ライフサイエンスコーパス: pantetheine

1 , BarA, and ArfA C2-A2-T2 but not to free HS-pantetheine.

2 atalyzes reversible thiol/disulfide redox on pantetheine.

3 The K(m) of free pantetheine (30-50 mM) was 3 orders of magnitude larger

4 Pantetheine also serves as an amino acid acceptor in rea

5 based on interligand NOEs between TLM and a pantetheine analog when both are bound simultaneously to

6 A detailed study of pantetheine analogues was performed in order to identify

7 Finally bioorthogonal pantetheine analogues were shown to target carrier prote

8 However, the adducts with R-3,4-decadienoyl-pantetheine and -N-acetylcysteamine are some 9- and >100

9 Pantetheine and its corresponding disulfide pantethine p

10 e truncation of CoA to 4-phosphopantetheine, pantetheine, and finally cysteamine was observed with Th

11 hin the phosphopantetheine arm overlaps, the pantetheine arm binds to the same pocket in two distinct

12 of CoASH, but the absence of density for the pantetheine arm indicates that it is flexible within the

13 of the 4'-phosphate at the distal end of the pantetheine arm is demonstrated to both facilitate deliv

14 the same as in the binary complex, while the pantetheine arm is more extended and approaches close to

15 Specifically, the pantetheine arm of CoA bound to one protomer within the

16 ng equivalents to the RHD, with the swinging pantetheine arm serving as a ca. 20 A bridge.

17 nside, suggesting that the attachment of the pantetheine arm to ACP must occur before complete assemb

18 ons that "simpler" thiols must have preceded pantetheine at the origin of life.

19 lts are consistent with a role for canonical pantetheine at the outset of life on Earth.

20 In the region of the phospho-pantetheine attachment site, significant similarity betw

21 ue modality that mimics (R)-beta-hydroxyacyl pantetheine binding to LpxA and displays how the peptide

22 the phenyl moiety partially fills the enzyme pantetheine binding tunnel.

23 nethiol (GlyPan), with one fewer carbon than pantetheine, can rescue a mutant E. coli strain MG1655De

24 ere shown to be effective substrates for the pantetheine-cleaving enzyme ThnT.

25 molecule and covalently transfers it to the pantetheine cofactor of an aryl-carrier protein of BasF,

26 in a three-step sequence in which a farnesyl-pantetheine conjugate is phosphorylated, adenylated, and

27 ingle-turnover reaction of 4-CBA, MgATP, and pantetheine corresponded to one-half of the starting 4-C

28 Free pantetheine could capture cysteinyl adenylate with a 25-

29 Substitution of CoA with the slow substrate pantetheine did not significantly alter the rate of the

30 nt in many origin-of-life scenarios, but how pantetheine emerged on the early Earth remains a mystery

31 Earlier attempts to selectively synthesize pantetheine failed, leading to suggestions that "simpler

32 f CoA docks to the PAPS domain, and the acyl-pantetheine group docks to the hydrophobic phenol bindin

33 The flavin of FAD and the pantetheine group of CoA contact the same region at the

34 The pantetheine group of CoA partially obstructs the active

35 ate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrie

36 ThnT is a pantetheine hydrolase from the DmpA/OAT superfamily invo

37 dimethyl, and beta-alanine-amide moieties of pantetheine in dilute water.

38 ielding and selective prebiotic syntheses of pantetheine in water.

39 l life on Earth, and its functional subunit, pantetheine, is important in many origin-of-life scenari

40 elevance of these transitions, we designed a pantetheine-like chloromethyl ketone inactivator and co-

41 l reversibility of post-translational custom pantetheine modification of Escherichia coli acyl carrie

42 yme has shown that the benzoyl thioester and pantetheine moieties of the substrate ligand are bound i

43 crystal structure of this complex, while the pantetheine moiety is clearly less extended.

44 The absence of long range NOEs along the pantetheine moiety is consistent with this region of the

45 Docking of the pantetheine moiety of the substrate identifies the loop

46 When L-threonyl-S-pantetheine or L-threonyl-S-(N-acetyl)cysteamine was use

47 rnative routes that begin with the uptake of pantetheine (PanSH) or 4'-phosphopantetheine (PPanSH) as

48 We exploited solvatochromic pantetheine probes attached to ACP that fluoresce when s

49 Es between the adenine H8 proton and several pantetheine protons in the bound form of HD-CoA indicate

50 Unexpectedly, the acyl-pantetheine thioester carbonyl is not hydrogen-bonded to

51 and MetRS, forming corresponding aminoacyl-S-pantetheine thioesters.

52 e that the percentage yield of pantethine to pantetheine through disulfide exchange is approximately

53 pha is the percentage yield of pantethine to pantetheine through disulfide exchange.

54 ntetheinase that catalyzes the hydrolysis of pantetheine to produce pantothenic acid (vitamin B5) and

55 acyl chain is transferred back from the ACP pantetheine to the KS cysteine before dissociation can o

56 ion between C2 of a carbapenam precursor and pantetheine, uniting initial bicycle assembly common to