ライフサイエンスコーパス: parental

1 ruses induced higher transduction than their parental AAV vectors (2- to 9-fold over AAV2), with the

2 conditions, where dissociation of the K409R parental Ab into half-Ab controls the rate of the reacti

3 2, 3], deafness [2], cross-fostering [4] and parental absence [5] have little or no effect on vocal d

4 Parental acceptance of multiple injections was associate

5 Analysis of the 19 parental accessions of the multiparent advanced generati

6 ost unchanged with additional adjustment for parental ADHD, infant birth weight, and gestational age.

7 Parental advocacy for their infant's best interest mimic

8 mechanism integral to other factors, such as parental age and mother's psychiatric disorder.

9 High parental age at childbirth has repeatedly been linked to

10 mood lability; psychosocial functioning; and parental age at mood disorder.

11 This is the first study to test for parental age effects on offspring LTL in a wild mammal p

12 Parental age is increasing rapidly in many countries.

13 (SES) at time of birth (P = 0.001), but not parental age nor maternal gestational weight gain, were

14 ociation scan, informed by these priors, for parental age of death in the UK Biobank study (n=116,279

15 degree relatives, we evaluated the impact of parental age on the risk of lymphoid neoplasms by subtyp

16 1978-2009 to investigate the relationship of parental age to risk of pediatric cancer.

17 lation-based record-linkage study, advancing parental age, especially advancing maternal age, was ass

18 th those in 5 other states lacking universal parental AHT education during the same period.

19 Here we profile parental allele-specific DNase I hypersensitive sites in

20 MBC4 and the parental allergens were purified to homogeneity.

21 ll epitope-containing parts on each of the 3 parental allergens, the hybrid molecule was designed to

22 len allergy and from mice immunized with the parental allergens.

23 ls suggest epigenetic inheritance induced by parental allergic disease activity.

24 neage of Eastern-Mediterranean origin as one parental ancestor of P. kl.

25 In children, risk factors related to parental and child psychologic and behavioral functionin

26 s is the product of a wide array of genetic, parental and environmental factors.

27 H3 and resulting gene expression patterns in parental and NOTCH1-expressing C2C12 cell lines.

28 cues, costs and constraints of plasticity in parental and progeny generations, and the dynamic nature

29 .IL-6 complex was observed in mice while the parental antibodies prolonged the serum half-life of IL-

30 ent from published methods, we assembled two parental antibody fragments in the hinge region by the p

31 Parental antibody pairs were rapidly reformatted into sc

32 for age, sex, anxiety severity, and level of parental anxiety.

33 We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness

34 ing trait-associated polygenic variation and parental behavior and characteristics relevant to childr

35 Parental behavior and knowledge were assessed through im

36 pressin inhibits nest building but not other parental behaviours.

37 mice that differ in their mating systems and parental behaviours.

38 potent and effective in TNBC cells than its parental BET inhibitor compound BETi-211.

39 h hayfever was more strongly associated with parental BHR and specific IgE measured before conception

40 CONCLUSION & CLINICAL RELEVANCE: Parental BHR and specific IgE were associated with offsp

41 ts to offspring, as idiolect is predicted by parental birthplace, even after controlling for shared p

42 The least stable isomer of the parental BN naphthalene series has been synthesized in a

43 with greater infant-specific activity in key parental brain regions, including the orbitofrontal cort

44 n the maternal brain reflect the building of parental capacity over time.

45 everal brain regions and circuits regulating parental care are shared by both sexes, some of the fund

46 What is the genetic basis of differences in parental care between promiscuous and monogamous mammal

47 Furthermore, some regions affect parental care broadly, whereas others affect specific be

48 h have sex-specific effects, suggesting that parental care can evolve independently in males and fema

49 ge by dissecting the genetic architecture of parental care in deer mice to discover an important cont

50 ic complex social behaviors, such as intense parental care in the Cebidae and the genus Saguinus.

51 dern Tanaidacea, and argue that this form of parental care may have played a role in the diversificat

52 ight neuropeptides have been associated with parental care previously, but all have roles in predicte

53 ), and decreased fish egg sizes (i.e., lower parental care) were related to elevated fish extirpation

54 , we identify 12 genomic regions that affect parental care, 8 of which have sex-specific effects, sug

55 rules can mediate complex behaviours such as parental care, and that care and cannibalism are antagon

56 In many species that have bi-parental care, food-sharing males provide vital nutritio

57 tudies have explored the optimal duration of parental care, particularly among large carnivores.

58 t important sense, underpinning mate choice, parental care, territoriality and even disease transmiss

59 l research on the motivational psychology of parental care.

60 contributes to interspecific differences in parental care.

61 considers its applicability to the domain of parental caregiving.

62 yadic path-analysis model indicated that the parental caudate-vmPFC connectivity in infancy predicted

63 n miRNA microarray analysis using RNA from a parental cell line, a Rho(0) line lacking mitochondrial

64 rforming a doxorubicin drug challenge on two parental cell lines (e.g., wild-type HeLa cells and MRP1

65 e is formed that radially expands toward the parental cell wall [1-3].

66 sion of p-Rb was lower in TamR cells than in parental cells, and the expression of gammaH2AX was sign

67 expressing wild-type GFP MHC-IIA behave like parental cells, displaying robust and active formation a

68 more resistant to NK cell cytotoxicity than parental cells.

69 , aggregation is reduced to the level of the parental cells.

70 lower in A549CisR and H157CisR cells than in parental cells.

71 tly less well than DNA derived from ctsM(+) (parental) cells.

72 procedure reduces confounding by unobserved parental characteristics that are shared by siblings.

73 cross feeding categories while adjusting for parental characteristics, daycare, region, and infant pl

74 Overprotective parental child-rearing style may increase the disease bu

75 g results with regard to the strength of the parental-child resemblance in dietary intake.

76 g due to the audiologist's recommendation or parental choice.

77 How parental chromatin becomes equalized and how imprinting

78 c errors and karyomapping to fingerprint the parental chromosomes in single cells from disaggregated

79 ative risk ratios (aRRR) for associations of parental clinical outcome with offspring allergic diseas

80 tant to mda-7/IL-24-mediated cell death than parental clones.

81 tion occurred and the presence or absence of parental conflict prior to separation.

82 ed, one avoiding inbreeding (equalisation of parental contributions (EC)) and the other forcing it (c

83 lted in inaccurate conclusions regarding the parental contributions to both the endosperm and early e

84 g in plant seeds has been to investigate the parental contributions to the transcriptomes of early em

85 The parental contributions to ZGA were highly asymmetric.

86 it that local mate competition combined with parental control over marriages may escalate conflict be

87 diagnosis offers a window of opportunity for parental counseling and management using procedures such

88 anced the antitumor efficacy achieved by the parental counterpart.

89 fission, generating 2 daughter crypts from 1 parental crypt.

90 potentially greater accuracy of progeny than parental cues to predict progeny selective environments.

91 lines thus derived faithfully retained their parental cystic and spiky morphologies and were termed C

92 ry conservation of molecular components of a parental decision making behaviour.

93 ration of evolutionary and causal aspects of parental decision making, by suggesting that selective i

94 A parental diagnosis of schizophrenia-but not of other psy

95 Factors other than parental dietary habits and home environment seem to hav

96 It has been widely recognized that parental dietary intake is an important and consistent f

97 ounsellor-driven Amagugu intervention to aid parental disclosure has potential for wide-scale impleme

98 he hypothesis is confirmed in other studies, parental disease activity assessed before conception may

99 However, we know little of how parental disease activity before conception influences o

100 d psychologic and behavioral functioning and parental distress and burden are also important.

101 DNA synthesis by processively unzipping the parental DNA helix.

102 es not affect transformation efficiency when parental DNA is used, suggesting that CtsM is important

103 All mutations were de novo where parental DNA was available.

104 tegy for improving aqueous solubility of the parental drugs, determining a positive impact also in th

105 to cross cell membranes with respect to the parental drugs, explaining their better 24 h in vitro cy

106 Being a woman, higher parental education and having a comorbid anxiety disorde

107 Parental education is located at the center of global ef

108 Lower parental education was associated with lower baseline HR

109 After adjusting for age, race, parental education, and prepregnancy lifestyle and CVD r

110 and hyperactivity, after adjusting for sex, parental education, low birth weight, preterm birth, par

111 ar across groups defined by parental income, parental education, number of siblings, and rural/urban

112 th) and socioenvironmental determinants (ie, parental education, socioeconomic status, home environme

113 at birth, father's age at birth and highest parental education.

114 ing and not significant after adjustment for parental educational level and whole-blood DHA.This stud

115 However, rather than increasing the male's parental effort, females appeared to suppress the male's

116 may be a cost-effective tool for increasing parental efforts toward reducing children's physical gro

117 Influence of intergenerational in utero parental energy and nutrient restriction on offspring gr

118 Our results highlight that parental environments can have substantial effects in of

119 Parental environments can influence offspring traits.

120 However, the magnitude of the impact of parental environments on offspring molecular phenotypes

121 After fertilization, the initially distinct parental epigenomes become largely equalized with the ex

122 e differences persisted after adjustment for parental ethnicity and smoking, prenatal glucocorticoid

123 lopolyploid F1 hybrids and suggest that high-parental expression-level dominance plays an important r

124 ional compromise: quick development benefits parental fecundity while slow development benefits offsp

125 Targeted deep sequencing of parental fibroblasts revealed that most variants detecte

126 sterol-containing particles (HSV(chol)) from parental fibroblasts, suggesting that the hydrocarbon ta

127 clones were rare variants inherited from the parental fibroblasts.

128 and hospital records were used to ascertain parental fractures.

129 iple disease-causing retrocopies of the same parental gene in a mammalian species.

130 red the associations between pseudogenes and parental genes (targets).

131 In plants, the timing and parental genome contributions to ZGA are unresolved.

132 Mammalian parental genomes contribute differently to early embryon

133 fic differentially methylated regions in the parental genomes that are associated with hybrid perform

134 ansmitted over nine generations according to parental genotype, with only 1-4% of CGs either losing o

135 nce and expression variation between the two parental genotypes, which may explain the contrasting gr

136 es are also contingent on and constrained by parental genotypes.

137 Parental hay fever and early exposure to D pteronyssinus

138 Early IgE sensitization onset, parental hay fever, and higher exposure to mites were as

139 biquitinations are induced by oxaliplatin in parental HCT116 cells.

140 h this mode of action, peroxide treatment of parental HeLa cells elevated phospho-Met levels whereas

141 ields are higher in SP100(-/-) cells than in parental HEp-2 cells.

142 and signaling among the resistant models and parental HER2(+) cells.

143 =40 years with BMD tests and self-reports of parental hip fracture between 2006 and 2014.

144 ring met the inclusion criteria; 13.6% had a parental hip fracture diagnosis in administrative data d

145 ar, and longer interval between BMD test and parental hip fracture diagnosis.

146 Agreement between parental hip fracture from offspring reports and diagnos

147 s to test the validity of offspring-reported parental hip fracture in a unique bone mineral density (

148 rs), adjusted for type of hospital at birth, parental history of allergies, mother's age at birth, fa

149 ted will face the challenge of disclosure of parental HIV infection status.

150 (FCS) was used to determine the affinity of parental (homodimer) and bispecific (heterodimer) intera

151 ty greater than or equivalent to that of the parental IgG1 scaffold.

152 s exceeded the number of active genes in the parental inbred lines significantly independent of treat

153 trends are similar across groups defined by parental income, parental education, number of siblings,

154 Both family (parental income-to-needs, occupation, and education leve

155 Non-parental infanticide is mediated by territorial cues and

156 06, through December 31, 2007, with complete parental information from national registers who were fo

157 nilateral retinoblastoma was associated with parental insecticide use (odds ratio [OR], 2.8; confiden

158 Studies suggest that a postnatal parental intervention may reduce the incidence of abusiv

159 t study included a structured questionnaire, parental interviews, clinical examinations and bronchodi

160 Maternal smoking data were collected through parental interviews.

161 genic carrier mutant compared to that of the parental invasive strain after exposure to human neutrop

162 xposure to human neutrophils to that for the parental invasive strain.

163 etween the sexes in the pattern and level of parental investment.

164 Auxiliary results show that parental investments in the emotional support of survivi

165 n is represented by the genotype of only one parental isolate.

166 in complete protection when challenged with parental isolates.

167 d, the magnitude of the chemical response to parental JA exposure was c. 10% of the direct JA treatme

168 d JA-responsive transcripts were affected by parental JA treatment.

169 t was associated with self-reported gains in parental knowledge that were retained for 7 months.

170 haracteristics in vitro when compared to the parental LaSota virus.

171 mtDNA restoration reversed this miRNA to parental level, suggesting that miR-663 may be epigeneti

172 puberty timing are associated with a longer parental life span (P 6.2 x 10-6 for fathers and P 2.0 x

173 Using genetic data of parental lifespan, the authors identify associations at

174 xhibit markedly enhanced potency compared to parental ligands (10- to 100-fold).

175 ient Cas9-directed genome editing, so that a parental line can be expeditiously engineered to harbor

176 ants that were fixed differences between the parental lineages, and that now appear in many new combi

177 nalyzed the transcriptomes of Brassica napus parental lines and their F1 hybrids at three stages of e

178 s-specific epigenetic divergence between the parental lines can directly or indirectly trigger hetero

179 as altered, but this was not observed in the parental lines.

180 ly altered in the F1 hybrids relative to the parental lines.

181 LX4720 compared to the respiration-competent parental lines.

182 n degradation compared with their respective parental lines.

183 Twelve pediatric recipients of parental living donor liver grafts, identified as operat

184 be efficiently separated from contaminating parental mAbs by differential protein A elution starting

185 n A elution starting from either a) purified parental mAbs, b) in-supernatant crossed parental mAbs,

186 ied parental mAbs, b) in-supernatant crossed parental mAbs, or c) co-transfected mAbs.

187 e and behavioral scores from IQ testing, and parental measures of development were tested by using an

188 offspring and investigate the importance of parental mental illness for such an association.

189 m allowed us to quantify the contribution of parental methylation differences to heterosis.

190 hat best predict sites that fail to maintain parental methylation state.

191 Parental mosaic mutations that were transmitted account

192 We observed a high degree of parental mosaicism indicating that a large fraction of t

193 apping of microbe-phenotype relationships in parental mouse strains and in mice with hybrid microbiot

194 Some of the parental mutations were pleiotropic, affecting multiple

195 carcasses but not in streams containing this parental nutrient input.

196 Yet, the possibility that chicks recognise parental odour at hatching has been completely overlooke

197 niopygia guttata) are capable of identifying parental odours at hatching.

198 elopment and offspring fitness to facilitate parental-offspring coadaptation.

199 within a novel neural circuit that regulates parental-offspring social behaviour in C. elegans and th

200 .5 log10), and smaller plaques than with the parental Oka (pOka) strain.

201 used in oil palm breeding programs to hasten parental palm selection.

202 ects of prenatal conditions on offspring and parental performance in the burying beetle Nicrophorus v

203 Our results suggest that parental pesticide exposure before or during pregnancy m

204 thout losing the crystalline symmetry of the parental phase and provides an effective platform for el

205 metabolic phenotypes are more contingent on parental phenotypes than others.

206 on in-person examination and those based on parental photographs.

207 al association with metabolic profile as for parental pre-pregnancy BMI associations but with greater

208 We examined relationships between parental pregnancy-related characteristics and NAFLD in

209 Examination of parental pregnancy-related characteristics may provide i

210 generations, and human studies indicate that parental prenatal exposures may play a part in developme

211 The parental protein target, the clade B strain B41 SOSIP.66

212 eptides composed of fragments distant in the parental protein.

213 -was associated with a 22q11.2 deletion, and parental psychiatric diagnoses other than schizophrenia

214 ustment for sociodemographic confounders and parental psychosocial covariates, the hazard ratio for a

215 Regular parental questionnaires identified children with eczema.

216 raphic and behavioral data were collected on parental questionnaires; a research nurse recorded anthr

217 ons that readily select for reversion in the parental rCan virus.

218 Levels of parental relatedness, measured through runs of homozygos

219 3222 British-Pakistani individuals with high parental relatedness, we estimate a mutation rate of 1.4

220 AD was defined by parental report of a typical itchy and/or flexural rash.

221 Outcomes were parental report of physician-diagnosed asthma or recurre

222 was the percentage of families stopping PS (parental report verified and unverified with the child's

223 Data on parental-reported eczema were available from birth until

224 Both interventions improved parental reports of children's protein intake.The result

225 Parental reports of the most common antibiotics (cephalo

226 We catalogued AEs from parental reports, daily symptom diaries, and dose escala

227 rst 6 years of life (1387 infants), based on parental reports.

228 nces between the intervention arms in either parental resource empowerment (0.07 units; 95% CI, -0.02

229 d health-related quality of life, as well as parental resource empowerment in the Connect for Health

230 ed by the Pediatric Quality of Life 4.0, and parental resource empowerment.

231 Both intervention arms led to improved parental resource empowerment: 0.29 units (95% CI, 0.22

232 Parental restrictive feeding (i.e., limiting food intake

233 128 SNPs, which was then applied to five bi-parental RIL populations to produce a consensus genetic

234 We also analyzed parental samples, when available, and found that de novo

235 study was to explore the association between parental separation during childhood (up to 18 years of

236 ons differ according to the age at which the parental separation occurred and the presence or absence

237 Exposure to parental separation or divorce during childhood has been

238 posite direction to our a priori hypothesis: Parental separation was associated with lower blood pres

239 The associations of parental separation with children's cardiometabolic risk

240 es might potentially acquire advantages from parental serotypes for enhancement of AAV transduction a

241 Nab activity from mouse sera immunized with parental serotypes.

242 eptor expression and global methylation in a parental sex-specific manner.

243 12 months (adjusted OR, 7.3; P = .007), and parental smoking (adjusted OR, 3.8; P = .028).

244 the Swedish Adoption/Twin Study of Aging and parental social class based on the Swedish socioeconomic

245 education, low birth weight, preterm birth, parental social class, maternal smoking and drinking, ma

246 These analyses took account of age, sex, parental socioeconomic background, education, and cognit

247 Confounding by parental socioeconomic status explained little of the in

248 ts [2.17 to 5.31] in the highest quartile of parental socioeconomic status).

249 ificantly higher in SP100(-/-) cells than in parental SP100(+/+) cells or in PML(-/-) cells.

250 , SP100(-/-) cells retain the sensitivity of parental SP100(+/+) cells to IFN-beta and support replic

251 itish-blue to pink (opal-crowned manakin) in parental species but are a much less reflective yellow i

252 The brilliant coloration of the parental species results from nanostructural organizatio

253 t of perturbed reference strains (RSs) and a parental strain (PS) to substantially improve the predic

254 fect the murine airway as efficiently as the parental strain and PM18 was killed more readily when in

255 Mutant cells were some 50% longer than parental strain cells, and at optimal growth temperature

256 V-1 0DeltaNLS relative to its fully virulent parental strain in C57BL/6 mice.

257 g that, while it is comparable to a virulent parental strain in terms of immunogenicity, HSV-1 0Delta

258 number of the mutant strain compared to the parental strain was observed in the small intestine and

259 prove the predicted flux distribution of the parental strain.

260 e identified by comparing the mutants to the parental strain.

261 t lacking ACT produced more biofilm than the parental strain; leading Irie et al. to propose the ACT-

262 r colonies inside the susceptible range, the parental strains and their representative inner colony m

263 s of mcrA deletant, mcrA overexpressing, and parental strains reveal that mcrA regulates at least ten

264 ithelial cells was studied, by comparing the parental strains RN6390 and MW2 and their DeltasfaA and

265 s tolerate patches of ribonucleotides on the parental strands to different extents.

266 Parental stress exposures are implicated in the risk for

267 important contribution of intergenerational parental stress in offspring neurodevelopment and diseas

268 Recent studies have shown that one of the parental subgenomes in ancient polyploids is generally m

269 Of the parental subgenomes, S chromosomes have degraded faster

270 3, exhibit up-regulated ST6Gal-I relative to parental Suit2 cells.

271 kely involving Zea mays ssp. mexicana as one parental taxon, and an unidentified cultivated maize var

272 By comparing these ALT cells with parental telomerase positive cells, we observed that ALT

273 etic markers, in particular for identity and parental testing in DNA forensics.

274 Parental testing revealed de novo CNVs in 11 (47.8%), wi

275 Insensitive parental thoughts and affect, similar to contempt, may b

276 ic and tumor-targeting properties similar to parental trastuzumab.

277 ate with the number of genomic copies of the parental tRNAs.

278 ompared with the SUVmax of the corresponding parental tumor.

279 ecapitulates the main characteristics of the parental tumors and may represent a useful asset for tes

280 rank order of uptake similar to that of the parental tumors.

281 tabolic characteristics of the corresponding parental tumors.

282 33-S1 grew to titers similar to those of the parental vaccine vector BNSP333, and the RABV G-MERS-CoV

283 Following challenge with the parental virulent virus, all pigs immunized by the intra

284 onses to a greater extent than that with the parental virus (pH1N1/NS1-wt), yet virus titers were not

285 mbinations that were more active than either parental virus complex.

286 The introduction of these changes into the parental virus conferred enhanced virulence in mice, alt

287 induced higher cell-to-cell fusion than the parental virus following infection in two tumor cell lin

288 utant S proteins were more virulent than the parental virus in hDPP4 KI mice.

289 iltrating T cells in vivo, compared with the parental virus lacking such effects.

290 Whereas the parental virus recognized alpha2,3-linked sialic acids p

291 es was more virulent in transgenic mice than parental virus, demonstrating that a few amino acid chan

292 slices from the porcine lung to passage the parental virus, isolates from each of the three passages

293 emination and greater pathogenicity than the parental virus.

294 mutant alone differed only slightly from the parental virus; however, the combination of both mutatio

295 und that, when segment 4 (HA) of coinfecting parental viruses was modified, there was a significant p

296 duce solid protection against challenge with parental viruses.

297 calls by infants is influenced by contingent parental vocal feedback.

298 es that almost always win fights against the parental wild-type Canton-S stock.

299 ness was longest (13.0 days) and the rate of parental work absenteeism was highest (136 days per 100

300 and viability compared with females with two parental X chromosomes.