ライフサイエンスコーパス: paradigm shift

1 The science of genetics is undergoing a paradigm shift.

2 erminants of complex disease is undergoing a paradigm shift.

3 -guided robots have the potential to offer a paradigm shift.

4 ochromocytoma field has recently undergone a paradigm shift.

5 sing and addressing these threats requires a paradigm shift.

6 ll and resources need to be accompanied by a paradigm shift.

7 global disease outbreaks as well as multiple paradigm shifts.

8 of sepsis, have been accompanied by episodic paradigm shifts.

9 of criticism have changed, reflecting recent paradigm shifts.

10 understanding of algae to identify potential paradigm shifts.

11 Recent evidence has, however, led to a paradigm shift according to which the ECM is increasingl

12 Paradigm-shifting advances have revealed that diverse me

13 n (1962) argued in his seminal discussion of paradigm shifts, an old paradigm cannot be abandoned unt

14 aused by RNA viruses represents an important paradigm shift and a new frontier for future antiviral t

15 pid development of new treatments requests a paradigm shift and a new way of thinking in the mind of

16 nslumenal endoscopic surgery may represent a paradigm shift and may offer significant benefits to pat

17 This work illustrates a paradigm-shifting and biomimetic approach and contribute

18 This resulted in a major paradigm shift, and consequently, the pool of eligible p

19 Cancer epidemiology is at the cusp of a paradigm shift, and the field will need to accelerate th

20 As with most new paradigm-shifting applications, it is not the last word

21 As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bond

22 This paradigm-shifting approach has a wide applicability to m

23 a number of challenges that call for novel, paradigm-shifting approaches.

24 e genome sequencing we are in the midst of a paradigm shift as it is now possible to interrogate the

25 Epigenetics research does not so much need paradigm shifts as the unraveling of an exceedingly comp

26 emonstrate comparable performance metrics is paradigm shifting, as these new materials offer the poss

27 This may mandate a paradigm shift away from advanced cardiac life support a

28 Insights gained bring the field closer to a paradigm shift away from devices and drugs, and toward b

29 Approval of this drug would represent a paradigm shift away from dual antiplatelet therapy towar

30 This approach represents a paradigm shift away from standard PCR-based approaches f

31 These results lead to a paradigm shift away from the concept that binding of the

32 A paradigm shift, based on data emerging from the oral mic

33 ake-up of individual tumours would involve a paradigm shift, but might lead to substantial therapeuti

34 However, this does not imply a paradigm shift, but simply a normal development of a you

35 erged from principles of basic immunology to paradigm-shifting clinical immunotherapy.

36 t to independently validate this potentially paradigm-shifting concept.

37 This paradigm shift concerning the cell of origin for the mos

38 We describe a paradigm shift currently under way in computer graphics

39 Paradigm-shifting discoveries about AD have been based o

40 While these new and potentially paradigm-shifting discoveries are intriguing, the field

41 ecognizes the architects of two of the great paradigm-shifting discoveries of the last half-century o

42 Schizophrenia treatment may see a paradigm shift due to development of new atypical antips

43 Demonstrating an important paradigm shift, effector Th40 cells from prediabetic mic

44 The new HFPEF paradigm shifts emphasis from LV afterload excess to cor

45 The workshop was motivated by the paradigm-shifting evidence derived from genomic data for

46 ollowed for longer durations may result in a paradigm shift for ankylosing spondylitis treatment simi

47 energy storage devices, and could provide a paradigm shift for architecture and design of flexible a

48 thout a clear picture, or truly represents a paradigm shift for cancer research.

49 o the primary therapy, suggesting a possible paradigm shift for clinical treatment of dormant disease

50 A paradigm shift for implantable medical devices lies at t

51 Processing in dry conditions represents a paradigm shift for incorporating high active-material ma

52 (6) AUPKE reflects a paradigm shift for live donation, converting a private r

53 erature tunability demonstrated represents a paradigm shift for nanoscale metamaterial and metasurfac

54 ed within a single nanorod and may provide a paradigm shift for one-dimensional tunnelled materials,

55 ncer, that occurs only during adulthood is a paradigm shift for pediatricians.

56 The method presents a paradigm shift for the addressing of plasmonic nanostruc

57 Our technique constitutes a paradigm shift for the analysis of complex molecular mix

58 -based MFC technology, which could provide a paradigm shift for the architecture and design of paper-

59 lecular imaging will represent a significant paradigm shift for the specialty but will ensure that nu

60 fficile infection, and possibly represents a paradigm shift for the treatment of diseases linked to i

61 The promise of a major paradigm shift for the treatment of respiratory and card

62 insight into HPA-HPG interaction provides a paradigm shift for work on stress-related reproductive d

63 Over the past few decades, this paradigm shifted for the chromosphere and corona that co

64 vaccine approaches have the potential to be paradigm shifting for the influenza vaccine field, with

65 ining these principles involves a conceptual paradigm shift from 'radical' prostatectomy to neurosurg

66 e genotype-phenotype relationship requires a paradigm shift from a focus on single SNPs to pathway as

67 management of breast cancer are undergoing a paradigm shift from a one-size-fits-all approach to an e

68 imate, which in recent years has undergone a paradigm shift from a text-book example of an extended g

69 ibrillation by inflammation and represents a paradigm shift from conventional antiarrhythmic drugs, w

70 ws promising results that signal a potential paradigm shift from conventional NMR data interpretation

71 ies, thereby presenting an opportunity for a paradigm shift from conventional restorative/prosthetic

72 Mastering the nonlinear channels requires paradigm shift from current modulation, coding and trans

73 s determine cell physiology and represents a paradigm shift from descriptive to predictive biology.

74 in information bandwidth have resulted in a paradigm shift from electrical to optical interconnects.

75 This brings a paradigm shift from expensive surgical treatment of cata

76 This has resulted in a paradigm shift from focusing on the carriage of antibiot

77 A paradigm shift from hard to flexible, organic-based opto

78 Going forward, we foresee a paradigm shift from individual techniques toward a unifi

79 Reducing the burden of stunting requires a paradigm shift from interventions focusing solely on chi

80 , maximizing conservation success requires a paradigm shift from maintaining ecosystems in idealized

81 a number of emerging applications require a paradigm shift from passivation to functionalization, wh

82 This is a paradigm shift from the current model of enamel developm

83 We propose a paradigm shift from the current postoperative risk adjus

84 data from the last 2 years have suggested a paradigm shift from the notion that DES are less safe th

85 s after keratorefractive surgery represent a paradigm shift from the previous gold standard of the cl

86 geriatric-specific markers is a substantial paradigm shift from the traditional preoperative evaluat

87 This represents a paradigm shift from traditional, enthalpy-based mechanis

88 The need for a paradigm shift from type-specific immunity against S. py

89 ine and subsequently adefovir, the treatment paradigm shifted from 4 to 6 months of conventional alfa

90 It also requires a second paradigm shift, from the classic infection control hiera

91 Paradigm-shifting gains in scientific knowledge are occu

92 Facilitating this evolving paradigm shift has been the growing contribution of func

93 This paradigm shift has generated a need for rapid screening

94 was first described and cultured, a complete paradigm shift has occurred in our clinical approach to

95 A paradigm shift has occurred in the management of advance

96 The paradigm shifts implicit in the supremacy of CAC herald

97 s within distinct healthy tissues provides a paradigm shift in adaptive immunity.

98 Together, these results represent a paradigm shift in anisotropic gold NP synthesis.

99 ty of raw food products, perhaps signaling a paradigm shift in approaches to food safety.

100 ently or soon to be available, that offers a paradigm shift in CAD management.

101 This paradigm shift in cancer cell biology and mitochondrial

102 therapy for B cell malignancies represents a paradigm shift in cancer immunotherapy.

103 A major paradigm shift in cancer research is the emergence of mu

104 fic, molecularly targeted agents signifies a paradigm shift in cancer therapy, with less reliance on

105 Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently receive

106 te antitumor T-cell immunity have heralded a paradigm shift in cancer treatment.

107 bcutaneous pulse generator could represent a paradigm shift in cardiac pacing.

108 This study provides proof of concept for a paradigm shift in cardiovascular intervention, suggestin

109 us disease represents an illness ready for a paradigm shift in care delivery and outcomes, and the pr

110 r kinase inhibitor (KI) therapy represents a paradigm shift in chronic lymphocytic leukemia (CLL) man

111 te the affective sphere of pain represents a paradigm shift in chronic pain management.

112 aluation of exosomal markers could lead to a paradigm shift in clinical analysis and associated care.

113 Reflecting a paradigm shift in clinical neuroscience, many chronic ps

114 us observations in rare subsets of cancer, a paradigm shift in clinical research is poised to ensure

115 an pathophysiology in many ways represents a paradigm shift in clinical-psychological and psychiatric

116 We advocate that it is time for a paradigm shift in comparative phylogeography, especially

117 area in the past 30 years have resulted in a paradigm shift in comprehending the stability and reacti

118 ked fleas described in our study calls for a paradigm shift in concepts of how Y. pestis is transmitt

119 early post-stimulus latencies has prompted a paradigm shift in conceptualizations of sensory organiza

120 f intrinsic microporosity (PIMs) represent a paradigm shift in conceptualizing molecular sieves from

121 serving many of these species necessitates a paradigm shift in conservation toward a holistic approac

122 ements of wearable electronics have caused a paradigm shift in consumer electronics, and the emerging

123 ellular protective immunities, and lead to a paradigm shift in cost-effective control and prevention

124 This paradigm shift in cytokine function offers a new framewo

125 cent decades, with the potential to create a paradigm shift in decision theories.

126 n, the therapeutic landscape has undergone a paradigm shift in determining safety, stability and effi

127 This may constitute a paradigm shift in developing efficient protocols for hig

128 of a causative link with malaria would be a paradigm shift in efforts to prevent and control hyperte

129 Therefore, this study provides a paradigm shift in how cPLA(2)alpha is activated during i

130 several disciplines, because it represents a paradigm shift in how scientists and clinicians can obse

131 g, and redirect our approaches likely with a paradigm shift in how the disease is viewed.

132 tates of the respiratory virome, and drive a paradigm shift in how the practicing pulmonologist views

133 of medulloblastoma, but this will require a paradigm shift in how we classify and study disease.

134 A paradigm shift in immunology has been the recent discove

135 A recent paradigm shift in implementing flexible electronics is t

136 in western and southern India, we show that paradigm shift in Indian groundwater withdrawal and mana

137 receptor in signaling pathways, represents a paradigm shift in its biological function.

138 The last decade has seen a paradigm shift in library construction, with particular

139 This poses a paradigm shift in management of patients with suspected

140 vements in the field have already produced a paradigm shift in melanoma treatment: Metastatic melanom

141 In the past two years, we have seen a paradigm shift in metagenomics to the application of cro

142 These results call for a paradigm shift in modeling the mechanical regulation of

143 thin materials has the potential to enable a paradigm shift in modern technologies by introducing mul

144 Discoveries over the past decade portend a paradigm shift in molecular biology.

145 The past few years have witnessed a paradigm shift in molecular systematics from phylogeneti

146 w generation of nanovesicles can represent a paradigm shift in nanomedicine: they may complement lipo

147 inal uptake and transport will bring forth a paradigm shift in nanoparticle engineering for oral deli

148 ) to affect synaptic transmission has been a paradigm shift in neuroscience research over the past de

149 rt X-ray pulse durations and is leading to a paradigm shift in our ability to explore nonlinear X-ray

150 The results from these studies created a paradigm shift in our collective thinking as to why reco

151 These findings represent a paradigm shift in our concepts of mt-nuclear interaction

152 process termed gliotransmission has caused a paradigm shift in our thinking about brain function.

153 This has led to a paradigm shift in our treatment methodology.

154 New findings necessitate a paradigm shift in our understanding of acute pancreatiti

155 ted many critical studies that have led to a paradigm shift in our understanding of cancer as a disea

156 ancer stem cell hypothesis that represents a paradigm shift in our understanding of carcinogenesis an

157 This work provides a paradigm shift in our understanding of HCV-specific immu

158 dentify and destroy tumor cells has driven a paradigm shift in our understanding of human cancer.

159 al approaches has the potential to produce a paradigm shift in our understanding of infectious diseas

160 e outline recent developments that support a paradigm shift in our understanding of lesion progressio

161 ascular changes caused by DM and represent a paradigm shift in our understanding of ocular diabetic c

162 A paradigm shift in our understanding of replacement of re

163 This model represents a paradigm shift in our understanding of SERCA regulation

164 These studies produce a paradigm shift in our understanding of the 24-h dynamics

165 These data represent a paradigm shift in our understanding of the function of C

166 This finding introduces a paradigm shift in our understanding of the heme-based di

167 n the solvent-filled interface and lead to a paradigm shift in our understanding of the mononuclear d

168 Emerging evidence supports a paradigm shift in our understanding of the renin-angiote

169 These data represent a paradigm shift in our understanding of the role of andro

170 This paradigm shift in our understanding of vascular-resident

171 These observations prompt a paradigm shift in P. vivax biology and open avenues to i

172 A paradigm shift in pacemaker technology has been the deve

173 A paradigm shift in pain management includes early treatme

174 to the pain expression pathway have led to a paradigm shift in pain management, allowing clinicians t

175 This is a paradigm shift in pathology, away from histomorphology a

176 Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care, resulting in subst

177 eart failure following infarction requires a paradigm shift in pharmacotherapy.

178 though operative modalities have undergone a paradigm shift in recent years.

179 ng and transplantation experiments support a paradigm shift in reproductive biology involving active

180 t article, Kalisch and colleagues advocate a paradigm shift in research on stress-related mental diso

181 As such, it now represents a paradigm shift in scientific research that has facilitat

182 This new guideline endorses a paradigm shift in strategies for reducing atheroscleroti

183 This represents a paradigm shift in structure determination methods, which

184 onal imaging and outline the potential for a paradigm shift in surgical and endoscopic visualization.

185 A recent paradigm shift in systems neuroscience is the division o

186 led "immunoparalysis" is currently causing a paradigm shift in the adjunctive treatment of sepsis fro

187 A paradigm shift in the approach to management of the olde

188 A sustained paradigm shift in the approach to treating sepsis has ye

189 Overall, this study represents a paradigm shift in the biological function of GRP-78.

190 the experimental data sets will enhance the paradigm shift in the community towards a much more dyna

191 From the 1860-1880s, they articulated a paradigm shift in the conceptualization of psychiatric d

192 ion of DES being safer than BMS represents a paradigm shift in the evolution of percutaneous coronary

193 on of unactivated C-H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis.

194 This represents a paradigm shift in the field, showing that GR uses multip

195 ike cells in human tissue has led to a major paradigm shift in the field.

196 s are well known, and the changing nature or paradigm shift in the imaging of this life-threatening d

197 The past decade has witnessed a paradigm shift in the initial treatment of multiple myel

198 ases of pituitary diseases, there has been a paradigm shift in the management by conservative measure

199 development of psoriasis has led to a major paradigm shift in the pathogenic model for this conditio

200 This may require a paradigm shift in the radiologic interpretation process.

201 stead of the functional groups, represents a paradigm shift in the standard logic of organic synthesi

202 in the brain." This prize recognizes both a paradigm shift in the study of cognitive neuroscience, a

203 ergence of this research has sparked a broad paradigm shift in the study of political behaviors towar

204 artilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skelet

205 ion of atrophic non-union and could enable a paradigm shift in the treatment of fractures at high ris

206 ptor and other ligands has led to a dramatic paradigm shift in the treatment of patients with metasta

207 We anticipate a paradigm shift in the treatment of selected B-cell malig

208 These recent discoveries may enable a paradigm shift in the treatment of this complex disease,

209 opment has the potential to cause a dramatic paradigm shift in the treatment of this disease.

210 tance led to significant advancements and to paradigm shift in the treatment.

211 rematurity, and are poised to benefit from a paradigm shift in the treatment.

212 the genesis, development, and future of this paradigm shift in the understanding of osteogenesis impe

213 This paper presents a paradigm shift in the understanding of the role of S in

214 for diet-induced thermogenesis, provoking a paradigm shift in the understanding of the role of the t

215 These findings suggested consideration of a paradigm shift in the understanding of the therapeutic r

216 This information could lead to a paradigm shift in the use of natural product drugs for m

217 Our methodology represents a paradigm shift in the use of NMR active tags in structur

218 Remote patient monitoring represents a paradigm shift in the way physicians care for patients.

219 ain cognitive abilities are bringing about a paradigm shift in the way scientists view the treatment

220 predict neurologic outcome would represent a paradigm shift in the way spinal cord injury clinical tr

221 , mirror visual feedback paves the way for a paradigm shift in the way we approach neurological disor

222 indings are directly relevant to the ongoing paradigm shift in the WM field.

223 his provides molecular genetic support for a paradigm shift in theories of lycophyte leaf evolution.

224 in chronic lymphocytic leukemia has led to a paradigm shift in therapy, and relapse has been uncommon

225 esonances or interference effects, marking a paradigm shift in thermal engineering approaches.

226 Epidemics require a paradigm shift in thinking about all possible solutions.

227 of myeloproliferative disorders calls for a paradigm shift in traditional diagnostics, which is base

228 ex vivo-generated EPC-TP likely represents a paradigm shift in transfusion medicine because of its po

229 whether the use of ocriplasmin will bring a paradigm shift in treating MHs or will be just an additi

230 This study demonstrates a paradigm shift in treatment of MAAA in Sweden, with EVAR

231 A major paradigm shift in understanding how CD4+ T cells contrib

232 With this paradigm shift in understanding of autoimmune inflammati

233 in the African Meningitis Belt represents a paradigm shift in vaccines against poverty: the developm

234 In recent years, there has been a paradigm shift in virology with the realization that ext

235 At the computational level, I describe a paradigm shift in which it is becoming increasingly comm

236 ge-scale analysis of proteins and facilitate paradigm shifts in biological concepts that address impo

237 One of the most significant paradigm shifts in membrane remodeling is the emerging v

238 This study points to the need for paradigm shifts in neuroscience modeling: greater emphas

239 inal imaging have proven fundamental to many paradigm shifts in our understanding and treatment of oc

240 Here we review two major recent paradigm shifts in our understanding of tissue macrophag

241 eractions in neuropsychiatric disorders, how paradigm shifts in the phenotypic classification of pati

242 t years, we have witnessed several important paradigm shifts in understanding the molecular basis of

243 These paradigm shifts in vascular engineering now offer a new

244 With the concept of paradigm shift, introduced by Kuhn, several new strategi

245 A similar major paradigm shift is emerging due to the rapidly expanding

246 ; however, recent literature suggests that a paradigm shift is in order.

247 A paradigm shift is made by a new study that monitors simu

248 ances in asthma genetics and conclude that a paradigm shift is needed, because a static model in whic

249 so to gain additional biological insights, a paradigm shift is needed.

250 This discovery indicates a paradigm shift is needed.

251 This author speculates that a paradigm shift is needed.

252 A paradigm shift is required if surgery is to be considere

253 A paradigm shift is taking place in medicine from using sy

254 A paradigm shift is underway in the field of quantitative

255 But a paradigm shift is underway.

256 escribe here how the initially controversial paradigm shift mandated revisions of cherished dogmas.

257 In these instances, a paradigm shift may be indicated, and the occasion of cat

258 Prions are a paradigm-shifting mechanism of inheritance in which phen

259 presented in this article represent a clear paradigm shift not only in expanding the molecular targe

260 A paradigm shift occurred at the turn of the 21st century.

261 The trend denotes a professional paradigm shift of major importance.

262 This collective knowledge compels a paradigm shift-one in which maternal transmission of mic

263 Catalyzed by paradigm-shifting public and private programs focusing u

264 al space expands under folding conditions, a paradigm-shifting realization that prompts an experiment

265 The paradigm shift resulting from radiosurgery continues to

266 pproach closely aligns with Kuhn's notion of paradigm shift, suggesting that this is a particularly g

267 l conditions, iOCT has the potential to be a paradigm-shifting technology in the operating room.

268 w areas in oncology have witnessed the major paradigm shift that has been noted in the understanding

269 therapies for skeletal regeneration offer a paradigm shift that may provide alternative solutions.

270 The recent paradigm shift that microglia are yolk sac-derived, not

271 l sustainability of the healthcare system, a paradigm shift that places more emphasis on cardiovascul

272 Together, these data support the emerging paradigm shift that pore-forming toxins, including CDCs,

273 It was Ginj et al. who proposed in 2006 the paradigm shift that radiolabeled sstr antagonists may pe

274 In this focused review, I examine recent paradigm shifts that have transformed our understanding

275 oxidative stress and will discuss the major paradigm shifts that the field has undergone and continu

276 oward this goal, we describe a method called PARADIGM-SHIFT that can predict whether a mutational eve

277 Paradigm shifts to MR imaging owing to concerns over rad

278 A paradigm shift toward biology occurred in the 1990s and

279 The recent literature signals a growing paradigm shift toward integrating therapeutics and diagn

280 nctional materials and devices may lead to a paradigm shift toward new, intelligent, and efficient co

281 The paradigm shift toward organ preservation in highly selec

282 er geneticists will be required to drive the paradigm shift toward personalized or precision medicine

283 A paradigm shift toward the development of nonantibiotic a

284 sults of this study demonstrate an important paradigm shift toward the selection of lower surgical ri

285 A paradigm shift towards 'general medical/psychiatry inter

286 rial and self-assembling peptides provides a paradigm shift towards development of antibacterial agen

287 mizing this uncertainty therefore requires a paradigm shift towards engineering at the genomic level.

288 To this end, we emphasize the need for a paradigm shift towards integrative disease modeling and

289 ractice, although challenging, may lead to a paradigm shift towards more personalized therapy.

290 and programmed-death 1 (PD-1), has become a paradigm-shifting treatment in solid tumor oncology.

291 To achieve such a paradigm shift we must understand why development of dru

292 now, new large surveys are bringing about a paradigm shift--we can finally compare samples of hundre

293 future epidemiologic efforts that reflects a paradigm shift whereby studies are now being conducted w

294 Our study demonstrates that the ongoing paradigm shift, which recognizes that both biotic and ab

295 Our findings confirm and validate this paradigm shift while demonstrating the first successful

296 This second paradigm shift will require moving away from measurement

297 ervation of cis-acting controls constitute a paradigm shift with broad implications.

298 tents for vascular disease has resulted in a paradigm shift with significant improvement in therapeut

299 CML treatment received a paradigm shift with the launch of TKIs.

300 Nowadays, recent advances lead to a paradigm shift, with only 12% ES rate in low rectal canc