ライフサイエンスコーパス: passenger

1 ing of the N-terminal virulence region (the 'passenger').

2 ls are typically divided into 'drivers' and 'passengers'.

3 e-exome sequencing projects as 'drivers' or 'passengers'.

4 etastasis) and 248 were nonrecurrent (likely passenger).

5 n the metastases were much more likely to be passengers.

6 utation-based framework to pick drivers from passengers.

7 tug-of-war with frequent mildly deleterious passengers.

8 ss advantage of drivers and fitness costs of passengers.

9 t proportion of mutations are drivers versus passengers.

10 of thousands of additional mutations termed passengers.

11 rs, the CPQ-PRKDC fusion transcript may be a passenger aberration related to gene amplification.

12 al, but are obscured by overlaps with larger passenger aberrations.

13 and with split fares, hinting toward a wide passenger acceptance of such a shared service.

14 omic studies suggest that mildly deleterious passengers accumulate and can collectively slow cancer p

15 From simulations, we find that passengers accumulate and largely evade natural selectio

16 brane domain to translocate their N-terminal passenger across the bacterial outer membrane (OM).

17 sm that enables transport of the central AT 'passenger' across the OM remains unclear.

18 elucidate such requirements, we used a V(D)J passenger allele system to assay, in mouse GC B cells, s

19 bility that any observed candidate gene is a passenger alteration, given the frequency of alterations

20 focused on analyzing driver alterations, the passenger alterations also provide valuable information

21 The effects of passenger alterations on cancer fitness were unrelated t

22 cogenic or tumor suppressive genes, but also passenger and potential codriver genes.

23 quilibrium process coupled to folding of the passenger and propose a model connecting passenger confo

24 s, yet no causal link between the effects of passengers and cancer progression has been established.

25 latilization, and transfer of pesticide when passengers and flight attendants come in contact with th

26 -sharing that (i) scales to large numbers of passengers and trips and (ii) dynamically generates opti

27 g on the busway and observing and talking to passengers) and drawing on Normalization Process Theory

28 $9 per seat per one-way flight and costs per passenger are often greater than airport charges levied

29 Some passengers are deleterious to cancer cells, yet have bee

30 cancer genomics data and confirmed that many passengers are likely damaging and have largely evaded n

31 Passengers are widely believed to have no role in cancer

32 Our findings refute traditional paradigms of passengers as neutral events, suggesting that passenger

33 ves prefer to ride in AVs that protect their passengers at all costs.

34 gets SHM hotspots within V exon and S region passengers at similar frequencies and that the normal SH

35 These findings suggest that alloreactive passenger B cells/plasma cells within the kidneys of hig

36 uring its somatic evolution; most are termed passengers because they do not confer cancer phenotypes.

37 ms offers a unique opportunity to understand passenger behavior at a massive scale.

38 We describe how these changes in passenger behavior lead to possible overcrowding and mod

39 , possibly due to protection provided to the passengers by the bus.

40 Passengers can also become targets for immunotherapy or

41 A tumor's load of deleterious passengers can explain previously paradoxical treatment

42 Passengers can provide important information about the e

43 ment breakpoint (GRB) regions, as well as 38 passenger candidate genes (PCGs), altered in humans only

44 lters were loaded with exhaust from a modern passenger car diesel engine on a dynamometer sampled bef

45 les (DEP) collected from a light-duty diesel passenger car engine was examined using the dithiothreit

46 odern turbocharged gasoline direct injection passenger car equipped with a three-way catalyst and an

47 The analysis of the passenger car fleet development in the city of Copenhage

48 line-exhaust particle toxicity from a Euro-5 passenger car in a uniquely realistic exposure scenario,

49 CO2 emissions and fuel consumption of an HEV passenger car to a CV of the same make and model during

50 iesel blends on the exhaust emissions from a passenger car was examined.

51 o measure NH3, CO, and CO2 from the top of a passenger car.

52 routes for 100 gasoline vehicles, including passenger cars (PCs), passenger trucks (PTs), and hybrid

53 rium-based FBCs have been commercialized for passenger cars and heavy-duty vehicle applications.

54 my and greenhouse-gas emission standards for passenger cars and light trucks.

55 material substitution on GHG emissions from passenger cars and the steel and aluminum industries unt

56 ble to yields from dilute exhaust from older passenger cars and unburned gasoline.

57 We show that light-weighting of passenger cars can become a "gigaton solution": Between

58 2010 and 2050, persistent light-weighting of passenger cars can, under optimal conditions, lead to cu

59 Passenger cars in the United States (U.S.) rely primaril

60 Light-weighting of passenger cars using high-strength steel or aluminum is

61 to changes in the relative emission rates of passenger cars versus diesel trucks, and slight uptick t

62 laboratory studies with two gasoline-fueled passenger cars, we found that as much as 20-30% of the n

63 larger vehicles and light trucks relative to passenger cars.

64 Passenger CD4 lymphocytes might therefore contribute to

65 w graft-versus-host (GVH) allorecognition by passenger CD4 T cells within MHC class II-mismatched bm1

66 l microtubule bundles coated with chromosome passenger complex (CPC) and centralspindlin that instruc

67 row-inducing signaling complexes, chromosome passenger complex (CPC) and Centralspindlin, to a plane

68 midzone proteins, including the chromosomal passenger complex (CPC) and centralspindlin.

69 TD-60 has a typical chromosomal passenger complex (CPC) distribution in mitotic cells, b

70 The chromosomal passenger complex (CPC) in animals, consisting of Aurora

71 The chromosomal passenger complex (CPC) is a conserved, essential regula

72 The chromosome passenger complex (CPC) is a master regulator of mitosis

73 The chromosomal passenger complex (CPC) localizes to centromeres in earl

74 The chromosomal passenger complex (CPC) localizes to centromeres where i

75 Meiotic cells contain a second chromosomal passenger complex (CPC) population, with Aurora kinase B

76 During cytokinesis, the chromosomal passenger complex (CPC) promotes midzone organization, s

77 volved in the recruitment of the chromosomal passenger complex (CPC) to kinetochores in mitosis.

78 alin is a major component of the Chromosomal Passenger Complex (CPC) with well-known functions in mit

79 correlated with components of the chromosome passenger complex (CPC), a key regulator of mitosis.

80 hat perturbs localization of the chromosomal passenger complex (CPC), AURKC p.C229Y is a hypomorph th

81 The chromosomal passenger complex (CPC), composed of inner centromere pr

82 The highly conserved chromosomal passenger complex (CPC), containing mitotic kinase Auror

83 is activity is antagonized by the chromosome passenger complex (CPC), resulting in RhoA activation at

84 B, the catalytic subunit of the chromosomal passenger complex (CPC), uncovering a feedback mechanism

85 The four-subunit chromosomal passenger complex (CPC), whose enzymatic subunit is Auro

86 association of Shugoshin and the chromosomal passenger complex (CPC), without abolishing global Auror

87 1), a member of the four-subunit chromosomal passenger complex (CPC).

88 is an essential component of the chromosomal passenger complex and a member of the inhibitor of apopt

89 t localization of members of the chromosomal passenger complex and mitotic kinesin-like protein 1 and

90 The chromosomal passenger complex containing Aurora B can be found on a

91 Finally, the chromosomal passenger complex is required for cytokinesis only early

92 We further show that the chromosomal passenger complex orchestrates multiple centrosome-indep

93 s the catalytic component of the chromosomal passenger complex, an essential regulator of chromosome

94 is the catalytic component of the chromosome passenger complex, which is involved in correct chromoso

95 the passenger and propose a model connecting passenger conformation to secretion kinetics.

96 ollective benefits of sharing and individual passenger discomfort is lacking.

97 on cities, but this comes at the expense of passenger discomfort quantifiable in terms of a longer t

98 hat with increasing but still relatively low passenger discomfort, cumulative trip length can be cut

99 aim of cancer research, namely cancer driver-passenger distinction.

100 pansion of this study would make more driver-passenger distinctions for cancers with large genomic am

101 the targeted gene is flanked by ESC-derived passenger DNA potentially containing mutations.

102 - play a role in oncogenesis, and which are passengers - do not play a role.

103 mbrane protease IcsP yields highly pure IcsA passenger domain (residues 53-758).

104 Their mature form contains a passenger domain and a C-terminal beta-domain that ancho

105 model in which both the translocation of the passenger domain and the membrane integration of the bet

106 e evidence that the free energy derived from passenger domain folding contributes to secretion effici

107 Blocking pPL translocation by passenger domain folding favored stabilization of an alt

108 eriplasm lacks ATP, vectorial folding of the passenger domain in a C-to-N-terminal direction has been

109 The mechanism by which the passenger domain is secreted is poorly understood.

110 Although it was originally proposed that the passenger domain is translocated across the OM through a

111 c and describe the solution structure of the passenger domain obtained by small-angle X-ray scatterin

112 at vaccination with the recombinant secreted passenger domain of EatA (rEatAp) elicits high titers of

113 disrupt the folding of the C terminus of the passenger domain of the Escherichia coli O157:H7 autotra

114 ng an epitope tag into the N terminus of the passenger domain of the inverse autotransporter intimin,

115 acteria and facilitates the transport of the passenger domain onto the cell surface.

116 lacks ATP, the source of energy that drives passenger domain secretion is unknown.

117 The beta domain is required for passenger domain secretion, but its exact role in autotr

118 sporter protein with an approximately 80-kDa passenger domain that contains a subtilisin-related doma

119 experiments show direct binding of the IcsA passenger domain to both the WASP homology 1 (WH1) domai

120 t the beta domain does not simply target the passenger domain to the outer membrane, but promotes tra

121 ng step in autotransporter assembly and that passenger domain translocation does not require the inpu

122 hin these motifs slow the rate and extent of passenger domain translocation to the surface of bacteri

123 nsist of an N-terminal beta-helical domain ("passenger domain") that is secreted into the extracellul

124 sist of an N-terminal extracellular domain ('passenger domain') and a C-terminal beta-barrel domain t

125 t that, similar to the secretion of the VacA passenger domain, the N-terminal domains of protease-sus

126 cation unit and an extracellular effector or passenger domain.

127 ocess that entraps segments of an N-terminal passenger domain.

128 facilitates unidirectional secretion of the passenger domain.

129 s that contain an N-terminal extracellular ("passenger") domain and a C-terminal beta barrel ("beta")

130 They contain an N-terminal extracellular ("passenger") domain that folds into a beta-helical struct

131 el domain and an extracellular coiled-coil ("passenger") domain.

132 consisting of an N-terminal extracellular ('passenger') domain and a C-terminal beta barrel ('beta')

133 plasm that persists until the termination of passenger-domain translocation.

134 c proteases; and (v) inverse autotransporter passenger domains are translocated by a hairpin mechanis

135 ant Escherichia coli, Y. pestis, or purified passenger domains.

136 We found that passengers dramatically reduced proliferative fitness (

137 s on two major roads to carry at least three passengers during peak hours.

138 known whether deletion of MIR-491 is only a passenger event or has an important role.

139 more refined picture of the major driver and passenger events in the elucidation of cancer progressio

140 reliable distinction between true driver and passenger events.

141 the therapeutically targetable fusions from passenger events.

142 ancer genomes, but many of these are random, passenger events.

143 behaved as wild-type KEAP1, thus are likely passenger events.

144 hing such "driver" mutations from innocuous "passenger" events is critical for prioritizing the valid

145 along with many more pathologically neutral "passenger" events.

146 n reduce in-cabin UFPs by approximately 90%, passenger-exhaled carbon dioxide (CO2) can quickly accum

147 Pathobionts (or bacterial passengers) exploit disrupted host homeostasis to flouri

148 believed to have no role in cancer, yet many passengers fall within protein-coding genes and other fu

149 Worldwide, 2.75 billion passengers fly on commercial airlines annually.

150 adictory reports regarding the importance of passenger folding as a driving force for OM translocatio

151 arian AVs (that is, AVs that sacrifice their passengers for the greater good) and would like others t

152 s for a Sec23b gene trap allele, excluding a passenger gene mutation as the cause of the pancreatic l

153 Passenger gene mutations, which do not have known or pre

154 cogenes are overexpressed, while coamplified passenger genes may be silenced epigenetically.

155 ulnerabilities resulting from co-deletion of passenger genes neighboring TSG.

156 enge the simple dichotomy between driver and passenger genes.

157 tiple cancer lineages augmented by a common "passenger" genomic alteration.

158 During short haul flight, aisle passengers have higher fomite exposure.

159 than previously thought, and may simply be a passenger in the adenoma-carcinoma sequence.

160 can accurately predict the fitness costs of passengers in cell lines and in human breast cancers.

161 econd, AID mutates targets in diverse non-Ig passengers in GC B cells at levels similar to those of V

162 ically active driver mutations over inactive passengers in high-throughput sequencing cancer data set

163 lective benefits of sharing as a function of passenger inconvenience, and to efficiently compute opti

164 retained the ability to be incorporated as a passenger into F-driven VLPs, provided that the F protei

165 In vitro, the purified YapV passenger is functional and rich in beta-sheet structure

166 The collective deleterious effect of passengers is currently an unexploited therapeutic targe

167 y to distinguish functional aberrations from passengers is to identify those aberrations that are rec

168 The BC mass emissions per passenger-km were similar to gasoline vehicles, but the

169 between 53 and 940 g of CO2 equivalents per passenger-km.

170 recipient-type cells showed a high degree of passenger leukocyte chimerism by immunohistochemistry an

171 lized ex vivo lung perfusion (EVLP) to study passenger leukocyte migration from donor lungs into the

172 Passenger leukocyte transfer from the donor lung to the

173 e obtained from chimeric swine, in which the passenger leukocytes (but not the parenchyma) were major

174 lung transplantation, and the role played by passenger leukocytes in the rejection or acceptance of a

175 potential immunological advantage of lacking passenger leukocytes including antigen-presenting cells.

176 The chimeric lungs containing passenger leukocytes matched to the lung recipient (grou

177 Therefore, the depletion of passenger leukocytes may be clinically applicable as a s

178 Our data indicate that recipient-matching of passenger leukocytes significantly prolongs lung allogra

179 r organs depends on the trafficking of donor passenger leukocytes to the secondary lymphoid organs of

180 (group 2), both the donor parenchyma and the passenger leukocytes were major histocompatibility compl

181 ed whether recipient-matching of donor graft passenger leukocytes would impact graft survival in a pr

182 cal data also suggest an association between passenger load and response to therapeutics, yet no caus

183 assengers as neutral events, suggesting that passenger load reduces the fitness of cancer cells and s

184 e developed new genomic measures of damaging passenger load that can accurately predict the fitness c

185 on of adaptive drivers, but incurs a harmful passenger load that can outweigh driver benefit.

186 duction of genomic instability and increased passenger load.

187 To assess this, we introduced increasing passenger loads into human cell lines and immunocompromi

188 A method for in-use measurement of passenger locomotives, using a portable emissions measur

189 ion rates of two-stroke engines used in many passenger locomotives.

190 Passenger lymphocyte syndrome (PLS) is an immune-mediate

191 ty is expected to bring about destruction of passenger lymphocytes within heart allografts, this proc

192 In this study, we measure the passenger methylation patterns of a specific CpG region

193 Passenger microbiota may play a role in the maintenance

194 This study reveals how commensal and passenger microorganisms could be important in promoting

195 NA reads uncovered 207 unknown minor strand (passenger) microRNAs of known microRNA loci and 495 nove

196 em cells carry a 129-associated inactivating passenger mutation on the caspase-11 locus, essentially

197 ying a surrogate tumor antigen (mimicking a "passenger" mutation) by T(E) cells requires action of IF

198 entirely discordant in twin pairs and likely passenger mutations acquired during leukemic cell prolif

199 from sequence data, due to a large number of passenger mutations and lack of comprehensive sequence i

200 nating between driver (cancer-promoting) and passenger mutations are becoming increasingly important.

201 e required for the cancer phenotype, whereas passenger mutations are irrelevant to tumor development

202 Due to the overwhelming number of passenger mutations in the human tumor genome, it is dif

203 o estimate the number and possible effect of passenger mutations in transgenic mice of interest.

204 e for cancer (driver mutations) from random, passenger mutations is a key challenge in cancer genomic

205 tumorigenesis in each patient from a sea of passenger mutations is necessary for translating the ful

206 probabilities and frequencies of successive passenger mutations ordered by their time of appearance.

207 that nearly all these mice possess multiple passenger mutations potentially influencing the phenotyp

208 ter-arising subclones, resulting in numerous passenger mutations that are responsible for intratumora

209 to distinguish driver mutations from neutral passenger mutations to facilitate the identification of

210 Annotating these passenger mutations to the reported genetically modified

211 l evolution with the emergence of driver and passenger mutations under the infinite-allele assumption

212 this phenotypic interference of 129-derived passenger mutations with several case studies and develo

213 e little or no effect on tumour progression (passenger mutations).

214 Even with respect to these passenger mutations, our analysis suggests that the gene

215 sformation assays differentiated driver from passenger mutations, revealing that PIK3CA variant activ

216 landscape in AML and distinguish driver from passenger mutations, we compared the mutational profiles

217 utations occur alongside thousands of random passenger mutations--a natural consequence of cancer's e

218 described together with putative driver and passenger mutations.

219 n of patterns that differentiate driver from passenger mutations.

220 ver mutations from a larger number of random passenger mutations.

221 le for tumorigenesis while a larger body of "passenger" mutations occur in the tumor but do not progr

222 ic variants, but most of these variants are "passenger" mutations that are phenotypically neutral and

223 fferentiate these mutations from the benign "passenger" mutations which occur in the tumor but do not

224 targets noncoding regions causing numerous "passenger" mutations, but it has the potential to genera

225 Consider a banal scenario: a seated passenger on a crowded bus stands up and someone takes h

226 he main mode of transport for over 5 million passengers on an average weekday.

227 ause this process, with the biota as passive passengers on continental blocks.

228 are insufficient to distinguish driver from passenger or bystander mutations.

229 of links in a transport network that satisfy passengers or cargo transportation demands while minimiz

230 he role of air travel in bringing infectious passengers or vectors to previously non-endemic areas.

231 itor cells generated in the yolk sac and of 'passenger' or 'transitory' myeloid cells that originate

232 with rider capacity of up to 10 simultaneous passengers per vehicle.

233 strates that even species as abundant as the passenger pigeon can be vulnerable to human threats if t

234 opulations will be more genetically diverse, passenger pigeon genetic diversity was surprisingly low.

235 This result suggests that the passenger pigeon was not always super abundant but exper

236 The extinct passenger pigeon was once the most abundant bird in Nort

237 The passenger pigeon was once the most abundant bird in the

238 m most of the genome, we calculated that the passenger pigeon's effective population size throughout

239 e role of natural population dynamics in the passenger pigeon's extinction remains unexplored.

240 acted with human exploitation in causing the passenger pigeon's rapid demise.

241 41 mitochondrial and 4 nuclear genomes from passenger pigeons and 2 genomes from band-tailed pigeons

242 genomes from band-tailed pigeons, which are passenger pigeons' closest living relatives.

243 Passenger pigeons' large population size appears to have

244 These passengers present a barrier to cancer progression descr

245 Accurate mitosis requires the chromosomal passenger protein complex (CPC) containing Aurora B kina

246 Physician passengers provided medical assistance in 48.1% of in-fl

247 me that when translocation was blocked an AT passenger remained unfolded in the periplasm.

248 nd which mutations are drivers and which are passengers remains to be determined.

249 o the plus end by Kip2, but is not a passive passenger, resisting its own plus-end-directed motion.

250 Thus, in contrast to the traditional 'passenger' role of a co-repressor, CBFA2T2 functions syn

251 erra Leone as of Sept 1, 2014 (reductions in passenger seats by 51% for Liberia, 66% for Guinea, and

252 d an in vivo assay to study AID targeting of passenger sequences replacing a V exon.

253 ail yard (RY) and over-the-rail (OTR) during passenger service.

254 st in trains; however, the average number of passengers sharing an indoor space was highest in trains

255 y stochastic events will be inconsequential "passengers," some will confer a fitness advantage to a c

256 and booster seat use for child motor vehicle passengers, speed limit and drunk driving laws, and alco

257 nding of duplex siRNA bound to AGO1 requires passenger strand cleavage in vitro.

258 Moreover, passenger strand cleavage is required for assembly of ac

259 rects gene silencing, is retained, while the passenger strand is degraded.

260 In particular, a passenger strand miR, miR-21*, was identified as a poten

261 inducing the microRNA (miRNA) miR-33 and its passenger strand miR-33*, Mtb inhibited integrated pathw

262 nthetic click conjugation of polymers to the passenger strand of an siRNA duplex followed by annealin

263 Typically, Argonaute slices and releases the passenger strand of duplex sRNA to generate active silen

264 miR-122*, the passenger strand of miR-122, regulates the activity of p

265 at internal positions of both the guide and passenger strand of siRNAs and may increase the silencin

266 is regulatory circuit, namely, miR-122*, the passenger strand of the abundantly expressed liver-speci

267 activity when placed near the 5'-end of the passenger strand.

268 ed a relatively high abundance of many miRNA passenger strands ("star" miRNAs), which normally underg

269 rosophila, C3POs cleave the fragmented siRNA passenger strands and facilitate the activation of RNA-i

270 A walk of (S)-GNA along the guide and passenger strands of a GalNAc conjugate duplex targeting

271 ants dramatically overaccumulated microRNA* (passenger) strands, and immunoprecipitated ALG-1(anti) c

272 Most of the somatic alterations are passengers that are neutral to tumor cell selection.

273 gene" mutations; the remaining mutations are passengers that confer no selective growth advantage.

274 estrians or sacrificing themselves and their passenger to save the pedestrians.

275 r maybe, just maybe, he intended for another passenger to sit comfortably, to increase the happiness

276 of origin coincides with an increase in air passengers to Brazil from ZIKV-endemic areas, as well as

277 nificantly associated with the volume of air passengers to China (P = 0.006), parasite prevalence in

278 We randomize the intervention, which nudges passengers to complain to their drivers directly, across

279 Disruptions, or shocks, force passengers to make different decisions concerning which

280 and folding of the beta-barrel but also for passenger translocation.

281 om freight are projected to grow faster than passenger transportation or other major end-use sectors,

282 ding insulation, electricity generation, and passenger transportation.

283 f check-ins and checks-out is considered and passengers travel along fastest paths in a network affec

284 ne vehicles, including passenger cars (PCs), passenger trucks (PTs), and hybrid electric vehicles (HE

285 pecially great as the electrification of the passenger vehicle fleet (from HEVs to PHEVs to BEVs) inc

286 emissions savings from hybridization of the passenger vehicle fleet.

287 ly 30% of the average gasoline use in a U.S. passenger vehicle in 2007.

288 ower steering motor embedded in conventional passenger vehicles and drive motor/generator embedded in

289 d electronic (EE) components of conventional passenger vehicles and in the end-of-life vehicle shredd

290 Modern passenger vehicles are commonly equipped with cabin air

291 hicles, many scarce metals (SMs) are used in passenger vehicles because of their unique physical and

292 n-use NOx emissions from small-engine diesel passenger vehicles produced a significant contribution t

293 easingly embedded in other products, notably passenger vehicles.

294 ir total masses in 100 hypothetical midrange passenger vehicles.

295 onsumption and GHG emissions from light-duty passenger vehicles.

296 f mutations in the exome of cancer cells are passengers, which do not affect the reproductive rate of

297 Passengers who had previously travelled frequently on re

298 male and 34.8% of female students rode as a passenger with a marijuana-using driver (P = .21).

299 t least a 2-fold increase in risk of being a passenger with another user; the reverse was also true.

300 It emerged that there were two groups of passengers with different experiences and attitudes.