ライフサイエンスコーパス: paralog

1 or F508del NBD1 versus WT and for the SUMO-2 paralog.

2 when distinct isoforms become fixed in each paralog.

3 rwater habitats, while sticklebacks lost one paralog.

4 riple paralogs, culminating in tens of EXO70 paralogs.

5 ing rapidly evolving orthologs or undetected paralogs.

6 ts different functions for the Set3 and Set4 paralogs.

7 lausible pathway for diversification of NusG paralogs.

8 r near four of the six D. pseudoobscura Ago2 paralogs.

9 ins assist this reaction including the RAD51 paralogs.

10 that express the two zebrafish QRFP receptor paralogs.

11 hanism of RAD51 filament remodeling by RAD51 paralogs.

12 omonas reinhardtii, which contains three AGO paralogs.

13 e (hGH) multigene cluster contains five gene paralogs.

14 e binding site strikingly different from its paralogs.

15 undamentally distinct classes: orthologs and paralogs.

16 n 1), suggesting that these two proteins are paralogs.

17 between kindlin-3 and the two other kindlin paralogs.

18 vergence of Pol I- and Pol III-specific AC40 paralogs.

19 diversification among the core eudicot PDAT paralogs.

20 clade, KAI2d, contains the majority of KAI2 paralogs.

21 y, coding sequence length, and the number of paralogs.

22 were found to convert with their functional paralogs.

23 neofunctionalization of recently duplicated paralogs.

24 ereas active marks are associated with their paralogs.

25 onnected to the core through the Prp42/Prp39 paralogs.

26 muscle, we searched for additional myospryn paralogs.

27 C ACID INDUCED1 (AZI1) gene and three of its paralogs.

28 ution rates in FIS2 and MEA but not in their paralogs.

29 hogenic Candida genomes encode the two TAF12 paralogs.

30 n embryo, activation of posterior Hox genes (paralogs 9-13) in the tail-bud correlates with the slowi

31 The human ESCO1 and ESCO2 paralogs acetylate the cohesin complex subunit SMC3 to r

32 us, we propose a quantitative model of STAT5 paralog activity whereby relative abundance imposes func

33 inference, Bayesian concordance analysis and paralog age distributions to resolve relationships among

34 The fourth paralog (All1123) does not seem to be involved in photop

35 Two of the other Anabaena paralogs (All3221 and Alr4783) were shown to be very goo

36 Surprisingly, only one paralog (All4941) was able to interact with the antenna

37 o the open state more readily than the ssTnC paralog, an unfavorable transition that would decrease t

38 owering in tomato was driven by the florigen paralog and flowering repressor SELF-PRUNING 5G (SP5G).

39 ead, gene duplication with divergence of one paralog and weak positive selection appear to underlie h

40 d, the ancestral functions are split between paralogs and a novel function arises in the copy under r

41 ty between the tightly conserved cyclophilin paralogs and exhibit significant off-target effects, imm

42 though Notch1 and Notch2 are closely related paralogs and function through the same canonical signali

43 mportant differences for the NRR among NOTCH paralogs and homologs.

44 inhibitor: high-binding affinity to all RAF paralogs and maintenance of the OFF/autoinhibited state

45 cuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will

46 veloped to distinguish between orthologs and paralogs and to classify paralogs into subtypes dependin

47 togenetic mapping of ribosomal genes and Hox paralogs and with microsatellite data, brings a closer l

48 of putative homologous genes (orthologs and paralogs) and further utilized in context of guided expe

49 ations in different genes, between different paralogs, and even between different classes of mutation

50 nerated data for all gene copies (homeologs, paralogs, and segregating alleles) present in each of th

51 The Arabidopsis thaliana POT1a and POT1b paralogs are atypical: they do not exhibit telomeric DNA

52 re Ca(2+)-activated Cl(-) channels, most ANO paralogs are Ca(2+)-dependent phospholipid scramblases t

53 and E2 profiling revealed that while the two paralogs are highly homologous, RC3H2 and RC3H1 are diff

54 Different NMII paralogs are often coexpressed in cells and can copolyme

55 Nested duplications and losses of CYC2-like paralogs are pervasive but may not correlate with transi

56 The modeled structures of each of the paralogs are similar at each temperature, with the excep

57 BRCA2 and the Rad51 paralogs are tumor suppressors and critical mediators of

58 RAD51 mediator proteins (i.e. paralogs) are critical for efficient HR in mammalian cel

59 SMITTING TRACT (NTT) and two closely related paralogs as being required for the initiation of the roo

60 human p190A, but not its 50% identical p190B paralog, associates with all 13 eIF3 subunits and severa

61 ation in leukemia, little is known about its paralog ASXL2, which is frequently mutated in acute myel

62 RAD51 paralog B (RAD51B), the preferential translocation partn

63 llagen type VIII alpha 1 (COL8A1), and RAD51 paralog B (RAD51B)] were examined.

64 tor B, collagen type VIII alpha 1, and RAD51 paralog B] were examined.

65 canonical PHD and bromodomain modules of the paralog BAZ1A.

66 better elucidate the role of BB0405 and its paralog BB0406 during infection and in serum resistance,

67 nization of rodents with BBI39, or a diverse paralog, BBI36, or their combination impaired pathogen a

68 ctive inhibitors are not available for Bcl-2 paralog Bfl-1.

69 in vivo, CCCTC-binding factor (CTCF) and its paralog brother of the regulator of imprinted sites (BOR

70 he same fold as angiogenin and other RNase A paralogs, but the toxin does not share sequence similari

71 However, all three paralogs can be re-expressed upon malignant transformati

72 However, individual paralogs can confer vastly different effects upon cellul

73 ere, we demonstrate that MondoA, but not its paralog carbohydrate-responsive element-binding protein,

74 Y) and APETALA1 (AP1), together with the AP1 paralog CAULIFLOWER (CAL), control the onset of flower d

75 te the molecular properties of CDK12 and its paralog CDK13.

76 s and oncogenesis, the cellular roles of its paralog, CDK19, are poorly studied.

77 for diversity with 1867 core proteins and a paralog-collapsed pan-genome size of 11,694 proteins.

78 mined the expression of FIS2, MEA, and their paralogs, compared their cytosine and histone methylatio

79 We recently discovered that a RAD51 paralog complex from C. elegans, RFS-1/RIP-1, functions

80 ction, we investigated a heterodimeric Rad51 paralog complex, RFS-1/RIP-1, and uncovered the molecula

81 s show how the functional differentiation of paralogs continues to shape regulatory network architect

82 We propose that pairs of Dpr/DIP paralogs contribute to layer-specific patterns of synapt

83 Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squam

84 onstrate that overexpression of either LIN28 paralog cooperates with the Wnt pathway to promote invas

85 are also observed between Cdc34 and the Cul1 paralog Cul2, implicating the same mechanism for the Cdc

86 yst subunits are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs.

87 The CXCL4 paralog CXCL4L1 is a less studied chemokine that has bee

88 Using mouse models of paralog deficiency, we demonstrate that they are not equ

89 Surprisingly, Roquin paralog-deficient NKT cells are, in striking contrast to

90 e, we functionally deconstruct the SMARCA2/4 paralog dependence of cancer cells using bioinformatics,

91 1 target genes are significantly enriched in paralogs derived from the whole-genome salicoid duplicat

92 unequivocally identified, whereas the alpha paralog did not work and yielded only an inconclusive di

93 ell understood, but the long-term impacts of paralog differentiation on the regulation of metabolism

94 We identified two type 2 deiodinase paralogs, dio2a and dio2b, responsible for conversion of

95 killifish and black bream, express these old paralogs divergently in black- and clearwater habitats,

96 se factors Sup45-Sup35 (eRF1-eRF3) and their paralogs Dom34-Hbs1 affect the total population of ubiqu

97 ta point towards asymmetric expression (i.e. paralog dose), rather than distinct functional propertie

98 cing of the penultimate exon of DVL1 and its paralogs DVL2 and DVL3 to search for potential disease-a

99 Here, we show that two Arabidopsis thaliana paralogs encoding plant-specific histone deacetylases, H

100 rily conserved microRNA (miRNA) clusters and paralogs ensures that miRNAs efficiently exert their bio

101 Loss of both Esrp1 and its paralog Esrp2 results in widespread developmental defect

102 ined how the glucocorticoid receptor and its paralogs evolved to bind activating response elements [(

103 that the ancestral DBD from which GR and its paralogs evolved was capable of binding both nGRE and (+

104 y inference step to account for same-species paralogs evolving at different rates, and (ii) minimizin

105 A pollen-specific depletion of the closest paralog, EXO70C1, using artificial microRNA in the exo70

106 The two paralogs expressed in mammals, Cks1 and Cks2, share an o

107 ane-bound compartments is encoded by several paralog families, including small GTPases, coiled-bundle

108 ne (part of the SMARCD1, SMARCD2 and SMARCD3 paralog family) reveal an evolutionarily conserved role

109 Retention or loss of paralogs following duplication correlates strongly with

110 allowed reliable assignment of orthologs and paralogs for most genes; (ii) orthology-based approach,

111 HD3 as defining the selectivity of these two paralogs for NPF-containing binding partners, and we pre

112 NIP4;1 and NIP4;2 are paralogs found exclusively in the angiosperm lineage.

113 P2 requires dimerization with itself or with paralogs FoxP1 and FoxP4.

114 position promotes divergence of the AtPOT1b paralog from the ancestral POT1 protein.

115 iphon and the presumably more primitive OCP2 paralog from the same organism, we show that an NTD-CTD

116 her uncover large clusters encoding multiple paralogs from several Tribolium-specific microRNA famili

117 To gain insight into Rad51 paralog function, we investigated a heterodimeric Rad51

118 mice demonstrated that Fmr1, along with its paralog Fxr2, regulate circadian behavior, and that thei

119 e show that genetic redundancy of Gata3 with paralog Gata2 in trophoblast progenitors ensures the suc

120 ed selectivity for Hsp90beta among all Hsp90 paralogs, GBA thus provides a new chemical tool to study

121 ike ORFs that show evidence of ongoing inter-paralog gene conversion.

122 n though silk-specific genes belong to multi-paralog gene families.

123 CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA

124 ption factor families contain highly related paralogs generated by gene duplication, and functional d

125 Here, we describe the cloning of two paralog genes, H03-IPSE and H06-IPSE, which are ortholog

126 rated that, in the absence of SLT2, the GGA1 paralog GGA2 is essential for cells to survive under cel

127 LE, CARBON METABOLISM-INVOLVED (GNC) and its paralog GNC-LIKE/CYTOKININ-RESPONSIVE GATA FACTOR1 (GNL)

128 To distinguish critical paralog groups (CPGs) from other paralogs in human signa

129 transcriptional regulation than non-critical paralog groups (non-CPG).

130 , the results revealed two distinct types of paralog groups in the signaling network: CPGs and non-CP

131 and two other Tetrahymena RPA large subunit paralogs had higher DNA binding affinity than their larg

132 cTnC for Ca(2+) overall, whereas each of the paralogs has increased affinity at 28 degrees C compared

133 es and modes of silencing, of individual AGO paralogs have been well documented in multicellular euka

134 eins can bind a carotenoid and the different paralogs have distinct functions.

135 constraints that are subtler due to how the paralogs have diversified.

136 s expression pattern, most of the novel Ago2 paralogs have independently specialized to testis-specif

137 effects of exon structure divergence between paralogs have never before been studied on a genome-wide

138 Teleost-specific TnC paralogs have not yet been functionally characterized.

139 analyses, we show that most testis-specific paralogs have significantly lower genetic diversity than

140 ervations indicated that the CELA1 and CELA3 paralogs have some different but also overlapping specif

141 These data suggest that key IIS/TOR paralogs have sub- or neofunctionalized between mammals

142 We found that both paralogs HoxA alpha and beta were distinguishable withou

143 Genetic loss of all three Hox6 paralogs (Hoxa6, Hoxb6 and Hoxc6) leads to a dramatic lo

144 city and ROS levels as compared with another paralog, Hsp34.

145 divergence and conservation between soybean paralogs (i.e., the soybean genome is the product of two

146 nction of two putative zebrafish IL-2Rgammac paralogs, il-2rgammac.a and il-2rgammac.b, and downstrea

147 Three mammalian IMP paralogs (IMP1-3) have been identified that are expresse

148 BOI1 and BOI2 are paralogs important for the actin cytoskeleton and polar

149 he importance of inhibiting one or the other paralog in different disease states remains unknown.

150 c to RSC, as it does not target SWI/SNF, its paralog in Saccharomyces cerevisiae Extensive mutational

151 coded valine-glycine repeat protein G (VgrG) paralogs in Agrobacterium tumefaciens C58 specifically c

152 CYC2-like paralogs in HCL show differential expression with higher

153 sh critical paralog groups (CPGs) from other paralogs in human signaling networks, we developed a sig

154 Germline knockout of both paralogs in mice results in early embryonic lethality.

155 the biochemical properties of the J-protein paralogs in relation to their association with the impor

156 demonstrate differential propensities of CHS paralogs in terms of the accumulation of flavonoids and

157 Here we identify two boule paralogs in the freshwater planarian Schmidtea mediterra

158 We found two paralogs in zebrafish, prps1a and prps1b and characteriz

159 dogenous expression of one of the two mglur6 paralogs in zebrafish.

160 ns, leaving groups of similar genes - termed paralogs - in the genome.

161 lutionary history of these enzymes and their paralogs, in which horizontal gene transfer played an im

162 ermore, we show that expression of each SUMO paralog inhibits IFN-gamma-induced transcription without

163 interacting proteins in the case of multiple paralogs inside a species, down to the prediction of res

164 tween orthologs and paralogs and to classify paralogs into subtypes depending on the duplication mech

165 s advancing our understanding of how a RAD51 paralog is involved in maintaining genomic stability and

166 defining orthologs and separating them from paralogs is a complex task that may not always be suited

167 Fam20A, a Fam20C paralog, is essential for enamel formation, but the bioc

168 trols shoot branching, whereas its ancestral paralog, KAI2, mediates karrikin-specific germination re

169 ing knockdown of kmt2d and the two zebrafish paralogs kdm6a and kdm6al, we analyzed morphants for dev

170 e role in silencing, the T. delbrueckii SIR1 paralog KOS3 was essential for silencing.

171 -incompatibility locus (S locus) consists of paralogs (Lal2, SCRL) of the canonical Brassicaceae S lo

172 StART-like domains from Ysp2p and its paralog Lam4p specifically bind sterols, and Ysp2p, Lam4

173 ymus, T cell-specific ablation of the Roquin paralogs leads to a dramatic expansion of NKT17 cells, w

174 : lamina-associated protein 1 (LAP1) and its paralog, luminal domain like LAP1 (LULL1).

175 These seem to be out-paralogs maintained from ancient duplications associated

176 essed (gce) gene has duplicated to yield the paralog Methoprene-tolerant (Met).

177 ncy was addressed by co-deleting the closest paralog, Mll2.

178 ast cancer, elevated levels of the mammalian paralogs MMP2, MMP9, and MMP13 are associated with a 4-

179 Myc and its paralog MycN are thought to be functionally redundant, b

180 MYRF-1 and its paralog MYRF-2 are functionally redundant specifically i

181 hat mice lacking Nms and its closely related paralog, Nmu, do not lose in vivo circadian rhythms.

182 s sequential inactivation of PTB and the PTB paralog nPTB in HAFs.

183 Catalytically inactive enzyme paralogs occur in many genomes.

184 The plastid targeting of AZI1 and AZI1 paralogs occurs through a mechanism that may enable/faci

185 nature function of AGO2, the closest genetic paralog of AGO3, in host antiviral defence.

186 metallo-beta-lactamase superfamily and is a paralog of CPSF-73, the endonuclease for pre-mRNA 3'-end

187 CTCFL, a paralog of CTCF, also known as BORIS (brother of regulat

188 The physiological role of LepA, a paralog of EF-G found in all bacteria, has been a myster

189 We report that rec-1 encodes a distant paralog of HIM-5, which was discovered by whole-genome s

190 Here, we describe the role of LbtP, a paralog of LbtU, in iron acquisition in the L. pneumophi

191 Siglec-9, the functionally equivalent human paralog of Siglec-E, occurs as a monomer.

192 to the gene ALBINO4 (ALB4), which encodes a paralog of the well-known thylakoid protein targeting fa

193 accessory subunit N7BM (NDUFA12), whereas a paralog of this subunit, the assembly factor N7BML (NDUF

194 AIAP3, is a secretory cell-specific Munc13-4 paralog of unknown function.

195 genes such as UTY (KDM6c), the male-specific paralog of UTX (KDM6a) We propose that an NKX3.1-G9a-UTY

196 XLF (XRCC4-like factor/Cernunos), and PAXX (paralog of XRCC4 and XLF).

197 interacting proteins (DIPs), comprising nine paralogs of another subclass of Ig-containing proteins,

198 IgSF) domains discovered a network formed by paralogs of Beaten Path (Beat) and Sidestep (Side), a li

199 tiana benthamiana incorporates two different paralogs of each catalytic subunit into active proteasom

200 Further we tested, whether paralogs of Hox gene clusters originated from this paddl

201 Divergent paralogs of ITS sequences, including putative pseudogene

202 There are four additional sequence paralogs of LdtMt2 encoded by the genome of this pathoge

203 s japonicus mutants defective in AM-specific paralogs of lipid biosynthesis genes (KASI and GPAT6).

204 haliana), there are two catalytically active paralogs of PDX1 (PDX1.1 and PDX1.3) producing the vitam

205 ants of "super-rogue" psbA4 genes, divergent paralogs of psbA genes encoding the D1 core subunit of p

206 issect the functions of two pairs of ancient paralogs of the GALactose sugar utilization network in t

207 We have identified two zebrafish paralogs of the human COL15A1 gene, col15a1a and col15a1

208 oteins (Helical Carotenoid Proteins [HCPs]), paralogs of the N-terminal domain of OCP, were described

209 ns elsewhere in the genome, in this case, in paralogs of the same gene family.

210 at Nedd4-2 exhibits broad specificity for E2 paralogs of the Ubc4/5 clade to assemble Lys(63)-linked

211 stress-induced Hsp90alpha, the two cytosolic paralogs of this molecular chaperone.

212 y 20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, calle

213 Such RdRP paralogs often participate in distinct RNA silencing pat

214 enitor Aegilops tauschii contains W2 and Iw2 paralogs on chromosome 2D.

215 nd related species express two distinct AC40 paralogs, one of which assembles into Pol I and the othe

216 Of the four human Argonaute (AGO) paralogs, only AGO2 has been shown to have slicer activi

217 ess, and 'bowtieness' when compared to other paralogs or other proteins in the signaling network.

218 d on two separate plasmids, and are probably paralogs or pseudoparalogs.

219 in turn, been restricted to proteins without paralogs, or to bacterial systems with the corresponding

220 Most paralogs originating from the Salicaceae whole-genome du

221 nsferases CREB-binding protein (CBP) and its paralog p300 play a critical role in numerous cellular p

222 ctivators CREB-binding protein (CBP) and its paralog p300 to activate CREB-dependent gene transcripti

223 Genome duplication in eukaryotes created paralog pairs of ribosomal proteins (RPs) that show high

224 that genes encoding human PDIA1 and its two paralogs PDIA8 and PDIA2 are each flanked by genes encod

225 hat a mutation in one of the three mammalian paralogs, PEX11beta, results in a neurological disorder.

226 uncovered the molecular basis by which Rad51 paralogs promote HR.

227 ion of eIF5, 5MP1 and 5MP2, the second human paralog, promotes ATF4 expression in certain types of hu

228 e trans-golgi network at a pH of 6.5 while a paralog, proprotein convertase 1/3, activates in secreto

229 Many genomes contain families of paralogs--proteins with divergent function that evolved

230 either Rad51 recombinase nor the yeast Rad52 paralog Rad59 has this activity.

231 ion or by gene conversion, in which the babB paralog recombines into the babA locus.

232 pon cellular processes, e.g., specific yeast paralogs regulate actin organization, bud site selection

233 Rab11 and its paralogs regulate multiple secretory and endocytic recyc

234 Altogether, we show that Roquin paralogs regulate the development and function of NKT ce

235 f K. stuttgartiensis, kustc0694 is one of 10 paralogs related to octaheme hydroxylamine (NH2OH) oxido

236 in diverse organisms, frequently as multiple paralogs representing the distinct clades.

237 is highly down-regulated in yeast lacking RP paralogs required for normal mitochondrial function (e.g

238 g of any such duplication(s) and patterns of paralog retention could help explain the rapid radiation

239 omotes its own accumulation, and that of its paralog RNF169, but how they recognize ubiquitylated chr

240 (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap1, assembles into rootlets o

241 Mammalian genomes contain two Sec23 paralogs, Sec23A and Sec23B.

242 Doubling binding site numbers switched paralog sensitivity, by placing the Neurexin2 AS4 exon u

243 protein (GODZ; also known as DHHC3) and its paralog Sertoli cell gene with a zinc finger domain-beta

244 Most of the Y-linked genes have autosomal paralogs, so autosome-to-Y transposition must be the mai

245 itive accumulation has allowed us to predict paralog-specific behaviors of different cross-linking pr

246 around a target exon, rather than different paralog-specific protein-RNA binding sites, controls fun

247 +) binding site; this region is also home to paralog-specific sequence substitutions that we predict

248 r whether specialized ribosomes exist and if paralog specificity controls translation.

249 ion may confer specialized functions, and RP paralog specificity defines a novel means of translation

250 onstrate that SRGAP2A and its human-specific paralog SRGAP2C co-regulate the development of excitator

251 strong synthetic lethal interaction with its paralog STAG1.

252 However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which the

253 We propose that Rad51 paralogs stimulate HR by remodeling the Rad51 filament,

254 we use the two Schizosaccharomyces pombe HP1 paralogs, Swi6 and Chp2, as model systems to compare and

255 interacted with CLF, its partially redundant paralog SWINGER (SWN), and LHP1.

256 ichiometry of complexes, which often involve paralog switching.

257 The wheat genome contains two VIT paralogs, TaVIT1 and TaVIT2, which have different expres

258 The inactive PRMT paralog, TbPRMT1(PRO), is essential for catalytic activi

259 The P. furiosus genome encodes an NfnI paralog termed NfnII, and the two are differentially exp

260 sheep, the BST2 gene is duplicated into two paralogs termed oBST2A and oBST2B.

261 antation stage of the mouse embryo, when its paralogs Tet2 and Tet3 are not detectably expressed.

262 rage number of footprint differences between paralogs than TDs.

263 NPP7 is the only paralog that can cleave SM, and its activity requires th

264 of ABHD5 and ABHD4, a functionally distinct paralog that diverged from ABHD5 500 million years ago,

265 ryonic lethality due to expression of UTY, a paralog that lacks H3K27 demethylase activity, suggestin

266 reductase domain of the upstream module by a paralog that produced the enantiomeric ACP-bound diketid

267 -like 1 (TBL1) and TBL1 related (TBLR1), two paralogs that are core components of NCoR/SMRT.

268 (renamed IFIT1B) are not orthologs, but are paralogs that diverged >100 mya.

269 Prozymes are catalytically inactive enzyme paralogs that dramatically stimulate the function of wea

270 ls) eta and iota are Y-family DNA polymerase paralogs that facilitate translesion synthesis past dama

271 cies that have HP1 proteins possess multiple paralogs that perform non-overlapping roles in vivo.

272 , NusG frequently co-exists with specialized paralogs that regulate expression of a small set of targ

273 SLM2 and Sam68 are splicing regulator paralogs that usually overlap in function, yet only SLM2

274 or TnC1a) and slow-skeletal (ssTnC or TnC1b) paralogs through potential-of-mean-force calculations.

275 des, which might enable paleoduplicated PDAT paralogs to either become nonfunctionalized or develop d

276 les, and simultaneously to match interacting paralogs, to identify interprotein residue-residue conta

277 le simulations have calculated that the cTnC paralog transitions from the closed to the open state mo

278 OMERE REPEAT BINDING PROTEIN1 (TRB1) and its paralog TRB3.

279 ues, we show that the RhoGEF Kalirin and its paralog Trio play critical and redundant roles in excita

280 e of the redundant functions of OCRL and its paralog type 2 inositol polyphosphate-5-phosphatase (INP

281 Pro814Leu variant in the major human Munc13 paralog UNC13A (also known as Munc13-1).

282 l18, also known as Pcgf2 and one of six Pcgf paralogs, uniquely regulates PRC1 to specify mesoderm ce

283 study we have modeled the structures of the paralogs using molecular dynamics simulations at 18 degr

284 drug development.IMPORTANCE The Vpr and its paralog Vpx are accessory proteins encoded by different

285 ead wheat, miRW1 accumulated, W1-COE and its paralog W2-COE were down-regulated, and the phenotype wa

286 Lower expression of the SMARCA2 paralog was associated with cellular sensitivity to EZH2

287 Of the HoxD, only the beta paralog was unequivocally identified, whereas the alpha

288 ses of mitosis where it colocalizes with its paralog WDR62, which plays a key role at MSP.

289 bp each), ReCHS1 and ReCHS2, encoding unique paralogs were isolated and characterized.

290 amilies, such as metalloproteases-associated paralogs, were exclusively identified in pathogenic spec

291 he family, GluRS, LysRS and CysRS often have paralogs, whereas AsnRS, GlnRS, PylRS and SepRS are ofte

292 strocyte-derived neurotrophic factor, a CDNF paralog, which corresponds to its intracellular mode of

293 Furthermore, we find that paralogs with divergent exon structure demonstrate reduc

294 ion in a variety of tissues when compared to paralogs with identical exon structures and singletons.

295 other splicing regulators within families of paralogs with indistinguishable RNA binding sites.

296 ility, we targeted the N. benthamiana NbAGO1 paralogs with one sgRNA and also multiplexed two sgRNAs

297 frequently observed among duplicated genes (paralogs) with overlapping functions.

298 ed which mammalian alpha-actinin and filamin paralogs would be mechanoaccumulative.

299 s at the ZCN8 locus and its nearly identical paralog ZCN7 during the floral transition.

300 eterozygous deletions of ZIC1 and its nearby paralog ZIC4 on chromosome 3q25.1 are associated with Da