ライフサイエンスコーパス: papillary muscle

1 echogenic intracardiac focus (ie, calcified papillary muscle).

2 on and lateral displacement of the posterior papillary muscle.

3 ocardial infarction, including the posterior papillary muscle.

4 t and no-flow ischemia in an isolated rabbit papillary muscle.

5 n of leaflet tissue attached to the anterior papillary muscle.

6 yocardium near the insertion of the anterior papillary muscle.

7 the wall of the left ventricle overlying the papillary muscle.

8 r LV free wall near the root of the anterior papillary muscle.

9 into the myocardium underlying the infarcted papillary muscle.

10 bundles isolated from mouse left ventricular papillary muscles.

11 annular dilatation with displacement of the papillary muscles.

12 he ventricle and improved orientation of the papillary muscles.

13 ional changes were also assessed in isolated papillary muscles.

14 fibre bundles prepared from left ventricular papillary muscles.

15 raction is described in 25 reperfused rabbit papillary muscles.

16 ule depolymerization in both control and PAB papillary muscles.

17 ed IGF-1-positive inotropic action in ferret papillary muscles.

18 aequorin-loaded rat whole hearts and ferret papillary muscles.

19 mRNA expression in stretched and unstretched papillary muscles.

20 nulus and its spatial relationship with both papillary muscles.

21 e stretch activation response of the cardiac papillary muscles.

22 on (MI), with leaflet tethering by displaced papillary muscles.

23 o displaced the posterior annulus toward the papillary muscles.

24 elaxation in both isolated hearts and intact papillary muscles.

25 strating enlarged interventricular septa and papillary muscles.

26 tion (61 %) or relaxation (59 %) of isolated papillary muscle, (2) fractional shortening (50 %), ampl

27 nnulus (6) and at the tips and bases of both papillary muscles (4).

28 s (14% decrease in peak developed pressure), papillary muscles (53% decrease in maximum developed for

29 ventricular myocytes (-60%, P<.005) and rat papillary muscles (-55%, P<.05).

30 on (Group II), whereas 26 did (Group III: 12 papillary muscle, 7 subendocardial, 7 transmural).

31 force recovered to 60 +/- 3 % (n = 7) in NTG papillary muscles, 98 +/- 2 % (n = 5) in muscles from TG

32 reimplantation, and early dehiscence of the papillary muscle anastomosis.

33 on the leaflets due to displacement of their papillary muscle and annular attachments, which restrict

34 lar cavity and the direct continuity between papillary muscle and anterior leaflet associated with a

35 lic mitral annulus dimensions, components of papillary muscle and leaflet displacement, were calculat

36 he tethering line connecting the annulus and papillary muscle and reflects limitation of anterior mot

37 of leaflet tissue attached to the posterior papillary muscle and restriction of leaflet tissue attac

38 ction potentials were recorded from isolated papillary muscle and sinoatrial node by microelectrode t

39 e that increases isometric force in isolated papillary muscle and the extent of shortening in isolate

40 at the free margin of the leaflets tethering papillary muscles and absent/short tendinous cords.

41 osin in distinct areas such as at the tip of papillary muscles and at the base close to the valvular

42 Contracting isolated papillary muscles and cardiomyocytes from controls and m

43 s, with a wide array of malformations of the papillary muscles and chordae, that can be detected by t

44 Fiber bundles were dissected from papillary muscles and detergent extracted.

45 Fibrosis of the papillary muscles and inferobasal left ventricular wall,

46 aflets and left ventricular (LV) fibrosis of papillary muscles and inferobasal wall.

47 x-ray microanalysis (EPMA) of rapidly frozen papillary muscles and trabeculae incubated with ryanodin

48 er in 6 of 6 cardiac arrest patients (4 from papillary muscle) and Purkinje origin of dominant VE was

49 function were assessed by echocardiographic, papillary muscle, and isolated cardiomyocyte studies.

50 quence similar to sinus rhythm or arose near papillary muscles, and (2) stable pattern, in which acti

51 oronary snare and marker placement (annulus, papillary muscles, and anterior and posterior leaflets).

52 impairment of lateral shortening between the papillary muscles, and not passive ventricular size, tha

53 rdium interface in areas of trabeculation or papillary muscles, and of the atrioventricular ring.

54 urements (perfused isolated hearts, isolated papillary muscles, and skinned fiber preparations), bioc

55 volume, tethering volume, bending angle, and papillary muscle angle were measured.

56 zing restrictive mitral annuloplasty (RA) or papillary muscle approximation with undersizing restrict

57 K(+)), and lactate (L(-)) in ischemic rabbit papillary muscle are presented for the first time.

58 -dimensional relationship of the annular and papillary muscle attachments of the valve so as to incre

59 the anterior wall, one set at the tip of the papillary muscle (basal) and one at the site of papillar

60 , the force-frequency relationships of mouse papillary muscle bundles were measured in the presence o

61 ntegrin, depresses the force production from papillary muscle bundles, partly associated with changes

62 432, reversed the activity of RGD peptide on papillary muscle bundles.

63 ted the hypothesis that repositioning of the papillary muscles can be achieved by injection of polyvi

64 roapical extension can mechanically displace papillary muscles, causing MR despite the absence of bas

65 erences were estimated at a tissue (isolated papillary muscle), cellular (isolated left ventricular c

66 After infarction, the anterior papillary muscle continued to shorten normally, but at E

67 ulted from maintenance of the mitral annular papillary muscle continuity during mitral valve repair.

68 Intact papillary muscle data demonstrated prolonged force trans

69 display a predisposition for trabecular and papillary muscle defects, ventricular septal defects, co

70 valve replacement, the technical problems of papillary muscle dehiscence and mitral regurgitation app

71 -skinned fiber bundles from left ventricular papillary muscle demonstrated a significant inhibition o

72 This papillary muscle discoordination with minimal annular di

73 mmetrical mitral annular (MA) dilatation and papillary muscle dislocation are implicated in the patho

74 e from infarction or cardiomyopathy produces papillary muscle displacement and annular dilatation, ca

75 Apical and posterolateral papillary muscle displacement caused decreased leaflet m

76 over time with mechanical stretch created by papillary muscle displacement through cell activation, n

77 ateral annular dilatation, lateral posterior papillary muscle displacement, and apical PL restriction

78 stress, function, and sphericity) and local (papillary muscle displacements and regional wall motion

79 imension, left ventricular volume, and inter-papillary muscle distance were measured.

80 ntly change left ventricular volume or inter-papillary muscle distance.

81 deformation were observed in the area of the papillary muscle during isovolumic contraction.

82 sually caused by chordae tendinae rupture or papillary muscle dysfunction.

83 chanical stretch of the inferobasal wall and papillary muscles, eventually leading to myocardial hype

84 train relations in resting right ventricular papillary muscles exhibited 60% greater strains (P:<0.01

85 t rate and resonant frequency of the cardiac papillary muscles expressing the mutant essential light

86 The obstacle, together with the papillary muscle, facilitated the transition from VF to

87 uctural heart disease can originate from the papillary muscles, fascicles, and mitral annulus.

88 ead morphology, can help distinguish between papillary muscle, fascicular, and mitral annular VAs.

89 Patients undergoing catheter ablation for papillary muscle, fascicular, or mitral annular VAs were

90 in detergent-treated mouse left ventricular papillary muscle fiber bundles where the endogenous trop

91 illary muscle (basal) and one at the site of papillary muscle fiber insertion (apical).

92 creased approximately 20% in Tg-E22K skinned papillary muscle fibers and intracellular [Ca2+] and for

93 f the ATPase and force in transgenic skinned papillary muscle fibers from mutated versus control mice

94 Detergent-skinned papillary muscle fibers from non-TG (NTG) and TG mouse h

95 ients were significantly decreased in intact papillary muscle fibers from Tg-E22K compared to Tg-WT m

96 e were generated, and the skinned and intact papillary muscle fibers from the Tg-D166V mice were exam

97 Skinned papillary muscle fibers from transgenic mice expressing

98 Low-angle X-ray diffraction studies on papillary muscle fibers in rigor revealed a decreased in

99 gle myosins in relaxed permeabilized porcine papillary muscle fibers indicated slightly differently o

100 RLC (RLC-PAGFP) exchanged into permeabilized papillary muscle fibers.

101 tes (g(app)) was observed in freshly skinned papillary muscle fibers.

102 echanical coupling deficits, we compared the papillary muscle force generated by electrically stimula

103 on fraction, systolic blood pressure, and LV papillary muscle force while LV end-diastolic and systol

104 r dilatation, leaflet tethering by displaced papillary muscles frequently induces mitral regurgitatio

105 In isolated papillary muscle from SERCA2 transgenic mice, the time t

106 arction, total displacement of the posterior papillary muscle from the midseptal annulus ("saddle hor

107 ilarly, the contractile behavior of isolated papillary muscles from diabetic SERCA2a mice was not dif

108 ong the muscle fibers or in fiber tension in papillary muscles from heterozygous global Vcl null mice

109 gitation (MR) relates to displacement of the papillary muscles from ischemic ventricular distortion.

110 We also isolated papillary muscles from the right ventricle of NTG and TG

111 anical protocol to isometrically contracting papillary muscles from two rabbit heart populations: (1)

112 determine the mechanism by which annular and papillary muscle geometric alterations result in MR, we

113 mitral annulus at end systole; the posterior papillary muscle geometry was unchanged.

114 cadaver, early myocardial infarction of the papillary muscles had been missed.

115 mias (VAs) arising from the left ventricle's papillary muscles has been associated with inconsistent

116 Papillary muscles have been implicated in arrhythmogenes

117 7 patients with non-prolapse of the ruptured papillary muscle head into the left atrium.

118 transients in electrically stimulated intact papillary muscles; however, the R58Q mutation also resul

119 Papillary muscle hypertrophy that produced midcavitary o

120 KI hearts exhibited atrial enlargement, papillary muscle hypertrophy, and fibrosis.

121 free wall near the insertion of the anterior papillary muscle in 6 pigs.

122 rane potential was recorded in 10 guinea pig papillary muscles in a tissue bath using a double-barrel

123 is was detected at histology at the level of papillary muscles in all patients, and inferobasal wall

124 arction (MI), leaflet tethering by displaced papillary muscles induces mitral regurgitation (MR), whi

125 The prognostic significance of papillary muscle infarction (PapMI) on hard clinical out

126 In HCM, outflow obstruction due to anomalous papillary muscle insertion directly into anterior mitral

127 er in 1997 who demonstrated direct anomalous papillary muscle insertion into the anterior mitral leaf

128 on induces an unloading of myocardium at the papillary muscle insertion site and that the resulting h

129 y to a depression of local function near the papillary muscle insertion site.

130 m(2)), and lack of echocardiographic scar at papillary muscle insertion sites (all P<0.05) and, when

131 eline had a 106 +/- 74 ms time delay between papillary muscle insertion sites (p < 0.001 vs. normal).

132 ordinated timing of mechanical activation of papillary muscle insertion sites appears to be a mechani

133 ults from improved coordinated timing of the papillary muscle insertion sites, using the novel approa

134 argins of the mitral leaflet unencumbered by papillary muscle insertion, and in 1 patient probably re

135 d direct endocardial mapping of the anterior papillary muscle insertion.

136 ssels, ridges of endocardial trabeculae, and papillary muscle insertions.

137 lso determined the kinetics of relaxation of papillary muscles isolated from all four groups of anima

138 to the obstacle and another attaches to the papillary muscle, it may result in stable VT with figure

139 deling (apical and posterior displacement of papillary muscles) leads to excess valvular tenting inde

140 was created within the ventricular septum to papillary muscle level; also, in 1 patient, attachment o

141 ilization by an external patch device of the papillary muscle-LV wall complex that controls mitral va

142 al echocardiographic examination for erratic papillary muscle motion in all patients with suspected r

143 ersus 3.1+/-2.7 (P=0.02), with the posterior papillary muscle moving more laterally (6.8+/-3.4 versus

144 (32 [63%] male; mean age 61+/-15 years) with papillary muscle (n=18), fascicular (n=15), and mitral a

145 n=37; 38.1%), LV trabeculations (n=5; 5.2%), papillary muscle (n=3; 3.1%), and apical-septal bundle (

146 Higher-resolution imaging revealed that papillary muscles (n=10) were most affected.

147 in of dominant VE was seen in 5 of 8 (3 from papillary muscle) nonarrest patients.

148 ation normalized myocardial contractility in papillary muscles of PAB cats but did not alter contract

149 ications of catheter ablation of VA from the papillary muscles of the left ventricle with either cryo

150 erolateral papillary muscle or posteromedial papillary muscles of the left ventricle.

151 ctions of the outflow tract alternating with papillary muscle or fascicular origin.

152 from the outflow tract alternating with the papillary muscle or fascicular region (7 of 9 [78%] vs.

153 oci being mapped at either the anterolateral papillary muscle or posteromedial papillary muscles of t

154 herical remodeling distal to the tips of the papillary muscles (P<0.001).

155 aim of this study was to define the role of papillary muscles (PAPs) in post-infarction ventricular

156 we sought to identify mitral valve (MV) and papillary muscle (PM) abnormalities that predisposed to

157 ral regurgitation (MR) was first ascribed to papillary muscle (PM) contractile dysfunction.

158 ) has been attributed to annular dilatation, papillary muscle (PM) displacement ("apical leaflet tent

159 Although papillary muscle (PM) displacement is recognized in func

160 The role of papillary muscle (PM) in the generation and maintenance

161 , involving subendocardial structures as the papillary muscle (PM) or trabeculae.

162 le (LV) may alter tricuspid annulus size and papillary muscle (PM) positions leading to TR.

163 cle, 8 on the mitral annulus (MA), 1 on each papillary muscle (PM) tip, and 1 on the anterior and pos

164 around the mitral annulus (MA) and 1 on each papillary muscle (PM) tip.

165 The mid-systolic 3D relations of the papillary muscle (PM) tips and mitral valve were reconst

166 try and dynamics of the mitral annulus (MA), papillary muscle (PM), and the chordae tendineac, chorda

167 d that this focal source is located near the papillary muscle (PM).

168 odeling increases tethering to the infarcted papillary muscle (PM).

169 The papillary muscles (PMs) play an important role in normal

170 me was increased tethering distance from the papillary muscles (PMs) to the anterior annulus, especia

171 et tethering by displaced attachments to the papillary muscles (PMs), it is incompletely treated by a

172 tricular remodeling with displacement of the papillary muscles (PMs).

173 implanted to silhouette the LV, annulus, and papillary muscles (PMs); 3 transmural bead columns were

174 r placement (left ventricle, mitral annulus, papillary muscles [PMs], and leaflets).

175 veloped that allows independent variation of papillary muscle position, annular size, and transmitral

176 r dilatation increased regurgitation for any papillary muscle position, creating clinically important

177 lvular repair technique addressing posterior papillary muscle (PPM) displacement.

178 igated in an isolated, blood-perfused rabbit papillary muscle preparation with a confined extracellul

179 Papillary muscle relocation restores the physiologic con

180 ute reverse remodeling of the ventricle with papillary muscle repositioning to decrease MR.

181 Papillary muscle retraction was combined with apical MI

182 ocardiograms of 21 consecutive patients with papillary muscle rupture (20 involved the left ventricle

183 Papillary muscle rupture (PMR) is an infrequent but cata

184 The single patient with right ventricular papillary muscle rupture showed erratic motion as well a

185 ses include right ventricular infarction and papillary muscle rupture with acute severe mitral regurg

186 left ventricle is useful in the diagnosis of papillary muscle rupture, especially in those patients i

187 In some patients with papillary muscle rupture, the ruptured head may not prol

188 7 (35%) of 20 patients with left ventricular papillary muscle rupture, the ruptured head was not seen

189 d but was less sensitive in the diagnosis of papillary muscle rupture.

190 e as the left ventricle (LV) dilated and the papillary muscles shifted posteriorly and mediolaterally

191 s force and [Ca(2+)]i measurements on intact papillary muscles show that enhancement of relaxation in

192 orce and [Ca(2+)]in measurements in isolated papillary muscles showed that the increased force and tw

193 s prominent erratic motion or flutter of the papillary muscle still attached to the left ventricular

194 Mechanical performance of skinned papillary muscle strips derived from mutant and wild-typ

195 nical properties of skinned left ventricular papillary muscle strips from mouse hearts bearing the R4

196 Papillary muscle studies revealed isoproterenol hyporesp

197 s study sought to investigate the benefit of papillary muscle surgery on long-term clinical outcomes

198 tility at 16 hrs as assessed by the isolated papillary muscle technique.

199 Mechanical stresses imposed by papillary muscle tethering increase MV leaflet area and

200 chordae can improve annuloplasty by reducing papillary muscle tethering.

201 extending to the inferior apex displaces the papillary muscles, tethering the mitral leaflets to caus

202 ium while at the same time repositioning the papillary muscles that become apically tethered in MR.

203 Papillary muscles that lie within an infarct zone might

204 ithin the body and to study the integrity of papillary muscles, the fibrous tissue of cardiac valve a

205 R by correcting the position of the affected papillary muscle, thus relieving apical tethering.

206 ps: 1) markedly increased r of the posterior papillary muscle tip (10.3 versus 6.4 mm, MR versus no-M

207 its attachments to the anterior annulus and papillary muscle tip (angular difference = 3 +/- 7 degre

208 the intercommissural dimension with anterior papillary muscle tip displacement toward the annulus is

209 a (MAA), anterior (APM), and posterior (PPM) papillary muscle tip distances to midseptal MA ("saddle

210 The anterior papillary muscle tip in EXP was displaced from CTL by 2.

211 end-systole) and increased r of the anterior papillary muscle tip; 2) dilation (in the septal-lateral

212 anterior and posterior mitral leaflets, and papillary muscle tips and bases in 2 groups of sheep.

213 Both papillary muscle tips avulsed in the first animal, leavi

214 ETHODS AND Under cardiopulmonary bypass, the papillary muscle tips in 6 adult sheep were retracted ap

215 Under cardiopulmonary bypass, the papillary muscle tips in 6 sheep were retracted apically

216 creasing the leaflet tethering distance from papillary muscle tips to the anterior mitral annulus (P<

217 markers were sutured to the mitral annulus, papillary muscle tips, and leaflet edges in 13 sheep.

218 ords at anterior mitral leaflet (S1 and S2), papillary muscle tips, fibrous trigones, mitral annulus,

219 illow height (P<0.0001), longer lengths from papillary muscles to coaptation (P<0.0001), and more fre

220 cTnC for the thin filament in reconstituted papillary muscles to provide evidence of an allosteric m

221 e with MR (>/= moderate) had higher systolic papillary muscle-to-annulus tethering length (P < 0.01).

222 was associated with a decrease in infarcted papillary muscle-to-mitral annulus tethering distance (2

223 Papillary muscle VAs were distinguished electrocardiogra

224 Patients with papillary muscle VAs were older and had higher prevalenc

225 thm, the accuracy rates for the diagnosis of papillary muscle VAs, fascicular VAs, and mitral annular

226 syndrome is characterized by fascicular and papillary muscle VE that triggers ventricular fibrillati

227 tion, the normal shortening of the posterior papillary muscle was obliterated to allow its tip to mov

228 n of isolated rat left ventricular posterior papillary muscle was virtually eliminated at the end of

229 The contractility of cardiac papillary muscles was also restored in CRISPR-edited car

230 and cryostat sections of rat left ventricle papillary muscles, we localized AKAP100 to the nucleus,

231 oporation and conduction block thresholds in papillary muscles were 281+/-64 V and 380+/-79 V, respec

232 RV trabeculations and papillary muscles were considered cavity volume.

233 Left ventricular papillary muscles were excised from aortic-banded or sha

234 Accordingly, RV papillary muscles were isolated from 25 cats with RV pre

235 transients in electrically stimulated intact papillary muscles were observed in Tg-R145G compared wit

236 Papillary muscles were stretched from 88 to 98% of the l

237 e into a cylindrical construct, resembling a papillary muscle, which we have termed a cardioid.

238 o, in 1 patient, attachment of anterolateral papillary muscle with the lateral free wall was partiall

239 staining of transverse cross-sections of the papillary muscles with AKAP100 plus alpha-actinin-specif

240 0.75) and posterior (r=0.70) displacement of papillary muscle, with confirmation in multivariate anal

241 rated anterior displacement of hypertrophied papillary muscles within the left ventricular cavity and

242 or motion relative to the posteriorly placed papillary muscles without a decrease in total orifice ar