ライフサイエンスコーパス: pantothenate kinase

1 s the starting metabolite, phosphorylated by pantothenate kinase.

2 ural substrate PA for phosphorylation by the pantothenate kinase.

3 ackup" regulator of pathway flux relative to pantothenate kinase.

4 ions of the phosphoryl transfer mechanism of pantothenate kinase.

5 N-alkylpantothenamides are substrates for pantothenate kinase.

6 miR107 is located in intron 5 of the pantothenate kinase 1 (PANK1) gene.

7 Mutations in the pantothenate kinase 2 (PANK2) gene have been identified

8 Pantothenate kinase 2 (PANK2) is an essential regulatory

9 disease have mutations in the gene encoding pantothenate kinase 2 (PANK2); these patients are said t

10 Mutations in the pantothenate kinase 2 gene cause a severe form of neurod

11 Predicted levels of pantothenate kinase 2 protein correlate with the severit

12 The PANK2 gene encodes the human pantothenate kinase 2 protein isoforms, and PANK2 mutati

13 Pantothenate kinase, a key enzyme in the universal biosy

14 In bacteria, regulation of pantothenate kinase activity is a major factor in contro

15 ramatically in a yeast mutant with defective pantothenate kinase activity.

16 ry properties exhibited by the family of the pantothenate kinases allowed the rate of CoA biosynthesi

17 gulator, and antimetabolite binding sites on pantothenate kinase and provide a framework for studies

18 PANK2 mutations cause pantothenate kinase-associated neurodegeneration (PKAN),

19 Pantothenate kinase-associated neurodegeneration (PKAN,

20 den-Spatz syndrome, the disorder was renamed pantothenate kinase-associated neurodegeneration after d

21 Pantothenate kinase-associated neurodegeneration is a fo

22 PanK2(G521R), the most frequent mutation in pantothenate kinase-associated neurodegeneration, was de

23 In all patients with pantothenate kinase-associated neurodegeneration, whethe

24 ndings in six cases of molecularly confirmed pantothenate kinase-associated neurodegeneration.

25 e identify prominent ubiquinated deposits in pantothenate kinase-associated neurodegeneration.

26 isoforms, and PANK2 mutations are linked to pantothenate kinase-associated neurodegeneration.

27 e 2 (PANK2); these patients are said to have pantothenate kinase-associated neurodegeneration.

28 The activity of the second pantothenate kinase, AtPANK2, was confirmed by its abili

29 e structural information on Escherichia coli pantothenate kinase by determining the structure of the

30 We used yeast and its pantothenate kinase Cab1 as models to characterize mode

31 Pantothenate kinase catalyzes a key regulatory step in c

32 Pantothenate kinase catalyzes the first step in the bios

33 Pantothenate kinase (CoaA) catalyzes the first and regul

34 Pantothenate kinase (CoaA) is a key regulator of coenzym

35 CoA biosynthesis in bacteria and mammals is pantothenate kinase (CoaA), which governs the intracellu

36 , both active sites of the dimeric mammalian pantothenate kinases coordinately switch between the on

37 atment for neurodegeneration associated with pantothenate kinase deficiency.

38 The two enzymes have homologous pantothenate kinase domains, but AtPANK2 also carries a

39 of two new classes of compounds that inhibit pantothenate kinase from M. tuberculosis are described,

40 s, including the finding of mutations in the pantothenate kinase gene and ferritin light chain gene,

41 ow that HSS is caused by a defect in a novel pantothenate kinase gene and propose a mechanism for oxi

42 Although two eukaryotic-type putative pantothenate kinase genes (PanK1 and PanK2) have been id

43 , especially given the existence of multiple pantothenate kinase genes in humans and multiple PanK2 t

44 perature-sensitive mutation of the bacterial pantothenate kinase in E. coli strain ts9.

45 Given the role of pantothenate kinase in production of Coenzyme A and in p

46 trate the key role of feedback regulation of pantothenate kinase in the control of intracellular CoA

47 ns indicate that this type of "bifunctional" pantothenate kinase is conserved in other higher eukaryo

48 Pantothenate kinase is the master regulator of CoA biosy

49 Pantothenate kinase isoform PanK3 is highly related to t

50 report here the characterization of a second pantothenate kinase of Arabidopsis, AtPANK2, as well as

51 contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse.

52 berculosis enzyme but similar to that in the pantothenate kinases of other organisms.

53 In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyze

54 al and animal coenzyme A (CoA) biosynthesis, pantothenate kinase (PANK) activity is critical in regul

55 In contrast, a novel type III pantothenate kinase (PanK) catalyzes the first committed

56 Pantothenate kinase (PanK) catalyzes the first step in t

57 Pantothenate kinase (PanK) catalyzes the first step of t

58 Pantothenate kinase (PanK) is a key regulatory enzyme in

59 Pantothenate kinase (PanK) is a rate-determining enzyme

60 Pantothenate kinase (PanK) is a regulatory enzyme that c

61 Pantothenate kinase (PanK) is the key regulatory enzyme

62 Pantothenate kinase (PanK) is the key regulatory enzyme

63 y enzymatic phosphorylation with E. faecalis pantothenate kinase (PanK).

64 The mouse murine pantothenate kinase (Pank1) gene consists of seven intro

65 The human isoform 2 of pantothenate kinase (PanK2) is localized to the mitochon

66 In contrast to all known pantothenate kinases, SaCoaA activity is not feedback-re

67 The absence of feedback regulation at the pantothenate kinase step allows the accumulation of high

68 s to the highest resolution reported for any pantothenate kinase structure.

69 quence that is more similar to the mammalian pantothenate kinases than the prototypical bacterial Coa

70 in human brain, distinguishing it from other pantothenate kinases that do not possess mitochondrial-t

71 ate specificities associated with endogenous pantothenate kinase, the first enzyme in the CoA biosynt