ライフサイエンスコーパス: paradoxical

1 m that also promotes sRNA generation remains paradoxical.

2 ited classic negative-feedback responses, or paradoxical.

3 y be greater than muscle power without being paradoxical.

4 R (F-IRKO) had a 95% reduction in WAT, but a paradoxical 50% increase in BAT with accumulation of lar

5 = 30 breaths/min or use of accessory muscles/paradoxical abdominal movements).

6 The paradoxical ability of digoxin-like CTSs to reactivate t

7 ment-inhibitory potential, rationalizing the paradoxical ability of the BRC repeats to either stabili

8 ated with ATP7A inactivation in tissues with paradoxical accumulation of copper (i.e. renal epithelia

9 mechanistic questions as illustrated by the paradoxical action and side effects of RAF inhibitors.

10 Dissociating MAPK pathway inhibition from paradoxical activation might yield both improved safety

11 inhibitors (vemurafenib/PLX4720, RAFi) cause paradoxical activation of the MAPK pathway in BRAF-fusio

12 n, delays acquired resistance, and abrogates paradoxical activation of the MAPK pathway in preclinica

13 of hyperproliferative skin conditions due to paradoxical activation of the mitogen-activated protein

14 Heidorn and colleagues report that paradoxical activation of the RAF-RAS-MEK-ERK pathway by

15 e properties, LY3009120 demonstrates minimal paradoxical activation, inhibits MEK1/2 phosphorylation,

16 ough the bulk of the cortex shows wake-like, paradoxical activation.

17 This is linked to "paradoxical" activation of melanoma-associated fibroblas

18 A paradoxical adaptive problem for teachers with good inte

19 Paradoxical adipose hyperplasia is a rare, previously un

20 rare adverse effect following cryolipolysis: paradoxical adipose hyperplasia.

21 a2AR) agonists, but their chronic use causes paradoxical adverse effects.

22 based differences do not seem to explain the paradoxical age-based racial disparities after trauma ob

23 ne signaling during development causes these paradoxical aggressive and affective phenotypes.

24 anticancer drug paclitaxel (Taxol) exhibits paradoxical and poorly understood effects against slow-g

25 Targeted therapies elicit seemingly paradoxical and poorly understood effects on tumor immun

26 equence, we propose the case definitions for paradoxical and unmasking CMV-IRR.

27 ork offers a mechanistic explanation for the paradoxical antitumorigenic roles of E+P in breast cance

28 -HT4 agonist RS 67333 was found to produce a paradoxical anxiolytic-like effect similar to that produ

29 poson activity and altogether illustrate the paradoxical arms race between genome evolution and stabi

30 olution of sexual traits is often considered paradoxical as, although they enhance reproductive succe

31 The paradoxical association between overweight and mortality

32 We aimed to provide insight into the paradoxical association of LDL cholesterol with AF by ev

33 ings offer a mechanistic explanation for the paradoxical association of some high-grade breast tumors

34 common properties of MGEs, and the seemingly paradoxical bacterial behaviours of transformation and c

35 the existence of the EMT in sarcomas appears paradoxical because these cancers are, by definition, me

36 steroid treatment in muscular dystrophy are paradoxical because these steroids are also known to tri

37 hort of transcripts increased during torpor, paradoxical because transcription effectively ceases at

38 t dilute nectar in bat-pollinated plants as "paradoxical" because bats prefer concentrated nectar, bu

39 s, most ecological models which exhibit such paradoxical behavior depend on the presence of exogenous

40 The perplexing and paradoxical behavior of KACh channels is due to the intr

41 ccordingly, both knockout models displayed a paradoxical behavioral response to amphetamine reminisce

42 . targeting like-minded individuals) creates paradoxical behaviour such as non-transitive dynamics.

43 , NMe-Phe(4), Gly-ol(5)]-enkephalin produces paradoxical behavioural responses: early-phase analgesia

44 The mechanism of this paradoxical binding behavior has been unclear.

45 e, providing a potential novel mechanism for paradoxical BRAF activation.

46 species with internal fertilization may seem paradoxical, but birds have managed to do it multiple ti

47 Patients with paradoxical C-IRIS (n = 27), compared with patients with

48 Escaping narwhals displayed a paradoxical cardiovascular down-regulation (extreme brad

49 dentify an eosinophil-mediated mechanism for paradoxical caspofungin activity and support the future

50 es with uveitis-associated glaucoma in which paradoxical changes in RNFL thickness were noted.

51 We further suggest that BCCIP represents a paradoxical class of modulators for tumorigenesis as a s

52 ation (unmasking CMV-IRR) and 20 experienced paradoxical clinical worsening of retinitis (paradoxical

53 paradoxical clinical worsening of retinitis (paradoxical CMV-IRR).

54 , clinicians have consistently described the paradoxical co-existence in posttraumatic stress disorde

55 parsimonious explanation for the apparently paradoxical combination of disinhibition and severe akin

56 This paradoxical combination of increased energy demands alon

57 Paradoxical components act bifunctionally in signaling n

58 hrough its ability to recruit a complex with paradoxical components, coordinates ERK pathway spatiote

59 and inactivation would produce consistent or paradoxical conclusions regarding interneurons' computat

60 ng systems, perturbation methods may lead to paradoxical conclusions: for any given pair of two compo

61 Connectivity analyses revealed paradoxical coupling in prefrontal-amygdala circuits, in

62 tivated protein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling respo

63 These paradoxical data implicate that additional acetylation m

64 in sensitivity specifically in EC leads to a paradoxical decline in endothelial function, mediated by

65 ed an upstream regulator of Pak2, we found a paradoxical decrease in baseline activation of CDC42 in

66 eticulum (ER) stress in SMCs, which led to a paradoxical decrease of protein levels through increased

67 ing an eye is unnecessary for producing this paradoxical deprivation effect: interocular suppression

68 ced GI Hyperalgesia, is characterized by the paradoxical development of or increases in abdominal pai

69 on of the S cones is revealed in a seemingly paradoxical dilation of the pupil to greater S-cone phot

70 e ratio of single units with anticipated and paradoxical discharge was similar in HFrEF (18:7) and co

71 This paradoxical displacement, conventionally called 'Hoover'

72 effect to severe adverse effects, including paradoxical drug-induced arrhythmia.

73 Despite their anti-inflammatory action, paradoxical drug-induced inflammatory events have been o

74 No cases of paradoxical drug-related neurological worsening were rec

75 sitivity to caspofungin and abolition of the paradoxical effect (resistance at high caspofungin conce

76 p90 expression was sufficient to abolish the paradoxical effect and therefore optimize the antifungal

77 munity in times of starvation and exerting a paradoxical effect in overnutrition.

78 Underlying this paradoxical effect may be the underuse of insulin, but a

79 This paradoxical effect may reflect a disruption of homeostat

80 ividual neuronal responses could explain the paradoxical effect of CBZ at the network level.

81 in experimental animal models, and the often paradoxical effect of exposure timing and dose on diseas

82 yl-phenyl)-ethyl]-amide) (ORG27569), has the paradoxical effect of increasing the equilibrium binding

83 beta production by PAI-1, which explains the paradoxical effect of PAI-1 deficiency in promoting card

84 Our results indicate a paradoxical effect of rapamycin on insulin resistance be

85 We devised a model to explain this paradoxical effect of reward by considering a new factor

86 The antifungal "paradoxical effect" has been described as the reversal o

87 f activity of L4 FS neurons contradicts the "paradoxical effect" predicted in networks stabilized by

88 GAGs exhibit a paradoxical effect, as they convert PrP into protease-re

89 ssion (>/=1.5-fold) and is essential for the paradoxical effect.

90 One plausible explanation underlying the paradoxical effects of beta2AR and PAR2 agonism in asthm

91 These observations explain the paradoxical effects of cAMP on collagen expression.

92 udy provides a potential explanation for the paradoxical effects of CBZ on epileptiform activity.SIGN

93 the Allee effect can explain the apparently paradoxical effects of dispersal on spread and have impl

94 the underlying mechanisms of these seemingly paradoxical effects of lithium, in which fine-tuned regu

95 e locus and this may account for some of the paradoxical effects of LKB1 during tumorigenesis.

96 To explain the paradoxical effects of PIN1 on p27 levels and cell cycle

97 hnique to analyze how Ito accounts for these paradoxical effects on EADs by influencing the dynamic e

98 dient with reduced (classical) or preserved (paradoxical) ejection fraction.

99 Paradoxical emboli lead to strokes and cerebral abscesse

100 ough the serious nature and complications of paradoxical embolism are recognized, the disease entity

101 found both pulmonary embolism due to DVT and paradoxical embolism due to existing patent foramen oval

102 Paradoxical embolism is an important clinical entity amo

103 or-risk or covert cardiac sources, veins via paradoxical embolism, and non-occlusive atherosclerotic

104 on the different clinical manifestations of paradoxical embolism, describes the diagnostic tools for

105 ommendations for the secondary prevention of paradoxical embolism.

106 onsequently, cause serious conditions due to paradoxical embolus.

107 PA receptor upregulation, it also produces a paradoxical enhancement in membrane AMPA receptor subuni

108 The paradoxical enhancement in phytoplankton near an island-

109 to selectively target tumors and prevent the paradoxical ERK activation could increase the feasibilit

110 It is unknown whether "paradoxical" ERK activation occurs after sorafenib thera

111 In some cases, there is evidence for paradoxical escape from defensin neutralization or enhan

112 This paradoxical exacerbation of prenatal Zika virus exposure

113 ry is in a chronic state of hypoxia owing to paradoxical excess activity of monoamine receptors (5-HT

114 bitory transmitter but can sometimes produce paradoxical excitatory effects through synaptic networks

115 ioral and neural results suggested that this paradoxical experience resulted from parallel evaluation

116 By accounting for otherwise paradoxical experimental findings, our results demonstra

117 offers a plausible explanation for seemingly paradoxical expression of mitochondrial dynamics and dea

118 g elevated state anxiety may account for the paradoxical facilitation of performance on tasks that re

119 accurate sensory cancellation and explaining paradoxical features of negative images.

120 We investigated this seemingly paradoxical finding by assessing components of this asso

121 Exploration of this paradoxical finding may lead to a better understanding o

122 tation studies, we recently demonstrated the paradoxical finding that, early in rejection, C3(-/-) tr

123 weight loss due to advanced HF leads to this paradoxical finding.

124 Here we resolve these paradoxical findings and show that the capacity of LYVE-

125 ure challenge will be to understand how such paradoxical findings can be reconciled and how GR ultima

126 Organoid models therefore clarify the paradoxical findings from SELECT and demonstrate that Vi

127 Here, we discuss these paradoxical findings in the context of CTLA-4-mediated l

128 d, on cardiovascular disease; however, these paradoxical findings might have resulted from suboptimal

129 These paradoxical findings suggest that the approach for asses

130 l proliferation into account may explain the paradoxical findings that aging itself and slowed aging

131 rmine the neural mechanisms underlying these paradoxical findings, we trained monkeys to discriminate

132 hypothetical mechanisms that may explain our paradoxical findings.

133 noncoding ribonucleic acids (RNAs) remained paradoxical for a long time.

134 The regulatory mechanisms of this paradoxical function of the cervix are unknown.

135 Here, we report that ROQUIN has a paradoxical function on Tfh differentiation mediated by

136 e mechanisms employed for their numerous and paradoxical functions that ultimately link environmental

137 Such paradoxical gain of function (not pertinent in vivo due

138 echanism requiring CD8(+) T cells, which was paradoxical given the drug's reported ability to inhibit

139 This is paradoxical, given that ECA was first identified based o

140 Such a reproducible localization is paradoxical, given that reading is a recent invention th

141 The seemly paradoxical Gq agonist-stimulated phosphoinositide produ

142 henotype induced by MPL P106L belongs to the paradoxical group, where low MPL levels on platelets and

143 Regardless of the clinical relevance of this paradoxical growth effect, understanding the specific ac

144 very of IL-10 and anti-TGFbeta resulted in a paradoxical hastening of fibrosis, warranting further in

145 g to heterodimerization with C-Raf causing a paradoxical hyperactivation of MAPK pathway.

146 can drive some differentiation and generates paradoxical hypermethylation of CpG islands.

147 We examined the paradoxical hypothesis that the alpha-receptor inverse a

148 Paradoxical immune reactions associated with tumor necro

149 Incidence of paradoxical immune reconstitution inflammatory syndrome

150 to anti-TNF therapy, and some patients show paradoxical immune side effects, which are poorly unders

151 with multiple neurologic complications and a paradoxical immunologic phenotype characterized by sever

152 inflammatory signalling is unclear owing to paradoxical in vitro and in vivo findings.

153 hich they can bore have remained elusive and paradoxical, in that, as oxygenic phototrophs, cyanobact

154 (A3B(del)), which has been associated with a paradoxical increase in breast cancer risk.

155 lowing SGLT2 inhibition is associated with a paradoxical increase in EGP.

156 annini and colleagues independently report a paradoxical increase in endogenous glucose production in

157 Importantly, we observed a paradoxical increase in ERK signaling in mid-neurogenesi

158 ivation of inhibitory interneurons elicits a paradoxical increase in inhibitory synaptic input.

159 rome c oxidase activity in all tissues yet a paradoxical increase in lifespan.

160 K2 chemical inhibitors are shown to induce a paradoxical increase in MK production, both in vitro and

161 This paradoxical increase in POMC activity was crucial for CB

162 These mice have both a paradoxical increase in PPARgamma phosphorylation at ser

163 pofunction model of schizophrenia predicts a paradoxical increase in synaptic glutamate release.

164 mals had decreased crypt apoptosis but had a paradoxical increase in villus apoptosis compared with s

165 to intra-VTA infusions of AMPA, suggesting a paradoxical increase in VTA AMPA receptor responsiveness

166 els of 5-methylcytosine (5mC), it results in paradoxical increase of 5-hydroxymethylcytosine (5hmC),

167 thromboembolic-related adverse events but a paradoxical increased hemorrhagic risk.

168 Paradoxical increases in signal at very high concentrati

169 The paradoxical induction of a tumor suppressor in HSCs duri

170 e mechanisms underlying its preferential and paradoxical induction of FSHbeta by low frequency GnRH p

171 The paradoxical inhibitory effect of cocaine and methylpheni

172 Defective SAP induces paradoxical inhibitory function of the 2B4 coreceptor an

173 Unlocking the mechanistic detail of these paradoxical innate immune events will be crucial for und

174 A paradoxical inspiratory rise in right atrial pressure (i

175 adiponectin secretion as the explanation for paradoxical insulin receptoropathy-related hyperadiponec

176 iers by exposing participants to a long-term paradoxical intervention campaign expressing extreme ide

177 ctions: Participants who were exposed to the paradoxical intervention, which took place in proximity

178 tivity, associative learning deficits, and a paradoxical inversion of psychostimulant responses.

179 Type I JAK2 inhibitors induce paradoxical JAK2 hyperphosphorylation in these leukemias

180 on motor symptoms and Parkinson's disease', 'Paradoxical kinesia', 'Psychogenic parkinsonism', 'Funct

181 n occur with reduced (classic) or preserved (paradoxical) left ventricular ejection fraction (LVEF).

182 Patients with paradoxical LF-LG AS and NF-LG AS have increased risk of

183 atients with severe aortic stenosis (AS) and paradoxical low flow (PLF) have worse outcome compared w

184 f patients with low ejection fraction (LEF), paradoxical low flow (PLF), and normal flow (NF) after a

185 eft ventricular ejection fraction, including paradoxical low-flow (i.e., stroke volume index <35 ml/m

186 compare the natural history of patients with paradoxical low-gradient (PLG) or high-gradient (HG) SAS

187 nt of LTP-like cortical plasticity forming a paradoxical LTD in comparison to HS.

188 K inhibitor is co-administered, as it blocks paradoxical MAPK activation.

189 accelerates cutaneous wound healing through paradoxical MAPK activation; addition of a mitogen-activ

190 rder to eliminate the issues associated with paradoxical MAPK pathway activation and to provide thera

191 HIFI explains how labor can progress despite paradoxical metabolic challenge, and provides a new mech

192 ational analysis of AP initiation revealed a paradoxical mismatch between the AP threshold and Na(+)

193 , it is becoming evident that the effects of paradoxical mitogen-activated protein kinase pathway act

194 ion, high pro-apoptotic NOXA expression, and paradoxical, MYCN-driven upregulation of NOXA.

195 erlap, the presence of eye closure myotonia, paradoxical myotonia, and an increase in short exercise

196 The reason underlying this paradoxical observation remains to be explored.

197 This seemingly paradoxical observation suggests that either patients wi

198 se data help explain, in part, the seemingly paradoxical observations that CD8(+) T cells displaying

199 dings suggested that CAI2 contributes to the paradoxical overexpression of p16 in neuroblastoma, wher

200 ain-relieving effects (analgesic tolerance), paradoxical pain (hyperalgesia), and addiction.

201 ulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appe

202 established by the parasite could lead to a paradoxical pathogenic role for Tregs.

203 These compounds do not drive paradoxical pathway activation and inhibit MEK/ERK in BR

204 Because of paradoxical pathway activation, both agents were demonst

205 These results suggest that paradoxical percepts reflect tradeoffs between sensitivi

206 This approach helps to understand paradoxical phenomena, such as the faster-is-slower effe

207 Another paradoxical phenomenon found within the framework of qua

208 This seemingly paradoxical phenotype is due to lower glucose utilizatio

209 This paradoxical phenotype results from an ectopic interactio

210 This paradoxical phenotype was caused by a dampened inflammat

211 f XAL2 in SAM transitions and the apparently paradoxical phenotypes of XAL2 and other MADS-box (SOC1,

212 To explain these paradoxical phenotypes, we hypothesized that an insulin-

213 th dysautonomia often have unpredictable and paradoxical physiological responses to various periopera

214 These traits may explain the paradoxical picture of a person who may appear "normal"

215 This paradoxical preference may account for the frequency wit

216 These data illustrate the paradoxical pro-tumor role for CXCR3 in lung immunobiolo

217 nerable to the development of resistance and paradoxical promotion of tumor growth.

218 mit TSC-associated tumour growth but lead to paradoxical promotion of tumour cell survival upon treat

219 by body mass index (BMI), appears to have a paradoxical protective effect in several chronic disease

220 activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting ang

221 ffusion-weighted imaging (DWI) for assessing paradoxical puborectalis syndrome (PPS) in patients with

222 s of complex ocular motor disorders, such as paradoxical pupillary constriction to darkness, benign t

223 single SNPs in isolation may account for the paradoxical racial risk of AF among white individuals an

224 Whether paradoxical RAF activation could explain these BRAF wild

225 (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation.

226 sis but appears inessential for tuberculosis paradoxical reactions.

227 (SFK) signaling or mutant NRAS, which drive paradoxical reactivation of the pathway.

228 ) and controls (27:5), whereas LBPP elicited paradoxical reflex excitation in a greater proportion of

229 that this distinction can create a seemingly paradoxical relationship between 3C and FISH, both in mi

230 uations in cell growth may contribute to the paradoxical relationship between dispersal and spread.

231 To trace the origin of this paradoxical resilience, we systematically tuned the micr

232 Ischemia uncovers a paradoxical resistance of T2DM hearts to APD adaptation.

233 We assessed the prevalence of paradoxical response in current and former smokers with

234 Hatzivassiliou and colleagues examined the paradoxical response of RAF-WT tumors to treatment with

235 Paradoxical response to beta(2) agonists is associated w

236 However, there are also reports of a paradoxical response to beta(2) agonists resulting in br

237 A paradoxical response was independently associated with w

238 Paradoxical response was noted in 453 (5%) of 9986 patie

239 Compared with white patients, a paradoxical response was twice as common in African-Amer

240 classified into two groups on the basis of a paradoxical response, defined as at least a 12% and 200

241 xidative stress, HPbetaCD addition induces a paradoxical response, increasing cholesterol accumulatio

242 =0.023) were independently associated with a paradoxical response.

243 endent risk for major arrhythmic events, and paradoxical responses to beta-adrenergic agents.

244 hat the reversal of stimulus motion triggers paradoxical responses to electrosensory contrast.

245 ced network models predict that ISNs produce paradoxical responses to perturbation, but experimental

246 This seemingly paradoxical result was linked to NEMO-mediated regulatio

247 To understand this paradoxical result, we applied a capillary isoelectric f

248 nly are these results reminiscent of classic paradoxical results from evolutionary game theory, but t

249 mple potential resolutions to the previously paradoxical results.

250 This can lead to paradoxical results.

251 xposure to amphetamine, suggesting that this paradoxical return of striatal activity to a more stable

252 e mbp mRNA in oligodendrocytes, indicating a paradoxical role for the retrograde dynein/dynactin comp

253 Here, we characterize and reconcile the paradoxical role of ghrelin in the acquisition of fearfu

254 study provides insight into an unanticipated paradoxical role of Rosi in mediating hyper-inflammatory

255 Because of the seemingly paradoxical SCFA activities in regulating T cells, we in

256 We performed an ecological analysis of this paradoxical seasonality in a Peruvian shantytown over 4

257 However, this paradoxical self-reactivity correlated with these VH4-34

258 1 cm(2); mean gradient >/=40 mm Hg), and (c) paradoxical severe (n=141; aortic valve area, </=1 cm2 a

259 edicting mortality in moderate to severe and paradoxical severe aortic stenosis (AS) patients with pr

260 pecifically, the X chromosome has acquired a paradoxical sex-biased function by redistributing gene c

261 key feature of this signaling network is the paradoxical signaling loop.

262 and the spine volume can be described using paradoxical signaling loops.

263 Thus, a paradoxical situation develops in which the high affinit

264 This paradoxical situation reflects our lack of knowledge abo

265 In order to investigate this seemingly paradoxical situation, 2-MIB stability was reinvestigate

266 CSDS affected numerous endpoints, including paradoxical sleep (PS) and slow-wave sleep (SWS), as wel

267 ng cortical activation during waking (W) and paradoxical sleep (PS, also called REM sleep), yet also

268 e similarly more activated during waking and paradoxical sleep (PS; aka REM) than during slow-wave sl

269 l state instability, abnormal transitions to paradoxical sleep, and cataplexy, hallmarks of narcoleps

270 he upper tier of imaging sites that showed a paradoxical slow increase in activity during adaptation,

271 n-noxious warm and cold temperatures cause a paradoxical, sometimes painful, sensation of burning hea

272 b directly activated the fibroblasts through paradoxical stimulation of the mitogen-activated protein

273 for the pervasiveness of this theoretically paradoxical strategy.

274 Unexpectedly, Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from

275 anifestations being postural hypotension and paradoxical supine hypertension.

276 onfirm a novel form of excess adiposity with paradoxical suppression of leptin expression, and sugges

277 specific T-cell responses and development of paradoxical TB-IRIS on antiretroviral therapy (ART).

278 cross-sectional analyses of human PBMCs from paradoxical TB-IRIS patients and non-IRIS controls (HIV-

279 s in IL-6, is associated with development of paradoxical TB-IRIS.

280 It seems paradoxical that the heterodimer should bind more strong

281 awkish participants that were exposed to the paradoxical thinking intervention expressed less support

282 ectiveness of a "real world," multichanneled paradoxical thinking intervention, with messages dissemi

283 Based on the paradoxical thinking principles, the intervention involv

284 theory of persuasion based on the concept of paradoxical thinking.

285 d intraocular pressure was associated with a paradoxical thinning of the RNFL and increased cupping.

286 hat JAK2 chemical inhibitors could promote a paradoxical thrombocytosis when used at suboptimal doses

287 in the form of ventricular septal defect and paradoxical thromboembolism.

288 Fifty years ago, Michel Jouvet used the term paradoxical to define REM sleep because of the simultane

289 Paradoxical to its importance for generating a diverse T

290 eleterious passengers can explain previously paradoxical treatment outcomes and suggest that it could

291 th ageing that could be exploited to improve paradoxical triggering and other changes in protective s

292 The immunopathogenesis of paradoxical tuberculosis-associated immune reconstitutio

293 promote their invasive behaviors, leading to paradoxical tumor aggression after therapy.

294 Our data also revealed paradoxical tumor suppressor functions for Abl kinases i

295 However, a paradoxical upregulation of proteins involved in cellula

296 of RAF kinases can induce a dose-dependent "paradoxical" upregulation of the downstream mitogen-acti

297 the DePAC project was that a widely-held but paradoxical view that palliative care and dying patients

298 eezers experiments we report here that, in a paradoxical violation of mechanically driven activation

299 Notch ligand Dll4 inhibits tumor growth in a paradoxical way.

300 d resistance, often in complex and seemingly paradoxical ways.