ライフサイエンスコーパス: partial inhibition

1 itric oxide synthase (eNOS), produced only a partial inhibition.

2 whereas either treatment alone gives rise to partial inhibition.

3 nocytes with clodronate resulted in a modest partial inhibition.

4 sma from the low-dose group resulted in only partial inhibition.

5 DNA-binding domains of USF1 or USF2 produced partial inhibition.

6 dependent kinases or NADPH oxidases rendered partial inhibition.

7 eutralizing antibody against MCP-1 exhibited partial inhibition.

8 200 microm DMNB-cAMP caused stable but only partial inhibition.

9 A subset of the dogs (5/13) showed partial inhibition (30-49%) of the clinical signs with C

10 at doses up to 5 microm, and exhibited only partial inhibition (50%) of the 26 S ubiquitin-independe

11 exposing myocytes to nicotine for 4 to 24 h (partial inhibition after 1 h).

12 were RPMI medium, MIC end point criterion of partial inhibition, and incubation for 24 h.

13 binds to an exosite, displays noncompetitive partial inhibition, and is synergistic with a competitiv

14 nists in the cultures themselves led to only partial inhibition (approximately 60%), whereas inclusio

15 inhibitor of the DHDPS reaction that causes partial inhibition (approximately 90%) at saturating con

16 ulfated coumarins suggesting that allosteric partial inhibition arises from catalytic dysfunction of

17 f cAMP-response element-binding protein, yet partial inhibition by a dominant negative cAMP-response

18 t in C-1Sec7 of Ser199 or Pro209 resulted in partial inhibition by BFA, whereas replacement of Gln970

19 ng digitonin permeabilization, compared with partial inhibition by BoNT/A, suggesting the importance

20 Ca2+ andMg2+, pH sensitivity, reversibility, partial inhibition by DIDS and Mn2+) are shared with the

21 Only partial inhibition by dominant-negative AKT and no inhib

22 Partial inhibition by pertussis toxin was observed.

23 There appeared to be partial inhibition by substrate, and excess pyridoxal 5'

24 Without the C-terminal domain, partial inhibition by the epsilon N-terminal domain is d

25 The partial inhibition by unmethylated DNA is caused by a de

26 This partial inhibition can be reversed by the addition of 1-

27 d upon expression of SOCS-1 or SOCS-3, while partial inhibition (CIS, SOCS-2) or no inhibition (SOCS-

28 Their partial inhibition gives rise to the full dynamics of th

29 R-Met and U-87 MG xenografts but showed only partial inhibition in HT-29 xenografts.

30 show that Bop1Delta expression results in a partial inhibition in the conversion of the 36S to the 3

31 A partial inhibition in the differentiation of CD44+25+ pr

32 agment containing residues 1-107 also showed partial inhibition in these assays.

33 te cyclase, whereas the other drugs produced partial inhibition, indicating the drugs are inducing sl

34 demonstrate that PERK haploinsufficiency or partial inhibition led to reduced ER stress-induced infl

35 as 2 microg/ml when MIC endpoint criteria of partial inhibition [MIC-2] were used).

36 of two E2 per EST subunit suggests that the partial inhibition occurs through binding at an alloster

37 Furthermore, partial inhibition of 7, 8-benzoflavone metabolism by ph

38 iological, and behavioral effects in mice of partial inhibition of a hippocampal cAMP phosphodiestera

39 gainst a portion of the repeat region caused partial inhibition of AC toxin-induced hemolysis without

40 We have tested whether partial inhibition of ACAT1 and ACAT2 (expressed in live

41 mmended doses of ACE inhibitors provide only partial inhibition of ACE in chronic heart failure (CHF)

42 homeostasis (Na(+), K(+), Ca(2+)) due to the partial inhibition of active Na(+) and K(+) transport.

43 ibition of AEA accumulation correlating with partial inhibition of AEA hydrolysis.

44 l lines lacking activating PI3KCA mutations, partial inhibition of Akt signaling synergized with camp

45 rent excitation because it was eliminated by partial inhibition of alpha-amino-3-hydroxy-5-methyl-4-i

46 a coli genes whose expression was induced by partial inhibition of ALS were sought.

47 peptides (25 micro mol/L) and demonstrates a partial inhibition of angiogenesis ( approximately 40%)

48 oxic T lymphocyte (CTL) responses and led to partial inhibition of angiogenesis.

49 the activity of the p38 MAPK, provided only partial inhibition of apoptosis and had no effect on nec

50 Partial inhibition of apoptosis due to LAQ824 or Apo-2L/

51 ppression of TGFbeta1 signals results in the partial inhibition of AR-mediated metastasis.

52 low extracellular substrate concentrations, partial inhibition of ATP synthesis lowered, whereas sup

53 chromosomes in anaphase is very sensitive to partial inhibition of Aurora kinase activity by ZM447439

54 on of GAG/PG-mediated attachment resulted in partial inhibition of bacterial attachment, suggesting t

55 uding tight binding to actin filament sides, partial inhibition of barbed end elongation, inhibition

56 A partial inhibition of basal and stimulated GEP productio

57 days in physiologic growth factors achieved partial inhibition of Bcr-Abl and downstream targets p-C

58 Furthermore, we provide evidence that the partial inhibition of beta 2m by antisense RNA results i

59 Ranolazine, however, did demonstrate a partial inhibition of beta-oxidation in a dose-dependent

60 Partial inhibition of beta-oxidation led to persisting T

61 Even partial inhibition of betaARK1 activity enhances beta-ad

62 , a new mutant was obtained that resulted in partial inhibition of both processes and also showed an

63 r adequate forces to drive the process, that partial inhibition of branching and polymerization lead

64 neutrophil infiltration and resulted in only partial inhibition of C-mediated hemolytic activity in v

65 A partial inhibition of C/EBP activity in Irf8(-/-) haemat

66 The partial inhibition of c27/25 mRNA translation, even when

67 ant conferred resistance to phagocytosis and partial inhibition of C3 deposition on the S. pyogenes s

68 Partial inhibition of Ca2+ responses and inositol phosph

69 It is concluded that partial inhibition of calcium-induced calcium release in

70 presence of Z-VAD-fmk was associated with a partial inhibition of caspase-8, whereas no effects on c

71 Partial inhibition of CB1R activity in Cnr1(F238L) mutan

72 tes with heparin or heparinase I resulted in partial inhibition of cell adhesion to Cyr61.

73 leads to a complete loss of tip growth and a partial inhibition of cell division, resulting in plants

74 ics was used to determine the effects of the partial inhibition of cell wall synthesis on the status

75 Partial inhibition of cerebrospinal fluid leukocyte infl

76 A mAb to CXCR4, 12G5, showed partial inhibition of chemotaxis and calcium influx indu

77 The role of PKA was suggested by partial inhibition of cholinergic stimulation by the spe

78 After partial inhibition of complex I of the ETC with amytal,

79 disrupted, cytokinesis becomes sensitive to partial inhibition of contractility.

80 The results strongly suggest a partial inhibition of current flow through the FMRFamide

81 of signal recognition particle caused only a partial inhibition of CYP2E1 translation under in vitro

82 ential upon reoxygenation, suggesting that a partial inhibition of cytochrome c oxidase had existed.

83 We conclude that partial inhibition of cytochrome oxidase during hypoxia

84 of dominant negative Foxo1 mutant results in partial inhibition of dex/cAMP-induced G6p and Pepck exp

85 Chk1 RNA interference combined with partial inhibition of DNA replication was sufficient to

86 h substitutions at either Lys6 or Arg28 show partial inhibition of DNA strand exchange activity, yet

87 nd breaks on metaphase chromosomes following partial inhibition of DNA synthesis.

88 t metaphase chromosome gaps and breaks after partial inhibition of DNA synthesis.

89 Partial inhibition of DPAGT1 with small interfering RNA

90 otoxicity to TS inhibition and indicate that partial inhibition of dUTPase is a viable therapeutic ap

91 nhibits HGF-induced cell migration with only partial inhibition of EGF-induced cell motility.

92 ve inhibitor of p38 MAPK kinase, resulted in partial inhibition of either p38- or strain-activated hB

93 O in xenobiotic oxidation in mammals and the partial inhibition of elevated AO activity by a range of

94 Partial inhibition of EMC-6 caused decreased expression

95 Partial inhibition of endogenous SFK activity with the A

96 e of N-p-tosyl-L-chloromethyl ketone and the partial inhibition of enzyme activity by diisopropyl flu

97 Partial inhibition of eotaxin release was also seen with

98 We recently showed that partial inhibition of ERK and JNK signaling before the o

99 ydrophobic molecule, diffuses into cells and partial inhibition of FAAH has a pronounced effect upon

100 ISIS 2302 demonstrated partial inhibition of factor X activation by the factor

101 ically inactive NEP protein also resulted in partial inhibition of FAK phosphorylation and cell migra

102 ced morphological changes and exhibited only partial inhibition of FAK site-specific tyrosine phospho

103 However, the partial inhibition of FGF receptor down-regulation in FR

104 om complete inhibition of bacterial NAGS, to partial inhibition of fish NAGS, to activation of frog a

105 Although treatment with R115777 resulted in partial inhibition of FTase activity in mononuclear cell

106 Partial inhibition of glucocerebrosidase activity in PrP

107 in vps21Delta and vps27Delta strains caused partial inhibition of glucose-dependent dissociation.

108 found that moderate increases in H2O2 during partial inhibition of glutathione (GSH) peroxidase by me

109 ligonucleotides, or wortmannin resulted in a partial inhibition of GM-CSF-mediated pro-survival activ

110 5R1489E in a wild-type yeast strain caused a partial inhibition of growth which was reversed by overe

111 nding to the erythrocytes is disrupted, only partial inhibition of hemolysis is mediated by TT30 in s

112 iation of the two proteins, and results in a partial inhibition of HGF-mediated activation of c-Met a

113 SIS3 also produces partial inhibition of Hoxd11/lacZ expression in cultured

114 Partial inhibition of HP1 family proteins accelerates th

115 ketone (z-VAD-fmk), and found that it caused partial inhibition of hydrogen peroxide formation as wel

116 ppaB dependent transcription, which involved partial inhibition of IkappaB and RelA/p65 serine phosph

117 hythmia in human ventricles, and establishes partial inhibition of IKs as a potential anti-arrhythmic

118 A partial inhibition of IL-2 and IL-13 production (30 and

119 Inhibition of either MAPK or PKC resulted in partial inhibition of IL-8-stimulated polymorphonuclear

120 ct of dominant-negative Stat5 expression was partial inhibition of IL3-dependent growth.

121 but not wild-type Dicer, also resulted in a partial inhibition of Influenza A virus-but not poliovir

122 naling in SCA2 pathogenesis and suggest that partial inhibition of InsP3-mediated Ca2+ signaling coul

123 Partial inhibition of insulin secretion results in impai

124 hypotheses that in nondiabetic individuals, partial inhibition of insulin secretion with the ATP-sen

125 ISIS 2302 showed partial inhibition of intrinsic tenase activity (to appr

126 Partial inhibition of IP3K causes a significant reductio

127 DP pool was experimentally reduced by either partial inhibition of isoprenoid synthesis pathway by fo

128 I-2) on Ser-71, which resulted in partial inhibition of its ATP-dependent phosphatase acti

129 Further, there was only partial inhibition of k(1) and k(2), which showed two pa

130 nule EC treated identically resulted in only partial inhibition of lymphocyte migration (<40%).

131 r downstream signal of PI3K resulted in only partial inhibition of mechanical stretch-induced prolife

132 Here we report that the partial inhibition of mechanistic target of rapamycin (m

133 Partial inhibition of mitochondrial respiration enhances

134 This work investigates if partial inhibition of mitochondrial respiratory chain pr

135 Partial inhibition of mitochondrial respiratory complex

136 Previous studies have suggested that partial inhibition of Mmp20 expression is involved in th

137 Our results suggest that even partial inhibition of MOZ may reduce the proliferative c

138 on the growth rate of these cells and only a partial inhibition of mRNA export.

139 These data suggest that partial inhibition of mTORC1 by rapamycin can be overcom

140 Scratch assays showed partial inhibition of MVS and zinc on EC migration.

141 ocytes to ouabain concentrations that caused partial inhibition of Na+/K+-ATPase but no loss of viabi

142 We showed before that in cardiac myocytes partial inhibition of Na+/K+-ATPase by nontoxic concentr

143 before that in neonatal rat cardiac myocytes partial inhibition of Na+/K+-ATPase by nontoxic concentr

144 f ouabain, i.e. net influx of Ca2+ caused by partial inhibition of Na+/K+-ATPase, also initiates the

145 Partial inhibition of NAPQI formation by CYP2E1 inhibito

146 Importantly, partial inhibition of Nav1.6 channels was sufficient to

147 th EDN3, on the other hand, resulted in only partial inhibition of neuronal differentiation.

148 Partial inhibition of neuronal energy metabolism convert

149 Dasatinib caused a partial inhibition of neutrophil responses triggered by

150 Anti-CXCL8 neutralizing antibody induced a partial inhibition of NK cell differentiation, which sug

151 KK45R, but not Akt-AAA, caused a significant partial inhibition of NO production in response to adipo

152 Partial inhibition of NO production restored gastric COX

153 the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear accumulation.

154 produced a curvilinear Dixon plot suggesting partial inhibition of nucleotide activation.

155 These results explain the partial inhibition of OASS by SAT on complex formation a

156 Partial inhibition of omega-Aga-IIIA binding by omega-co

157 eutralization of TNF functional activity and partial inhibition of other secondary biologic effects o

158 ut not prevent, senescence may be related to partial inhibition of p16 expression, as the Id-1-overex

159 ted to decrease platelet aggregation through partial inhibition of PAR1 signaling.

160 pothesis that OGs are generated in planta by partial inhibition of pathogen-encoded polygalacturonase

161 Partial inhibition of phosphorylation of ERK in wild-typ

162 satory increase in MAPK activity and in only partial inhibition of PI-3 kinase activity.

163 The ultimate effect of partial inhibition of Plk1 was the formation of micronuc

164 of the immediate early protein ICP27 causes partial inhibition of pre-mRNA splicing, with the result

165 d ADH/alpha-crystallin were adjusted so that partial inhibition of protein aggregation at 60 degrees

166 Partial inhibition of PTPases by OVA mimicked TCDD in pr

167 N17-Cdc42 caused only partial inhibition of Ras-induced low-serum growth, howe

168 -response curves, cross-desensitization, and partial inhibition of release by procaine.

169 breath of the postapneic period, there was a partial inhibition of renal SNA.

170 molecules are capable of sequence-dependent partial inhibition of replication in vitro.

171 Previous studies have demonstrated partial inhibition of retinal neovascularization in anim

172 concentrations of nine other agents produced partial inhibition of RyR1-mediated Ca(2)(+) release fro

173 , an activator of KATP channels, resulted in partial inhibition of S6K1 phosphorylation by 20 mmol/l

174 a(2+) content on SERCA activity during acute partial inhibition of SERCA.

175 t, findings that correlate with the observed partial inhibition of SK-RC-45-induced apoptosis in the

176 The partial inhibition of SK1 expression by small interferen

177 Mice treated with AMD3100 display a partial inhibition of skeletal regrowth associated with

178 Allosteric partial inhibition of soluble, monomeric proteases can o

179 e probes establish the concept of allosteric partial inhibition of soluble, monomeric proteins.

180 Partial inhibition of Sp1 expression using small interfe

181 n adipose-specific Rab10 KO female mice, the partial inhibition of stimulated glucose uptake in adipo

182 o effects on GABAA receptors that produces a partial inhibition of T-type Ca2+ current with reasonabl

183 nd functional activity of myosin-5B in vitro Partial inhibition of the actin-activated steady-state A

184 dotHCTnI(R145G) small middle dotHCTnC), only partial inhibition of the actin-tropomyosin-myosin ATPas

185 emodeling and strand pairing activities, and partial inhibition of the ATPase activity.

186 e, (p-Cl)Phe, and Trp we observe biphasic or partial inhibition of the BrAAP activity.

187 Nontoxic concentrations of ouabain, causing partial inhibition of the cardiac myocyte Na(+)/K(+)-ATP

188 We have shown previously that partial inhibition of the cardiac myocyte Na(+)/K(+)-ATP

189 Partial inhibition of the enzyme activity was observed i

190 hydrolase with 100 microM of 5b resulted in partial inhibition of the enzyme without any apparent ch

191 by using antisense oligonucleotides led to a partial inhibition of the Epo-independent proliferation

192 rotection of telomeric DNA was identified by partial inhibition of the expression of GAPDH using smal

193 We conclude that both partial inhibition of the firing of a subset of origins

194 Partial inhibition of the gene's expression by antisense

195 n merotelic correction is conserved, because partial inhibition of the human kinesin-5 homolog Eg5 us

196 ed to remove CO from solution, there is only partial inhibition of the incorporation of CO(2)-derived

197 of disulfide and non-disulfide linkages, and partial inhibition of the kinase activity.

198 ated degranulation in human mast cells and a partial inhibition of the later calcium response at high

199 We found that partial inhibition of the MEK-ERK pathway, one of the mi

200 chondrial dysfunction based upon the chronic partial inhibition of the mitochondrial enzyme cytochrom

201 Thus, partial inhibition of the MuLVs could be the result of v

202 osolic Ca(2+) increase upon stimulation, and partial inhibition of the plasma membrane Ca(2+)-ATPase,

203 lity-increasing protein (rBPI21) resulted in partial inhibition of the PMNL activation and phagocytos

204 thrombin was correlated quantitatively with partial inhibition of the rate of the thrombin-antithrom

205 n susceptible embryo fibroblasts resulted in partial inhibition of the replication of a flavivirus bu

206 In contrast to normal cells, partial inhibition of the spliceosome in MYC-hyperactiva

207 the increase in the SR load was prevented by partial inhibition of the SR Ca(2+) with thapsigargin, c

208 as primarily a consequence of selective and partial inhibition of the synthesis of the linear arabin

209 Furthermore, the partial inhibition of the T882A-catalyzed BC domain reac

210 t for patients with KCNQ2 encephalopathy, as partial inhibition of these channels counteracts the inc

211 The partial inhibition of these injuries by sCR1 may have fu

212 videnced by an increase in PARP cleavage and partial inhibition of this effect by the pan-caspase inh

213 em on platelet membranes is supported by the partial inhibition of thrombin-induced Ca2+ influx by wo

214 e possibility that obesity may be treated by partial inhibition of TKT in adipose tissue.

215 aB activation by thalidomide correlated with partial inhibition of TNF-induced degradation of an inhi

216 ant proteins (M68I, H195Y, and P318S) showed partial inhibition of TnrA DNA binding.

217 3'-FAM OMe 12-mer oligonucleotide exhibited partial inhibition of trans-activation activity, but thi

218 Partial inhibition of translation by cycloheximide, or o

219 tion of replication fork velocity but not by partial inhibition of translation or transcription.

220 red whether other agents also produce only a partial inhibition of transmission.

221 ng loop failed to inhibit FXIIa but retained partial inhibition of trypsin (Ki = 11.7 +/- 1.2 mum) an

222 on of phosphatidylinositol-3-kinase leads to partial inhibition of tumor angiogenesis, thus demonstra

223 Partial inhibition of VEGF achieved by inducible gene ta

224 Partial inhibition of viral DNA synthesis caused defects

225 k4, but not cdk2, kinase activity, producing partial inhibition of VSMC growth in vitro.

226 te, to which the binding of Zn(2+) exhibited partial inhibitions of both Cd(2+) and Hg(2+) bindings.

227 hibitor, and a dominant negative PKC exhibit partial inhibition on Wnt-mediated transcriptional activ

228 -pyridine (MPEP) site on mGlu5 but have only partial inhibition or no functional effects on the mGlu5

229 ic rate and substrate binding, implying that partial inhibition or selective inhibition with regard t

230 ; 2), the distance between RyR clusters; 3), partial inhibition or stimulation of SR Ca(2+) pumps; 4)

231 five categories: activation, autoactivation, partial inhibition, substrate inhibition, and biphasic s

232 Neutralization of IL-2 resulted in partial inhibition, suggesting that other cytokines also

233 2 signaling by two distinct mechanisms: by a partial inhibition that is decreased at elevated STAT5b

234 However, only partial inhibition was achievable, even at the highest c

235 In contrast, only partial inhibition was observed by UV-inactivated organi

236 ressing TRPC3, TRPC6, or TRPC7 and that this partial inhibition was observed whether the channels wer

237 At higher xanthine concentrations, partial inhibition was seen, suggesting formation of a s

238 However, at higher xanthine concentrations, partial inhibition was seen, suggesting the formation of

239 To understand the partial inhibition, we solved the co-crystal structure o

240 and 3-isobutyl-1-methylxanthine (970 microM, partial inhibition) were also substantially higher than

241 take phase during MCO of DTT but causes only partial inhibition when added after the reaction is well

242 the cells sampled, 54 of 137 (40%) achieved partial inhibition when tested with 60 msec tones, and t

243 n by SDS, guanidine, heat (55 degrees C), or partial inhibition with DCI, proteasomes still functione