ライフサイエンスコーパス: paraoxonase

1 enzymes cellular glutathione peroxidase and paraoxonase).

2 hiolactonase is identical with that of human paraoxonase.

3 herence, without increases in HDL-associated paraoxonase.

4 c properties, and physiological roles of the paraoxonases.

5 ON1 suggest an anti-atherogenic function for paraoxonases.

6 d covered by this review have indicated that paraoxonase 1 'status' (i.e. activity and/or concentrati

7 Low serum paraoxonase 1 (PON1) activity determined with paraoxon a

8 terol (HDL-C), apolipoprotein A-I (Apo A-I), paraoxonase 1 (PON1) activity, hepatic gene expression,

9 s may be related to decreased HDL-associated paraoxonase 1 (PON1) activity.

10 proficient organophosphatases such as serum paraoxonase 1 (PON1) and the organophosphate-hydrolyzing

11 Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein-associ

12 documented that apoA-I, myeloperoxidase and paraoxonase 1 (PON1) form a complex in HDL that is criti

13 e high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) hydrolyzes lactones, aromatic ester

14 Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)

15 Paraoxonase 1 (PON1) is a high-density lipoprotein-assoc

16 Serum paraoxonase 1 (PON1) is a native lactonase capable of pr

17 Paraoxonase 1 (PON1) is reported to have antioxidant and

18 cysteine ligase catalytic subunit (Gclc) and paraoxonase 1 (PON1).

19 HDL's paraoxonase 1 activity was unaffected by calcium treatme

20 n only a small component of the variation in paraoxonase 1 activity.

21 h both coronary heart disease and diminished paraoxonase 1 activity.

22 Two antiinflammatory HDL components, paraoxonase 1 and apolipoprotein A-I, were also measured

23 protein, cholesterol ester transfer protein, paraoxonase 1 and platelet activating factor acetylhydro

24 erstanding the basic biochemical function of paraoxonase 1 and the discovery of possible modulators o

25 mechanisms underlying the mode of action of paraoxonase 1 and the factors which modulate its activit

26 r regional cord blood DNA methylation at the Paraoxonase 1 gene (PON1) that persisted in early childh

27 coronary heart disease risk factor than the paraoxonase 1 genetic polymorphisms.

28 New findings on the role of paraoxonase 1 in homocysteine metabolism are reviewed, a

29 Paraoxonase 1 is much the most extensively researched an

30 Experiments with transgenic paraoxonase 1 knock-out mice indicate the potential for

31 gh-density lipoprotein is largely due to the paraoxonase 1 located on it.

32 Studies using paraoxonase 1 null mice by gene targeting and transgenic

33 The recent controversy over whether paraoxonase 1 or platelet-activating factor acetylhydrol

34 that genetic epidemiological studies of the paraoxonase 1 polymorphisms in relation to coronary hear

35 disease (MND) is supported by association of paraoxonase 1 polymorphisms with amyotrophic lateral scl

36 sgenic mice corroborated the hypothesis that paraoxonase 1 protects against atherosclerosis.

37 Paraoxonase 1 protects against protein N-homocysteinylat

38 an underestimate of the true contribution of paraoxonase 1 to coronary heart disease because these po

39 cleotide polymorphisms (SNPs) from the PON1 (paraoxonase 1) gene influence the ability to metabolize

40 During the past decade, paraoxonase 1, a HDL-associated protein, has been demons

41 We conclude that, in addition to paraoxonase 1, both paraoxonase 2 and paraoxonase 3 prot

42 In contrast to paraoxonase 1, the other two members of the paraoxonase

43 ein 8, lysosome C, prenylcysteine oxidase 1, paraoxonase 1, transthyretin, serum amyloid A4, and fibr

44 isease risk associated with polymorphisms of paraoxonase 1, which are most active in lipid peroxide h

45 ar biology of the antiatherosclerotic enzyme paraoxonase 1.

46 utritional and pharmacological regulation of paraoxonase 1.

47 Human serum paraoxonase-1 (HuPON1) has the capacity to hydrolyze ary

48 cluding apolipoprotein (apo) A-II, apoE, and paraoxonase-1 (P < 0.05).

49 lated hepatic CAT (activity and expression), paraoxonase-1 (PON-1) expression and down-regulated heme

50 Paraoxonase-1 (PON-1) is involved in the prevention of a

51 Paraoxonase-1 (PON1) is an HDL-associated protein of 354

52 Paraoxonase-1 (PON1) is associated with high-density lip

53 ty of high density lipoprotein (HDL)-derived paraoxonase-1 (PON1) was investigated, using peroxidized

54 Paraoxonase-1 (PON1), an high density lipoprotein (HDL)-

55 ffer cell expression of a transgene encoding paraoxonase-1 (PON1), whose plasma activity correlates w

56 Using LE-PCR, we determined the human paraoxonase-1 [PON1] molecular haplotypes at three loci

57 y antioxidant/anti-inflammatory capacity and paraoxonase-1 activity were not significant.

58 ioxidant/anti-inflammatory capacity, and (3) paraoxonase-1 activity.

59 haptoglobin, and hemopexin) and depleted of paraoxonase-1 after SFA-HFD in comparison with MUFA-HFD.

60 otein activity), HDL antioxidant properties (paraoxonase-1 arylesterase activity and total HDL antiox

61 creased HDL ability to esterify cholesterol, paraoxonase-1 arylesterase activity, and HDL vasodilator

62 y, we show that PPARgamma induces macrophage paraoxonase 2 (PON-2), an enzyme that degrades QS molecu

63 The intracellular lactonase paraoxonase 2 (PON2) hydrolyzes and inactivates 3OC12 an

64 cells damaged by C12-HSL exposure, while the paraoxonase 2 (PON2) inhibitor (Triazolo[4,3-a]quinolone

65 ssed genes associated with cancer, including paraoxonase 2 (PON2), whereas DKONR MEF expressed little

66 e found that p53 transcriptionally represses paraoxonase 2 (PON2), which regulates GLUT1-mediated glu

67 up-regulated, whereas antioxidant proteins, paraoxonase 2 and glutathione peroxidase 3, were down-re

68 ast 2 years suggesting a protective role for paraoxonase 2 and paraoxonase 3 in the development of at

69 ude that, in addition to paraoxonase 1, both paraoxonase 2 and paraoxonase 3 proteins are protective

70 mbers of the paraoxonase gene family, namely paraoxonase 2 and paraoxonase 3, are either undetectable

71 Adenovirus-mediated expression of human paraoxonase 2 or paraoxonase 3 proteins protects against

72 and paraoxonase 3, are either undetectable (paraoxonase 2) or detected at very low levels (paraoxona

73 Paraoxonase 2-deficient mice develop significantly large

74 Paraoxonase-2 (PON-2) is a membrane-bound lactonase with

75 se effects are dependent on the induction of paraoxonase-2, a QS hydrolyzing enzyme, that mitigates t

76 al cells by a mechanism that is mediated via paraoxonase-2.

77 Paraoxonase 3 (PON3) is a member of the PON family, whic

78 ting a protective role for paraoxonase 2 and paraoxonase 3 in the development of atherosclerosis in m

79 ion to paraoxonase 1, both paraoxonase 2 and paraoxonase 3 proteins are protective against the develo

80 ediated expression of human paraoxonase 2 or paraoxonase 3 proteins protects against the development

81 raoxonase 2) or detected at very low levels (paraoxonase 3) on HDL, and are considered to participate

82 xonase gene family, namely paraoxonase 2 and paraoxonase 3, are either undetectable (paraoxonase 2) o

83 and lowest PON1 activity quartiles were, for paraoxonase, 3.4 (95% CI, 2.1-5.5; P < .001) and for ary

84 port the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO).

85 otect is a decrease in the activity of serum paraoxonase, a serum esterase carried on HDL that has pr

86 1, PON3 has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones s

87 protein, phospholipid transfer protein, and paraoxonase activities) were measured at the end of each

88 Turkey and chicken, like most birds, lack paraoxonase activity and are very susceptible to organop

89 HDL with purified paraoxonase restored both paraoxonase activity and the ability to protect against

90 eatment increased plasma HDL cholesterol and paraoxonase activity compared with PBS and inhibited inc

91 ctivity is minimal, whereas the kcat for the paraoxonase activity is negatively perturbed by up to 10

92 ructurally and functionally critical for the paraoxonase activity of PON1 prevent it from being able

93 The H115W variant of G2E6 has paraoxonase activity similar to that of wild-type G2E6,

94 ed in patients on HD, whereas HDL-associated paraoxonase activity was lowest in patients on PD.

95 pre-beta mobility and enriched in apoA-I and paraoxonase activity were found in plasma.

96 hosphates (OPs) by OPH and determining serum paraoxonase activity which appears to be important for p

97 rrelated less strongly (r=-0.36, P=0.025 for paraoxonase activity) or did not correlate at all (pheny

98 otein lipid hydroperoxides (LOOH), increased paraoxonase activity, increased plasma HDL-cholesterol l

99 rmation of pre-beta HDL containing increased paraoxonase activity, resulting in significant improveme

100 ith pre-beta mobility enriched in apoA-I and paraoxonase activity.

101 zed phospholipids or PAF, yet displayed full paraoxonase activity.

102 ect associated with a 5-fold increase in HDL paraoxonase activity.

103 ability to hydrolyze oxidized lipids in LDL, paraoxonase also alters the oxidative state of macrophag

104 t was associated with a decreased content of paraoxonase, an enzyme that protects against LDL oxidati

105 These and other data indicate that paraoxonase, an organophosphate-detoxifying enzyme whose

106 dicates that both the serum concentration of paraoxonase and an individual's genotype are related to

107 in the genes for glutathione S-transferase, paraoxonase and apolipoprotein E on the risk of coronary

108 Serum paraoxonase and aryl esterase activity did not differ be

109 rtile (23/315 [7.3%]) and 235/324 [7.7%] for paraoxonase and arylesterase, respectively) compared wit

110 311 [25.1%] and 75/319 [23.5%]; P < .001 for paraoxonase and arylesterase, respectively).

111 specifically by the OPases, mammalian serum paraoxonase and bacterial organophosphorus hydrolase (OP

112 nalyses showed that 2 Delta variables, Delta paraoxonase and Delta HDL(2), were significantly heritab

113 s with respect to the mechanism of action of paraoxonase and differences between the family members t

114 The activities of paraoxonase and platelet-activating factor acetylhydrola

115 ptoglobin-related protein (Hpr), hemoglobin, paraoxonase, and apoA-II, whereas TLF2 is a larger, poor

116 protein associated with the plasma esterase, paraoxonase, and clusterin.

117 eins: apolipoprotein AI, apolipoprotein AII, paraoxonase, and the primate-specific haptoglobin-relate

118 ains mainly apoA-I and Hpr, trace amounts of paraoxonase, apoA-II, and haptoglobin, but no detectable

119 oteins associated with HDL metabolism (e.g., paraoxonase, apolipoprotein A-I, lecithin:cholesterol ac

120 Common polymorphisms in genes encoding paraoxonase are established risk factors in a variety of

121 ess index (OSI), lipid hydroperoxide levels, paraoxonase, arylesterase, and ceruloplasmin activity, p

122 lipid hydroperoxides, and the activities of paraoxonase, arylesterase, and ceruloplasmin.

123 Serum paraoxonase/arylesterase (PON) is an "A" esterase found

124 Until recently, only the serum paraoxonase/arylesterase (PON1) had been purified and ch

125 erol acyltransferase and apolipoprotein E is paraoxonase associated with non-HDL lipoproteins.

126 The displacement of paraoxonase by serum amyloid A may explain in part the p

127 ted with HDL such as PAF acetylhydrolase and paraoxonase can participate in the elimination of biolog

128 h free ghrelin and paraoxon, a substrate for paraoxonase, can inhibit this interaction.

129 is detoxified by the serum Hcy-thiolactonase/paraoxonase carried on high density lipoprotein.

130 0 times more sensitive for OPH and mammalian paraoxonase detection than existing methods.

131 lexes, as was total dimethylphosphates after paraoxonase expression was considered.

132 advances have been made in research into the paraoxonase family and atherosclerosis, much more needs

133 The paraoxonase family consists of three members (PON1, PON2

134 otein-associated antioxidant enzymes such as paraoxonase from inhibition and protect apoA-I from oxid

135 underscore the utility of all members of the paraoxonase gene family as therapeutic targets for the t

136 The paraoxonase gene family contains at least three members:

137 paraoxonase 1, the other two members of the paraoxonase gene family, namely paraoxonase 2 and paraox

138 the discovery that two other members of the paraoxonase gene family, PON2 and PON3, may also have im

139 Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in p

140 Paraoxonase has a genetic polymorphism that results in a

141 of studies of genetic determinants of serum paraoxonase have reported apparently conflicting results

142 ic lesion development, supporting a role for paraoxonase in atherogenesis.

143 also to coronary heart disease, implicating paraoxonase in the development of atherosclerosis.

144 Paraoxonase is an arylesterase enzyme that is expressed

145 The exact mechanism by which paraoxonase is cardioprotective is not clear, although i

146 hough there have been suggestions that serum paraoxonase is important in protecting against coronary

147 Human serum paraoxonase is located on an HDL.

148 s suggested these proteins interact with the paraoxonase-like MEC-6 and the cholesterol-binding stoma

149 An additional protein, the paraoxonase-like protein MEC-6, is essential for transdu

150 The levels of paraoxonase mRNA decreased in B6 mice upon challenge wit

151 ed from the B6 and C3H parental strains, low paraoxonase mRNA levels segregated with aortic lesion de

152 rties, along with the HDL-associated enzymes paraoxonase, platelet activating factor acetylhydrolase

153 e that alterations in the relative levels of paraoxonase, platelet-activating factor acetylhydrolase,

154 anti- to a proinflammatory particle and that paraoxonase plays a role in this transformation.

155 ommon polymorphism at codon 192 in the human paraoxonase (PON) 1 gene has been shown to be associated

156 Since 3OC12-HSL can be degraded by paraoxonase (PON) family members, we hypothesized that P

157 hown to be hydrolytically inactivated by the paraoxonase (PON) family of calcium-dependent esterases,

158 The paraoxonase (PON) gene family includes three members, PO

159 Paraoxonase (PON) is transported primarily on apolipopro

160 eased apolipoprotein J (apoJ), and decreased paraoxonase (PON) mRNA levels.

161 Paraoxonase (PON), a high-density lipoprotein-associated

162 sly shown that two antioxidant-like enzymes, paraoxonase (PON)-1 and PON3, are high density lipoprote

163 iated with HDL; apolipoprotein J (apoJ), and paraoxonase (PON).

164 There was significantly reduced plasma paraoxonase (PON-1) activity, impaired HDL vascular anti

165 92R, L55M, and T(-107)C polymorphisms in the paraoxonase PON1 gene and the S311C polymorphism in the

166 density lipoprotein (HDL)-associated enzyme paraoxonase (PON1) contributes significantly to the deto

167 The hypothesis that paraoxonase (PON1) has a role in preventing atherosclero

168 Paraoxonase (PON1) hydrolyses organophosphate insecticid

169 Human HDL-associated paraoxonase (PON1) hydrolyzes a number of toxic organoph

170 Serum paraoxonase (PON1) is an enzyme associated exclusively w

171 Serum paraoxonase (PON1) is an esterase that is associated wit

172 A physiological role for paraoxonase (PON1) is still uncertain, but it catalyzes

173 uses on the functional genomics of the human paraoxonase (PON1) polymorphisms.

174 Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits L

175 Paraoxonase (PON1), carried on high-density lipoproteins

176 Pseudomonas diminuta, and a mammalian serum paraoxonase (PON1), confirmed that the analogues mimic t

177 Serum paraoxonase (PON1), present on high density lipoprotein,

178 Paraoxonases (PONs) are a family of lactonases with prom

179 Paraoxonases (PONs) are a family of proteins that may pl

180 Serum paraoxonases (PONs) are detoxifying lactonases that were

181 c diet but increased in C3H, indicating that paraoxonase production is under genetic control.

182 The structural portion of the paraoxonase protein is encoded by nine exons that form t

183 loning and characterization of human PON2, a paraoxonase-related gene-2 that is physically linked wit

184 Several important advances in the field of paraoxonase research have occurred during this review pe

185 (192) and PON1 L(55)Q(192) isoforms of human paraoxonase, respectively.

186 n of the apoAII transgenic HDL with purified paraoxonase restored both paraoxonase activity and the a

187 increased periodontitis risk nor an impaired paraoxonase status.

188 accelerated in the presence of rabbit serum paraoxonase, suggesting that organophosphorus hydrolase

189 ere hydrolyzed in human plasma by the enzyme paraoxonase to the respective hydroxy acids, which were

190 -spanning protein with limited similarity to paraoxonases, which are implicated in human coronary hea

191 homocysteine thiolactone, the thiolactonase/paraoxonase would protect proteins against homocysteinyl