ライフサイエンスコーパス: paramount

1 atient Protection and Affordable Care Act is paramount.

2 le and when to apply an external stimulus is paramount.

3 allergies, their detection and treatment is paramount.

4 tions, and clinical judgment continues to be paramount.

5 glycan-reactive NAb repertoire is therefore paramount.

6 ng NP colloidal stability and aggregation is paramount.

7 alisation and overuse of drug treatments are paramount.

8 h risk of secondary CNS relapse is therefore paramount.

9 communicate clinically relevant variants is paramount.

10 handling and minimal sample preparation are paramount.

11 presents an optimal strategy, sensitivity is paramount.

12 prevalence setting where cost issues remain paramount.

13 ions with the biological environment becomes paramount.

14 kidney disorders in a personalized manner is paramount.

15 t, maximizing the value of care delivered is paramount.

16 enotypic similarity to the original tumor is paramount.

17 atory mechanisms of Shh canonical pathway is paramount.

18 ions, participant and investigator safety is paramount.

19 ne, the elucidation of conserved epitopes is paramount.

20 ty trends, that is, molecular parameters, is paramount.

21 ish better-tailored treatment medications is paramount.

22 ' full understanding of their medications is paramount.

23 for a highly stable support (such as TRO) is paramount.

24 actical test, with lower detection limit, is paramount.

25 h for alternative or complementary therapies paramount.

26 average, and control of inflammation remains paramount.

27 improved efficacy that are safe is therefore paramount.

28 for interprofessional nutrition education is paramount.

29 nologies, although clinical judgment remains paramount.

30 w HPAI viruses in different avian species is paramount.

31 Thus the need for alternative treatments is paramount.

32 lial sodium channel (ENaC), are regulated is paramount.

33 iquitin-26S proteasome system is also likely paramount.

34 y, where precise and accurate positioning is paramount.

35 chanisms by which these viruses reproduce is paramount.

36 xpensive molecular chromophores is therefore paramount.

37 on Sequencing, automatic training has become paramount, allowing genome annotation pipelines to keep

38 Epidermal cell differentiation is a paramount and conserved process among plants.

39 xtures of inorganic and organic compounds is paramount and not afforded by other less portable instru

40 Prompt recognition is paramount and, without early treatment, this disorder is

41 aematuria as the major presenting symptom is paramount, and early diagnosis with individualised treat

42 The need for novel treatments is paramount, and future efforts to improve outcomes and qu

43 The kinetics of protein ubiquitylation are paramount as a balance must be achieved between the rapi

44 nce, nonmaleficence and sometimes justice is paramount as well.

45 of its application to challenging systems of paramount biological importance.

46 ble precursors has long been recognized as a paramount challenge in synthetic chemistry.

47 A paramount challenge in the development of advanced nucle

48 For cancer detection, a paramount challenge still exists in the search for metho

49 Two paramount challenges are the lack of an adequate trainin

50 ore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgica

51 However, its instability in air is of paramount concern for practical applications.

52 For all three lakes, the paramount contamination occurred in the early 1970s.

53 ging pathogens when containment of spread is paramount; delays of <1.5 years are ideal.

54 ern of sulfation on the PG sugar chains is a paramount determinant of a diverse and flexible set of o

55 Assessing the tumor invasiveness is a paramount diagnostic step to improve the patients care.

56 realized, a change in experimental design is paramount: effective transcriptomics requires phylogeny-

57 its relative and absolute configurations-is paramount, enabling one to understand its biological act

58 Tuberculosis (TB) is a paramount example of a chronic infection in which antimi

59 lection advantages that have resulted in the paramount fixation of the ACKR1 rs2814778(G) polymorphis

60 ure and integrate this dynamic interface, is paramount for developing precision diagnostics and thera

61 the final elemental distribution, which are paramount for device optimization, are still poorly unde

62 te mounting evidence that toxin detection is paramount for diagnosis, conventional toxin immunoassays

63 Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell ma

64 identified primary miRNA sequences that are paramount for effective expression of mature miRNAs, and

65 acement on soil organic carbon (SOC) remains paramount for effectively managing ecosystems to mitigat

66 Resolution and sensitivity are paramount for extracting detailed structural information

67 rreversible hair cell loss in mammals become paramount for hearing protection.

68 This is paramount for improving ovarian cancer patients' respons

69 ual adsorption sites, the tuning of which is paramount for optimizing the storage performance.

70 continues, making ongoing close observation paramount for patients undergoing this surgery.

71 ontrol strategies for biological networks is paramount for practical applications that involve reprog

72 e range expansions during climate warming is paramount for predicting population extirpations and pre

73 portance of dietary lipids during infancy is paramount for rapid growth and development.

74 egrating methods for genetic manipulation is paramount for regenerative purposes.

75 molecular testing with mutation analysis is paramount for selection of appropriate therapy.

76 d DNA copy-number typing of single cells are paramount for studying genomic heterogeneity and enablin

77 erstanding and forecasting of Sahel drought, paramount for successful adaptation strategies in a chan

78 Precise spatiotemporal gene regulation is paramount for the establishment and maintenance of cell-

79 derstanding the role of metabolised forms is paramount for the in-depth comprehension of adverse effe

80 Yet, the time domain is paramount for the observation and study of complex biolo

81 c responses are evolutionarily conserved and paramount for tissue and organismal health.

82 Laboratory mice, while paramount for understanding basic biological phenomena,

83 derstanding the nonlinearity of the brain is paramount for understanding the relationship between bra

84 these trimers and higher-order oligomers is paramount for understanding their role in neurodegenerat

85 Paramount fundamental questions remain unanswered that r

86 safety of any new curative therapies will be paramount given the excellent safety of currently approv

87 genetic resistance studies in this shrimp of paramount global economic importance.

88 The paramount goal in the treatment of type 1 diabetes is th

89 ionalization of aliphatic C-H bonds remain a paramount goal of organic synthesis.

90 xicological signaling pathways is one of the paramount goals of modern toxicology.

91 assess the usefulness of including DPT as a paramount gold standard diagnostic tool (prior to desens

92 tumors as summarized in this review will be paramount if Precision Oncology is ultimately to lead to

93 owever, the length of the glycol chain is of paramount importance and the present studies show that t

94 This is of paramount importance as preferential degradation of (S)-

95 tter interactions in many-body systems is of paramount importance both for fundamental understanding

96 mation in the attenuation map (mu map) is of paramount importance for accurate brain PET quantificati

97 f the properties of nanocrystals (NCs) is of paramount importance for any applicative development.

98 ous identification of biothreat agents is of paramount importance for confirmation of the event and t

99 lar characterization of DNA and/or RNA is of paramount importance for disease diagnostics and to foll

100 fine details of PTIR analysis has become of paramount importance for extending complex IR analysis m

101 of film formation and crystallization is of paramount importance for further advances.

102 e nature of Cas9's off-target activity is of paramount importance for its practical use.

103 ypic plasticity in crops such as maize is of paramount importance for maintaining and increasing yiel

104 se three-dimensional libraries has become of paramount importance for obtaining better leads for drug

105 ignals still remains challenging despite the paramount importance for practical applications.

106 ge from it effectively and efficiently is of paramount importance for precision medicine, and a major

107 Proper chromosome segregation is of paramount importance for proper genetic inheritance.

108 n to halt ventricular fibrillation remain of paramount importance for saving lives.

109 nature and causes of their variability is of paramount importance for society.

110 roteins of the mitochondrial proteome, is of paramount importance for the bioenergetic machinery of o

111 These observations are of paramount importance for the conservation and exploitati

112 sis of release characteristics of CRFs is of paramount importance for the design and development of n

113 ort of engineered nanoparticles (ENPs) is of paramount importance for the formation and validation of

114 Electrostatic gates are of paramount importance for the physics of devices based on

115 arvesting complex (LHC) protein family is of paramount importance for this function and can form ligh

116 , and under electron beam irradiation, is of paramount importance for this technique to contribute to

117 mics of dissolved organic matter (DOM) is of paramount importance for understanding DOM stability and

118 s of magma storage and remobilization are of paramount importance for understanding volcanic processe

119 Awareness of one's own abilities is of paramount importance in adaptive decision making.

120 ny different organs and have proven to be of paramount importance in advancing our knowledge of norma

121 onmental health, thus their monitoring is of paramount importance in analytical chemistry.

122 Directional cell migration is of paramount importance in both physiological and pathologi

123 Stability is of paramount importance in colloidal applications.

124 onally accepted, reproducible criteria is of paramount importance in evaluating and comparing clinica

125 ndaries and discovery of cryptic taxa are of paramount importance in interpreting ecological and evol

126 g and its detection and quantification is of paramount importance in many areas of current research.

127 s through the introduction of fluorine is of paramount importance in medicinal chemistry.

128 ticles (FENPs) in aquatic environments is of paramount importance in order to assess the risk related

129 edicting plant response to disturbance is of paramount importance in our changing world.

130 igh-throughput screening (HTS) methods is of paramount importance in the early stage of drug discover

131 nally important in inflammation, which is of paramount importance in the pathogenesis of retinal neov

132 ough the gelator-gelator interactions are of paramount importance in understanding gelation, the solv

133 A question of paramount importance is how to control the formation of

134 Reinforcing the paramount importance of graft outcomes encompassed the p

135 ent evolution of groups, and it stresses the paramount importance of the life cycle: only by evaluati

136 on of carbon in carbon-based materials is of paramount importance since the properties of such materi

137 both diseased and healthy tissues, it is of paramount importance that this challenge is addressed.

138 recording (e.g., NIH BRAIN Project) it is of paramount importance that we have statistically reliable

139 ositing a pinhole-free perovskite film is of paramount importance to achieve high performance perovsk

140 polymer-fullerene organic solar cells is of paramount importance to boost the performance of such pr

141 this (1)H NMR study provides information of paramount importance to design sound in vitro digestion

142 The accurate staging of liver fibrosis is of paramount importance to determine the state of disease p

143 Given their growing number, it is of paramount importance to discover novel inhibitors target

144 Maintaining genomic integrity is of paramount importance to embryonic stem cells (ESCs), as

145 in appropriate cellular compartments are of paramount importance to exert their biological functions

146 chemical methods for their preparation is of paramount importance to facilitate exploration of their

147 cid sites in zeolite-based catalysts is of a paramount importance to further improve their catalytic

148 The honey bee is of paramount importance to humans in both agricultural and

149 For their promise to be fulfilled, it is of paramount importance to identify the mechanisms of resis

150 It is of paramount importance to improve the control over large a

151 aining substrates and alumina surfaces is of paramount importance to industrial and academic catalysi

152 ilm thickness and architecture, which are of paramount importance to meet the application requirement

153 olecule bridging conducting electrodes is of paramount importance to molecular spintronics.

154 equent and more intense heat waves, it is of paramount importance to quantify the health risks relate

155 Moving forward, it is of paramount importance to recognize the heterogeneity of D

156 w adjuvants and vaccination strategies is of paramount importance to successfully fight against many

157 These advances have made this topic of paramount importance to the understanding of schizophren

158 It is therefore of paramount importance to understand the mechanisms throug

159 Ferroelectrics (FEs) are materials of paramount importance with a wide diversity of applicatio

160 t-of-care (POC) viral load measurement is of paramount importance with significant impact on a broad

161 CE The development of an HIV-1 vaccine is of paramount importance, and broadly neutralizing antibodie

162 n single-molecule fluorescence imaging is of paramount importance, as it dictates the amount of relev

163 the management of such complications are of paramount importance, particularly in an era when TAVR e

164 r receptor (EGFR) in biological fluids is of paramount importance, since it has significant applicati

165 iers, where it exerts a protective effect of paramount importance.

166 late into major biogeographic patterns is of paramount importance.

167 ferentiating it from pancreatic cancer is of paramount importance.

168 tions of the different curli proteins are of paramount importance.

169 bility of bromine and captured mercury is of paramount importance.

170 nderstanding TBX5 regulation is therefore of paramount importance.

171 lity of the reference sequence is clearly of paramount importance.

172 eby they influence disease development is of paramount importance.

173 causative organism, diagnostic tests are of paramount importance.

174 the molecular mechanisms of metastasis is of paramount importance.

175 phenotypes, identifying their targets is of paramount importance.

176 erstanding the mechanisms driving them is of paramount importance.

177 vorable influence of living donor type is of paramount importance.

178 etric transrectal ultrasound and mpMRI is of paramount importance.

179 as a companion drug for existing drugs is of paramount importance.

180 ir beneficial effects on human health are of paramount importance.

181 nnate immunity in the pulmonary system is of paramount importance.

182 t) protein can activate microglia is thus of paramount importance.

183 y metal contamination in potable water is of paramount importance.

184 d manufacturing practice compatibility is of paramount importance.

185 e effective medical pH imaging methods is of paramount importance.

186 how much effort we should expend can assume paramount importance.

187 Determining these structures is thus of paramount importance.

188 to prioritize these variants is therefore of paramount importance.

189 s involved in CD20 regulation seems to be of paramount importance.

190 to manage excess body weight is therefore of paramount importance.

191 ls capable of hosting external molecules are paramount in basic and applied research.

192 Abiotic drivers (discharge anomalies) were paramount in determining long-term fish abundances, wher

193 It is now recognized that PRRs are paramount in instructing an appropriate adaptive immune

194 The need to assess autonomic function is paramount in many experimental paradigms because of the

195 counseling and access to specialist care are paramount in optimizing disease management.

196 Knowledge of these interactions is paramount in optimizing the success of antiviral therapy

197 o microbial antigen exposure to cells, being paramount in orchestrating the onset, magnitude, and com

198 ts in switching time and switching energy is paramount in order to design nanoscale structures with e

199 Inflammation is paramount in pancreatic oncogenesis.

200 on of right ventricular (RV) dysfunction are paramount in perioperative management.

201 to random imperfections in periodic media is paramount in photonics research.

202 pplications with the hardware itself will be paramount in successfully using quantum computers in the

203 Paramount in the clot's capability to stem haemorrhage a

204 -reported outcomes (PROs) in surgery remains paramount in the current medical climate.

205 receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of syna

206 ropeptides and hormones in energy balance is paramount in the search for approaches to mitigate the o

207 Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologically relevant mole

208 ecedented specificity and precision has been paramount in this endeavor.

209 on and adequate classification of agents are paramount in this molecular age to devise appropriate su

210 dge of the human atrial fibrous structure is paramount in understanding the mechanisms of atrial elec

211 utes to emissive solid-state materials is of paramount interest, and in this report we describe the b

212 non-invasive delivery approaches are also of paramount interest.

213 avated from the central places of the ruling paramounts, particularly lithic artifacts associated wit

214 of cell-associated nanoparticles (NPs) is a paramount question in both nanomedicine and nanotoxicolo

215 he subcortical auditory nervous system is of paramount relevance for human communication, and it has

216 nd binding toward its molecular target is of paramount relevance in drug design.

217 ultidrug-resistant profiles, is certainly of paramount relevance, given its obvious effect on the cha

218 Autophagy plays a paramount role in mammalian antiviral immunity including

219 plied perspective, materials science plays a paramount role in shaping our present and in contributin

220 We have found that dynamic effects have a paramount role in the selectivity observed for these rea

221 t be a surprise because it parallels water's paramount role in the structure and function of soluble

222 sults demonstrate that the 3d dopant plays a paramount role in the surface phase transition, which pr

223 e severely immunodeficient, highlighting the paramount role of IRAK kinases in innate immunity.

224 al seed endosperm remain unknown despite the paramount role of this process in plant growth.

225 the dilation of the pulmonary arteries as a paramount sign of PAH, we hypothesized that the ascendin

226 It is of paramount significance for chemical identification purpo

227 ting proteins within cellular contexts is of paramount significance in elucidating their biological f

228 pronouncement of death is a determination of paramount social, legal, and ethical import.

229 rials for the last five decades, which offer paramount technological importance.

230 l result in improved clinical outcomes makes paramount the reassessment of neoadjuvant ADT with more

231 differential diagnosis of parkinsonism is of paramount therapeutic and prognostic importance.

232 tifying the source of resurgent parasites is paramount to a strategic, successful intervention for ma

233 ous disease, and stratification of tumors is paramount to achieve better clinical outcomes.

234 heterojunction (BHJ) organic solar cells is paramount to achieve high-efficiency devices.

235 these severely affected children, it is also paramount to address the larger proportion of ZIKV-expos

236 It is paramount to apply a strong level of scientific rigor to

237 selection of the appropriate methodology is paramount to avoid misdiagnosis and guide therapy.

238 Postfire reassembly of vegetation--paramount to C storage and biodiversity conservation--fr

239 testing (AST) by the clinical laboratory is paramount to combating antimicrobial resistance.

240 the mechanisms underlying gene regulation is paramount to comprehend the translation from genotype to

241 r basis for viral latency and persistence is paramount to controlling or eliminating HCMV infection.

242 s reinforces gender and other stereotypes is paramount to creating a culture of inclusivity.

243 nsitivity to external climate forcing, it is paramount to determine its past behaviour by using palae

244 covariates and environmental predictors, are paramount to develop a more complete understanding of th

245 the causes of these persistent illnesses is paramount to develop appropriate therapeutic protocols.

246 rstanding the mechanisms underlying SUDEP is paramount to developing preventative strategies.

247 d to understand the underlying mechanisms is paramount to discover new therapeutics.

248 ental evidence that self-organization can be paramount to enhancing ecosystem persistence.

249 Recent literature shows it is paramount to extend the amount of biopsies and to alter

250 stalled or damaged DNA replication forks is paramount to genomic integrity and recent work points to

251 d of prognostic factors for complications is paramount to guide therapeutic decisions.

252 to cellular and organismal survival and are paramount to health.

253 Rapid and accurate detection of pathogens is paramount to human health.

254 Clean water is paramount to human health.

255 area and reduced water availability make it paramount to identify and develop strategies to allow cr

256 ur in children who do not have asthma, it is paramount to identify genetic and environmental factors

257 It is thus paramount to identify predictive markers of risk, partic

258 change and strong managerial leadership was paramount to implement and sustain the new scheduling pr

259 A rapid diagnosis of IA is paramount to improve survival.

260 Consideration of DDIs is paramount to improving medication adherence and mitigati

261 he developing sympathetic nervous system, is paramount to improving patient outcomes.

262 em and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes.

263 enoid cyclase as a template for catalysis is paramount to its function, and protein engineering can b

264 Proton pumping is paramount to keep normal cells alive, e.g. for lysosomal

265 ontrol of mitochondrial protein synthesis is paramount to maintain proteostasis.

266 ICANCE STATEMENT Predicting future reward is paramount to optimal behavior.

267 ing the specific actions of echinocandins is paramount to optimizing their use at either standard or

268 sulin granule exocytosis and endocytosis are paramount to pancreatic beta cell dysfunction in diabete

269 on of the likelihood for future treatment is paramount to parents, as are the implications for recurr

270 Predicting future reward is paramount to performing an optimal action.

271 agement and multidisciplinary involvement is paramount to save the lives of these women.

272 als that pi-donating dialkylamide groups are paramount to successful phosphinidene transfer; poorer p

273 arameters of the employed DrewPhos ligand is paramount to suppressing isomerization and promoting eff

274 of the innate and adaptive immune systems is paramount to the development of protective humoral and c

275 defence-arousal system and its integrity is paramount to the expression of survival behaviours.

276 Postexercise nutrition is paramount to the restoration of muscle energy stores by

277 mical composition of biological materials is paramount to the study of natural phenomena.

278 chanisms of transcription factor activity is paramount to the understanding of gene expression patter

279 es coupled with reduced drug prices has been paramount to the VA's success in curing HCV infection.

280 Paramount to these efforts is reducing pregnant women an

281 types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate

282 rize this difficult to analyze interface are paramount to uncovering the mechanism of their associati

283 atic processes in active volcanic systems is paramount to understand magma chamber dynamics and the t

284 d a life-cycle based experimental regime are paramount to understanding changes in Ag speciation and

285 nd host cell over the course of infection is paramount to understanding mechanisms of pathogenesis an

286 Quantifying the tautomerization rate is paramount to understanding these compounds' tautomerizat

287 e functioning of the pancreatic beta cell is paramount to whole-body glucose homeostasis, and beta-ce

288 ymerase (PARP) Tankyrase (TNKS and TNKS2) is paramount to Wnt-beta-catenin signaling and a promising

289 e fighting multidrug-resistant bacteria is a paramount topic.

290 The development of quantum networks will be paramount towards practical and secure telecommunication

291 or family, acts as a xenobiotic sensor and a paramount transcriptional regulator of drug-metabolizing

292 In the phase III PARAMOUNT trial, pemetrexed continuation maintenance the

293 rt Failure With Preserved Ejection Fraction (PARAMOUNT) trial at baseline, 12 and 36 weeks after rand

294 rt failUre with preserved ejectioN fracTion (PARAMOUNT) trial, in which the angiotensin receptor nepr

295 amed reactions of fundamental importance and paramount utility in organic synthesis have been reinves

296 ency on the likelihood of mutation events is paramount when following this approach.

297 s, metabolic bone disease, and malignancy is paramount when managing such patients.

298 ound that storage conditions of a column are paramount, which can either prevent or accelerate the pr

299 for professions in which memory function is paramount yet insufficient sleep is pervasive (e.g., avi

300 or accurate interpretation of social cues is paramount yet insufficient sleep is pervasive.