ライフサイエンスコーパス: paradigm

1 otherwise "impoverished" laboratory exposure paradigm.

2 Ts) is an important potential cancer therapy paradigm.

3 are now underway to expand the reach of this paradigm.

4 m baseline) in response to tail pinch stress paradigm.

5 ses of a ramp-and-hold visuomotor adaptation paradigm.

6 ater he was studied in a cocaine-food choice paradigm.

7 of studies that could inform this treatment paradigm.

8 sing the behavioral pattern separation (BPS) paradigm.

9 not be explained by the canonical signalling paradigm.

10 we show how these animals differ from such a paradigm.

11 plores the chemically inducible dimerization paradigm.

12 be accounted for by the classic induced-fit paradigm.

13 We adopted a different paradigm.

14 an unfamiliar mouse in a social interaction paradigm.

15 s completed a right-hand, paced tapping fMRI paradigm.

16 duced fear expression in a fear-conditioning paradigm.

17 h dimensionality and nonconvexity of the NMF paradigm.

18 has emerged as a promising cancer treatment paradigm.

19 ecreased the activation of caspase-3 in both paradigms.

20 y affect progressive entrustment in training paradigms.

21 n big data approaches to clinically relevant paradigms.

22 important to revisit existing data analysis paradigms.

23 on in both in vitro and in vivo experimental paradigms.

24 that can be assessed using sequence-learning paradigms.

25 ot been studied using dynamic tissue culture paradigms.

26 ss three emotional reactivity and regulation paradigms.

27 (MRD) is increasingly influencing treatment paradigms.

28 stabilization may lead to efficient learning paradigms.

29 hat patients treated under the drip-and-ship paradigm also benefit from bridging therapy, with no sta

30 rgic controls (n = 42) performed a dual-task paradigm and a verbal learning and memory test during an

31 overy of VEGF-PDGFRs binding challenges this paradigm and calls for investigation of other ligand-rec

32 experiments obeying the modulated excitation paradigm and exploiting phase sensitive detection (PSD).

33 am- and LHb-lesioned rats in our operant CTA paradigm and found that LHb lesion significantly attenua

34 , we design a two-step reward-based decision paradigm and implement it in a reaching task experiment.

35 avioural effects in the learned helplessness paradigm and regulates molecular events implicated in th

36 ssessed through the use of a vending machine paradigm and snack food taste tests (SFTTs).

37 ments of objective speed using an adaptation paradigm and video recordings of natural human locomotio

38 l-described appetitive and aversive learning paradigms and combining them in a single training sessio

39 le more efficient evaluation of AG treatment paradigms and structural modifications to reduce hair ce

40 Our findings deviate from established paradigms and warrant further assessment of the pathogen

41 with increased amygdala activity in a stress paradigm, and being brought up in a city with increased

42 Novel concepts and paradigms are described here that have emerged, targetin

43 ephales promelas) and suggest different test paradigms are required for that species.

44 yeloma is considered a continuously evolving paradigm as a result of the growing availability of new

45 tates are solutions to the deterministic FBA paradigm as the stochastic elements dissipate, and C) RA

46 traditionally investigated using habituation paradigms, assuming that babies' memories in laboratory

47 nce in working memory and object recognition paradigms at baseline and after psychotogenic drug chall

48 et of diabetes, every other day for 4 weeks (paradigm B).

49 h clinical benefit using a learn-and-confirm paradigm based on data from different clinical studies o

50 s the clinical value of a granzyme B imaging paradigm, biopsy specimens from melanoma patients on che

51 Recent findings established a new paradigm by uncovering that their association with magne

52 specific manner in response to injury, and a paradigm by which lncRNAs encoding small polypeptides ca

53 Our BMI paradigm can dissect the contribution of different eleme

54 ults suggest that using a novel, yet simple, paradigm can result in meaningful pupil metrics that cor

55 Explore/exploit paradigms can offer psychiatry research a new approach t

56 This article reviews several potentially paradigm-changing mechanisms enabled by defects, size ef

57 asia caused by germline mutations has led to paradigm-changing precision prevention efforts, includin

58 s have focused on males as one commonly used paradigm-chronic social defeat stress-has proven challen

59 iciency in Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in fami

60 Using a novel paradigm combining neuroimaging with hand tracking, the

61 Our behavioral paradigm could be used to further investigate effects of

62 -reactivity task (day 7; n=81) and a bar lab paradigm (day 8).

63 itical problems with the molecular recording paradigm: determining recording start times and coping w

64 witnessed a dramatic change in the treatment paradigms due to the development of improved surgical st

65 red for associative learning in conditioning paradigms, e.g., two-way active avoidance and fear condi

66 frontal cortex and utilized a series of task paradigms, each measuring a different aspect of recogniz

67 unds represents a test bed to establish this paradigm, enabling rapid, mobile, and widespread deploym

68 tiate into sciences with a restricted set of paradigms, examples, and techniques, developmental biolo

69 In renewal paradigms, extinguished behavior recovers when tested ou

70 Using an established mating paradigm, fetal microchimeric cells present in maternal

71 included a resting state and an experimental paradigm focusing on the anticipation of actively touchi

72 DCC serves as a clear paradigm for addressing how condensins target large chro

73 stent with the established effector-immunity paradigm for antibacterial T6SS substrates, the toxic ac

74 Quest MRI is a promising in vivo paradigm for bridging brain subfield oxidative stress an

75 increasingly become an appealing therapeutic paradigm for cancer treatment due to its great potential

76 being identified is challenging the current paradigm for cell type definition in the Cell Ontology.

77 stimulus responsive polymers to introduce a paradigm for creating actively deployable 3D structures

78 ast and present MLL-FP models may serve as a paradigm for designing more flexible and dynamic preclin

79 nal and screening approach should stand as a paradigm for determining resistance mutations and their

80 R1 and HoxA5 as potential targets provides a paradigm for developing strategies to treat respiratory

81 pecific biological effects constitutes a new paradigm for environmental health but still lacks high-t

82 rlying binge eating and provide a behavioral paradigm for future genome-wide association studies in p

83 We suggest this study provides a paradigm for how KLFs work in incoherent feed-forward lo

84 antibody complexes, we propose a mechanistic paradigm for IL-23 and IL-12 whereby cognate receptor bi

85 rs, D(2)GIS devices offer a high-performance paradigm for imaging across the electromagnetic spectrum

86 se findings elucidate an NFAT-MAPK signaling paradigm for induction of isletokine expression in beta-

87 Drosophila melanogaster is the paradigm for insect development, whereas comparative tra

88 This work provides a paradigm for interphase design to address the dendrite c

89 ne expression that benefits the partner is a paradigm for microbial interactions that cannot be obser

90 Thus, we establish a new paradigm for mosquito surveillance that takes advantage

91 tistics for C. elegans vulval development, a paradigm for organogenesis.

92 helial migration and establishes a different paradigm for planar cell-cell signaling.

93 A paradigm for pneumococci is their interaction with the a

94 of the two-dimensional Fermi-Hubbard model-a paradigm for strongly correlated fermions on a lattice-i

95 vioral states in C. elegans, and establish a paradigm for the elucidation of obesity-relevant mechani

96 uropean rabbits in Australia and Europe is a paradigm for the evolution of a pathogen in a new host s

97 e CIA-targeting factors and represents a new paradigm for the insertion of the Fe/S cofactor into a r

98 lex contributions of p53 define a biological paradigm for the p53 regulator network in the heart unde

99 Our study thus represents a new paradigm for the rational design of ionophores that can

100 velopment of pulmonary fibrosis and may be a paradigm for the regulation of tissue repair.

101 ecedented extent, thereby establishing a new paradigm for thermodynamic analysis of precipitate assem

102 structure of Escherichia coli has become the paradigm for this class of secondary active transporters

103 blished Bacillus amyloliquefaciens LoaP as a paradigm for this protein subgroup and showed that it re

104 both a fundamental step of development and a paradigm for tissue formation and remodeling.

105 , and heart failure, providing an attractive paradigm for treatment of cardiac hypertrophy and heart

106 as a phase-separated compartment provides a paradigm for understanding its structure, biogenesis, an

107 nesis of adult enteric neurons and provide a paradigm for understanding the enteric nervous system in

108 s fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug met

109 Our strategy thus enables a new paradigm for using air-stable molecular dopants to impro

110 Here, we summarize new quantitative paradigms for assessing the self, drawn from psychology,

111 and Candida albicans have served as crucial paradigms for CPR species and oral fungi, respectively.

112 Globalization has driven new paradigms for drug discovery and development.

113 Our findings revise prevailing paradigms for linear, time-invariant resonant systems, c

114 valuation of current conservation management paradigms for the black rhinoceros.

115 in this setting, provide one of the simplest paradigms for the study of mechanosensory transduction.

116 be preferable to traditional CS-reactivation paradigms for treating disorders that involve multiple C

117 ilation differed from the classical "enteric paradigm" for nitrogen utilization.

118 This paradigm has changed rapidly, due to the antifibrotic ap

119 This experimental paradigm has provided fundamental information regarding

120 language control within artificial switching paradigms has been heavily studied, the neurobiology of

121 The most important change to these paradigms has been the integration of spinal stereotacti

122 The PARADIGM-HF (Prospective Comparison of ARNI With an ACE-

123 Patients with diabetes and HFrEF enrolled in PARADIGM-HF who received sacubitril/valsartan had a grea

124 Among the 8399 patients enrolled in PARADIGM-HF, 7623 (91%) completed KCCQ scores at randomi

125 An emerging paradigm holds that resistance to the development of all

126 In a texture-based, change-detection paradigm, human performance and reaction times improved

127 xclusion, using a novel social feedback fMRI paradigm in a population-derived sample of adolescents.

128 Using an associative learning paradigm in C. elegans, we investigated the effects of D

129 on cancer cells can significantly change the paradigm in cancer treatment management.

130 We developed a novel hand-rearing paradigm in European starling nestlings (Sturnus vulgari

131 a conditioned place preference/reinstatement paradigm in mice to directly test the hypothesis that co

132 Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, name

133 The observational fear (OF) paradigm in rodents, in which the subject is exposed to

134 hniques and provide the foundation for a new paradigm in teaching and assessing hands-on clinical ski

135 The dominant paradigm in understanding drug action focuses on the int

136 We use a simple habituation-dishabituation paradigm in which animals must discriminate between two

137 activity while participants performed a new paradigm in which both processes are quantified.

138 n learn categories by a transitive inference paradigm in which novel exemplars of five categories wer

139 acquired fMRI data in an incidental-viewing paradigm in which subjects performed an attention-demand

140 , analyzed in comparison with 3 by different paradigms in a rat model of oxaliplatin-induced neuropat

141 werful strategy for promoting new reactivity paradigms in base-metal catalysis.

142 The data suggest new paradigms in cardiac adrenergic signaling mechanisms.

143 aking important inroads toward new treatment paradigms in polypoid CRS.

144 predictions were tested in a double oddball paradigm, in which frequent standard stimuli and rare od

145 The "bounded rationality" paradigm incorrectly equates rationality with forming ac

146 A completely different paradigm is based on three-terminal stochastic units whi

147 f computationally hard problems wherein this paradigm is fundamentally inefficient.

148 Our novel paradigm is immersive, enabling us to measure vigor in t

149 This new paradigm is propitious for enhanced detection and charac

150 The generally accepted paradigm is that such aging is gradual and its origin is

151 We found that our paradigm is well tolerated in children as young as 6 yea

152 optimization of poststroke physical therapy paradigms is challenged in part by a lack of objective t

153 rent multiple phenotype association analysis paradigm lacks breadth (number of phenotypes and genetic

154 ther publication year, functional MR imaging paradigm, magnetic field strength, statistical threshold

155 Through a "design-build-test" cycle paradigm, massive libraries of genetically engineered mi

156 r results demonstrate that a US-reactivation paradigm may be preferable to traditional CS-reactivatio

157 We postulate that this new paradigm may be the preferred approach for training and

158 exhibit AD pathology, but the overexpression paradigm may cause additional phenotypes unrelated to AD

159 This effect demonstrates that the para-meta paradigm no longer holds if appropriate substituents and

160 Following the general paradigm of ab initio methods for low-resolution restora

161 program may significantly alter the current paradigm of AHF patient care.

162 The human brain is the elemental paradigm of an efficient robust modular system interconn

163 This finding demonstrates a general paradigm of anion-regulated evolution of distinctive TMS

164 We propose a novel paradigm of atrial ECC that is based on tandem activatio

165 f paper folding, has recently inspired a new paradigm of design for mechanical metamaterials and depl

166 Our study demonstrates a new paradigm of DNA methylation-mediated gene activation and

167 3 weeks of environmental enrichment (EE), a paradigm of enhanced sensory, motor, and cognitive stimu

168 vulval precursor cells, a well-characterized paradigm of epidermal growth factor receptor (EGFR)-Ras-

169 ator of cardiac hypertrophy and define a new paradigm of gene regulation in the heart, where controll

170 We conclude that the paradigm of metabolic bioactivation uncovered here shoul

171 of NH4(+) in these electrodes point to a new paradigm of NH4(+) -based energy storage.

172 nance imaging (rs-fcMRI) and the distinctive paradigm of rapid mood normalization following ketamine

173 autism.SIGNIFICANCE STATEMENT We use a novel paradigm of repetitive whisker stimulation and in vivo c

174 ork constitutes a stepping stone towards the paradigm of self-correcting quantum information processi

175 t outcomes, potentially shifting the current paradigm of sepsis management.

176 Our findings may spur a paradigm of soliton dynamics in soft matter, with a rich

177 nic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for signi

178 This may be considered a paradigm of the ground work needed to tackle the molecul

179 In the conventional paradigm of the progression of left ventricular hypertro

180 force-induced gating, which could serve as a paradigm of the tether model.

181 More recently, an emerging paradigm of transition-metal signaling, where dynamic ch

182 This study demonstrates the paradigm of uniting simulation and experiment in a stati

183 tional Epigenetic Modules (FEM), the current paradigm of using the spin-glass algorithm to integrate

184 15 healthy controls completed two laboratory paradigms of 'simulated' drug choice (choice for drug-re

185 stolic), which lack mechanistic specificity, paradigms of cardiac disease have evolved to conceptuali

186 ons of different noise sources in well-known paradigms of cell-size control, such as adder (division

187 This work extends the paradigms of HDR-mediated gene conversion and establishe

188 Our findings refute traditional paradigms of passengers as neutral events, suggesting th

189 or the scientific community highlighting key paradigms of the type I IFN response.

190 The present paradigm offers an opportunity to study how sensory and

191 e way for a cost-effective high power device paradigm on an Si CMOS platform are demonstrated.

192 This is a new paradigm on how PGPB promote growth of microalgae which

193 es to the traditional "download and analyze" paradigm on local computing resources has led to a rapid

194 ed the effects of a second laboratory stress paradigm on reward prediction error (RPE) signaling in t

195 In this study, we tested current paradigms on factors setting thermal limits by investiga

196 Here, we created a novel paradigm optimized to dissociate the subtypes of reward-

197 ique features of giant viruses with previous paradigms or to propose a completely new vision of the l

198 with each other-has enforced a "homochiral" paradigm over the field of dynamic DNA nanotechnology.

199 and its constituent actors is changing this paradigm, particularly given the phylogenetic range and

200 l Pavlovian fear conditioning and extinction paradigms, pharmacological inactivation of area 25 decre

201 The Darwin-Bateman paradigm predicts that this should also hold for hermaph

202 ling female rats were exposed to a 7 day CVS paradigm previously shown to upregulate BNST PAC1 recept

203 Although a few paradigms probed fear conditioning/extinction or utilize

204 The paradigms proposed in this review aim to enhance the cli

205 Motor adaptation paradigms provide a quantitative method to study short-t

206 ehensive In Vitro Proarrhythmia Assay (CiPA) paradigm provides lessons from the cardiac field that al

207 on high-fat diet feeding, and this injection paradigm reduced high-fat intake and obesity in diet-ind

208 next-generation sequencing to probe how this paradigm relates to human Vdelta2(neg) T cells, implicat

209 ture, and related approaches with behavioral paradigms relevant to cocaine phenotypes.

210 erature tunability demonstrated represents a paradigm shift for nanoscale metamaterial and metasurfac

211 ed within a single nanorod and may provide a paradigm shift for one-dimensional tunnelled materials,

212 ws promising results that signal a potential paradigm shift from conventional NMR data interpretation

213 s determine cell physiology and represents a paradigm shift from descriptive to predictive biology.

214 Together, these results represent a paradigm shift in anisotropic gold NP synthesis.

215 Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently receive

216 te antitumor T-cell immunity have heralded a paradigm shift in cancer treatment.

217 serving many of these species necessitates a paradigm shift in conservation toward a holistic approac

218 in western and southern India, we show that paradigm shift in Indian groundwater withdrawal and mana

219 This has led to a paradigm shift in our treatment methodology.

220 Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care, resulting in subst

221 on of unactivated C-H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis.

222 These findings suggested consideration of a paradigm shift in the understanding of the therapeutic r

223 Remote patient monitoring represents a paradigm shift in the way physicians care for patients.

224 in chronic lymphocytic leukemia has led to a paradigm shift in therapy, and relapse has been uncommon

225 A paradigm shift is made by a new study that monitors simu

226 so to gain additional biological insights, a paradigm shift is needed.

227 nctional materials and devices may lead to a paradigm shift toward new, intelligent, and efficient co

228 Paradigm-shifting gains in scientific knowledge are occu

229 eractions in neuropsychiatric disorders, how paradigm shifts in the phenotypic classification of pati

230 In this focused review, I examine recent paradigm shifts that have transformed our understanding

231 This reactivity paradigm should be considered along with thermodynamic a

232 g-term kidney allograft survival, management paradigms should promote prompt diagnosis and treatment

233 Studies using a novel serial cue paradigm showed that episodic encoding is dependent on b

234 the strengths of different driver prediction paradigms.Significance: These findings assess state-of-t

235 The current paradigm states that all newly made ILCs originate from

236 the biological carbon pump other than broad paradigms such as diatoms contributing disproportionally

237 Here, we propose an alternative paradigm that can lead to substantial further improvemen

238 The hyperhemolysis paradigm that describes overlapping "hyperhemolytic-endo

239 lar mineralization, we challenge the popular paradigm that electrostatic attraction is solely respons

240 Taken together, our results support a new paradigm that GOT enables metabolism of otherwise neurot

241 These data challenge the current paradigm that in vivo physiological TH action is mediate

242 d neuroimaging of Pavlovian fear reversal, a paradigm that involves flexible updating when the contin

243 Our findings challenge the current paradigm that nuclear export regulates the proteolysis o

244 his "immunophage synergy" contrasts with the paradigm that phage therapy success is largely due to ba

245 rially by macaque monkeys using a behavioral paradigm that provides no explicit feedback about catego

246 Here a closed-loop cavitation controlling paradigm that sustains stable cavitation while suppressi

247 Our results reveal a paradigm that the known interaction of many proteins wit

248 The result is a new paradigm that thinks about the dissemination of medical

249 we report the development of a new screening paradigm that utilizes an active site mutant D134A (D3.3

250 We report a new version of the social defeat paradigm that works in female mice.

251 mly rooted in the current structure-function paradigm, the mechanistic basis for allostery in the abs

252 evice concept that fundamentally breaks this paradigm-the sensors remain dormant with near-zero power

253 wever, unlike the long-range apparent motion paradigm, this was unaffected by different combinations

254 Applying this paradigm to a dodecahedral viral capsid, a computer-deri

255 fore, we used a thymidine kinase/ganciclovir paradigm to ablate both dividing NG2(+) cell populations

256 Overall, these results may be utilized as a paradigm to aid in the rational development of other eff

257 Metasurfaces enable a new paradigm to control electromagnetic waves by manipulatin

258 Here we use a 'two-hit' immune-activation paradigm to determine whether perinatal immune activatio

259 Our development of a single paradigm to dissociate distinct processing components th

260 Our development of a single paradigm to dissociate each of these components may aid

261 according to the multitarget-directed ligand paradigm to exert combined activity at human fatty acid

262 linker histone phosphorylation, serving as a paradigm to explore the role of linker histones in bio-s

263 s have led us to entertain expansions of our paradigm to include new theoretical questions, new crite

264 vel unconditioned-stimulus (US) reactivation paradigm to interfere with the ability of multiple cues

265 udy, we employed an adapted change detection paradigm to investigate the effects of two depth cues, b

266 Here, we use ectopic eye formation as a paradigm to investigate the emergence and integration of

267 ivity of the epialleles, and we extended our paradigm to naturally occurring phenotypes.

268 Here we introduce a novel behavioural paradigm to study this issue.

269 e offer and validate a novel virtual reality paradigm to study threat-related learning and extinction

270 perspective, we apply the precision medicine paradigm to the emerging use of extracorporeal CO2 remov

271 model system that uses a controlled stimulus paradigm to understand the mechanisms by which top-down

272 nologies, informatics and practical clinical paradigms to apply these principles in stroke and realis

273 and unique properties, graphene opens up new paradigms to realize this concept, but so far this has b

274 We propose that, contrary to the established paradigm, TRPV4 is activated by increased cell volume ir

275 grade 3 PGD was analyzed under the Bayesian paradigm, using logistic model and areas under the recei

276 To our knowledge, this is the first paradigm validating modulation of paxillin to inhibit an

277 A passive oddball paradigm was adopted to examine two groups (16 in the au

278 wo-concentration" acetylcholine or carbachol paradigm was developed and validated to determine alpha4

279 This paradigm was then used in layers I-IV of slices of the r

280 The quantification of Sudan III, as a paradigm, was performed in varying levels (0.14-7.1g/kg)

281 n, using the Pavlovian-instrumental transfer paradigm, we assessed the effects of manipulations of th

282 Contrary to the prevailing paradigm, we found unique cellular requirements for B7 a

283 rough a biochemical and structural screening paradigm, we have identified JNJ0966, a highly selective

284 ng a novel modification of the reinstatement paradigm, we show that achieving cocaine use reversed th

285 In this paradigm, we treated timed-pregnant mice with polyinosin

286 In summary, these findings suggest a new paradigm where IL-4-dependent up-regulation of Cox-1 exp

287 has been shown to be abnormally activated in paradigms where individuals had to specifically attend t

288 cipants performed a modified location-cueing paradigm, where false information about the percentage o

289 Collectively, our work establishes a paradigm whereby CV malformations result from primary or

290 thma, particularly when a precision medicine paradigm, wherein a biomarker or gene expression pattern

291 ented with the local-global auditory oddball paradigm, which distinguishes 2 levels of processing: sh

292 ignals and rs-fMRI via a new neuromodulation paradigm, which exploits these power synchronization mec

293 took advantage of a spatial alignment effect paradigm, which typically refers to a decrease of reacti

294 We expect that this paradigm will also enable potential applications in dive

295 veloping effective strategies under this new paradigm will require deeper understanding of the long-t

296 abolism in vivo Further development of these paradigms will lead to new treatment options with glutam

297 I then illustrate this paradigm with a few examples from the recent literature

298 o this end, we paired a sensory interference paradigm with an echolocation task.

299 this effect, we then combined the adaptation paradigm with TMS.

300 RNA binding unites two archetypal regulatory paradigms within a single protein.