H1N1 challenge were vaccines that contained the

110 temperature-sensitive, live-attenuated 2009 pandemic H1N1 IAV (pH1N1 LAIV).

111 It was reported that for the 2009 pandemic H1N1 IAV (pH1N1) only the PA-X protein had this

112 ed with alum, the protective efficacy of the pandemic H1N1 influenza (pH1N1) vaccine was substantiall

113 Here, we show that both 2009 pandemic H1N1 influenza A (H1N1) virus and highly pathog

114 a COBRA-based vaccine for both seasonal and pandemic H1N1 influenza virus isolates.

115 ently characterized two swine viruses of the pandemic H1N1 lineage, A/swine/Virginia/1814-1/2012 (pH1

116 gglutinin was identified that increases 2009 pandemic H1N1 virus binding to human-like alpha2,6-linke

117 The 2009 pandemic H1N1 virus continues to circulate and reassort

118 we show that distinct mutations in the 2009 pandemic H1N1 virus genome have occurred with increased

119 tibodies specific for the HA1 subunit of the pandemic H1N1 virus, and analyzed the correlation with t

120 H1N1 viruses that are derived from the 2009 pandemic H1N1 viruses.

121 During the 2015-16 influenza season, when pandemic H1N1 was the predominant virus, studies from th

122 tion of multiple IAV strains including H1N1, pandemic H1N1, H3N2 and H5N1, which supports the "wedge"

123 s during the 2012-2013 (H3N2) and 2013-2014 (pandemic H1N1; H1N1pdm) flu seasons.

124 al vector expressing NA from avian (H5N1) or pandemic (H1N1) influenza virus, elicited NA-specific an

125 People continue to spread the 2009 H1N1 pandemic (H1N1pdm09) IAV to pigs, allowing H1N1pdm09 to

126 Our findings suggest that the 2009 influenza pandemic has an evident impact on the relative burden of

127 The seventh cholera pandemic has heavily affected Africa, although the origi

128 ructions in Bayesian phylogeography of virus pandemics have been improved by utilizing a Bayesian sto

129 Additionally, the 2009 IAV pandemics highlighted the role of pigs in the emergence

130 o promote virus release from infected cells, pandemic HIV-1 group M strains evolved Vpu as a tetherin

131 rse primate lentiviruses including different pandemic HIV-1 group M subtypes for their ability to dow

132 from diverse primate lentiviruses including pandemic HIV-1 group M subtypes, we demonstrate that Nef

133 rrelates with their phylogenetic distance to pandemic HIV-1.

134 ture and the formation of novel epidemic and pandemic IAV strains.

135 Pandemic IAV suppresses this immunogenic DC cell death.

136 DC infected with seasonal IAV, but not with pandemic IAV, enhance maturation of uninfected DC and T

137 Pandemic IAVs emerge through reassortment of vRNA in ani

138 sentative group I (H5N1) and group II (H7N9) pandemic IAVs in mice and ferrets and could be used to b

139 s involved in the continually evolving HIV-1 pandemic.IMPORTANCE Very little is known about the ances

140 nt, which predate the first reported cholera pandemic in 1817, broadens our understanding of the hist

141 ses is important because H2 viruses caused a pandemic in 1957 and could cross into humans again.

142 The spread of the 2009 H1N1 influenza pandemic in England was characterized by two major waves

143 The recent Zika pandemic in the Americas is linked to congenital birth d

144 ecently as a global health threat, causing a pandemic in the Americas.

145 f the vaccination program in relation to the pandemic in the Northern hemisphere.

146 We simulated influenza pandemics in Chicago using agent-based transmission dyna

147 ct of vaccine interventions during influenza pandemics in Chicago, and assist in vaccine intervention

148 tury [4]; and the most recent 19(th) century pandemic, in which Y. pestis spread worldwide [5] and be

149 veloped to indefinitely control the HIV/AIDS pandemic; in individual patients, these engineered molec

150 mplex 5 (A:cc5), has caused three successive pandemics, including epidemics in sub-Saharan Africa.

151 (Bd) has caused the greatest known wildlife pandemic, infecting over 500 amphibian species.

152 Emerging pandemic infectious threats, inappropriate antibacterial

153 ine candidate expressing NA (PIV5-NA) from a pandemic influenza (pdmH1N1) virus or highly pathogenic

154 The risk of emerging pandemic influenza A viruses (IAVs) that approach the de

155 a mixing vessel for the generation of novel pandemic influenza A viruses through reassortment becaus

156 The 2009 pandemic influenza A(H1N1) (A[H1N1]pdm09) vaccine compon

157 After 2009, pandemic influenza A(H1N1) [A(H1N1)pdm09] cocirculated w

158 onfidence interval [CI], 2.61-6.13) for 2009 pandemic influenza A(H1N1) and 1.76 (95% CI, 1.33-2.32)

159 Three donor ferrets infected with 2009 pandemic influenza A(H1N1) underwent daily quantitative

160 To evaluate whether pandemic influenza A(H1N1) vaccination in pregnancy incr

161 s season was characterized by a delayed 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) epidemic

162 3N2) virus infection (P = .002) but not 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) or influ

163 nfluenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains

164 unit vaccine (ISV) targeting monovalent 2009 pandemic influenza A(H1N1) virus or live-attenuated infl

165 Among patients with 2009 pandemic influenza A(H1N1), ratios for hIVIG (n = 9) ver

166 asonal influenza A/Panama/2007/99 (H3N2) and pandemic influenza A/Netherlands/602/2009 (H1N1) viruses

167 Seasonal and pandemic influenza is a cause of morbidity and mortality

168 International Health Regulations (2005), and Pandemic Influenza Preparedness Framework-strives for a

169 paradigms in disease, ranging from cancer to pandemic influenza to Alzheimer's disease.

170 le with multiple gene segments from the 2009 pandemic influenza virus strain without prior adaptation

171 HA protein is central to the emergence of a pandemic influenza virus, its required molecular propert

172 tween prior exposures to seasonal and recent pandemic influenza viruses and the development of hetero

173 Pandemic influenza viruses have consistently higher atta

174 In addition to seasonal infections, emerging pandemic influenza viruses present a continued threat to

175 These results show how pandemic influenza viruses subvert the immune response.

176 -reactive T cells provide protection against pandemic influenza viruses.

177 icant epidemiological impact on seasonal and pandemic influenza.

178 t have contributed to disease severity after pandemic initiation.

179 The current global obesity pandemic is clearly linked to both the increasing preval

180 We have developed pandemic live attenuated influenza vaccines (pLAIVs) aga

181 s for vaccination and influenza epidemic and pandemic mitigation strategies.

182 unemployment, were assessed as predictors of pandemic mortality in Chicago.

183 n ST131, with accurate identification of the pandemic multidrug-resistant clonal subgroup ST131-H30.

184 Current pandemic O1 Vibrio cholerae biotype El Tor is resistant

185 Influenza pandemics occur unpredictably when zoonotic influenza vi

186 Despite a large body of evidence showing the pandemic of chronic kidney disease, the impact of pre-op

187 We now face a global CPO pandemic of high mortality.

188 Although the rising pandemic of obesity has received major attention in many

189 To be able to curb the global pandemic of physical inactivity and the associated 5.3 m

190 The global pandemic of physical inactivity requires a multisectoral

191 The 14th-18th century pandemic of Yersinia pestis caused devastating disease o

192 Furthermore, IAVs can cause unpredictable pandemics of great consequence when viruses not previous

193 The impact of the pandemic on mortality was delayed in several countries,

194 gize to markedly blunt the effect of the HIV pandemic on society.

195 possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti

196 humans, causing sporadic infections and even pandemic outbreaks.

197 1.04% (95% CI: 0.15, 3.2) for the 2009 H1N1 pandemic, owing to the late timing of the vaccination pr

198 important source of influenza A virus (IAV) pandemics, owing to large, diverse viral reservoirs in p

199 ome highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficien

200 iments involving the creation of potentially pandemic pathogens.

201 Eurasian avian-like (EA) swine H1N1 and 2009 pandemic (pdm/09) H1N1 viruses, reassortment between the

202 proportions of influenza B cases in the pre-pandemic period (2003-2008) negatively correlated with t

203 oncern due to the potential acquisition of a pandemic phenotype.

204 st that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored.

205 hich novel strains of IAVs with zoonotic and pandemic potential can emerge.

206 s and data sources, and assessed subnational pandemic potential for four viral haemorrhagic fevers in

207 issibility in ferrets and is associated with pandemic potential in humans.

208 lity of these viruses further highlights the pandemic potential of AIVs in the wild bird reservoir an

209 ut currently it is impossible to predict the pandemic potential of circulating avian influenza viruse

210 The tremendous pandemic potential of coronaviruses was demonstrated twi

211 The tremendous pandemic potential of coronaviruses was demonstrated twi

212 tment has implications for assessment of the pandemic potential of newly emerged influenza viruses, f

213 to quickly identify an emerging strain with pandemic potential.

214 ns and are therefore considered viruses with pandemic potential.

215 H5N1 viruses has raised concerns about their pandemic potential.

216 ction with these viruses and their perceived pandemic potential.

217 ing which factors are necessary to determine pandemic potential.

218 e role of pigs in the emergence of IAVs with pandemic potential.

219 s to expand their host range, virulence, and pandemic potential.

220 aviruses, which have high fatality rates and pandemic potential.

221 laxis or therapy of group I and II IAVs with pandemic potential.

222 major concern for emergence of viruses with pandemic potential.

223 ease the risk of human infection and elevate pandemic potential.

224 Current pandemic preparations involve stock- piling oseltamivir,

225 In conjunction with pandemic preparedness activities, assessments such as ou

226 viruses is critical for risk assessment and pandemic preparedness.

227 of the live attenuated influenza vaccine for pandemic preparedness.

228 lation for IAVs is an important component of pandemic preparedness.

229 asonal influenza virus infection and improve pandemic preparedness.

230 importance of developing an H10 vaccine for pandemic preparedness.IMPORTANCE Avian origin H10 influe

231 ccines against influenza virus and can guide pandemic-preparedness efforts directed against emerging

232 and drivers of such evolution, to prioritize pandemic prevention or response measures.

233 The 2009 H1N1 pandemic provided an opportunity to investigate whether

234 inistration, the government faced unexpected pandemics, ranging from the HIV/AIDS pandemic, which beg

235 e heterogeneous landscape and drivers of the pandemic remains unclear.

236 AVs) cause seasonal epidemics and occasional pandemics, representing a serious public health concern.

237 Influenza pandemics require rapid deployment of effective vaccines

238 with a focus on the epidemiology of the CPE pandemic; review risk factors for colonization and infec

239 al influenza viruses is key to understanding pandemic risk and informing preparedness.

240 o improve surveillance efforts to assess the pandemic risk by emerging influenza viruses.

241 Thus, pandemic risk may be seasonal and predictable, with the

242 d be considered during the assessment of the pandemic risk of zoonotic influenza A viruses.

243 ng, prompting a need for tools to assess the pandemic risk posed by a detected virus.

244 andemic arose from a region not considered a pandemic risk, owing to an expansion of IAV diversity in

245 catastrophic, strong, and moderate influenza pandemic scenarios, due to their larger social contact n

246 rical pandemics, but also early increases in pandemic severity and multiple waves of transmission.

247 e analyse the time periods between influenza pandemics since 1700 under different assumptions to dete

248 However, each of the six pandemics since 1889 emerged in the Northern Hemisphere

249 the adaptation to the eye, possibly enabling pandemic spread.

250 es (T2D) has attained the status of a global pandemic, spreading from affluent industrialized nations

251 The threat of an influenza A virus pandemic stems from continual virus spillovers from rese

252 the laboratory strain (A/PR/08/1934) or the pandemic strain (A/CA/04/2009) of IAV.

253 ous pandemic strain stimulates immunity to a pandemic strain identified decades later.

254 resistant to polymyxins, whereas a previous pandemic strain of the biotype Classical is polymyxin-se

255 mains unclear whether exposure to a previous pandemic strain stimulates immunity to a pandemic strain

256 c detection of particular strains, such as a pandemic strain versus a previous seasonal influenza, pl

257 le in the emergence of genetically "shifted" pandemic strains as well as its potential role as a cata

258 ns to determine whether the emergence of new pandemic strains is a memoryless or history-dependent pr

259 the natural history of GAS, the evolution of pandemic strains, and novel roles for several key virule

260 easonal IAVs, but not with the 1918 and 2009 pandemic strains, induces global RNA degradation.

261 olecular and evolutionary changes leading to pandemic strains.

262 r cross-neutralizing antibodies to potential pandemic strains.

263 Because viral pandemics, such as influenza, Ebola, and Zika, are becom

264 n, or spillover, are therefore key goals for pandemic surveillance programs.

265 The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century esta

266 er of the human immunodeficiency virus (HIV) pandemic, the Democratic Republic of the Congo (DRC) is

267 Historically it was responsible for three pandemics: the Plague of Justinian in the 6(th) century

268 H2 influenza viruses represent a pandemic threat due to continued circulation in wild bir

269 The pandemic threat posed by emerging zoonotic influenza A v

270 ivity patterns under the pressure posed by a pandemic threat.

271 Most pandemic threats are caused by viruses from either zoono

272 , and the scientific community to respond to pandemic threats when sufficient prior knowledge exists,

273 uses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such e

274 es, and enabled an international response to pandemic threats.

275 emerging influenza viruses continue to pose pandemic threats.

276 erface of influenza, with a focus on current pandemic threats.

277 ually, while emerging viruses pose potential pandemic threats.

278 cine against seasonal influenza and emerging pandemic threats.IMPORTANCE Seasonal influenza viruses c

279 e just after the flu season, suggesting that pandemic timing may be predictable.

280 ng social disruption, being able, early in a pandemic, to immunize those who had received prepandemic

281 The incidence of stillbirth following pandemic vaccination has been previously studied; howeve

282 ly required, would reduce the total doses of pandemic vaccine then needed, extending vaccine supplies

283 ved prepandemic vaccine with one dose of the pandemic vaccine, rather than the 2 doses typically requ

284 e relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial popu

285 Repeated spillovers of the H1N1 pandemic virus (H1N1pdm09) from humans to pigs resulted

286 g reassortants of CIV-H3N2 and the 2009 H1N1 pandemic virus (pdmH1N1) have been isolated.

287 virus reassortants resembling the 1918 human pandemic virus can become transmissible among mammals by

288 abs and lungs, following challenge with H1N1 pandemic virus.

289 inin (HA) protein or reassortment with other pandemic viruses endow HPAI H5N1 viruses with the potent

290 eins of avian-derived IAVs that became human pandemic viruses.

291 human immunodeficiency virus type 1 (HIV-1) pandemic was ignited in Leopoldville (now known as Kinsh

292 To address the chikungunya fever (CHIKF) pandemic, we used an EILV cDNA clone to design a chimeri

293 ng (21.96%), and moderate (11.73%) influenza pandemics were compared against vaccine intervention sce

294 pe, which is imperative in demonstrating how pandemics were spread in recent human history.

295 sporadic infections or spread worldwide in a pandemic when novel strains emerge in the human populati

296 xpected pandemics, ranging from the HIV/AIDS pandemic, which began during the Reagan administration,

297 large-scale antiviral interventions during a pandemic with co-circulation of AVS and AVR strains, our

298 Control of the HCV pandemic with drug treatment alone is likely to fail due

299 nza A viruses have caused a number of global pandemics, with considerable mortality in humans.

300 xplored birth cohort effects referencing the pandemic years (1957; 1968).