ライフサイエンスコーパス: panic disorder

1 ychiatric diagnoses (depression, anxiety and panic disorder).

2 ved a diagnosis (143 depression, 129 GAD, 30 panic disorder).

3 ocial anxiety disorder, specific phobia, and panic disorder.

4 itute a potential new treatment strategy for panic disorder.

5 prominently in many etiological accounts of panic disorder.

6 tions for novel treatments and prevention in panic disorder.

7 vents, is a psychophysiological correlate of panic disorder.

8 hysical symptoms prominently associated with panic disorder.

9 tical psychotherapy for patients with DSM-IV panic disorder.

10 anic-focused psychodynamic psychotherapy for panic disorder.

11 ere 49 adults ages 18-55 with primary DSM-IV panic disorder.

12 inical trial of subjects with primary DSM-IV panic disorder.

13 sions, a phenomenon similar to patients with panic disorder.

14 epression, generalized anxiety disorder, and panic disorder.

15 e effective than usual care for primary care panic disorder.

16 ithin a region previously linked strongly to panic disorder.

17 re, few such studies have been conducted for panic disorder.

18 dysfunction could be a pathogenic factor in panic disorder.

19 ion contributes to the pathogenesis of human panic disorder.

20 subjects) ascertained through probands with panic disorder.

21 normal cortical GABA levels in patients with panic disorder.

22 n patients with generalized social phobia or panic disorder.

23 being the most commonly used medication for panic disorder.

24 ficantly if the proband had panic attacks or panic disorder.

25 relevance to psychiatric conditions such as panic disorder.

26 eralized anxiety disorder, social phobia, or panic disorder.

27 onazepam with sertraline in the treatment of panic disorder.

28 euptake inhibitors in the acute treatment of panic disorder.

29 y might contribute to the pathophysiology of panic disorder.

30 A levels are abnormally low in patients with panic disorder.

31 erapy) has low efficacy for the treatment of panic disorder.

32 overestimations of the efficacy of SSRIs for panic disorder.

33 ering these medications for the treatment of panic disorder.

34 ent meta-analysis of non-SSRI treatments for panic disorder.

35 onsidered the first-line pharmacotherapy for panic disorder.

36 n the pathophysiology and treatment of human panic disorder.

37 of 2637 patients assessed had a diagnosis of panic disorder.

38 as been suggested to play a critical role in panic disorder.

39 ns are consistent with a pH dysregulation in panic disorder.

40 ese data support the learning perspective of panic disorder.

41 zodiazepines, which are widely used to treat panic disorder.

42 ication treatment was observed in visits for panic disorder.

43 ion manifested in panic attacks occurring in panic disorder.

44 tion for dissecting the bases of anxiety and panic disorders.

45 rk done regarding the long-term treatment of panic disorders.

46 ing instinctive fear and human emotional and panic disorders.

47 potential therapeutic target in anxiety and panic disorders.

48 rientation, 5.14 (95% CI=4.54-5.82); and for panic disorder, 1.45 (95% CI=1.15-1.85).

49 r (27%), generalized anxiety disorder (10%), panic disorder (10%), or complicated grief disorder (5%)

50 ssive-compulsive disorder, 2.5% vs. 6.7% for panic disorder, 12.6% vs. 25.3% for social phobia, 9.1%

51 MDD (47%), specific phobia (24%), panic disorder (16%), obsessive-compulsive disorder (9%)

52 umber at risk: 4200), PTSD 31.9% (4342), and panic disorder 21.2% (4953).

53 ory canopy, were studied in 50 patients with panic disorder, 21 with major depression, and 10 with pr

54 lized anxiety disorder (31%), agoraphobia or panic disorder (22%), social phobia (17%), and specific

55 have major depression (42.4% versus 12.6%), panic disorder (24.8% versus 4.0%), generalized anxiety

56 re non-Hispanic white (1957 [73.7%]), 98 had panic disorder, 252 had GAD, 67 were treated with a benz

57 anxiety disorder (21 versus 2%, P < 0.005), panic disorder (36 versus 13%, P < 0.001) and somatizati

58 number at risk: 3648), PTSD 9.3% (3761), and panic disorder 8.4% (3780).

59 rrent psychiatric disorders were as follows: panic disorder, 8.0% (95% CI, 4.6% to 12.7%), major depr

60 mmon current comorbid anxiety disorders were panic disorder (9.3%), specific phobias (8.8%), and soci

61 Comorbid bipolar and panic disorders aggregate in families.

62 , specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalised anxiety dis

63 in offspring of multiple anxiety disorders, panic disorder, agoraphobia, social phobia, and obsessiv

64 or depression, generalized anxiety disorder, panic disorder, agoraphobia, social phobia, animal phobi

65 ety disorders (generalized anxiety disorder, panic disorder, agoraphobia, social phobia, animal phobi

66 hymia, bipolar disorder), anxiety disorders (panic disorder, agoraphobia, specific phobia, social pho

67 ajor depression, 22 children of parents with panic disorder alone, 49 children of parents with major

68 the probands and first-degree relatives with panic disorder also had an affective disorder diagnosis.

69 These yielded heritabilities of 0.43 for panic disorder and 0.32 for generalized anxiety disorder

70 Fourteen patients with panic disorder and 14 controls, individually matched for

71 eteen patients with a DSM-IV-TR diagnosis of panic disorder and 19 healthy comparison subjects were r

72 n 19 individuals meeting DSM-IV criteria for panic disorder and 19 sex- and age-matched healthy compa

73 ith posttraumatic stress disorder (PTSD) and panic disorder and a subset of those reporting MCS, usin

74 reactivity in a large group of patients with panic disorder and agoraphobia (PD/AG).

75 tment with imipramine protects patients with panic disorder and agoraphobia from such reversals.

76 n, was associated with an increased risk for panic disorder and agoraphobia in offspring.

77 Panic disorder and agoraphobia patients differed substan

78 ntial, occurs in a minority of patients with panic disorder and agoraphobia who are in stable remissi

79 disorder significantly increases the risk of panic disorder and any anxiety disorder.

80 Panic disorder and avoidant personality disorder were as

81 Given the observed association between panic disorder and bipolar disorder and the potential ne

82 Individuals with panic disorder and comorbid depression, indicative of a

83 ps of children: 1) offspring of parents with panic disorder and comorbid major depression (N=179), 2)

84 ebo-controlled, efficacy trials of SSRIs for panic disorder and compared these results to findings ob

85 ing high-risk study of offspring at risk for panic disorder and depression (N=278) that had included

86 ve Experiences Scale scores and diagnoses of panic disorder and dissociative disorders were also asso

87 Panic disorder and GAD do not contribute to adverse preg

88 Panic disorder and generalized anxiety disorder are prev

89 Only for panic disorder and generalized anxiety disorder could th

90 Telephone-based collaborative care for panic disorder and generalized anxiety disorder is more

91 evaluation of hypertension, arrhythmias, or panic disorder and in the follow-up of patients with par

92 ated with specific disorders, and 2) whether panic disorder and major depression have a familial link

93 ificant associations between the presence of panic disorder and major depression in parents and patte

94 -6 years): 129 children of parents with both panic disorder and major depression, 22 children of pare

95 cence in offspring of parents with confirmed panic disorder and major depressive disorder.

96 ed study tested the hypothesis that parental panic disorder and offspring response to CO(2) are assoc

97 anxiety disorder in childhood leads to adult panic disorder and other anxiety disorders.

98 .7, 9.3) than with any panic, which included panic disorder and panic attacks (OR = 2.1; 95% CI, 1.1,

99 Both parental panic disorder and parental major depression, individual

100 Patients with panic disorder and patients with premenstrual dysphoric

101 Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are cons

102 iety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically co

103 proclivity toward fear overgeneralization in panic disorder and provide a methodology for laboratory-

104 a and the number of articles published about panic disorder and/or agoraphobia (i.e., disorders of co

105 e as many published empirical articles about panic disorder and/or agoraphobia (N=365) as there were

106 jects included 200 offspring of parents with panic disorder and/or major depression and 84 comparison

107 nhibition in young offspring of parents with panic disorder and/or major depression.

108 (n = 51), comorbid MDD and anxiety (n = 59), panic disorder and/or social anxiety disorder without co

109 , post-traumatic stress disorder [PTSD], and panic disorder), and spirometric abnormalities.

110 iety disorder, 6.8% (CI, 5.3% to 8.6%) had a panic disorder, and 6.2% (CI, 4.7% to 7.9%) had a social

111 st strongly in generalized anxiety disorder, panic disorder, and agoraphobia, whereas the second load

112 sion, phobias, generalized anxiety disorder, panic disorder, and bulimia nervosa), and four were "ext

113 l illnesses (eg, asthma) commonly occur with panic disorder, and certain lifestyle factors (eg, smoki

114 icide attempt, psychosis, mania, depression, panic disorder, and delirium, confusion, or disorientati

115 generalized anxiety disorder, social phobia, panic disorder, and posttraumatic stress disorder) among

116 he life course for major depressive episode, panic disorder, and posttraumatic stress disorder.

117 Major depressive disorder (MDD), panic disorder, and social anxiety disorder are among th

118 et was lower and rates of attempted suicide, panic disorder, and substance abuse were higher than amo

119 idence rates of depression, mania, delirium, panic disorder, and suicidal behaviors in patients treat

120 cifically post-traumatic stress disorder and panic disorder, and therefore represents an endophenotyp

121 (AOR, 2.8; 95% CI, 1.4-5.4) and symptoms of panic disorder (AOR, 4.8; 95% CI, 1.6-14.4) than partici

122 vious finding that offspring of parents with panic disorder are at high risk for behavioral inhibitio

123 ings, generalized anxiety disorder (GAD) and panic disorder are common but underrecognized illnesses.

124 to test the hypothesis that individuals with panic disorder are impaired in associative learning task

125 n that recommendations to use SSRIs to treat panic disorder are not being followed.

126 Patients with panic disorder are overly sensitive to unpredictable ave

127 sion were commonest aged 45-64 years, whilst panic disorder/attacks were more common in those 16-44 y

128 reliably induce panic attacks in humans with panic disorder but not in healthy controls.

129 ictability could be etiologically related to panic disorder by sensitizing an individual to danger, u

130 ed assessment of this potential correlate of panic disorder by testing the degree to which panic pati

131 In a rat model of panic disorder, chronic inhibition of GABA synthesis in

132 The patterns of bipolar disorder and panic disorder comorbidity observed in families imply a

133 ls, delayed pCO(2) recovery in subjects with panic disorder could reflect slower pH normalization in

134 d to explain these results: 1) subjects with panic disorder demonstrate greater alkalosis to hyperven

135 s directly compensatory, or 2) subjects with panic disorder demonstrate reduced or blunted alkalosis,

136 nalyze rapid mood switching as a function of panic disorder diagnosis, sex, and familial risk for pan

137 For example, adults with panic disorder did not have histories of juvenile disord

138 o healthy comparison subjects, patients with panic disorder displayed equivalent levels of fear-poten

139 The learning perspective of panic disorder distinguishes between acute panic and anx

140 ndard CBT and pharmacotherapy treatments for panic disorder do not need to be "tailored" to be effect

141 dal CO(2) (pCO(2)) recovery in subjects with panic disorder during hyperventilation suggested altered

142 reuptake inhibitors (SSRIs) in patients with panic disorder (e.g., APA's practice guideline for panic

143 psychiatric disorders (anxiety, depression, panic disorder), epilepsy, asthma, and some congenital h

144 iological challenge and pathologic marker in panic disorder, evokes intense fear and panic attacks in

145 l from 4.0 to 2.2/1000PYAR, and incidence of panic disorder fell from 0.9/1000PYAR in 1998 to 0.5/100

146 disorder (e.g., APA's practice guideline for panic disorder, Food and Drug Administration approval of

147 tment program for primary care patients with panic disorder from the perspective of the payer.

148 Panic disorder, GAD, or use of benzodiazepines or seroto

149 For panic disorder, generalized anxiety disorder, and probab

150 yses of data from family and twin studies of panic disorder, generalized anxiety disorder, phobias, a

151 Panic disorder, generalized anxiety disorder, phobias, a

152 ary care outpatients who were diagnosed with panic disorder, generalized anxiety disorder, social pho

153 e this different respiratory response in the panic disorder group, brain pH increases were not signif

154 f healthy subjects showed pH blunting in the panic disorder group.

155 Patients with panic disorder had a 22% reduction in total occipital co

156 Although subjects with panic disorder had greater hypocapnea during hyperventil

157 Subjects with panic disorder had lower pCO(2) during hyperventilation

158 d feasible screening instruments for GAD and panic disorder has the potential to improve detection an

159 ly, pharmacological treatment guidelines for panic disorder have changed as newer treatment options h

160 GAD and the Patient Health Questionnaire for panic disorder, have good performance characteristics an

161 risk of a family member being diagnosed with panic disorder if the proband with bipolar disorder had

162 Familial panic and the diagnosis of panic disorder in an individual subject increased the od

163 has been implicated in an increased risk of panic disorder in humans.

164 unique studies for the detection of GAD and panic disorder in primary care patients Across all studi

165 Risk of panic disorder in relatives with bipolar disorder was in

166 ies have demonstrated a higher prevalence of panic disorder in women than in men.

167 predicted new onset of depression, parental panic disorder independently predicted new onset of soci

168 Parental panic disorder, independently of parental depression, pr

169 Panic disorder is a common mental disorder that affects

170 Panic disorder is a prevalent, often disabling condition

171 Panic disorder is a severe anxiety disorder with recurre

172 whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching i

173 Panic disorder is associated with reductions in total oc

174 anxiety disorder were more likely to develop panic disorder later on (odds ratio=3.45; 95% CI=2.37-5.

175 of 131 offspring (ages 9-19) of parents with panic disorder, major depression, and no mental disorder

176 d in several debilitating conditions such as panic disorder, major depression, schizophrenia, alcohol

177 ation anxiety disorder with regard to future panic disorder, major depressive disorder, any anxiety d

178 family study suggests that panic attacks and panic disorder may be related genetically to bipolar dis

179 ctivation in humans, and HPA disturbances in panic disorder may be secondary to manipulable cognitive

180 Primary care patients with panic disorder (N=232) who were participating in a rando

181 rents with major depression without comorbid panic disorder (N=59), and 4) offspring of parents with

182 recurrent major depressive disorder (N=224), panic disorder (N=75), bipolar II disorder (N=62), or bi

183 In adjusted models, neither panic disorder nor GAD was associated with maternal or n

184 9), and 4) offspring of parents with neither panic disorder nor major depression (N=113).

185 comparison children of parents with neither panic disorder nor major depression.

186 In human anxiety disorders--such as panic disorder, obsessive-compulsive disorder, post-trau

187 Aggregation was also seen for panic disorder, obsessive-compulsive disorder, posttraum

188 d), asthma was more strongly associated with panic disorder (odds ratio [OR] = 4.0; 95% confidence in

189 val of particular SSRIs for the treatment of panic disorder), only a modest increase in their use was

190 disorder (OR, 1.47; 95% CI, 1.12-1.93), and panic disorder or agoraphobia (OR, 1.27; 95% CI, 1.01-1.

191 To determine whether panic disorder or generalized anxiety disorder (GAD) in

192 fferences were not accounted for by parental panic disorder or major depression or by parental histor

193 spring of adults presenting for treatment of panic disorder or major depressive disorder.

194 9 respondents who met DSM-III-R criteria for panic disorder or panic attacks were analyzed to test fo

195 National Comorbidity Survey respondents with panic disorder or panic attacks, female respondents were

196 .9), anxiety (OR 3.2, 95% CI 2.8 to 3.6) and panic disorder (OR 3.4, 95% CI 2.9 to 4.0).

197 pts in multivariate analysis: pre-enlistment panic disorder (OR = 0.1 [95% CI, 0.0-0.8]), pre-enlistm

198 ariables, active asthma predicted subsequent panic disorder (OR = 4.5; 95% CI, 1.1, 20.1), and the pr

199 xiety disorder (OR, 1.3; 95% CI, 1.06-1.49), panic disorder (OR, 1.3; 95% CI, 1.06-1.59), and social

200 ssion (OR, 4.8 [95% CI, 1.2-19.4]; P < .05), panic disorder (OR, 14.5 [95% CI, 5.7-36.6]; P < .001),

201 y (OR, 2.7 [95% CI, 1.1-6.3]; P < .001), and panic disorder (OR, 3.1 [95% CI, 1.5-6.5]; P < .01) and

202 0.46, P<0.001), and the panic item predicted panic disorder (OR=49.61, P<0.001).

203 1.6)], panic attacks [OR = 1.6 (1.1, 2.1)], panic disorder [OR = 1.6 (1.01, 2.3)], GAD [OR = 1.8 (1.

204 Registry data show that maternal panic disorder, or anxiety disorders in general, increas

205 nual (DSM)-III neurotic disorder, dysthymia, panic disorder, or generalised anxiety.

206 Panic attacks are a hallmark in panic disorder (PAND).

207 Neither parents with panic disorder, parents with major depression, or offspr

208 Thirteen panic disorder participants and 13 matched control subje

209 tly greater increase in the visual cortex of panic disorder participants.

210 sual cortex and anterior cingulate cortex of panic disorder participants.

211 cificity of CO(2)-induced anxiety by testing panic disorder patients and clinical populations with re

212 l dysphoric disorder was similar to that for panic disorder patients and higher than that for normal

213 zodiazepine administration were tested in 10 panic disorder patients and nine healthy comparison subj

214 2) inhalation has been used to differentiate panic disorder patients from normal subjects and other c

215 nd response to 7% CO(2 )better distinguished panic disorder patients from normal subjects than respon

216 Panic disorder patients had a deficient GABA neuronal re

217 Panic disorder patients had a higher rate of CO(2)-induc

218 tudy, the authors tested the hypothesis that panic disorder patients have a deficient GABA neuronal r

219 Individuals with panic disorder (PD) exhibit a hypersensitivity to inhale

220 ecular genetics approaches in examination of panic disorder (PD) has implicated several variants as p

221 r such models constitute relevant models for panic disorder (PD) in humans.

222 e, to our knowledge, have been completed for panic disorder (PD) in this setting.

223 Panic disorder (PD) is a debilitating anxiety disorder c

224 Prior evidence suggests panic disorder (PD) is characterized by neurometabolic a

225 rasting the SAD group to a separate group of panic disorder (PD) subjects.

226 own to produce more anxiety in patients with panic disorder (PD) than in healthy comparison subjects

227 with generalized anxiety disorder (GAD) and panic disorder (PD) to generate individual subject treat

228 The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) ar

229 (PTSD), generalized anxiety disorder (GAD), panic disorder (PD), and phobias (agoraphobia, social ph

230 (MD), generalized anxiety disorder (GAD) and panic disorder (PD), as well as depressed affect and anx

231 idemiology of DSM-IV panic attacks (PAs) and panic disorder (PD).

232 s postulated to be a familial risk marker of panic disorder (PD).

233 aimed to evaluate CRHR1 as a risk factor for panic disorder (PD).

234 ed a possible syndrome in some families with panic disorder (PD).

235 upports that there is a genetic component to panic disorder (PD).

236 hether these features discriminated SAD from panic disorder (PD, N=16), and SAD from controls in an i

237 Individuals with panic disorder perceive panic attacks as unpredictable.

238 In panic disorder, persistent symptoms of anxiety are cause

239 months, including major depressive disorder, panic disorder, posttraumatic stress disorder (PTSD), op

240 me, migraine, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, premenstr

241 4.5; 95% CI, 1.1, 20.1), and the presence of panic disorder predicted subsequent asthma activity (OR

242 drugs that are clinically effective against panic disorder preferentially alter rodent flight behavi

243 ave suggested that most patients treated for panic disorder receive forms of psychotherapy other than

244 Parental panic disorder, regardless of comorbidity with major dep

245 emission, and no difference in likelihood of panic disorder remission.

246 ysis of controlled studies of treatments for panic disorder revealed no significant differences betwe

247 Scores on the Panic Disorder Severity Scale are also highest for PD-AG

248 The Panic Disorder Severity Scale, rated by blinded independ

249 Generalized Anxiety Disorder Severity Scale, Panic Disorder Severity-Self-report Scale, Social Phobia

250 f paroxetine in the treatment of depression, panic disorder, social anxiety disorder, posttraumatic s

251 and adolescents with confirmed diagnoses of panic disorder, social anxiety disorder, specific phobia

252 ughts and attempts, psychiatric comorbidity (panic disorder, social phobia, and drug dependence), dis

253 Associations between AUD and panic disorder, specific phobia, and generalized anxiety

254 tion (73% versus 39%), using the Multicenter Panic Disorder Study response criteria.

255 These results suggest that individuals with panic disorder suffer from a deficit in declarative asso

256 The false-suffocation hypothesis of panic disorder suggested delta-opioid receptors as a pos

257 d anxiety disorder and social phobia but not panic disorder, suggesting that PersDs have a differenti

258 ntribute to the maintenance and worsening of panic disorder symptoms by increasing anticipatory anxie

259 hotherapy was less effective for symptoms of panic disorder than treatment with either cognitive beha

260 T1rho imaging may provide information about panic disorder that is distinct from conventional BOLD i

261 ive care (CC) intervention for patients with panic disorder that provided increased patient education

262 For panic disorder, the remaining variance in liability coul

263 In individuals with panic disorder there is evidence of decreased central ga

264 plasma) have been within reference limits in panic disorder, thus far there has been no direct assess

265 omly assigned 115 primary care patients with panic disorder to a CC intervention that included system

266 sed psychotherapy (given to 30 patients with panic disorder), to results obtained with recommended st

267 sion, generalized anxiety disorder (GAD), or panic disorder; understand the predictive value of indiv

268 A CC intervention for patients with panic disorder was associated with significantly more an

269 d with bipolar disorder had panic attacks or panic disorder was calculated with logistic regression a

270 Panic disorder was present in 17% of the relatives with

271 -2 was an effective screening tool; however, panic disorder was rare.

272 The best-performing test for panic disorder was the Patient Health Questionnaire, wit

273 r depression, regardless of comorbidity with panic disorder, was associated with increased risks for

274 Nine subjects with panic disorder were compared to 11 healthy subjects at b

275 viduals with DSM-IV-defined anxiety syndrome panic disorder were compared with 21 unaffected healthy

276 A total of 443 patients with panic disorder were enrolled in the Harvard/Brown Anxiet

277 ilial effect persisted when individuals with panic disorder were excluded from the analysis.

278 Fifty patients with panic disorder were randomized into a double-blind clini

279 Twenty-eight untreated patients with panic disorder were randomized to a single session of ex

280 Asymptomatic medicated patients with panic disorder were studied during regulated hyperventil

281 lists, the majority inexperienced in CBT for panic disorder, were trained to deliver the CBT and coor

282 ere assessed in 14 unmedicated patients with panic disorder who did not have major depression and 14

283 ssive-compulsive disorder, social phobia, or panic disorder who received placebo in three randomized,

284 ts (n = 42), treatment-seeking patients with panic disorder with agoraphobia (n = 25), and 17 healthy

285 al factor in the etiology and maintenance of panic disorder with agoraphobia (PD/A).

286 ontrol participants as well as patients with panic disorder with agoraphobia and generalized social a

287 Evidence suggests that panic disorder with agoraphobia is characterized by dysf

288 y (CBT) is an effective treatment option for panic disorder with agoraphobia, the neural substrates o

289 ated with treatment outcome in patients with panic disorder with agoraphobia.

290 on-free patients with a primary diagnosis of panic disorder with agoraphobia.

291 ted with treatment response in patients with panic disorder with agoraphobia.

292 Inherited risk for panic disorder with bipolar disorder may indicate a shar

293 y disorders, the authors found that parental panic disorder with comorbid major depression was associ

294 Risk for panic disorder with familial bipolar disorder appears to

295 Subjects met DSM-IV criteria for panic disorder with no more than mild agoraphobia.

296 eatment center with a principal diagnosis of panic disorder with or without agoraphobia, generalized

297 ng specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-co

298 riteria for a principal current diagnosis of panic disorder with or without agoraphobia.

299 of parents with depression (with or without panic disorder), with the highest rates in the offspring

300 ession (N=179), 2) offspring of parents with panic disorder without comorbid major depression (N=29),