ライフサイエンスコーパス: panic

1 (2), which might be related to CO(2) induced panic.

2 ch, in summary, is with interest and without panic.

3 lization, all of which are key components of panic.

4 yet understudied, conditioning correlate of panic.

5 and societal concern, sometimes bordering on panic.

6 vely specific association between asthma and panic.

7 Moral panic about the claim that antidepressant serotonin reup

8 the same CpG was positively associated with Panic and Agoraphobia scale (PAS) scores (beta=0.005, SE

9 gnoses of anxiety, mixed anxiety/depression, panic and anxiety symptoms.

10 f panic disorder distinguishes between acute panic and anxious apprehension as distinct emotional sta

11 with time after ICU discharge, particularly panic and confusion.

12 r groups: offspring of referred parents with panic and depression (N=137), offspring of referred pare

13 Parental panic and depression interacted to predict specific phob

14 atients with other anxiety disorders (mainly panic and posttraumatic stress disorders) had decreased

15 if purposefully released, would cause public panic and social disruption.

16 = 0.20-0.21); this association broadened to panic and social phobia symptoms in adolescence (r = 0.1

17 at the amygdala is not required for fear and panic, and make an important distinction between fear tr

18 rks (labeled SEEING, RAGE, FEAR, LUST, CARE, PANIC, and PLAY systems) that evoke distinct emotion act

19 ed positive screens for depression, anxiety, panic, and posttraumatic stress disorder in relation to

20 or depressive, bipolar, generalized anxiety, panic, and posttraumatic stress) and externalizing (atte

21 em may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a pote

22 Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebro

23 that carbon dioxide inhalation could induce panic anxiety in a group of rare lesion patients with fo

24 with focal bilateral amygdala lesions report panic anxiety in response to intravenous infusions of is

25 The induction of panic anxiety provides further evidence that the amygdal

26 not strictly required for the experience of panic anxiety, and suggest that neural systems beyond th

27 a are fundamental to the human experience of panic anxiety, but it remains unclear how the brain dyna

28 brospinal fluid compared to subjects without panic anxiety.

29 s known about the cardiovascular sequelae of panic anxiety.

30 ptive channels would be sufficient to elicit panic anxiety.

31 hological pain that may arise from excessive PANIC arousal, and 3) facilitation of social joy through

32 rgy were important confounders of the asthma-panic association.

33 No subject had a panic attack before hyperventilation.

34 , the exact mechanism of lactate eliciting a panic attack is still unknown.

35 During the panic attack, a strong association with the surrounding

36 icipation of the next uncued (unpredictable) panic attack.

37 f internal and external cues predictive of a panic attack.

38 in both twins, with one twin experiencing a panic attack.

39 tion exists about the epidemiology of DSM-IV panic attacks (PAs) and panic disorder (PD).

40 any anxiety disorder [OR = 1.3 (1.1, 1.6)], panic attacks [OR = 1.6 (1.1, 2.1)], panic disorder [OR

41 , neutral conditioned stimuli present during panic attacks acquire panicogenic properties.

42 ed anxiety and sympathetic drive seen during panic attacks and in hypercapnic states such as COPD.

43 Panic attacks are a hallmark in panic disorder (PAND).

44 Panic attacks are relatively common among postmenopausal

45 Individuals with panic disorder perceive panic attacks as unpredictable.

46 o Pavlovian conditioning, failure to predict panic attacks could be due to a basic deficit in conditi

47 ion between A2AR polymorphisms and phobia or panic attacks in humans and prompts a therapeutic intere

48 oradrenergic agent yohimbine reliably induce panic attacks in humans with panic disorder but not in h

49 r in panic disorder, evokes intense fear and panic attacks in susceptible individuals.

50 ompleted a questionnaire about occurrence of panic attacks in the previous 6 months.

51 of the respiratory dysfunction manifested in panic attacks occurring in panic disorder.

52 set and was less likely to be complicated by panic attacks or alcoholism.

53 tic anxiety ratings, but not the presence of panic attacks or of any lifetime anxiety disorder, added

54 sorder, with anxiety disorders (particularly panic attacks) being the most common comorbid condition.

55 ionnaire-2 [PHQ-2], GAD-2, and an item about panic attacks), and a diagnostic evaluation using PHQ-9

56 two were characterized by past or concurrent panic attacks, a rate that was not significantly differe

57 A 6-month history of full-blown panic attacks, endorsed by 10% of postmenopausal women i

58 of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amy

59 common in women and are not associated with panic attacks, suggesting a late-life subtype.

60 the pattern observed during the 34 reported panic attacks.

61 AS predicts panic attacks.

62 ically to suppress excessive arousal such as panic attacks.

63 nxiety disorder with recurrent, debilitating panic attacks.

64 condition caused by the experience of uncued panic attacks.

65 n implicated in the pathophysiology of acute panic attacks.

66 nxious children susceptible to CO(2)-induced panic, but the effects of parent diagnosis were not cons

67 Ebola outbreak because it shows how fear and panic can endanger the individual, our society, and our

68 y responses to acute exposure to a threshold panic challenge (ie, 20% CO(2)/normoxic gas).

69 ith panic, resulting in the proliferation of panic cues.

70 r (27%), generalized anxiety disorder (10%), panic disorder (10%), or complicated grief disorder (5%)

71 MDD (47%), specific phobia (24%), panic disorder (16%), obsessive-compulsive disorder (9%)

72 lized anxiety disorder (31%), agoraphobia or panic disorder (22%), social phobia (17%), and specific

73 anxiety disorder (21 versus 2%, P < 0.005), panic disorder (36 versus 13%, P < 0.001) and somatizati

74 Primary care patients with panic disorder (N=232) who were participating in a rando

75 recurrent major depressive disorder (N=224), panic disorder (N=75), bipolar II disorder (N=62), or bi

76 .9), anxiety (OR 3.2, 95% CI 2.8 to 3.6) and panic disorder (OR 3.4, 95% CI 2.9 to 4.0).

77 pts in multivariate analysis: pre-enlistment panic disorder (OR = 0.1 [95% CI, 0.0-0.8]), pre-enlistm

78 xiety disorder (OR, 1.3; 95% CI, 1.06-1.49), panic disorder (OR, 1.3; 95% CI, 1.06-1.59), and social

79 ssion (OR, 4.8 [95% CI, 1.2-19.4]; P < .05), panic disorder (OR, 14.5 [95% CI, 5.7-36.6]; P < .001),

80 y (OR, 2.7 [95% CI, 1.1-6.3]; P < .001), and panic disorder (OR, 3.1 [95% CI, 1.5-6.5]; P < .01) and

81 0.46, P<0.001), and the panic item predicted panic disorder (OR=49.61, P<0.001).

82 Panic attacks are a hallmark in panic disorder (PAND).

83 Individuals with panic disorder (PD) exhibit a hypersensitivity to inhale

84 ecular genetics approaches in examination of panic disorder (PD) has implicated several variants as p

85 Panic disorder (PD) is a debilitating anxiety disorder c

86 Prior evidence suggests panic disorder (PD) is characterized by neurometabolic a

87 rasting the SAD group to a separate group of panic disorder (PD) subjects.

88 with generalized anxiety disorder (GAD) and panic disorder (PD) to generate individual subject treat

89 The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) ar

90 (PTSD), generalized anxiety disorder (GAD), panic disorder (PD), and phobias (agoraphobia, social ph

91 (MD), generalized anxiety disorder (GAD) and panic disorder (PD), as well as depressed affect and anx

92 idemiology of DSM-IV panic attacks (PAs) and panic disorder (PD).

93 aimed to evaluate CRHR1 as a risk factor for panic disorder (PD).

94 s postulated to be a familial risk marker of panic disorder (PD).

95 hether these features discriminated SAD from panic disorder (PD, N=16), and SAD from controls in an i

96 umber at risk: 4200), PTSD 31.9% (4342), and panic disorder 21.2% (4953).

97 number at risk: 3648), PTSD 9.3% (3761), and panic disorder 8.4% (3780).

98 1.6)], panic attacks [OR = 1.6 (1.1, 2.1)], panic disorder [OR = 1.6 (1.01, 2.3)], GAD [OR = 1.8 (1.

99 Fourteen patients with panic disorder and 14 controls, individually matched for

100 eteen patients with a DSM-IV-TR diagnosis of panic disorder and 19 healthy comparison subjects were r

101 n 19 individuals meeting DSM-IV criteria for panic disorder and 19 sex- and age-matched healthy compa

102 reactivity in a large group of patients with panic disorder and agoraphobia (PD/AG).

103 Panic disorder and agoraphobia patients differed substan

104 disorder significantly increases the risk of panic disorder and any anxiety disorder.

105 Panic disorder and avoidant personality disorder were as

106 Individuals with panic disorder and comorbid depression, indicative of a

107 ing high-risk study of offspring at risk for panic disorder and depression (N=278) that had included

108 Panic disorder and GAD do not contribute to adverse preg

109 cence in offspring of parents with confirmed panic disorder and major depressive disorder.

110 ed study tested the hypothesis that parental panic disorder and offspring response to CO(2) are assoc

111 anxiety disorder in childhood leads to adult panic disorder and other anxiety disorders.

112 Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are cons

113 iety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically co

114 proclivity toward fear overgeneralization in panic disorder and provide a methodology for laboratory-

115 (n = 51), comorbid MDD and anxiety (n = 59), panic disorder and/or social anxiety disorder without co

116 ings, generalized anxiety disorder (GAD) and panic disorder are common but underrecognized illnesses.

117 to test the hypothesis that individuals with panic disorder are impaired in associative learning task

118 Patients with panic disorder are overly sensitive to unpredictable ave

119 reliably induce panic attacks in humans with panic disorder but not in healthy controls.

120 ictability could be etiologically related to panic disorder by sensitizing an individual to danger, u

121 ed assessment of this potential correlate of panic disorder by testing the degree to which panic pati

122 ls, delayed pCO(2) recovery in subjects with panic disorder could reflect slower pH normalization in

123 d to explain these results: 1) subjects with panic disorder demonstrate greater alkalosis to hyperven

124 s directly compensatory, or 2) subjects with panic disorder demonstrate reduced or blunted alkalosis,

125 For example, adults with panic disorder did not have histories of juvenile disord

126 o healthy comparison subjects, patients with panic disorder displayed equivalent levels of fear-poten

127 The learning perspective of panic disorder distinguishes between acute panic and anx

128 ndard CBT and pharmacotherapy treatments for panic disorder do not need to be "tailored" to be effect

129 dal CO(2) (pCO(2)) recovery in subjects with panic disorder during hyperventilation suggested altered

130 l from 4.0 to 2.2/1000PYAR, and incidence of panic disorder fell from 0.9/1000PYAR in 1998 to 0.5/100

131 e this different respiratory response in the panic disorder group, brain pH increases were not signif

132 f healthy subjects showed pH blunting in the panic disorder group.

133 Although subjects with panic disorder had greater hypocapnea during hyperventil

134 Subjects with panic disorder had lower pCO(2) during hyperventilation

135 d feasible screening instruments for GAD and panic disorder has the potential to improve detection an

136 has been implicated in an increased risk of panic disorder in humans.

137 unique studies for the detection of GAD and panic disorder in primary care patients Across all studi

138 predicted new onset of depression, parental panic disorder independently predicted new onset of soci

139 Panic disorder is a common mental disorder that affects

140 Panic disorder is a severe anxiety disorder with recurre

141 anxiety disorder were more likely to develop panic disorder later on (odds ratio=3.45; 95% CI=2.37-5.

142 In adjusted models, neither panic disorder nor GAD was associated with maternal or n

143 disorder (OR, 1.47; 95% CI, 1.12-1.93), and panic disorder or agoraphobia (OR, 1.27; 95% CI, 1.01-1.

144 To determine whether panic disorder or generalized anxiety disorder (GAD) in

145 fferences were not accounted for by parental panic disorder or major depression or by parental histor

146 spring of adults presenting for treatment of panic disorder or major depressive disorder.

147 Thirteen panic disorder participants and 13 matched control subje

148 tly greater increase in the visual cortex of panic disorder participants.

149 sual cortex and anterior cingulate cortex of panic disorder participants.

150 Individuals with panic disorder perceive panic attacks as unpredictable.

151 drugs that are clinically effective against panic disorder preferentially alter rodent flight behavi

152 Scores on the Panic Disorder Severity Scale are also highest for PD-AG

153 The Panic Disorder Severity Scale, rated by blinded independ

154 Generalized Anxiety Disorder Severity Scale, Panic Disorder Severity-Self-report Scale, Social Phobia

155 tion (73% versus 39%), using the Multicenter Panic Disorder Study response criteria.

156 These results suggest that individuals with panic disorder suffer from a deficit in declarative asso

157 The false-suffocation hypothesis of panic disorder suggested delta-opioid receptors as a pos

158 ntribute to the maintenance and worsening of panic disorder symptoms by increasing anticipatory anxie

159 T1rho imaging may provide information about panic disorder that is distinct from conventional BOLD i

160 In individuals with panic disorder there is evidence of decreased central ga

161 -2 was an effective screening tool; however, panic disorder was rare.

162 The best-performing test for panic disorder was the Patient Health Questionnaire, wit

163 Nine subjects with panic disorder were compared to 11 healthy subjects at b

164 viduals with DSM-IV-defined anxiety syndrome panic disorder were compared with 21 unaffected healthy

165 Twenty-eight untreated patients with panic disorder were randomized to a single session of ex

166 Asymptomatic medicated patients with panic disorder were studied during regulated hyperventil

167 ts (n = 42), treatment-seeking patients with panic disorder with agoraphobia (n = 25), and 17 healthy

168 al factor in the etiology and maintenance of panic disorder with agoraphobia (PD/A).

169 ontrol participants as well as patients with panic disorder with agoraphobia and generalized social a

170 Evidence suggests that panic disorder with agoraphobia is characterized by dysf

171 y (CBT) is an effective treatment option for panic disorder with agoraphobia, the neural substrates o

172 ted with treatment response in patients with panic disorder with agoraphobia.

173 ated with treatment outcome in patients with panic disorder with agoraphobia.

174 on-free patients with a primary diagnosis of panic disorder with agoraphobia.

175 eatment center with a principal diagnosis of panic disorder with or without agoraphobia, generalized

176 ng specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-co

177 , post-traumatic stress disorder [PTSD], and panic disorder), and spirometric abnormalities.

178 of parents with depression (with or without panic disorder), with the highest rates in the offspring

179 ved a diagnosis (143 depression, 129 GAD, 30 panic disorder).

180 ychiatric diagnoses (depression, anxiety and panic disorder).

181 rientation, 5.14 (95% CI=4.54-5.82); and for panic disorder, 1.45 (95% CI=1.15-1.85).

182 ssive-compulsive disorder, 2.5% vs. 6.7% for panic disorder, 12.6% vs. 25.3% for social phobia, 9.1%

183 re non-Hispanic white (1957 [73.7%]), 98 had panic disorder, 252 had GAD, 67 were treated with a benz

184 , specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalised anxiety dis

185 in offspring of multiple anxiety disorders, panic disorder, agoraphobia, social phobia, and obsessiv

186 or depression, generalized anxiety disorder, panic disorder, agoraphobia, social phobia, animal phobi

187 ety disorders (generalized anxiety disorder, panic disorder, agoraphobia, social phobia, animal phobi

188 hymia, bipolar disorder), anxiety disorders (panic disorder, agoraphobia, specific phobia, social pho

189 iety disorder, 6.8% (CI, 5.3% to 8.6%) had a panic disorder, and 6.2% (CI, 4.7% to 7.9%) had a social

190 l illnesses (eg, asthma) commonly occur with panic disorder, and certain lifestyle factors (eg, smoki

191 icide attempt, psychosis, mania, depression, panic disorder, and delirium, confusion, or disorientati

192 generalized anxiety disorder, social phobia, panic disorder, and posttraumatic stress disorder) among

193 he life course for major depressive episode, panic disorder, and posttraumatic stress disorder.

194 Major depressive disorder (MDD), panic disorder, and social anxiety disorder are among th

195 et was lower and rates of attempted suicide, panic disorder, and substance abuse were higher than amo

196 idence rates of depression, mania, delirium, panic disorder, and suicidal behaviors in patients treat

197 cifically post-traumatic stress disorder and panic disorder, and therefore represents an endophenotyp

198 In a rat model of panic disorder, chronic inhibition of GABA synthesis in

199 iological challenge and pathologic marker in panic disorder, evokes intense fear and panic attacks in

200 Panic disorder, GAD, or use of benzodiazepines or seroto

201 GAD and the Patient Health Questionnaire for panic disorder, have good performance characteristics an

202 Parental panic disorder, independently of parental depression, pr

203 of 131 offspring (ages 9-19) of parents with panic disorder, major depression, and no mental disorder

204 d in several debilitating conditions such as panic disorder, major depression, schizophrenia, alcohol

205 ation anxiety disorder with regard to future panic disorder, major depressive disorder, any anxiety d

206 Registry data show that maternal panic disorder, or anxiety disorders in general, increas

207 Neither parents with panic disorder, parents with major depression, or offspr

208 In panic disorder, persistent symptoms of anxiety are cause

209 months, including major depressive disorder, panic disorder, posttraumatic stress disorder (PTSD), op

210 and adolescents with confirmed diagnoses of panic disorder, social anxiety disorder, specific phobia

211 Associations between AUD and panic disorder, specific phobia, and generalized anxiety

212 lists, the majority inexperienced in CBT for panic disorder, were trained to deliver the CBT and coor

213 ocial anxiety disorder, specific phobia, and panic disorder.

214 ese data support the learning perspective of panic disorder.

215 zodiazepines, which are widely used to treat panic disorder.

216 ication treatment was observed in visits for panic disorder.

217 ion manifested in panic attacks occurring in panic disorder.

218 itute a potential new treatment strategy for panic disorder.

219 prominently in many etiological accounts of panic disorder.

220 tions for novel treatments and prevention in panic disorder.

221 vents, is a psychophysiological correlate of panic disorder.

222 hysical symptoms prominently associated with panic disorder.

223 tical psychotherapy for patients with DSM-IV panic disorder.

224 anic-focused psychodynamic psychotherapy for panic disorder.

225 ere 49 adults ages 18-55 with primary DSM-IV panic disorder.

226 inical trial of subjects with primary DSM-IV panic disorder.

227 sions, a phenomenon similar to patients with panic disorder.

228 epression, generalized anxiety disorder, and panic disorder.

229 e effective than usual care for primary care panic disorder.

230 ithin a region previously linked strongly to panic disorder.

231 relevance to psychiatric conditions such as panic disorder.

232 of 2637 patients assessed had a diagnosis of panic disorder.

233 as been suggested to play a critical role in panic disorder.

234 ns are consistent with a pH dysregulation in panic disorder.

235 sion were commonest aged 45-64 years, whilst panic disorder/attacks were more common in those 16-44 y

236 sion, generalized anxiety disorder (GAD), or panic disorder; understand the predictive value of indiv

237 potential therapeutic target in anxiety and panic disorders.

238 tion for dissecting the bases of anxiety and panic disorders.

239 ing instinctive fear and human emotional and panic disorders.

240 The twin who did not panic displayed signs of impaired cardiorespiratory inte

241 sions revealed that CO2 can trigger fear and panic even in the absence of amygdalae, suggesting the i

242 it has demonstrated preliminary efficacy of panic-focused psychodynamic psychotherapy for panic diso

243 Subjects in panic-focused psychodynamic psychotherapy had significan

244 All subjects received assigned treatment, panic-focused psychodynamic psychotherapy or applied rel

245 this study was to determine the efficacy of panic-focused psychodynamic psychotherapy relative to ap

246 Furthermore, those receiving panic-focused psychodynamic psychotherapy were significa

247 cacy randomized controlled clinical trial of panic-focused psychodynamic psychotherapy, a manualized

248 errors correlated with subjective reports of panic for the high compared with low probability of capt

249 rder (ie, major depressive episode, phobias, panic, generalized anxiety disorder, and obsessive-compu

250 2 broad groups of disorders dichotomized as panic-generalized-agoraphobic anxiety vs the specific ph

251 on between a fungal endophyte and a tropical panic grass allows both organisms to grow at high soil t

252 t also varied by diagnosis (bipolar I > or = panic > bipolar II > or = major depressive disorder) but

253 ced anxiety in both patients, and full-blown panic in one (patient B.G.).

254 ministered during two separate conditions: a panic induction and an assessment of cardiorespiratory i

255 at has relevance today-namely, that fear and panic intensified the disruption of society and damage t

256 Although the major societal burden of panic is caused by PD and PA-AG, isolated PAs also have

257 ontrol worrying: OR=10.46, P<0.001), and the panic item predicted panic disorder (OR=49.61, P<0.001).

258 -or-flight response, as well as anxiety- and panic-like behaviors in rodents.

259 cytochemistry, we found that rats exhibiting panic-like responses (e.g., L-AG plus lactate) had incre

260 odium lactate infusions or yohimbine elicits panic-like responses (i.e., anxiety, tachycardia, hypert

261 of saralasin into the DMH did not block the panic-like responses elicited by intravenous infusions o

262 glutamate receptors regulate lactate-induced panic-like responses in rats with GABA dysfunction in th

263 utamatergic receptors in the lactate-induced panic-like responses in these rats.

264 tative substrates for sodium lactate-induced panic-like responses in vulnerable subjects.

265 DMH of these panic-prone rats also elicited panic-like responses that were blocked by pretreatment w

266 ry only those rats with L-AG pumps exhibited panic-like responses to lactate infusions.

267 n the dorsomedial hypothalamus (DMH) develop panic-like responses, defined as tachycardia, tachypnea,

268 physiological components of lactate-induced panic-like responses.

269 or developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic ge

270 In 'sudden onset' cases, panic (n=29, 59%), dissociative symptoms (n=19, 39%) and

271 of referred parents with depression without panic (N=48), and offspring of nonreferred parents with

272 ors including: cold, heat, hypoxia, pain and panic on the contributions of fR and VT to VE to see if

273 t generalized anxiety, obsessive-compulsive, panic, or posttraumatic stress disorders; social phobia;

274 anic disorder by testing the degree to which panic patients and healthy subjects manifest generalizat

275 Panic patients displayed stronger conditioned generaliza

276 Conditioned fear in panic patients generalized to rings with up to three uni

277 rms included depression, dysthymia, anxiety, panic, phobia, obsession, compulsion, posttraumatic, car

278 ect injections of A-II into the DMH of these panic-prone rats also elicited panic-like responses that

279 sizing neurons is necessary for developing a panic-prone state in the rat panic model, and either sil

280 ceptor antagonist saralasin into the DMH of "panic-prone" rats blocked the anxiety-like and physiolog

281 a sporadic cluster of mental comorbidities (panic, PTSD, conduct disorder and substance use disorder

282 re during the circa-strike threat, and these panic-related locomotor errors were correlated with midb

283 cardiac sensation, patient A.M., who did not panic, reported a complete lack of awareness for dyspnea

284 wers brain pH and induces anxiety, fear, and panic responses in humans.

285 stemic ORX-1 receptor antagonists blocks the panic responses.

286 o stimuli resembling those co-occurring with panic, resulting in the proliferation of panic cues.

287 They did differ in panic symptom responses, which were unaffected by the in

288 The correspondence between panic symptoms and functional T1rho response identified

289 D was not associated with CO(2) sensitivity (panic symptoms and respiratory physiologic response).

290 No relationships were found between panic symptoms and the BOLD signal.

291 Conditioned stimuli triggering panic symptoms are not limited to the original condition

292 shing checkerboard and their relationship to panic symptoms assessed using the Beck Anxiety Inventory

293 Panic symptoms were elicited by a bolus injection of the

294 escape behavior, self-reports of anxiety and panic symptoms, autonomic arousal (heart rate and skin c

295 gnificantly greater reduction in severity of panic symptoms.

296 center implicated in attention, arousal, and panic that projects throughout the brain.

297 The recurrence risk for depression or panic was much shorter after rapid than after gradual di

298 ganized ranging from anxious apprehension to panic with increasing proximity of interoceptive threat.

299 prevalence estimates are 22.7% for isolated panic without AG (PA only), 0.8% for PA with AG without

300 (N=137), offspring of referred parents with panic without depression (N=26), offspring of referred p