ライフサイエンスコーパス: parapertussis

1 saccharide plus an O-antigen-like repeat (B. parapertussis).

2 hooping cough in humans (B. pertussis and B. parapertussis).

3 d 82% (95% CI, 69-90%) effectiveness against parapertussis.

4 lla bronchiseptica and the human pathogen B. parapertussis.

5 nchiseptica (RB50), and other isolates of B. parapertussis.

6 i) phase Bordetella pertussis and Bordetella parapertussis.

7 hinzii, Bordetella pertussis, or Bordetella parapertussis.

8 rtussis, Bordetella holmesii, and Bordetella parapertussis.

9 . pertussis and B. bronchiseptica but not B. parapertussis.

10 trains of B. pertussis and two strains of B. parapertussis.

11 parapertussis and cloned part of it from B. parapertussis.

12 is and also to a lesser extent by Bordetella parapertussis.

13 of two palmitate acyl chains is unique to B. parapertussis.

14 PCR for Bordetella pertussis and Bordetella parapertussis.

15 sitive samples, 13.99% were identified as B. parapertussis.

16 nd B. holmesii and 68% and 72% identified B. parapertussis.

17 lates, which were positive with IS1001 of B. parapertussis.

18 lated pathogens, Bordetella pertussis and B. parapertussis.

19 y of the acellular vaccine Adacel against B. parapertussis.

20 efficiently mediate opsonophagocytosis of B. parapertussis.

21 tion against B. pertussis but not against B. parapertussis.

22 tor is a potential protective antigen for B. parapertussis.

23 urface and complement-mediated killing of B. parapertussis.

24 rger than that induced by B. pertussis or B. parapertussis.

25 human-adapted subspecies B. pertussis and B. parapertussis.

26 50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. p

27 ctiveness of pertussis vaccine in preventing parapertussis among Oregon children 2 months to 10 years

28 se are the first LPS mutants generated in B. parapertussis and B. bronchiseptica and the first deep r

29 Resistance is not efficiently acquired by B. parapertussis and B. bronchiseptica mutants lacking O an

30 to PT, we examined the ptx genes of both B. parapertussis and B. bronchiseptica to determine whether

31 We have found that B. parapertussis and B. bronchiseptica, unlike B. pertussis

32 Our analysis indicates that B. parapertussis and B. pertussis are independent derivativ

33 Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely

34 pertussis was differentiated from Bordetella parapertussis and Bordetella bronchiseptica by hybridiza

35 The pathogenic bacteria Bordetella parapertussis and Bordetella bronchiseptica express a li

36 Bordetella parapertussis and Bordetella bronchiseptica resist killi

37 by the closely related pathogens Bordetella parapertussis and Bordetella bronchiseptica.

38 Bordetella parapertussis and Bordetella pertussis are closely relat

39 is also highly conserved in both Bordetella parapertussis and Bordetella pertussis.

40 in Bordetella bronchiseptica and Bordetella parapertussis and cloned part of it from B. parapertussi

41 of cytokines involved in the clearance of B. parapertussis and immunomodulation that delays effective

42 tigen is a critical protective antigen of B. parapertussis and its inclusion can substantially improv

43 ferentiate B. pertussis, B. holmesii, and B. parapertussis and provided protocols and training to 19

44 examined clinical features of patients with parapertussis and the effect of antibiotic use for treat

45 uate antibiotic effectiveness for preventing parapertussis and to determine risks and benefits of ant

46 s, 12 were positive (9 B. pertussis and 3 B. parapertussis) and 68 specimens were negative by all met

47 detella bronchiseptica, B. pertussis, and B. parapertussis) and its role in their biofilm development

48 ., including 4 of B. bronchiseptica, 5 of B. parapertussis, and 5 of B. pertussis, were studied.

49 nes are highly conserved in B. pertussis, B. parapertussis, and B. avium.

50 Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related

51 es specificities of Bordetella pertussis, B. parapertussis, and B. bronchiseptica might be explained

52 ica cluster, which includes B. pertussis, B. parapertussis, and B. bronchiseptica.

53 d identification of Bordetella pertussis, B. parapertussis, and B. holmesii was developed using multi

54 Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely

55 ion of this gene in B. pertussis, Bordetella parapertussis, and Bordetella bronchiseptica by allelic

56 isaccharide on the LPS core is present in B. parapertussis, and further suggests that the wild-type w

57 n B. pertussis and B. holmesii; IS1001 of B. parapertussis; and the IS1001-like sequence of B. holmes

58 e toxins encoded by B. bronchiseptica and B. parapertussis are active.

59 Bordetella pertussis and Bordetella parapertussis are closely related endemic human pathogen

60 Although both B. pertussis and B. parapertussis are more closely related to B. bronchisept

61 species, Bordetella pertussis and Bordetella parapertussis are nonmotile human pathogens, while Borde

62 Here we show that B. pertussis and B. parapertussis are predominantly differentiated from B. b

63 tussis Tohama I, B. pertussis 18-323, and B. parapertussis ATCC 15311.

64 d, the batB gene of human-derived Bordetella parapertussis (B. parapertussis(hu)) contains a large in

65 ty-eight hours after infection, wild-type B. parapertussis bacteria but not the O antigen-deficient m

66 B. bronchiseptica but not B. pertussis or B. parapertussis bacterial numbers during the first 72 h.

67 e passive transfer of sera raised against B. parapertussis, but not B. parapertussis Deltawbm, reduce

68 Interestingly, B. parapertussis, but not B. pertussis, produces an O antig

69 B. parapertussis can also cause whooping cough, and B. bron

70 Bordetella parapertussis causes the prolonged coughing illness know

71 efficient protection against a subsequent B. parapertussis challenge.

72 d are well studied, the strain of Bordetella parapertussis chosen for sequencing is a recent human cl

73 Thus, the O antigen of B. parapertussis confers asymmetrical cross-immunity betwee

74 and found that both B. bronchiseptica and B. parapertussis contain at least certain of these genes, i

75 oth Bordetella bronchiseptica and Bordetella parapertussis contain regions homologous to the ptx gene

76 B. parapertussis contains a putative pagP homolog (encoding

77 In B. bronchiseptica and B. parapertussis, delta wlb mutants also lacked O-antigen.

78 S), which contains the O antigen, but not B. parapertussis Deltawbm LPS drastically improved the effi

79 The B. parapertussis Deltawbm mutant was severely defective in

80 an isogenic mutant lacking the O antigen, B. parapertussis Deltawbm, induced antibodies that recogniz

81 raised against B. parapertussis, but not B. parapertussis Deltawbm, reduced B. parapertussis loads i

82 B. pertussis and B. parapertussis Deltawlb mutants were also defective compa

83 mercial laboratories for B. pertussis and B. parapertussis detection.

84 Since B. parapertussis did not cause severe disease in IL-1R(-/-)

85 In contrast, LpxA from B. parapertussis did not display relaxed specificity but wa

86 gly, serum antibody-mediated clearance of B. parapertussis did not require Fc receptors that are requ

87 in TLR4-deficient mice, B. pertussis and B. parapertussis do not.

88 that also causes whooping cough, Bordetella parapertussis, does not.

89 of infection, immunization with wild-type B. parapertussis elicited a strong antibody response to the

90 pertussis, B. bronchiseptica, or Bordetella parapertussis eliminated the clumped-growth phenotype an

91 a has a wide host range, B. pertussis and B. parapertussis evolved separately from a B. bronchiseptic

92 Bordetella bronchiseptica and Bordetella parapertussis express a surface polysaccharide, attached

93 ted the simple and effective isolation of B. parapertussis from ovine nasal swabs and, in successfull

94 f leukocytes in lungs and in clearance of B. parapertussis from the lungs.

95 s an improved selective medium to isolate B. parapertussis from the nasal cavities of conventionally

96 detella pertussis, B. bronchiseptica, and B. parapertussis genome assemblies permitted the identifica

97 The increasing incidence of B. parapertussis has been attributed to the lack of cross p

98 of Bordetella bronchiseptica and Bordetella parapertussis have DNA homologous to vag-8.

99 ertussis have been well studied, those of B. parapertussis have not.

100 septica, Bordetella pertussis and Bordetella parapertussis have the recycling/salvage pathway genes p

101 ous bordetellae, Bordetella pertussis and B. parapertussis, have emerged in historical times as co-do

102 according to pathogen host range and that B. parapertussis(hu) most likely acquired its fhaS allele f

103 Notably, the genes present in B. parapertussis(hu) strains were pseudogenes, and the gene

104 es both human-infective (B. pertussis and B. parapertussis(hu)) and non-human-infective (B. bronchise

105 f human-derived Bordetella parapertussis (B. parapertussis(hu)) contains a large in-frame deletion re

106 ng inoculation with B. pertussis, but not B. parapertussis, IL-1R(-/-) mice showed elevated bacterial

107 eltawbm) mutants of B. bronchiseptica and B. parapertussis in a variety of assays relevant to natural

108 Attempts to assess the prevalence of B. parapertussis in conventionally reared sheep by nasal sw

109 ment in the detection of B. pertussis and B. parapertussis in nasopharyngeal specimens.

110 ntiating Bordetella pertussis and Bordetella parapertussis in nasopharyngeal swabs was developed.

111 ant investigation of the relative role of B. parapertussis in the resurgence of whooping cough.

112 apting to infect humans, B. pertussis and B. parapertussis independently modified their LPS to reduce

113 Together, these data indicate that B. parapertussis induces the production of IL-10, which fac

114 Bordetella parapertussis infection causes pertussis-like illness th

115 chiseptica, while no role for TLR4 during B. parapertussis infection has been described.

116 pertussis vaccines have little effect on B. parapertussis infection or disease suggest that the prot

117 Immunity induced by B. parapertussis infection protected against subsequent inf

118 In addition, nine cases of B. parapertussis infection were also confirmed by using the

119 It was concluded that B. parapertussis infections are more common than previously

120 After finding that several children with B. parapertussis infections exhibited modest antibody titer

121 statewide pertussis outbreak, 443 Bordetella parapertussis infections were reported among Wisconsin r

122 is infections but did not protect against B. parapertussis infections.

123 The O antigen of B. parapertussis inhibited binding of antibodies to the bac

124 Here, we evaluated the outcome of B. parapertussis innate interaction with human macrophages,

125 Bordetella parapertussis is a human pathogen that causes whooping c

126 It was previously shown that B. parapertussis is able to avoid bacterial killing by poly

127 ent study explores the mechanism by which B. parapertussis is cleared from the lower respiratory trac

128 trometry analysis revealed that wild-type B. parapertussis lipid A consists of a heterogeneous mixtur

129 The addition of 10 microg of purified B. parapertussis lipopolysaccharide (LPS), which contains t

130 ut not B. parapertussis Deltawbm, reduced B. parapertussis loads in the lower respiratory tracts of m

131 old more stimulatory than B. pertussis or B. parapertussis LPS, respectively.

132 etella bronchiseptica (lpxA(Br)), Bordetella parapertussis (lpxA(Pa)), and Bordetella pertussis (lpxA

133 tes accumulated in the lungs, and cleared B. parapertussis more rapidly.

134 These results highlight the need for B. parapertussis opsonic antibodies to induce bacterial cle

135 ere pseudogenes, and the genes present in B. parapertussis(ov) strains were expressed at significantl

136 on-human-infective (B. bronchiseptica and B. parapertussis(ov)) strains.

137 ontains a putative pagP homolog (encoding B. parapertussis PagP [PagPBPa]), but its role in the biosy

138 nd receipt of azithromycin prophylaxis among parapertussis patient household members (HHMs) were also

139 Among 218 patients with parapertussis, pertussis-like symptoms were frequently r

140 ons in the locus in B. bronchiseptica and B. parapertussis prevent O-antigen biosynthesis and provide

141 Bordetella parapertussis, previously thought to be an obligate huma

142 The toxin encoded by the B. parapertussis ptx genes appeared more labile in culture

143 The B. bronchiseptica and B. parapertussis recipients were now able to biosynthesize

144 erase chain reaction results positive for B. parapertussis reported during October 2011-May 2012 were

145 nces IS481 and IS1001 of B. pertussis and B. parapertussis, respectively, and is performed using the

146 lation of CD4(+) T cells in the lungs and B. parapertussis-responsive IFN-gamma-producing cells in th

147 wlb locus of Bordetella bronchiseptica or B. parapertussis restored partial sensitivity to Ba1.

148 sis does not express the O antigen, while B. parapertussis retains it as a dominant surface antigen.

149 strains of B. pertussis and one strain of B. parapertussis revealed extensive divergence of gene orde

150 ssis strain 18323 and an ovine isolate of B. parapertussis show significant transcription of the gene

151 In vitro B. parapertussis-stimulated macrophages produced IL-10, whi

152 efficacy of B. pertussis vaccines against B. parapertussis suggest a lack of cross-protective immunit

153 control and clearance of B. pertussis or B. parapertussis, suggesting that IgA is not crucial to imm

154 hat in the absence of opsonic antibodies, B. parapertussis survives inside macrophages by preventing

155 at might be misclassified as pertussis if B. parapertussis testing is not performed.

156 ge genetic locus in B. bronchiseptica and B. parapertussis that is required for O-antigen biosynthesi

157 r the mechanism of protective immunity to B. parapertussis that is similar but distinct from that of

158 ice with Bordetella pertussis and Bordetella parapertussis, the causative agents of whooping cough.

159 he bacterial surface and was required for B. parapertussis to colonize mice convalescent from B. pert

160 t O antigen contributes to the ability of B. parapertussis to colonize the respiratory tract during t

161 hese data indicate that O antigen enables B. parapertussis to efficiently colonize the lower respirat

162 the absence of opsonins, O antigen allows B. parapertussis to inhibit phagolysosomal fusion and to re

163 The O antigen targets B. parapertussis to lipid rafts that are retained in the me

164 In addition, O antigen was required for B. parapertussis to systemically spread in complement-suffi

165 In other assays, B. parapertussis was distinct from all other species (in pi

166 B. parapertussis was more similar to B. bronchiseptica than

167 stingly, an O antigen-deficient strain of B. parapertussis was not defective in colonizing mice lacki

168 B. parapertussis was not detected in any specimens.

169 abs from conventionally reared sheep, and B. parapertussis was recovered from 31.5% of the samples.

170 In the case of B. parapertussis, which normally does not synthesize an app

171 e persistence of Bordetella pertussis and B. parapertussis within vaccinated populations and the reem

172 om a range of bacteria, is altered in the B. parapertussis WlbH protein.

173 etella bronchiseptica (wlbbr) and Bordetella parapertussis (wlbpa) were identified and cloned.