ライフサイエンスコーパス: parathyroid adenoma

1 1, a G1-S phase regulator, is upregulated in parathyroid adenomas.

2 the successful preoperative localization of parathyroid adenomas.

3 tion-mediated inactivation of these genes in parathyroid adenomas.

4 to be technically feasible in patients with parathyroid adenomas.

5 ere uremic hyperparathyroidism versus common parathyroid adenomas.

6 ures of this disorder, compared with primary parathyroid adenomas.

7 lation of CCND1 regulatory genes in sporadic parathyroid adenomas.

8 splicing appears to occur preferentially in parathyroid adenomas.

9 strategy to identify oncogenes activated in parathyroid adenomas.

10 ccurate in the detection and localization of parathyroid adenomas.

11 t contribute commonly to the pathogenesis of parathyroid adenomas.

12 precisely identified 51 of 53 (96%) primary parathyroid adenomas, 14 to 15 secondary hyperplasias an

13 f the 168 patients, 120 (71.4%) had a single parathyroid adenoma, 15 (8.9%) had double adenoma, and 3

14 Surgery revealed 19 solitary parathyroid adenomas, 2 parathyroid adenomas in one pati

15 Of the 254 patients, 206 (81%) had a single parathyroid adenoma, 28 (11%) had double adenomas, 19 (8

16 loration in a series of patients with missed parathyroid adenomas after failed procedures for primary

17 Parathyroid adenomas and hyperplasia can be grouped into

18 Parathyroid adenomas and hyperplasias had similar Ki-67

19 dionuclide counts were highest in the single parathyroid adenomas and lowest in hyperplastic glands.

20 characterized by the development of multiple parathyroid adenomas and multiple fibro-osseous tumors o

21 Endocrine tumors, such as parathyroid adenomas and pheochromocytomas, frequently h

22 QPTH verified the excision of the primary parathyroid adenomas and predicted normocalcemia in 50 o

23 th localizing studies that indicate a single parathyroid adenoma are candidates for such approaches,

24 to insulin-producing islet cell tumors, and parathyroid adenomas are also frequently observed.

25 Parathyroid adenomas are benign tumors in the parathyroi

26 The most common ectopic sites for parathyroid adenomas are thymus (17%), intrathyroidal (1

27 Parathyroid adenomas are usually monoclonal, suggesting

28 rule" for ex vivo counts not only applies to parathyroid adenomas but also to hyperplastic glands.

29 Parafibromin was expressed in four parathyroid adenomas but was absent from two parathyroid

30 s and knowledge of the potential location or parathyroid adenomas can lead to very high cure rates wi

31 n is widely ordered preoperatively to locate parathyroid adenomas, concern about a false-positive sca

32 rticularly helpful in locating the 2 ectopic parathyroid adenomas diagnosed in this cohort.

33 Five lesions were interpreted incorrectly as parathyroid adenoma (false-positive), and all lesions ha

34 In 25 parathyroid adenomas, frequent loss of heterozygosity, i

35 tiate between healthy parathyroid tissue and parathyroid adenoma from 18 patients.

36 ectin-3 expression, consistent with atypical parathyroid adenomas, from 9 months of age.

37 in several sporadic or nonhereditary tumors-parathyroid adenomas, gastrinomas, insulinomas, and bron

38 Although preoperative localization of parathyroid adenomas has become sensitive enough for cli

39 vary in the involvement of pheochromocytoma, parathyroid adenoma/hyperplasia and developmental abnorm

40 gery was successful in 57 patients (solitary parathyroid adenoma in 48 patients, double parathyroid a

41 ure, CT correctly identified the side of the parathyroid adenoma in 54 of 62 patients (87%), while se

42 y parathyroid adenoma in 48 patients, double parathyroid adenomas in 6 patients, and 10 hyperplastic

43 t-PET/CT in the preoperative localization of parathyroid adenomas in a large series of patients with

44 ping permitted identification and removal of parathyroid adenomas in all patients with positive sesta

45 revealed 19 solitary parathyroid adenomas, 2 parathyroid adenomas in one patient; and 3 hyperplastic

46 bi-SPECT in the preoperative localization of parathyroid adenomas in patients with primary hyperparat

47 rioperative adjuncts can be used to localize parathyroid adenomas, including sestamibi-SPECT scanning

48 Understanding of the ectopic locations of parathyroid adenoma is of utmost importance in the condu

49 A single missed parathyroid adenoma is the most common cause for a faile

50 gle- or dual-phase planar or SPECT study for parathyroid adenoma localization.

51 addition of CT to SPECT may further improve parathyroid adenoma localization.

52 six patients with a positive PTH gradient, a parathyroid adenoma (mean weight 636 +/- 196 mg) was res

53 he diagnostic sensitivities for detection of parathyroid adenomas of 43% (9 of 21) for dual-phase ses

54 of cases, the disease is caused by sporadic parathyroid adenoma or sporadic hyperplasia.

55 onventional SPECT in diagnosing and locating parathyroid adenomas or hyperplasia in patients with pri

56 14 in 94 patients with pathologically proven parathyroid adenomas or hyperplasia.

57 Parathyroid adenomas (PAs) causing primary hyperparathyr

58 al activity, and relative abundance of these parathyroid adenoma subpopulations likely reflect distin

59 Moreover, the parathyroid adenoma subtypes (chief cells and oxyphil ce

60 s had threefold more p27-positive cells than parathyroid adenomas, suggesting that p27 immunostaining

61 CT was used to localize a middle mediastinum parathyroid adenoma that was not detected with planar se

62 g technique for preoperative localization of parathyroid adenomas that involves multidetector CT imag

63 ng showed two related but different types of parathyroid adenomas that we have arbitrarily designated

64 prepared directly from a clinical sample of parathyroid adenoma tissue, transfected into NIH3T3 cell

65 (CDKN2A, CDKN2B and RASSF1A) was analysed in parathyroid adenoma tissues (n = 30).

66 ntraoperative frozen section because excised parathyroid adenomas uniformly have radionuclide ex vivo

67 ty of MIBI scintigraphy for the detection of parathyroid adenomas warrants further investigation.

68 The sensitivity for parathyroid adenomas was 89%-98%, while the sensitivity

69 or genes are involved in the pathogenesis of parathyroid adenomas, we performed a more comprehensive

70 In the 37 patients who underwent surgery, parathyroid adenomas were confirmed in 34 (92%) and hype

71 Abnormal parathyroid adenomas were found in 209 of 222 initial pr

72 d not been previously described for sporadic parathyroid adenomas were noted with CGH, i.e., gains on

73 4 cm) and weight (mean = 1.50 +/- 2.56 g) of parathyroid adenoma, whereas patients with false-negativ

74 tudied 25 patients with surgically confirmed parathyroid adenomas with 99mTc-sestamibi parathyroid sc

75 ology and tumor size on the detectability of parathyroid adenomas with 99mTc-sestamibi scans.

76 or was supported by mutation screening in 48 parathyroid adenomas with cystic features, which identif

77 cellent tool in preoperative localization of parathyroid adenomas with sensitivity, specificity, and