ライフサイエンスコーパス: parent compound

1 tabolite acts with greater efficacy than the parent compound.

2 but it was more readily mineralized than the parent compound.

3 ical and pharmacokinetic properties than the parent compound.

4 city are not always excreted faster than the parent compound.

5 ride (VC) which are even more toxic than the parent compound.

6 CDK2 liganded with distinct analogues of the parent compound.

7 species), many of which were specific to the parent compound.

8 pealing selectivity profile exhibited by the parent compound.

9 perties can differ greatly from those of the parent compound.

10 acious use of doses 150-fold higher than the parent compound.

11 none had more than twice the potency of the parent compound.

12 bition of enzyme activity as compared to the parent compound.

13 ing 21 chemical structures from the original parent compound.

14 essentially no oral bioavailability for the parent compound.

15 h a potency and effectiveness similar to the parent compound.

16 ic profile very similar to that shown by the parent compound.

17 8-substitutions provided no benefit over the parent compound.

18 cy, and effectiveness resembling that of the parent compound.

19 s solubility and oral bioavailability of the parent compound.

20 which is responsible for the toxicity of the parent compound.

21 the appearance of the V82A mutation than the parent compound.

22 that are more potent and less toxic than the parent compound.

23 he 0.1% level, with no interference from the parent compound.

24 tivity, but are 18-fold less active than the parent compound.

25 oups at C-7 retained the Src activity of the parent compound.

26 ear to be greatly improved compared to their parent compound.

27 wer affinity for these enzymes than does the parent compound.

28 approach from the one used to synthesize the parent compound.

29 icantly lower concentrations relative to the parent compound.

30 st MCF-7 and MCF-7/ADR cells compared to the parent compound.

31 hese compounds are comparable to that of the parent compound.

32 -induced dopaminergic neurotoxicity than its parent compound.

33 50) of >224 microM versus 160 microM for the parent compound.

34 ning of the group on the biologically active parent compound.

35 gnitude lower than that of the corresponding parent compound.

36 and not an ideal measure of exposure to the parent compound.

37 of the decrease in the concentration of the parent compound.

38 by ca. 200 nm compared to the unsubstituted parent compound.

39 pite occasionally high concentrations of the parent compound.

40 an and auxin plant hormones; <1% remained as parent compound.

41 bamazepine was significantly higher than the parent compound.

42 eature a similar bacterial toxicity than the parent compounds.

43 ure derivatives comparable in potency to the parent compounds.

44 harges were higher than those calculated for parent compounds.

45 ntly more reactive than their nonhalogenated parent compounds.

46 culture, up to 25-fold lower compared to the parent compounds.

47 ivity in strains that are insensitive to the parent compounds.

48 that differ in biological activity from the parent compounds.

49 e by a factor of about 2 with respect to the parent compounds.

50 or hole doping of their non-superconducting parent compounds.

51 'holes' are doped into the antiferromagnetic parent compounds.

52 rectly rather than daily intake estimates of parent compounds.

53 sue is the nature of the ground state of the parent compounds.

54 DNA cleavage activity was compared with the parent compounds.

55 d into the CuO(2) planes of their insulating parent compounds.

56 rrent method are formed from eight different parent compounds.

57 'holes' are doped into the antiferromagnetic parent compounds.

58 centrations, but to a lesser extent than the parent compounds.

59 -glutamyl conjugate were equipotent with the parent compounds.

60 ossess advantages conferred by both types of parent compounds.

61 el physical phenomena that are absent in the parent compounds.

62 els accurately predicted the binding for the parent compounds.

63 the bacterium Aliivibrio fischeri than their parent compounds.

64 the stomach and small intestine, containing parent compounds.

65 case of filamentous fungi than those for the parent compounds.

66 a, they showed to be more effective than the parent compounds.

67 s too were generally lower than those of the parent compounds.

68 ort half-lives and often lack specificity to parent compounds.

69 antimicrobial action than the corresponding parent compounds.

70 n with corresponding parameters found in the parent compounds.

71 PCBs may be more toxic and mobile than their parent compounds.

72 PDE10A enzyme to alter the planarity of the parent compound 1 and optimize its affinity for PDE10A.

73 ituents on both of the aromatic rings in the parent compound 1 were successfully replaced with metabo

74 The compounds are potential prodrugs for the parent compound 1, a highly potent antitumor agent.

75 The potency of 3 increases, over the parent compound 1, against fIIa (110-fold), much more th

76 7-disubstituted TAPy molecules and the known parent compound 1,3,6,8-tetraazapyrene (II) have been fu

77 ightly against the neuronal isoform over the parent compound (1).

78 ized as an extension of our discovery of the parent compound (+/-)-1.HCl as an anti-microtubule agent

79 ns and was up to 7-fold more potent than the parent compound (+/-)-1.HCl.

80 ikely due to biochemical transformation from parent compounds (17beta-estradiol, 4-nonylphenolpolyeth

81 increased the plasma exposure of the active parent compound 20-fold compared to when 1 was dosed ora

82 owed higher uptake (2.6- to 9-fold) than the parent compound 3-HPG.

83 g and 4g, respectively) as compared to their parent compounds (3a and 4a) in all cell lines.

84 ced pharmacological profiles compared to the parent compound 4, and the N-methylpyrrolidine analogue

85 compared to the different affinities of the parent compound (4).

86 ved metabolic stability in comparison to the parent compound 5 while retaining favorable pharmacologi

87 Unlike the parent compound, 7b is toxic to both p53 positive and ne

88 rameters with a four-pool model containing a parent compound, a metabolite, a volatile, and a NER poo

89 mass balances ranged from 49 to 130% of the parent compound added to the microsomal incubations.

90 and dopamine had different profiles than the parent compounds after MDMA administration.

91 Similar to its parent compound AG490, WP1066 inhibited the phosphorylat

92 mum, lambda(max) = 290 nm, compared with the parent compound, all-trans-retinol (lambda(max) = 325 nm

93 nding is the dominant bonding feature in its parent compound ammonia borane.

94 mechanisms distinct from those of either its parent compound, amonafide, or sorafenib.

95 The persistence of the parent compound and formation of incomplete intermediate

96 Accurate mass determination of the unknown parent compound and its fragments obtained in MS/MS prov

97 atio for the metabolites was higher than the parent compound and lower in the remaining nine subjects

98 The PK of the parent compound and major metabolites were apparently li

99 of unique interphase microtubules unlike the parent compound and other analogues.

100 P102A1 is capable of inactivating the active parent compound and the products of both known pathways

101 evated rates of [3 + 2] cycloaddition as the parent compound and were used for imaging glycans on liv

102 More than 100 parent compounds and 40 transformation products were det

103 minated heparin had higher activity than the parent compounds and authentic heparin, indicative of su

104 g differences of functional activity between parent compounds and expected metabolites.

105 29)Si HSQC, were assigned by comparison with parent compounds and GIAO-DFT calculations.

106 Bioaccumulation factors were calculated for parent compounds and metabolite enrichment factors for m

107 ptake, biotransformation, and elimination of parent compounds and metabolites were modeled with a fir

108 strongly affected internal concentrations of parent compounds and metabolites.

109 d after UV irradiation were analyzed for the parent compounds and products using a high performance l

110 15-2500-fold more active than the unmodified parent compounds and should be evaluated further for the

111 y concentration trends of the metabolite and parent compounds and the complementary use of HILIC.

112 eference for cis-amides as compared to their parent compounds and thus provide novel strategies for a

113 mation reactions were used to link potential parent compounds and TPs, while the structural similarit

114 ations of sum of parabens (Sigmaparabens = 6 parent compounds) and paraben-metabolites (Sigmametaboli

115 HDP-P-5-F-2dUrd) were synthesized from their parent compounds arabinofuranosylguanine (AraG) and 5-fl

116 The rotational constants for the parent compound are A = 5657.335(1), B = 5349.2807(5), a

117 Although dissipation half-lives of the parent compound are directly extractable from OECD 308 d

118 e in unhatched eggs, it can be inferred that parent compounds are absorbed into the bird through the

119 he predicted concentration profiles for both parent compounds are consistent with experimental data.

120 We show that its parent compound, argued to exist only as a weakly correl

121 e 14 (IC50=7.7 microM) were more potent than parent compounds as antiproliferation agents.

122 ons of up to 0.1 mug g(-1) were detected for parent compounds as well as terbutryn degradation produc

123 tantly, the reactive species need not be the parent compound, as both reactive impurities and breakdo

124 ofunctional-intercalative DNA adducts as the parent compounds, as demonstrated in a plasmid unwinding

125 rain (>96% of radioactivity was recovered as parent compound at 1 h after injection).

126 al plasma concentration corresponding to the parent compound at 40 min after injection.

127 ism was rapid, with approximately 50% of the parent compound at 5 min and 17% at 60 min after injecti

128 Furthermore, the parent compounds at a high concentration, as opposed to

129 uction between the active metabolite and its parent compound (B[a]PDE versus B[a]P) or between active

130 The undoped parent compound, BaTi(2)Sb(2)O [P4/mmm; a = 4.1196(1) A;

131 discovered BaTi2Sb2O superconductor and its parent compound BaTi2As2O form a symmetry-breaking nemat

132 We find that, unlike its parent compound BeH2, lithium-beryllium hydride LiBeH3 e

133 des, which are structurally related to their parent compound, BeH2, offer the highest hydrogen storag

134 ing affinities of L1 and L2, vis-a-vis their parent compound, benzenesulfonamide, for recombinant hum

135 omprising the EFGH- and BCDEFGH-rings of the parent compound, both of which surprisingly showed simil

136 altered membrane capacitance similar to the parent compound but produced no voltage-dependent fluore

137 and carbamazepine treatments was due to the parent compounds but that diclofenac was degraded in the

138 oved Src inhibitory activity compared to the parent compound, but other thiophene isomers were less a

139 ly weak inhibitors of gyrase relative to the parent compound, but their combination generates a more

140 c response are shifted with respect to their parent compounds, but the aromatic/nonaromatic character

141 was perhaps not realized until the anionic, parent compound Bzbr (K(i) = 3.7 microM) was compared to

142 In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformatio

143 ay were mineralized, while 21 and 35% of the parent compound carbon was incorporated into the biomass

144 The parent compound CDDO as well as the methyl ester of CDDO

145 a striking resemblance to those found in the parent compound, challenging the perception that spin ex

146 t is 2-3 orders of magnitude higher than the parent compound cocaine.

147 Chemical modification of the parent compound combined with prior mutagenesis of TSHR

148 The remedial injection successfully reduced parent compound concentrations on site.

149 All five parent compounds contributed to the observed inhibition

150 ing only a total of 52 Da to the mass of the parent compound, creating an efficient ligand as an exce

151 Its activity was very similar to the parent compound cryptophycin-24.

152 In analogy to the parent compound, crystals grown from benzene formed clat

153 The amphetamine parent compound decreased in the artificial streams from

154 microscopic analysis showed that, unlike the parent compounds, derivative 2b did not show any signifi

155 ) (8), Thr(10) (11), and Phe(11) (12) of the parent compound Des-AA(1,2,5)-[d-Nal(8),IAmp(9)]SRIF (4)

156 for the three CECs, a majority (>75%) of the parent compounds disappeared at the 15 min reaction time

157 r activity against drug-resistant cells than parent compound DNR.

158 are likely to have a higher NDMA FP than the parent compound due to a reduced steric hindrance and/or

159 nd subsequent NDMA formation compared to the parent compound during chloramination.

160 Parent compounds (e.g., buproprion, carbamazepine, lamot

161 strate improved properties compared to their parent compounds (e.g., circumventing multidrug resistan

162 e diagrams of Eu(Fe0.925Co0.075)2As2 and the parent compound EuFe2As2 were also made.

163 to understand how the magnetic phase of the parent compounds evolves.

164 six (epoxiconazole) BTPs were identified per parent compound except for prochloraz, which showed exte

165 tallography, and these complexes, like their parent compounds, exhibit linear N-U-N angles and short

166 rugs that are efficiently metabolized to the parent compound for improved solubility and ocular perme

167 logical superconductors), making it a unique parent compound for the study of these states and the ph

168 vity in the mutant receptors relative to the parent compound GC-1.

169 Moreover, the structures of parent compound GLB and its two major metabolites M1 and

170 ies indicate that apogossypol is superior to parent compound gossypol with respect to toxicology and

171 or binds in the active site similarly to its parent compound GSK180736A.

172 g data, we suggest the time until 50% of the parent compound has been transformed in the entire syste

173 The parent compound HBPG was uniquely active in viral infect

174 be affected by the influent concentration of parent compounds, hydraulic retention times, and chlorin

175 Treatment with the parent compound (I3C) or DIM (1 micromol/L) protected ag

176 al features and the protonation state of the parent Compound II when studied by EPR and 1H and 14N EN

177 brozil enhanced the antiandrogenicity of the parent compound in a model fish species, demonstrating t

178 provided zones of inhibition larger than the parent compound in agar diffusion assays against the ind

179 espectively] exhibit higher potency than the parent compound in inhibiting dihydrotestosterone (DHT)-

180 age of the administered NMP recovered as the parent compound in larvae compared to adults.

181 tain the low micromolar IC(50) values of the parent compound in Plasmodium falciparum (clone 3D7) inf

182 hate was metabolized more efficiently to the parent compound in vivo than 2-methoxyestradiol 17-phosp

183 LOBSTAHS putatively identified 1969 unique parent compounds in 21869 features that survived the mul

184 ts were detected in total, between 30 and 50 parent compounds in each two-week composite sample in co

185 und them to be comparable in activity to the parent compounds in inducing the release of IL-2, IL-4,

186 idation products are more effective than the parent compounds in inhibition.

187 erference from the many tens of thousands of parent compounds in the oil.

188 and quantitative analyses of metabolites and parent compounds in worm tissue, water, and sediment wer

189 ng that reversed the selectivity seen in the parent compound, in human hD2(L)R- or hD3R-transfected H

190 4 h at pH 4.7 was different from that of the parent compound indicating a different type of interacti

191 % per thousand of the delta(delta)13C of the parent compounds, indicating that pyrolysis-induced isot

192 The parent compound inhibits influenza virus sialidase at a

193 oninvasive character and the presence of the parent compound instead of its metabolites.

194 from multiple sources and transformation of parent compounds into degradates having estrogenic activ

195 Further, we show that only the intact parent compound is found in the region of interest.

196 LTC(4), the parent compound, is secreted from mast cells following C

197 to design an improved analog of the pyrrole parent compound, JG-03-14.

198 a superfused rat pituitary system than their parent compound JV-1-36 and had increased binding affini

199 JWH-210, JWH-250, RCS-4, and AM2201 and the parent compounds JWH-018, JWH-073, JWH-081, JWH-122, JWH

200 is derived from the Ruddlesden-Popper (R-P) parent compound La4Ni3O10-x by removing two oxygen atoms

201 rs were significantly more potent than their parent compounds lacking the amino acid group.

202 sed systemic dissemination relative to their parent compounds, leading to 30-fold increases in T-cell

203 Glutaric acid, the parent compound linked with human neurological manifesta

204 ivably be as dangerous and persistent as the parent compounds; most prominently, OH-PCBs are endocrin

205 The material is synthesized from the parent compound Na2IrO3 by a topotactic reaction where s

206 The parent compound Na2IrO3 is proposed to be relevant to th

207 ilized poly(dA).2poly(dT) much more than its parent compound, neomycin.

208 Compared to their parent compounds, nitric oxide-donating nonsteroidal ant

209 ed by modifying positions 5, 7, and 8 of the parent compound nitroxoline.

210 Significant reductions in extractable parent compound occurred under light conditions for prom

211 on its properties and is expected to be the parent compound of a new family of superconductors.

212 zatricyclo[3.3.1.1(3,7)]decan-2-one (3), the parent compound of a rare class of 90 degrees -twisted a

213 For Fe1+yTe, the parent compound of Fe1+ySe1-xTex superconductors, bulk-s

214 with the tripeptide GSH to produce LTC4, the parent compound of the cysteinyl leukotrienes, important

215 llurium (Fe(1+ y)Te), the nonsuperconducting parent compound of the iron chalcogenides, by using a ST

216 The layered telluride, Fe(1+x)Te, is a parent compound of the isostructural and superconducting

217 of long-range antiferromagnetic order in the parent compounds of high-transition-temperature (high-T(

218 The parent compounds of iron pnictide superconductors are ba

219 The parent compounds of the 1,5-benzodiazepine CCK receptor

220 The parent compounds of the cuprate and iron-pnictide superc

221 In the copper oxide parent compounds of the high-transition-temperature supe

222 This analogy is quite surprising as the parent compounds of the two families have rather differe

223 between ubiquitous antiferromagnetism in the parent compounds of unconventional superconductors and t

224 f vinblastine (CPD100) which converts to the parent compound only in the presence of lower oxygen lev

225 or no quantifiable systemic exposure to the parent compound or a presumed metabolite.

226 alt avoids isolation or concentration of the parent compound or HCl salt and will facilitate the use

227 The parent compound, oxybenzone, was also present in all sam

228 5c) were synthesized in four steps from the parent compound p-tert-butyldihomooxacalix[4]arene and o

229 of DSBFNPC show a strong resemblance to the parent compound, PC, and the ECL spectrum produced via r

230 rrow this gap we investigated the fate of 20 parent compounds (PCs) and 11 characteristic TPs in four

231 improved metabolic stability compared to the parent compound, PG648 (6).

232 tabolite CGP52421 is less selective than its parent compound, PKC412, and is more cytotoxic against p

233 Parent compound plus its metabolites resveratrol-3-O-glu

234 philic metabolites were identified, with 20% parent compound present at 90 min after injection in bab

235 HP) following exposure of female rats to the parent compound progesterone (P) produces a syndrome cha

236 However, their parent compound, protocatechuic acid, did not show this

237 Concentrations of parent compounds ranged from <10 to 3830 ng/L (gemfibroz

238 f Na(+) channel and IKr blockade by both the parent compound ranolazine and its active metabolites, w

239 nstrate a consistent pattern compared to the parent compound ratios.

240 e bloodstream, with 25% of the (11)C-labeled parent compound remaining 30 min after injection.

241 pheral metabolism, with approximately 40% of parent compound remaining at 30 min after injection.

242 Therefore, focusing solely on parent compound removal for contaminants of higher relat

243 (Ni(1-x)Fe(x)OOH) over their pure Ni and Fe parent compounds, resulting in one of the most active cu

244 These active metabolites may prolong the parent compound's psychotropic and physiological effects

245 of these active metabolites may prolong the parent compound's psychotropic and physiological effects

246 e derived, ecstasy has inherited some of its parent compound's reputation for being neurotoxic.

247 difluoro-GABA with that of the fluorine free parent compound showed that introduction of each fluorin

248 e most active derivatives and the unmodified parent compounds showed up to 6-fold higher activity in

249 MT dual epigenetic inhibitory profile of the parent compound, some analogues, notably 4a (UVI5008), a

250 Indeed, compared to the halogen free parent compounds, some 7-halogenated derivatives exhibit

251 1,029 inactive chemicals to detect possible parent compounds that might have active metabolites.

252 enoids in SRFA and provided insight into the parent compounds that must be diagenetically modified on

253 Like the parent compound, the cyclic derivative irreversibly acti

254 Similar to the parent compound, the new microporous materials are stabl

255 In comparison to the parent compounds, the 24-hydroxygemini required higher d

256 For the parent compounds, the amniotic fluid concentrations of s

257 siderably lower affinities compared to their parent compounds, the bivalent ligand approach led to si

258 rder of magnitude higher than those of their parent compounds, their future preparation and isolation

259 Parent compound tissue concentrations for both species c

260 in acidic urine, leading to delivery of the parent compounds to bladder.

261 First, rate constants for transformation of parent compounds to metabolites were correlated to those

262 re correlated to those for transformation of parent compounds to NER, leading to degradation half-liv

263 is of pharmaceutical metabolites back to the parent compound, treatment systems should be designed ba

264 ) resulting from partial dissociation of the parent compound [U2F](-).

265 Neither of the parent compounds, unconjugated Chl or polyamide 1, demon

266 nt and their potential to retransform to the parent compound, underlines the importance of including

267 bic structural transitions of "122" SrFe2As2 parent compound using combined high resolution synchrotr

268 -) mouse livers perfused with the respective parent compounds using a cassette dosing approach.

269 he interdimer interface when compared to the parent compound vinblastine.

270 Metabolism of this prodrug to the active parent compound was confirmed in rat kidney homogenates,

271 ooxygenase (BMO) that was oxidized after the parent compound was consumed.

272 The decay of the parent compound was monitored with HPLC/ITMS, and the co

273 ia from SFN-treated cells indicated that the parent compound was not responsible for the inhibition o

274 similar studies using solution dosing of the parent compound was observed in the in vivo studies in b

275 ion, only less than 5% and approximately 10% parent compound was present in blood, respectively.

276 rface water samples, median concentration of parent compounds was 110 ng/L reaching up to 6 mug/L for

277 50% current decrease) of individually tested parent compounds was 2.7 g/L for FF, 3.0 g/L for HMF, 1.

278 The extent of the metabolism of all three parent compounds was dependent on the microsomal prepara

279 were detected in 47% of the cases where the "parent-compound" was applied.

280 The parent compounds were active in all transactivation assa

281 Selected prodrugs and parent compounds were also tested for their cytotoxicity

282 affecting the separation of glucuronides and parent compounds were investigated by varying the applie

283 The highest concentrations of parent compounds were measured in effluent that was not

284 the high levels of in vitro activity of the parent compounds were retained and others deleted.

285 ymatic oxidation of the 2-butyl group of the parent compound, were synthesized from 6-chloro-2-iodo-9

286 es reduced the antimicrobial activity of the parent compound when conjugated to the xanthone scaffold

287 However, the parent compounds, when tested below their respective non

288 ino substituents are expected to emulate the parent compound which was shown to form crystals where t

289 the substitution of a carbonyl group in the parent compound with a sulfonyl in the PDK inhibitors.

290 by FVP methods and also by reactions of the parent compound with electrophiles, leading to a range o

291 Unlike its parent compound with low water solubility, intraperitone

292 hus provides the binding conformation of the parent compound with nNOS.

293 Thus, for the parent compound with R = H, i.e., [(bipy)Au(mu-O)(2)Au(b

294 netic data were collected for the respective parent compounds with a pent-4-enyl and a pent-4-enoyl c

295 entified that improve on the activity of the parent compound, with IC(50) values for induction of cel

296 minor role in elimination of the respective parent compound, with the exception of prochloraz.

297 radioactivity recovered from plasma was the parent compound, with the majority of radioactivity in t

298 Detecting metabolites and parent compound within a cell type is now a priority for

299 ase inhibition studies demonstrated that the parent compound (ZJ-43) exhibited potent inhibitory acti

300 d to both the mono-ester (PGI-02749) and the parent compound (ZJ-43) in both blood and brain.