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1 lism of APP results in possible autocrine or paracrine Abeta production to drive the microgliosis ass
3 FBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matri
5 promotes myocardial hypertrophy through the paracrine action of endothelium-derived NO, which trigge
6 pathogens in part through the autocrine and paracrine actions of alpha/beta interferon (IFN-alpha/be
7 ver and support a model in which EC BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate
8 nal differentiation of histamine neurons via paracrine actions or direct synaptic neurotransmission.
14 EN-null fibroblasts leading to a loss in the paracrine activation of NOTCH signaling from the surroun
16 As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as a
18 the different adipose depots; however, their paracrine and autocrine effects on de novo adipocyte for
19 iously implicated pathways and predict novel paracrine and autocrine loops involving cytokines, chemo
20 (IFN) IFNlambda1, which functions in both a paracrine and autocrine manner to protect trophoblast an
21 -6 activates a NF-kappaB signaling axis in a paracrine and autocrine manner, leading to bromodomain p
22 ct as 'synthetic stem cells' which mimic the paracrine and biointerfacing activities of natural stem
23 ential cell-specific regulation of autocrine/paracrine and juxtacrine signaling accounted for the dif
26 l to various target tissues in an autocrine, paracrine, and endocrine manner, thereby determining org
27 er, these results demonstrate that NPNT is a paracrine angiogenic factor and may play a role in patho
28 , whose mechanism of action is predominantly paracrine, are being widely tested for the treatment of
29 thway, we describe a mechanism through which paracrine ATP signalling enhances firing in a cell-speci
30 central auditory neurons can be modulated by paracrine ATP signalling, as shown for the cochlear nucl
31 c neuropeptide that has been shown to act as paracrine/autocrine factor in various malignancies inclu
33 and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity ag
35 duced guanylin loss silences the GUCY2C-cGMP paracrine axis underlying obesity-induced epithelial dys
36 ons result from primary or secondary loss of paracrine BMP signaling from preosteoblasts and dura, hi
38 -derived complement production and autocrine/paracrine C3ar1/C5ar1 signaling as crucial intermediary
39 ematopoietic cells initiates IL-1beta-driven paracrine cascades, which promote abnormal growth plate
41 the JCI, Peteranderl and colleagues define a paracrine communication between macrophages and type II
43 lary thyroid cancer tumors and the autocrine-paracrine conversion of SOD3 expression, which was enhan
44 Therefore, we tested the hypothesis that paracrine Cox-2-mediated signalling from macrophages dri
45 f hematopoietic regeneration and demonstrate paracrine cross-talk between BM osteolineage cells and e
46 a-analytic database analyses, we developed a paracrine cross-talk-based biological mechanism of DCIS
47 les (EVs) released by MSCs contribute to the paracrine crosstalk that shapes hematopoietic function.
49 t combines accelerated perfusion with direct paracrine delivery of a bioactive payload to transplante
54 r 11 (TNFSF11; also known as RANKL) is a key paracrine effector of progesterone signaling and that RA
55 o nonplacental cells through the activity of paracrine effectors, including the constitutive release
56 injury and aids muscle regeneration through paracrine effects and as a multipotent cell source, and
61 ponectin expression in EpAT is controlled by paracrine effects of oxidation products released from th
62 Finally, to study the nature of the hMSC paracrine effects on contractility, proteomic analysis o
65 s in young, pre-menopausal women could exert paracrine effects through the highly estrogen-responsive
66 ), and serum amyloid A2 (SAA2), which elicit paracrine effects to stimulate migration, invasion, and
67 To dissect the relative contributions of the paracrine effects, we first established a liver organoid
71 s, which allows the MAPK cascade to transmit paracrine EGF signals into spatially non-uniform ERK act
72 DE2 can mediate hyperpermeability effects of paracrine endothelial NP/GC-A/cGMP signaling and facilit
73 rowth factor (PDGF)/FGF receptor inhibitors, paracrine ERK activation in fibroblasts was blocked in o
74 only cell-autonomous cytoprotection but also paracrine establishment of a stress-resistant tumor nich
77 impaired ability to upregulate expression of paracrine factor genes and the conditioned media from th
79 monstrates the power of modified mRNA -based paracrine factor library screening to dissect signaling
80 ther, these results show that miR-9 is a key paracrine factor of BMSCs attenuating SAP targeting the
81 ue to RSV infection appears to function as a paracrine factor priming epithelial cells and monocytes
82 results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with chol
83 ein alpha-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly unde
84 through regulation of Fgf16, suggesting that paracrine factors could be of potential use in promoting
85 nder cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis.
86 support metabolism and express regenerative paracrine factors is a strategy to treat vasculopathies
87 g approach to probe the effect of individual paracrine factors on epicardial progenitors in the adult
89 st that these cells release cardioprotective paracrine factors that activate endogenous pathways, lea
91 ablishing this microenvironment by releasing paracrine factors that control the functions of surround
93 exert their beneficial effects by release of paracrine factors, microvesicles, and transfer of mitoch
94 doislets depends upon the combined action of paracrine factors, such as insulin and somatostatin, and
96 mportantly, while SHH acted exclusively in a paracrine fashion on PSCs and influenced the growth of P
98 mokine, CCL5, from ECs, which then acts in a paracrine fashion on TNBC cells to enhance their migrati
100 owards the primary chemoattractant, and in a paracrine fashion to mediate the recruitment of neighbor
101 by immune cells and acts as an autocrine or paracrine fashion to regulate the function of immune cel
102 pable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors, i
103 pable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors.
104 ta-catenin wild-type colon cancer cells in a paracrine fashion, whereas no hyperactivation was detect
106 eased the angiogenic potential of HUVEC in a paracrine fashion; conversely, knockdown of RPS15A in He
107 EGF, SEMA3A, TGF-beta, and CXCL12 signal in paracrine fashions between the podocytes, endothelium, a
109 diovascular effects appear to be mediated by paracrine FGF control of kidney FGFR1 and subsequent reg
110 fore, may have a more important autocrine or paracrine function that is confined within the adipose t
111 tor (TGF)-beta1 contributes to autocrine and paracrine functions in the tumor microenvironment (TME).
114 These studies reveal a role for the GUCY2C paracrine hormone axis as a novel compensatory mechanism
115 se C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universall
118 ed in intestinal epithelial cells, binds the paracrine hormones guanylin and uroguanylin, inducing cG
119 hich are peptides structurally homologous to paracrine hormones of the intestinal guanylate cyclase C
120 n together, our data support the notion that paracrine IGF1/IGF1R signaling initiated by RT-activated
121 val.Significance: These findings reveal that paracrine IGF1/IGF1R signaling promotes colorectal cance
122 ence spontaneous inflammasome activation and paracrine IL-1 signaling, which is sufficient to cause s
123 eased response to and secretion of autocrine/paracrine IL-10, IL-4, IL-22 and thymic stromal lymphopo
124 the spleen compete for a limiting supply of paracrine IL-2 generated by autoreactive CD4(+) T cells
127 ain vesicles but transmitter release appears paracrine in nature, due to the apparent lack of synapti
128 und is both necessary and sufficient for the paracrine induction of HIF1alpha in such cells under nor
129 endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesti
132 teolytic bone responses that involve complex paracrine interactions between tumor cells, osteoblasts,
133 tumor's genetic profile but also by complex paracrine interactions within the tumor microenvironment
134 of SS18-SSX2-transformed cells, indicating a paracrine link between the bone and synovial sarcomagene
135 findings suggest that an IL-1beta-dependent paracrine loop between infiltrated neutrophils/MDMs and
137 ions meclofenamate and tonabersat break this paracrine loop, and we provide proof-of-principle that t
139 secreted inflammatory signals, which through paracrine macrophage activation regulates the migratory
142 factor 1 (IGF1) is secreted in an autocrine/paracrine manner by GCs and activates the IGF1 receptor
143 1 by NK cells, which participated in an auto/paracrine manner in the suppressive activity of polymorp
145 gnal through endothelial CXCR2 receptor in a paracrine manner to promote endothelial tube formation,
146 retion of IL-2 that normally feeds back in a paracrine manner to promote STAT5 activation and IL-9 pr
147 irect targets of ETH and released in a broad paracrine manner within the CNS; by autocrine influences
148 weakly metastatic, non-EMT tumour cells in a paracrine manner, in part by non-cell autonomous activat
149 that mesenchymal stem cells (MSCs) act in a paracrine manner, the mechanisms are still not fully und
161 ese models revealed that this gap junctional/paracrine mechanism accounts for up to 23% of the suppre
163 s CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulate
164 igrating cells revealed a possible SCF/c-Kit paracrine mechanism contributing to migration via a subp
165 se is regulated by cardiac fibroblasts via a paracrine mechanism involving plasma membrane calcium AT
167 Together, these results identify a potential paracrine mechanism that coordinates neuronal homeostasi
168 cuit formation, but they also reveal a novel paracrine mechanism that regulates the assembly of these
175 ric Castleman's disease through autocrine or paracrine mechanisms during latency or productive replic
176 de arterial PCO2 /pH via cell-autonomous and paracrine mechanisms, and via input from other CO2 -resp
186 ng the secretion of extracellular, autocrine/paracrine mediators of glioma stem-like cell self-renewa
187 ivation, cell-cycle arrest, and secretion of paracrine mediators, including insulin-like growth facto
188 hway activator CHIR99021 results in distinct paracrine microenvironments codifying hPSCs towards defi
189 ulk tumor cell proliferation by induction of paracrine mitogenic signaling between heterogeneous mali
192 te that the mechanism is through overlapping paracrine or autocrine canonical WNT-beta-catenin signal
194 protein-coupled receptors (GPCRs) respond to paracrine or endocrine peptide hormones involved in cont
195 ulin target cell types through mechanisms of paracrine or endocrine regulation with robust effects on
198 s in Hyp mice, its putative role as an auto-/paracrine osteomalacia-causing factor has not been explo
201 (FGF) signaling pathways formed an autocrine/paracrine-positive feedback loop to drive the progressio
204 gered the expression of a specific subset of paracrine profibrotic factors, including Lcn2, Pdgfb, an
205 ) therapy in heart failure may be related to paracrine properties and systemic effects, including ant
206 In this study, we explored the importance of paracrine regulation by using an optogenetic strategy.
207 ted by lipotoxicity and were associated with paracrine regulation of glucocorticoid activity because
208 reted by neighbouring beta- and delta-cells (paracrine regulation) have been proposed to be important
209 ic intermediate of the BCAA valine, as a new paracrine regulator of trans-endothelial fatty acid tran
212 liferation, suggesting a potential endocrine/paracrine role for BMPs, but some of the mechanisms are
217 cribe a mechanism by which damage-associated paracrine secretory responses are restrained to preserve
218 e GPR91, which functions as an autocrine and paracrine sensor for extracellular succinate to enhance
220 PCa bone and visceral metastases, activating paracrine Shh signaling in tumor-stromal interactions.
221 ntiation through triggering the release of a paracrine signal from persistently activated beta-cells.
223 n receptor signalling nexus may operate as a paracrine signal that sustains tumour cell expansion and
224 SC-mediated heterocellular coupling (HC) and paracrine signaling (PS) on human cardiac contractility
225 s animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact reg
226 icroColonies') to quantitatively investigate paracrine signaling and the response to external stimuli
230 more slowly developing mechanisms involving paracrine signaling by extracellular peptides (C-type na
232 as ATP and ADP) and subsequent autocrine and paracrine signaling events through nucleotide receptors.
233 l breast cancer: TGFbeta is an autocrine and paracrine signaling factor that drives cell invasion and
234 zation are coupled by localized secretion of paracrine signaling factors by the differentiating hMSCs
236 s then applied to HMECs to determine whether paracrine signaling from PELP1-cyto-activated macrophage
237 CFB mechanical activation and found that 1) paracrine signaling from stretched cardiomyocytes induce
238 ata suggest that inhibition of Ezh2 promotes paracrine signaling in osteoblasts and has bone-anabolic
239 growth factor-1 receptor (IGF-1R) autocrine/paracrine signaling in patients with renal cell carcinom
240 ctivity not only disrupts IL-1 autocrine and paracrine signaling loops that can alert effector cells
242 minobutyric acid, an important autocrine and paracrine signaling molecule and a survival factor in is
243 hophysiological significance, the origin and paracrine signaling pathways that regulate epicardial ad
246 n interstitial fibrosis, and through altered paracrine signaling to cardiomyocytes, which become hype
247 These results suggest that autocrine and/or paracrine signaling via locally generated SPMs in the va
248 ation through inhibition of cell activation, paracrine signaling, and dampened cellular proinflammato
249 enous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and trig
250 ted therapy-induced stromal ELR(+) chemokine paracrine signaling, thus enhancing treatment response a
252 on of cancer by mediating stromal-epithelial paracrine signaling, which can aberrantly modulate cellu
261 between TAMs and GSCs through the PTN-PTPRZ1 paracrine signalling to support GBM malignant growth, in
262 daptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, which is amplified by c
264 fine-tuning the endosomal pH in response to paracrine signals and is therefore an important regulato
265 hed soluble chemokines can generate auto- or paracrine signals by binding and activating their transm
270 r, these studies highlight the importance of paracrine signals from the airway epithelium to the unde
274 s a novel approach to identify developmental paracrine signals regulating the differentiation of huma
276 n, including profibrotic and proinflammatory paracrine signals secreted by epithelial cells after eit
277 artment resulted from loss of stroma-derived paracrine signals that activate Yap1 and the Hedgehog pa
278 infiltration to the injured nerve, and sends paracrine signals to activate TRPA1 of ensheathed nocice
279 ly integrate fluctuating ionic, hormonal and paracrine signals to control the synthesis and secretion
282 lly, dampening a positive EGF-EGFR autocrine/paracrine stimulation loop induced by the post-surgical
283 a1, alpha3-null keratinocytes showed reduced paracrine stimulation of endothelial cell migration and
287 ilan-infected cells established an autocrine/paracrine TLR5 signaling loop resulting in constitutive
288 nsing of cytokine production was mediated by paracrine TNF-alpha-TNFR1 signaling rather than direct l
289 Moreover, AGR2 expression was inducible by paracrine transfer of ER stress and pro-inflammation bet
290 er damage, reactive oxygen species (ROS) and paracrine tumor necrosis factor (Tnf) from Kupffer cells
293 by LPA1-, Gi-, and COX1-dependent autocrine/paracrine TXA2 release and consequent TP activation.
294 ntrols cardiac oxygen (O2 ) consumption in a paracrine way by slowing respiration at the mitochondria
295 ut hair cycle quiescence and growth, whereas paracrine Wnt inhibition of inner bulge cells reinforces
296 decan-1 and that this binding contributes to paracrine Wnt pathway activation through the Wnt recepto
297 ESCs secrete Wnts that activate autocrine or paracrine Wnt/beta-catenin signaling to promote efficien
298 g activation by autocrine Wnt ligands and/or paracrine Wnts emanating from the bone marrow (BM) niche
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