ライフサイエンスコーパス: paraplegia

1 ure, renal and splenic microinfarctions, and paraplegia.

2 gene mutated in a form of hereditary spastic paraplegia.

3 mutated in the axonopathy hereditary spastic paraplegia.

4 ith the clinical phenomenon of delayed onset paraplegia.

5 oo-common clinical syndrome of delayed-onset paraplegia.

6 hic lateral sclerosis and hereditary spastic paraplegia.

7 ble immediate treatment to prevent permanent paraplegia.

8 the morbidity and mortality associated with paraplegia.

9 g endograft treatment suffered postoperative paraplegia.

10 common autosomal dominant hereditary spastic paraplegia.

11 sal treatment strategy in hereditary spastic paraplegia.

12 clinical presentation of progressive spastic paraplegia.

13 the chief gene mutated in hereditary spastic paraplegia.

14 complex but virtually eliminates the risk of paraplegia.

15 w" is simple but has an unacceptable risk of paraplegia.

16 ith a 50% probability of resultant permanent paraplegia.

17 with 22/38 (6.6% of cohort) sustaining total paraplegia.

18 pass support (P =.0005) were associated with paraplegia.

19 nd is associated with a reduced incidence of paraplegia.

20 e KIF5A, in a family with hereditary spastic paraplegia.

21 to phenotypes resembling hereditary spastic paraplegia.

22 rectly over the posterior cortex resulted in paraplegia.

23 mild Pelizaeus-Merzbacher disease or spastic paraplegia.

24 ed, and there were no instances of stroke or paraplegia.

25 ers such as Pelizaeus-Merzbacher and spastic paraplegia.

26 r spinal cord, remove macroglia, and produce paraplegia.

27 xia, Wilson's disease and hereditary spastic paraplegia.

28 e show progressive motor symptoms, a spastic paraplegia.

29 system for understanding hereditary spastic paraplegia.

30 e most frequent metabolic hereditary spastic paraplegia.

31 ighting the genetic heterogeneity of spastic paraplegia.

32 stent with a diagnosis of hereditary spastic paraplegia.

33 neuron diseases, such as hereditary spastic paraplegia.

34 ctor to early autonomic symptoms and spastic paraplegia.

35 ental defects and a familial form of spastic paraplegia.

36 n associated with a familial form of spastic paraplegia.

37 the most common cause of hereditary spastic paraplegia.

38 a diverse set of complex hereditary spastic paraplegias.

39 nesin family member 5A (KIF5A) cause spastic paraplegia 10.

40 R-shaping proteins, in families with spastic paraplegia 12 (SPG12).

41 ice-site) associated with hereditary spastic paraplegia 4 (HSP-SPG4) (SPG4:OMIM#182601) has suggested

42 ns in which cause autosomal-dominant spastic paraplegia 4 [SPG4]) have been described, their origins

43 d a necessary and conserved role for spastic paraplegia 7 (SPG7) in Ca(2+)- and ROS-induced PTP openi

44 dity included rupture (4.7%), stroke (4.7%), paraplegia (8.5%), bowel ischemia (7%), acute renal fail

45 p-Feil syndrome (8q22.2), hereditary spastic paraplegia (8q24), and benign adult familial myoclonic e

46 PG5) is a rare subtype of hereditary spastic paraplegia, a highly heterogeneous group of neurodegener

47 with various subtypes of hereditary spastic paraplegia, a highly heterogeneous group of neurodegener

48 entified in patients with hereditary spastic paraplegias, a diverse group of neurological disorders c

49 g a later step, result in hereditary spastic paraplegia accompanied by intellectual deficits.

50 tations in AP5Z1 and presenting with spastic paraplegia accompanied by neuropathy, parkinsonism and/o

51 Autosomal-dominant pure hereditary spastic paraplegia (AD-HSP) is characterized by the degeneration

52 isease autosomal dominant-hereditary spastic paraplegia (AD-HSP).

53 h autosomal dominant pure hereditary spastic paraplegia (ADPHSP), to examine the relative frequency o

54 ic occlusion is critical in the mechanism of paraplegia after aortic cross-clamping and may provide t

55 There was no clinical evidence of paraplegia after IRE ablation.

56 changes that may be adaptive in non-stepping paraplegia after SCI.

57 Permanent paraplegia after thoracic and thoracoabdominal aortic an

58 many candidate genes for hereditary spastic paraplegia also have central roles in lipid-droplet form

59 istance in activities of daily living, makes paraplegia an important target for prevention.

60 n genes usually associated with pure spastic paraplegia and also in the Parkinson's disease-associate

61 , we screened a cohort of hereditary spastic paraplegia and cerebellar ataxia cases (n = 618) for mut

62 ic neurological diseases (hereditary spastic paraplegia and cerebellar ataxia).

63 to be a frequent cause of hereditary spastic paraplegia and cerebellar ataxia.

64 ease the risk of spinal cord ischemia and/or paraplegia and consists of permissive hypertension after

65 gene data could explain a report of spastic paraplegia and dementia cosegregating in a family with d

66 who presented with bilateral lower extremity paraplegia and development of rhabdomyolysis of the para

67 ected subjects exhibited progressive spastic paraplegia and distal muscle wasting.

68 suffering from SPG4-type hereditary spastic paraplegia and explain why single amino acid exchanges l

69 EAE-related mortality, nonremitting spastic paraplegia and hemorrhagic inflammatory lesions.

70 logical disorders such as hereditary spastic paraplegia and hereditary sensory neuropathy.

71 improvement in rates of major complications, paraplegia and in-hospital mortality.

72 infantile-onset ascending hereditary spastic paraplegia and juvenile primary lateral sclerosis, sugge

73 There were no cases of postoperative paraplegia and no deaths.

74 intellectual disability, progressive spastic paraplegia and short stature, born to a consanguineous f

75 is a common theme between heritable spastic paraplegia and some inherited epilepsies.

76 rophic lateral sclerosis, hereditary spastic paraplegia and spinal muscular atrophy.

77 ovement disorders such as hereditary spastic paraplegias and cerebellar ataxias remain genetically un

78 frontotemporal dementia, hereditary spastic paraplegia, and 1-2% of familial amyotrophic lateral scl

79 tic paraparesis mimicking hereditary spastic paraplegia, and a multiple sclerosis-like illness.

80 rophic lateral sclerosis, hereditary spastic paraplegia, and cerebellar degenerations.

81 um hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus), and L1 knock-out mice di

82 lasia, retardation, adducted thumbs, spastic paraplegia, and hydrocephalus).

83 ated in the human disease hereditary spastic paraplegia, and its link to WASH suggests that misregula

84 , and dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration.

85 neurodegenerative disease hereditary spastic paraplegia, and of ichthyin, mutated in autosomal recess

86 c neuropathy, complicated hereditary spastic paraplegia, and select hereditary metabolic neuropathies

87 e found in patients with ichthyosis, spastic paraplegia, and severe neurodevelopmental defects.

88 on locus for mutations in hereditary spastic paraplegias, and katanin are related microtubule-severin

89 ta, rates of procedural success, stroke, and paraplegia appeared similar, while those for major compl

90 Hereditary spastic paraplegias are a clinically and genetically heterogeneo

91 The hereditary spastic paraplegias are a heterogeneous group of degenerative di

92 Hereditary spastic paraplegias are a large, diverse group of neurological d

93 Hereditary spastic paraplegias are heterogeneous neurological disorders cha

94 Hereditary spastic paraplegias are inherited neurological disorders charact

95 ed in autosomal recessive hereditary spastic paraplegia (ARHSP).

96 s and autosomal recessive hereditary spastic paraplegias (ARHSPs) are clinically and genetically hete

97 dominant pure or complex hereditary spastic paraplegia, as well as in two sporadic patients.

98 as a complicated form of hereditary spastic paraplegia, associated with mutation in the ethanolamine

99 aplegia, while all CI/R patients experienced paraplegia before bypass use.

100 ave been shown to cause a Hereditary Spastic Paraplegia called NTE-related Motor-Neuron Disorder.

101 axons, and support a model in which spastic paraplegia can be caused by impairment of axonal the SER

102 G)1 to -57], over half of hereditary spastic paraplegia cases are caused by pathogenic mutations in f

103 is an autosomal recessive hereditary spastic paraplegia caused by mutation in the spartin (SPG20) gen

104 Mutations in PNPLA6 also cause human spastic paraplegia characterized by motor neuron degeneration.

105 ous female member were affected with spastic paraplegia characterized by relatively late onset and mi

106 hese patients were upgraded to an incomplete paraplegia classification.

107 Hereditary spastic paraplegias comprise a group of clinically heterogeneous

108 Paraplegia continues to complicate thoracoabdominal aort

109 hese patients included dementia with spastic paraplegia, corticobasal degeneration syndrome, and stro

110 linked to diseases such as familial spastic paraplegia, developmental delay with premature death, an

111 We tested the hypothesis that paraplegia differentially increases blood pressure relat

112 Congestive heart failure, paraplegia, dyspnea at rest, and reoperation are associa

113 cord injury, stiff-person syndrome, spastic paraplegia, dystonia and Parkinson disease.

114 sorders, particularly the hereditary spastic paraplegias, emphasizing the importance of proper ER mor

115 veral causative genes for hereditary spastic paraplegia encode proteins with intramembrane hairpin lo

116 orders of ganglioside biosynthesis result in paraplegia, epilepsy, and intellectual disability.

117 Hereditary spastic paraplegia exhibits axonal degeneration that is maximal

118 The existence of hereditary spastic paraplegia families for whom the disorder is unlinked to

119 A 23-year-old man who had paraplegia from a C7-T1 subluxation as a result of a mot

120 Paraplegia from spinal cord ischemia is a devastating co

121 Autosomal dominant familial spastic paraplegia (FSP) is a genetically heterogeneous neurodeg

122 to positionally clone the hereditary spastic paraplegia gene are in progress.

123 ommon autosomal recessive hereditary spastic paraplegia gene products, the SPG15 protein spastizin an

124 Mutations in the Spastic Paraplegia Gene11 (SPG11), encoding spatacsin, cause the

125 veral loci known collectively as the spastic paraplegia genes (SPGs).

126 s in a number of other known complex spastic paraplegia genes, including five in SPG7 (5/97), four in

127 ore, the life expectancy of individuals with paraplegia has increased to near that of able-bodied ind

128 Paraplegia has significant medical, social, and financia

129 q, and 15q), and x-linked hereditary spastic paraplegia have been identified.

130 our experience, no episodes of postoperative paraplegia have occurred with the use of this technique.

131 Complex recessive spastic paraplegias have in the past been frequently associated

132 scular diseases including hereditary spastic paraplegia, hereditary sensory neuropathy type 1, and no

133 milar problems that cause hereditary spastic paraplegia (HSP) and Charcot-Marie-Tooth type 2 (CMT2) d

134 and lower motor neurons, hereditary spastic paraplegia (HSP) and distal hereditary motor neuropathy

135 al recessive (AR) complex hereditary spastic paraplegia (HSP) and juvenile onset amyotrophic lateral

136 Two syndromes - hereditary spastic paraplegia (HSP) and mycobacterial disease - thus occurr

137 rebellar ataxia (HCA) and hereditary spastic paraplegia (HSP) are scarce.

138 is an autosomal recessive hereditary spastic paraplegia (HSP) caused by frameshift mutations in the S

139 Hereditary spastic paraplegia (HSP) comprises a group of clinically and gen

140 Hereditary spastic paraplegia (HSP) describes a heterogeneous group of gene

141 Hereditary spastic paraplegia (HSP) is a clinically and genetically heterog

142 Hereditary spastic paraplegia (HSP) is a collection of neurological disorde

143 Hereditary Spastic Paraplegia (HSP) is a devastating neurological disease c

144 Complex hereditary spastic paraplegia (HSP) is a genetic disorder that causes lower

145 Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder that is

146 Hereditary spastic paraplegia (HSP) is a neurological syndrome characterize

147 The commonest cause of hereditary spastic paraplegia (HSP) is mutation in the spastin gene.

148 mal recessive complicated hereditary spastic paraplegia (HSP) that occurs with high frequency in the

149 Hereditary spastic paraplegia (HSP) type 2 is a proteolipid protein (PLP1)-

150 subunits cause a form of hereditary spastic paraplegia (HSP) with intellectual disability.

151 rumpellin, or REEP1 cause hereditary spastic paraplegia (HSP), a disease characterized by axonal dege

152 utosomal dominant form of hereditary spastic paraplegia (HSP), a motor-neurological disorder manifest

153 ranched ER morphology and hereditary spastic paraplegia (HSP), a neurodegenerative disease characteri

154 the most common cause of hereditary spastic paraplegia (HSP), a neurodegenerative disease that affli

155 n patients suffering from hereditary spastic paraplegia (HSP), a neurodegenerative disorder affecting

156 ns of various genes cause hereditary spastic paraplegia (HSP), a neurological disease involving dying

157 ve been reported to cause hereditary spastic paraplegia (HSP), although their impact at the cellular

158 , Multiple Sclerosis (MS) Hereditary Spastic Paraplegia (HSP), and Huntington's Disease (HD).

159 e-Tooth disease (CMT) and Hereditary Spastic Paraplegia (HSP), but the mechanism of its involvement i

160 In hereditary spastic paraplegia (HSP), the axons of cortical motor neurons de

161 ffect in humans with pure hereditary spastic paraplegia (HSP).

162 xon degenerative disease, hereditary spastic paraplegia (HSP).

163 tosomal recessive form of hereditary spastic paraplegia (HSP).

164 tin and atlastin, lead to hereditary spastic paraplegia (HSP).

165 The hereditary spastic paraplegias (HSPs) (SPG1-29) comprise a group of inherit

166 The hereditary spastic paraplegias (HSPs) are a genetically and clinically hete

167 The pure hereditary spastic paraplegias (HSPs) are a group of conditions in which th

168 Hereditary spastic paraplegias (HSPs) are a group of diseases caused by cor

169 Hereditary spastic paraplegias (HSPs) are a group of genetically heterogene

170 Hereditary spastic paraplegias (HSPs) are a large, genetically diverse grou

171 The hereditary spastic paraplegias (HSPs) are a rare and heterogeneous group of

172 The hereditary spastic paraplegias (HSPs) are characterized by spasticity of th

173 Hereditary spastic paraplegias (HSPs) are clinically and genetically hetero

174 The hereditary spastic paraplegias (HSPs) are genetic conditions characterized

175 Hereditary spastic paraplegias (HSPs) are genetically driven disorders with

176 The hereditary spastic paraplegias (HSPs) are genetically heterogeneous disorde

177 The hereditary spastic paraplegias (HSPs) are heterogeneous neurodegenerative d

178 Hereditary spastic paraplegias (HSPs) are neurodegenerative motor neuron di

179 ly of genes implicated in hereditary spastic paraplegias (HSPs) is quickly expanding, mostly owing to

180 Hereditary spastic paraplegias (HSPs), a group of neurodegenerative disorde

181 ne of several complicated hereditary spastic paraplegias (HSPs).

182 EEP1) are associated with hereditary spastic paraplegias (HSPs).

183 Hereditary spastic paraplegias (HSPs, SPG1-46) are inherited neurological d

184 Hereditary spastic paraplegias (HSPs; SPG1-45) are inherited neurological d

185 Hereditary spastic paraplegias (HSPs; SPG1-48) are inherited neurological d

186 Hereditary spastic paraplegias (HSPs; SPG1-76 plus others) are length-depen

187 The hereditary spastic paraplegias (HSPs; Strumpell-Lorrain syndrome, MIM numbe

188 osum agenesis, retardation, aphasia, spastic paraplegia, hydrocephalus).

189 um hypoplasia, retardation, aphasia, spastic paraplegia, hydrocephalus).

190 jor complication rate was 1.7 +/- 2.3%, with paraplegia in 0.4 +/- 0.0%.

191 duration of ischemia that produces permanent paraplegia in 50% of the animals in a group) of the cont

192 Paraplegia in both the SHR and WKY rats increased heart

193 In sharp contrast, paraplegia in the SHR increased systolic (6%) and diasto

194 far the most common cause of complex spastic paraplegia in the UK, with severe and progressive clinic

195 Paraplegia in the WKY rats reduced systolic (-4%) and di

196 ures, severe developmental delay and spastic paraplegia, in whom whole-genome sequencing revealed com

197 013) on acute complicated type B AD, stroke, paraplegia, in-hospital mortality and follow-up mortalit

198 These data demonstrate that paraplegia increased BP-CVD risk factors in normotensive

199 RMS in three unrelated patients with spastic paraplegia, intellectual disability, nystagmus, and obes

200 Hereditary spastic paraplegia is a highly heterogeneous group of neurogenet

201 Clinical data showed that spastic paraplegia is accompanied by a number of other features,

202 pure, autosomal dominant hereditary spastic paraplegia is caused by mutation in the ATL1 gene encodi

203 rm of autosomal recessive hereditary spastic paraplegia is caused by mutations in the SPG11/KIAA1840

204 Pure hereditary spastic paraplegia is characterized by length-dependent degenera

205 as either 'pure' or 'complex' where spastic paraplegia is complicated with additional neurological f

206 er limb spasticity, or complex where spastic paraplegia is complicated with additional neurological f

207 Hereditary spastic paraplegia is genetically diverse: loci for autosomal re

208 lity and morbidity associated with permanent paraplegia justifies the risks and uncertainties associa

209 n) and reperfusion that results in permanent paraplegia, Ku DNA binding was reduced.

210 nal, as yet undiscovered, hereditary spastic paraplegia loci.

211 inary retention as prodromes of irreversible paraplegia may allow earlier diagnosis and treatment in

212 ossibly of other forms of hereditary spastic paraplegia may involve perturbation of neuronal anterogr

213 uscular hypotonia that progressed to spastic paraplegia, microcephaly, foot deformity, decreased musc

214 the main regulator of the hereditary spastic paraplegia microtubule severing enzyme spastin.

215 Other features include spastic paraplegia, mild ataxia, mild cognitive deficiency and d

216 ces similar phenotypes of hereditary spastic paraplegia (mitochondrial dysfunction and defects in lip

217 al defects of an atypical hereditary spastic paraplegia mutant, ATL1-F151S, that is impaired in its n

218 Eleven patients with paraplegia (n = 6) or radiculopathy (n = 5) due to verte

219 Stroke and paraplegia occurred each in 8.0%, and endoleak was diagn

220 Paraplegia occurred in 15 of 64 survivors in group A (23

221 Paraparesis-paraplegia occurred in 7%, an incidence significantly (p

222 Paraplegia occurred in four (12%) of the no bypass group

223 ion and concomitant functional recovery from paraplegia occurring within 75 d.

224 nal cord injury manifested as paraparesis or paraplegia of 9.9% (9/91).

225 Importantly, the impact of paraplegia on BP-CVD risk factors was greater in the SHR

226 ive disorder mainly characterized by spastic paraplegia, optic atrophy and neuropathy (SPOAN).

227 e unusual combination of early-onset spastic paraplegia, optic atrophy, and neuropathy.

228 Thirty-five patients had paraplegia or paraparesis (5.4%).

229 low (ERPF) measurements in 197 patients with paraplegia or quadriplegia performed over a 21-y period,

230 l aortic aneurysm repair), and there were no paraplegias or strokes.

231 nction were more likely to have irreversible paraplegia (P < 0.01), despite presenting with a monopha

232 0.01]) retained independent association with paraplegia-paraparesis after multivariate analysis.

233 . 22 minutes, P <.0001) and a higher rate of paraplegia/paresis (30% vs. 2%, P =.01) as compared to t

234 ypass in the repair of BAI, the incidence of paraplegia/paresis has fallen.

235 hts into the pathology of hereditary spastic paraplegia, particularly how mutations in multiple, conv

236 linico-genetic work-up of hereditary spastic paraplegia, particularly in dominant cases, as the assoc

237 crotubule cytoskeleton in hereditary spastic paraplegia pathogenesis.

238 m mutations identified in hereditary spastic paraplegia patients.

239 uld not be excluded, and 29 sporadic spastic paraplegia patients.

240 sonism, muscle weakness, neuropathy, spastic paraplegia, personality/behavioral problems, and dystoni

241 fied as a complex form of hereditary spastic paraplegia, present in families from Kuwait, Italy and t

242 nstration of a role for a hereditary spastic paraplegia protein or ichthyin family member in a specif

243 2) and Bhlhb5 (mutated in Hereditary Spastic Paraplegia), providing a molecular handle to investigate

244 decreased coordination, widespread asthenia, paraplegia, quadriplegia, and sensory impairment.

245 ogression rate of 0.56 points on the Spastic Paraplegia Rating Scale per year was slightly lower than

246 linical severity was assessed by the Spastic Paraplegia Rating Scale.

247 Five of six patients with paraplegia recovered completely: One who was treated rec

248 eries of 97 index cases with complex spastic paraplegia referred to a tertiary referral neurology cen

249 Hereditary spastic paraplegia refers to a group of clinically similar disor

250 Paraplegia remains a devastating complication after thor

251 Paraplegia remains a devastating complication of thoraci

252 ment, and the postoperative complications of paraplegia, renal failure, and pulmonary insufficiency.

253 ariables including congestive heart failure, paraplegia, reoperation, dyspnea at rest, nongastric ban

254 Paraplegia resulting from ischemia is a catastrophic com

255 metabolism account for approximately 80% of paraplegia risk and intercostal blood flow accounts for

256 al aneurysm repair for factors that affected paraplegia risk including aneurysm extent, acuity, cardi

257 ion for the last 3 years further reduced our paraplegia risk index by 75%.

258 The paraplegia risk index declined from 0.20 to 0.05 (P < 0.

259 (IRP) using a highly accurate (r(2) > 0.88) paraplegia risk index we developed and published previou

260 This suggests a limit to paraplegia risk reduction in thoracoabdominal endograft

261 previously demonstrated an 80% reduction in paraplegia risk using hypothermia, naloxone, steroids, s

262 erging field support this prediction of high paraplegia risk with thoracoabdominal branched endograft

263 f other diseases--including familial spastic paraplegia, schizophrenia, bipolar affective disorder an

264 injuries has reduced the rates of death and paraplegia seen with open surgical treatment in the past

265 neurodegenerative disease hereditary spastic paraplegia, severs microtubules.

266 Pure hereditary spastic paraplegia (SPG) type 4 is the most common form of autos

267 The hereditary spastic paraplegias (SPG1-33) comprise a cluster of inherited ne

268 mutated in patients with hereditary spastic paraplegia, SPG11 and SPG15.

269 drome, and three forms of hereditary spastic paraplegia, SPG11, SPG15 and SPG49 caused by SPG11, ZFYV

270 s cause specific types of hereditary spastic paraplegia (SPG28 and SPG54, respectively), and the yeas

271 ntified in both a form of hereditary spastic paraplegia (SPG35) and a progressive familial leukodystr

272 The early onset hereditary spastic paraplegia SPG3A is caused by mutations in the atlastin/

273 mal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy.

274 cal resection and there was no postoperative paraplegia, stroke, or myocardial infarction.

275 es disease mechanisms for hereditary spastic paraplegia that involve dependence of the microtubule cy

276 osis and its differentiation from hysterical paraplegia, the second transverse myelitis and its conse

277 Prior to irreversible paraplegia, these patients presented with prodromes of f

278 Motor signs developed ascending from spastic paraplegia to tetraplegia and pseudobulbar palsy in the

279 Spastic paraplegia type 2 (SPG2) is allelic to Pelizaeus-Merzbac

280 Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin P

281 Spastic paraplegia type 5 (SPG5) is a rare subtype of hereditary

282 estigation; recent studies show that spastic paraplegia type 5, a progressive neuropathy, is caused b

283 Spastic paraplegia types 4 (prevalence, 0.91 per 100,000 populat

284 Using a rat model of ischemic paraplegia, we examined the expression of spinal AMPA re

285 ns cause a common form of hereditary spastic paraplegia, we suggest ER-shaping defects as a neuropath

286 utosomal dominant form of hereditary spastic paraplegia, which is a retrograde axonopathy primarily c

287 the use of bypass, no CI/R patient developed paraplegia, while all CI/R patients experienced parapleg

288 paired via clamp-and-sew technique developed paraplegia, while none of the seven CI/R patients repair

289 s with adult onset leukodystrophy or spastic paraplegia with early onset of urinary symptoms and spin

290 , and predominant complex hereditary spastic paraplegia with marked cognitive impairment, without any

291 ed to autosomal recessive hereditary spastic paraplegia with thin corpus callosum and axonal peripher

292 se of autosomal recessive hereditary spastic paraplegia with thin corpus callosum and peripheral axon

293 ings were neurogenic bladder (100%), spastic paraplegia with vibration loss (90%), and axonal neuropa

294 set, slowly progressive, complicated spastic paraplegia, with normal or near-normal psychomotor devel

295 centrifugal pump to reduce the incidence of paraplegia without the risk of systemic anticoagulation

296 essive type of cerebellar ataxia and spastic paraplegia, without intellectual disability.