ライフサイエンスコーパス: paracaspase

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1 he MLT1/MALT1 locus, which encodes the human paracaspase.

2 hoid tissue lymphoma translocation 1 (MALT1) paracaspase, a key component of the Carma1/Bcl10/MALT1 s

3 ver, the biochemical and structural basis of paracaspase action remains largely unknown.

4 d proteolytic cleavage is dependent on MALT1 paracaspase activity.

5 Paracaspase acts downstream of Bcl10 to induce NF-kappaB

6 Paracaspase and a ubiquitin-conjugating enzyme (UBC13) w

7 MALT1 is the only known paracaspase and is a critical mediator of B- and T-cell

8 The paracaspase and the Ig domains appear as a single foldin

9 erfering RNAs that reduced the expression of paracaspase and UBC13 abrogated the effects of Bcl10.

10 n of NF-kappaB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO.

11 strate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-rece

12 The paracaspase domain adopts a fold that is nearly identica

13 MALT1 paracaspase region, which contains the paracaspase domain and an ensuing Ig-like domain.

14 The paracaspase domain of MALT1, in a protease-independent m

15 caspases, the active and mature form of the paracaspase domain remains a single uncleaved polypeptid

16 or deciphering the function and mechanism of paracaspases exemplified by MALT1.

17 unctional connection between the caspase and paracaspase families to enable nonapoptotic processes.

18 ified two families of caspase-like proteins, Paracaspases (found in metazoans and Dictyostelium) and

19 MALT1/paracaspase is a caspase-like protein that contains an N

20 The paracaspase MALT 1 is a major player in lymphocyte activ

21 so called CARD11), the adaptor BCL10 and the paracaspase MALT1 (the CBM complex), linked to the inhib

22 The CARD domain protein BCL10 and paracaspase MALT1 are essential for the activation of Ik

23 The paracaspase MALT1 cleaves and removes negative checkpoin

24 The paracaspase MALT1 plays an important role in immune rece

25 s a complex with B cell lymphoma 10 (BCL10), paracaspase MALT1, and the inhibitors of kappaB kinase (

26 ion, and this activation is dependent on the paracaspase MALT1.

27 n and regnase-1 proteins were cleaved by the paracaspase MALT1.

28 CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1.

29 Paracaspase (MALT1), a member of an evolutionarily conse

30 ion fuses the BIR domains of c-IAP2 with the paracaspase/MALT1 (mucosa-associated lymphoid tissue) pr

31 Here we show that API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor p

32 Our studies reveal a novel paracaspase-mediated oncogenic gain-of-function mechanis

33 The human paracaspase prodomain binds Bcl10, a protein involved in

34 Metazoan paracaspase prodomains contain a death domain and immuno

35 ain (CARD)-containing protein Bcl10, and the paracaspase (protease related to caspases) MALT1 as crit

36 rmal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and

37 -A resolution crystal structure of the MALT1 paracaspase region, which contains the paracaspase domai

38 pase recruitment domains (CARDs), MALT1 is a paracaspase with structural similarity to caspases.

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