ライフサイエンスコーパス: past

1 major focus for drug discovery in the recent past.

2 ent, and highest in those who took it in the past.

3 iogeography that have been overlooked in the past.

4 ecurrence may have been more frequent in the past.

5 of atmospheric contamination occurred in the past.

6 Advances over the past 10 years have allowed large-scale assessment of one

7 ich somewhat surprisingly appeared to extend past 10 years of follow-up and include cancers at distan

8 quality of life have gained momentum in the past 10 years.

9 CTs published in high-impact journals in the past 10 years.

10 Despite advances over the past 100 years, endophthalmitis is an important sight-th

11 patients who had infectious enteritis in the past 12 months than in those who had not (95% CI, 3.1-5.

12 ge, access to and use of medical care in the past 12 months, and health status as reported by the res

13 nd 21% reported a dilated examination in the past 12 months.

14 t 5 sources of eye health information in the past 12 months.

15 Looking back at the past 12 years, we present here the 'golden set' of datab

16 uth has therefore persisted for at least the past 125 kyr.

17 In the past, (13)C NMR spectroscopy (irm-(13)C NMR) was mainly

18 pe for a set of baseline conditions over the past 15 000 years to assess past rates of emergence and

19 Over the past 15 years, characterisation of the systems that unde

20 rned area declined by 24.3 +/- 8.8% over the past 18 years.

21 ed undiagnosed diabetes increased during the past 2 decades (from 0.89% in 1988 to 1994 to 1.2% in 20

22 he incidence of IBD has been observed in the past 2 decades, mainly in developed countries but also i

23 ty rates have decreased substantially in the past 2 decades, this trend has been primarily limited to

24 During the past 2 decades, understanding how DDR drives cancer deve

25 Number of BCCs in the past 2 years and over lifetime (disease burden), risk fa

26 tries that have experienced shortages in the past 2 years and to describe factors contributing to the

27 of yellow fever in Angola and Brazil in the past 2 years, combined with global shortages in vaccine

28 For the past 2 years, the goal of our group has been to establis

29 For the past 2-3 years, direct lithography on NC films with e-be

30 ded interface have dominated research in the past 20 y, with many "low-shrinkage" composites being la

31 However, in the past 20 years it has been found that some assemblies con

32 Over the past 20 years, a large body of experimental and epidemio

33 d to have had a myocardial infarction in the past 20 years, multi-vessel coronary artery disease, his

34 Here we examine how, in the recent past (2000-2014), weather variations in 103 source count

35 Consumption of turkey during the past 24 hr was not associated with total arsenic or DMA

36 e of kestrel nesting advanced 15 days in the past 24 years and was positively associated with the SoG

37 uire expansion of high topography during the past 25 Myr.

38 as dominated the field of hepatology for the past 25 years, and its cure in the majority of treated p

39 tion have gradually gained importance in the past 25 years; these reforms were designed and implement

40 t during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (c

41 It past 3 years in 2017 after the first purchase of the dru

42 he dynamics of the phosphorus cycle over the past 3.5 billion years, it remains uncertain whether pho

43 ces in marine sedimentary rocks spanning the past 3.5 billion years.

44 rette smoking and e-cigarette use within the past 30 days (0 days [none], 1-2 days [infrequent], or >

45 g marijuana occasionally) and marijuana use (past 30 days).

46 controls, ED had higher total drinks in the past 30 days, higher levels of LPS, sCD14 and sCD163.

47 , and had used non-prescribed opioids in the past 30 days.

48 clinical and economic evaluations during the past 30 years.

49 subsequent cigarette smoking initiation and past 30-day cigarette smoking.

50 has been the success story of the century's past 4 decades.

51 to assess maladaptive grief symptoms in the past 4 weeks.

52 burning occurred at least three times in the past 4,500 years.

53 biomass and active layer thickening over the past 40 years not only have major implications for energ

54 Over the past 40 years, intramolecular hydroacylation has favored

55 ADP-ribosylated proteins identified from the past 40 years, with a hope to facilitate the research of

56 become a standard-of-care procedure over the past 40 years.

57 s and management of ROP has changed over the past 40 years; the role of anti-VEGF therapy remains to

58 r role in modulating CREB transcription, the past 5 years has seen an expansion in knowledge of new c

59 e British) and the number of partners in the past 5 years was greater (median 2 [IQR 1-4] for black C

60 In the past 5 years, e-cigarette use has been increasing rapidl

61 In just the past 5 years, over 100 antisense oligonucleotide-based t

62 In the past 5 years, Parkinson's disease cases developed additi

63 In the past 5 years, success of immune checkpoint inhibition ha

64 y disease or use of asthma medication in the past 5 years.

65 ein modeling tools has been developed in the past 5-10 years, yet few of these tools are integrated a

66 able jellyfish products twice yearly for the past 5-6 years.

67 sen across three Drosophila species over the past 5.4 million years (1.67 per million years for each

68 Over the past 50 years in pharmacology, an understanding of seven

69 Over the past 50 years one such lineage of meningococci, known as

70 t only at how sign has been studied over the past 50 years, but also at how the spontaneous gestures

71 In the past 50 years, significant progress in women's equality

72 been the foundation of our specialty for the past 50 years.

73 y seven Y-linked genes being gained over the past 63 million years (0.12 gene gains per million years

74 Purpose For the past 65 years, patient age at diagnosis has been widely

75 b therapy and observational studies from the past 7 years of clinical experience in Europe.

76 d with Cox regression with survival censored past 90 days.

77 te nature of the crown barbs, resulting from past admixture appears to have rendered a duller structu

78 ctical algorithm based on the combination of past alcoholism treatments and age.

79 Age and lack of past alcoholism treatments were independently associated

80 or role in shaping species' evolution in the past and could also play a major role in shaping their e

81 nostructures necessary for SM detection, the past and current methodologies for verifying SMSERS, and

82 BMI over 25 kg/m(2), diabetes, past and current smoking, red meat consumption, saturate

83 onable assumptions, one can incorporate both past and future exposures as multiple negative control e

84 the memory period lengthens is a blending of past and present information apparent in behavior, reach

85 al in space or time (as shown for the recent past) and are expected to drive major biodiversity loss

86 and dwindling size estimates for most of the past; and 2) the 'immigrant' haplotypes showing growth t

87 onding surface topography, and that over the past approximately 220 ka, at least, the changes are rel

88 [AJP at 175: Remembering Our Past As We Envision Our Future April 1995: Effect of Hea

89 [AJP at 175: Remembering Our Past As We Envision Our Future November 1946: The Geneti

90 e the commendable growth it had shown in the past both in teaching and research.

91 Advances in public health in the past century have seen a sharp increase in human life ex

92 e conterminous United States (U.S.) over the past century, and report trends in spring and fall frost

93 stem cell cues have been determined over the past century, but in the past decade, our molecular unde

94 oxies in lacustrine sediments to reconstruct past changes in primary production.

95 ons are guided by a few episodic memories of past choices.

96 Proxy-based indicators of past climate change show that current global climate mod

97 black carbon an essential tool for assessing past climate sensitivity and modeling future climate sce

98 archive of long-term ecological responses to past climate transitions.

99 strain levels of atmospheric oxidants during past climate transitions.

100 f body size evolution is primarily driven by past climate.

101 s, perhaps this is how a few corals survived past CO2 increases, such as the Paleocene-Eocene Thermal

102 ivities on TOC changes requires knowledge of past concentrations; however, water-monitoring data are

103 Returning reefs to past configurations is no longer an option.

104 Analysis of past data has indicated that the resurfacing progressed

105 e waters were analyzed using the data of the past decade (>200000 observations).

106 of MI did not significantly decrease in the past decade and has been consistently associated with wo

107 We examined how practice changes in the past decade correlated with time trends in average eGFR

108 trometry-based proteomic technology over the past decade from the viewpoint of our laboratory.

109 The past decade has brought tremendous progress in unravelin

110 n of computing and web technologies over the past decade has enabled the development of fully fledged

111 The past decade has seen significant advances in understandi

112 The past decade has seen the emergence of new diagnostics an

113 The past decade has witnessed great progress in the developm

114 Studies over the past decade have revealed a large number of disease-rela

115 ) has been increasing significantly over the past decade in part as a result of increased recognition

116 dicine as their professional career over the past decade is substantial.

117 An emerging theme over the past decade is that variations in these inhibitors predi

118 n-critical medical problem identified in the past decade of manned spaceflight.

119 This article will describe the past decade of work toward this goal and articulate both

120 Studies of human mobility in the past decade revealed a number of general scaling laws.

121 ecisively evaluated available data (from the past decade) pertaining towards fungal occurrence and le

122 lemented surgical safety intervention of the past decade, a review of literature, spanning surgery, a

123 s with the same receptor.IMPORTANCE Over the past decade, AAV vectors have emerged as leading gene de

124 For the past decade, advanced renal cell carcinoma (RCC) has bee

125 lococcus aureus (MRSA) has declined over the past decade, but it is unclear whether this represents a

126 for crop plants have been generated over the past decade, but these genomes are often fragmented and

127 s overall not appreciably increased over the past decade, except in preclinical stroke research, whic

128 During the past decade, genome-wide association studies (GWAS) have

129 During the past decade, knowledge of pathogen life history has grea

130 sed in the United States and Canada over the past decade, largely attributable to a notable increase

131 e advances in sequencing technology over the past decade, linkage map densities have been increasing

132 determined over the past century, but in the past decade, our molecular understanding of mechanobiolo

133 Over the past decade, percutaneous left atrial appendage closure

134 CO2 uptake rates have been growing over the past decade, reversing a trend of stagnant or declining

135 Over the past decade, studies have identified miRNAs as playing a

136 In the past decade, the focus has shifted to kinetically trappe

137 est has grown in precision medicine over the past decade, the principle of companion diagnostics has

138 d update the research in this field from the past decade.

139 e detection of PCa biomarker revealed in the past decade.

140 has risen rapidly in Southeast Asia over the past decade.

141 irtually no progress had been made until the past decade.

142 in the management of these patients over the past decade.

143 -movement (REM) sleep have occurred over the past decade.

144 the general population, and changes over the past decade.

145 lars awarded to dental institutions over the past decade; however, given the year-to-year variability

146 Over the past decades, increasing the concentration of FAEs and E

147 Over the past decades, polymeric micelles have emerged as one of

148 Over the past decades, the landscape of adult congenital heart di

149 tests for GERD have been developed over the past decades.

150 ovascular risk factors have changed over the past decades.

151 n sensitivity and size resolution during the past decades.

152 Deep-fat frying of the cowpea pastes decreased their TPC, radical scavenging capacitie

153 IgM) results in areas with various levels of past dengue virus (DENV) infection incidence.

154 rnstein and colleagues look for lessons from past discovery.

155 recensus sites may still be recovering from past disturbances, potentially skewing our interpretatio

156 s to climate (genetic differentiation due to past divergent climatic selection vs. plastic responses

157 ive DNA polymerases are unable to synthesize past DNA adducts that result from diverse chemicals, rea

158 the importance of considering the legacy of past ecosystem impacts and how recovery or persistence o

159 Bayesian estimation of past effective population sizes reveals two differing de

160 ion of the complexities of RAS that thwarted past efforts, and armed with new technologies and direct

161 gree to which debris-covered glaciers record past environmental conditions is debated.

162 he human genome sequence, which reveals many past epidemics of gammaretrovirus infection, and from re

163 actions among symbionts, which can depend on past events at multiple spatial scales.

164 pective of others, when imagining future and past events, and during mind wandering.

165 ptation to particular temporal properties of past events, such as the frequency of occurrence of a st

166 tic pollinators and antagonistic herbivores, past experience (learning) affects such decisions, which

167 ails when we encounter new problems in which past experience leads to a mental rut.

168 ngrams" are thought to represent memories of past experience.

169 GMP network proteins acquires knowledge from past experiences and enables bacteria to use it to direc

170 Similarly, past exposure to bleaching in 1998 and 2002 did not less

171 currently are infected with HBV or have had past exposure to HBV.

172 logical and life history traits to influence past extirpation probabilities of native freshwater fish

173 e-shelf channels have been changing over the past few centuries.

174 The past few decades have seen the consolidation of influenc

175 ocities have been explored in depth over the past few decades, but scholars have started to examine m

176 ng data are typically only available for the past few decades, if at all.

177 In the past few decades, minimally invasive methods that approa

178 Over the past few decades, NMR spectroscopy has become an establi

179 Our approach has evolved dramatically in the past few decades, where novel insights into the molecula

180 have been reported in large volumes over the past few decades.

181 , despite many neuroimaging studies over the past few decades.

182 ntly growing knowledge of ozonation over the past few years, the characterization of transformation p

183 tense research on Weyl semimetals during the past few years, we have come to appreciate that typical

184 g data has been extensively generated in the past few years, which poses a great challenge to data in

185 of perovskite solar cells has surged in the past few years, while the bandgaps of current perovskite

186 h has revolutionized genetic research in the past few years.

187 which have been developing rapidly over the past few years.

188 s in intron 1 could conceivably help explain past findings relating familial atypical thyroid functio

189 e weather occurrence across China during the past five decades.

190 In the past five years, human PSC-derived organoids with compon

191 aic power conversion efficiencies during the past five years, metal-halide perovskites (MHPs) have em

192 SSIs (n = 13) and hand plates (n = 6) in the past five years.

193 in comparison with the method chosen in the past for these measurements, i.e., isotope ratio mass sp

194 Methodological breakthroughs over the past four decades have repeatedly revolutionized transcr

195 However, past functional studies have focused largely on seed pro

196 water soluble index, enzyme susceptibility, pasting, gel texture, and thermal properties of the flou

197 Over the past half century there has been an increasing frequency

198 e most basic functions of life, and over the past half-century, these natural micellar structures hav

199 streamflow) at the sub-basin scale over the past half-century.

200 is essential for determining the impacts of past human activities on marine environments.

201 t archaeological evidence for the impacts of past hunter-gatherers, agriculturalists and urban settle

202 tors related to food unpredictability in the past, including stress, disease, micronutrient content o

203 s on each trial as a function of present and past information.

204 Past investigations indicated that APLP1 is involved in

205 ars to assess its potential as a habitat for past life and investigate the paleoclimate record preser

206 e reduction in the IgE binding properties of pastes made from treated cashew and pistachio nuts.

207 We conclude that the ongoing and past methane emission episodes at the investigated sites

208 l research of European developments over the past millennium suggests that such institutions become i

209 the appearance of larger ice sheets over the past million years was a consequence of an increase in t

210 However, all past models tested failed to reproduce the most salient

211 No participant had current or past neurological conditions or major medical conditions

212 l, with the strongest risk factors including past nonadherence and being an adolescent or young adult

213 , as such, would be part of the evolutionary past of all forms of modern life.

214 nality may compete with a bias that reflects past outcomes.

215 behavior by linking current opportunities to past outcomes.

216 n genetic diversity to those associated with past paleodrainage properties.

217 e primary outcome was detection of active or past placental malarial infection by histopathologic ana

218 ative importance can be assessed by tracking past population fluctuations over considerable time peri

219 cal processes with recombination can uncover past population history in unprecedented detail.

220 erences 38 Characterizing plant responses to past, present and future changes in atmospheric carbon d

221 Changes in the pasting profiles of heat-moisture treated starches were

222 stallinity, water solubility and absorption, pasting properties, reconstitution test, proximate compo

223 ditions over the past 15 000 years to assess past rates of emergence and investigate underlying cause

224 ales, but its existence over the most recent past remains unclear.

225 This finding is discussed in relation to past research on responses and entrainment to rhythms, a

226 In addition, past return and present risk modulated with the activity

227 vity in the cuneus; while present return and past risk modulated with the activity in the superior te

228 ty within paleodrainages can be explained by past riverine properties (i.e., area and number of river

229 ions, a model in which the recent history of past samples determines a belief about category means fi

230 -floating mire, yet it has formed during the past seven centuries and represents the greatest accumul

231 treme heat wave events have increased in the past several decades and are likely to continue to incre

232 The past several decades have witnessed the rapid developmen

233 Over the past several decades, BP has declined and hypertension c

234 ves among diverse porous materials, over the past several decades, ideal molecular sieves for the sep

235 Over the past several decades, numerous studies have greatly expa

236 Over the past several decades, we have learned a tremendous amoun

237 graphic distribution have increased over the past several decades.

238 The past several years have seen an explosion in development

239 In the past several years, inflammasome activation and subseque

240 Over the past several years, numerous studies have been performed

241 During the past several years, the number of contacts with Dutch PC

242 Over the past several years, there has been a considerable amount

243 lantic have shown a marked decrease over the past several years.

244 Past studies did not consider the role of non-neuronal c

245 f the 2015 EN event and its differences from past super EN events is crucial for improving EN predict

246 otopic labeling, have not been considered in past syntheses.

247 Over the past ten years or so, great advances in our understandin

248 n, which enables error-prone DNA replication past the adduct.

249 ve addition of subducted N to the mantle and past the zones of arc magma generation.

250 In the recent past, the intradermal delivery of NPs, via novel dissolv

251 In the past, this diverse collection of sequences from human as

252 osteosarcoma (OS) has improved little in the past three decades, and better models for study are need

253 the beta-catenin signaling pathway over the past three decades, attempts to develop therapies target

254 chemical cues have been elucidated over the past three decades, the mechanisms that animals use to s

255 United States (FluMist) have arisen over the past three seasons (2013-2014, 2014-2015, and 2015-2016)

256 ends current input with that from the recent past to guide ongoing decision making.

257 Infrared spectroscopy has been used in the past to probe the dynamics of internal proton transfer r

258 l diagenesis, allowing the identification of past TOC variations in northern lakes of Europe and Nort

259 In 1816, the coldest summer of the past two centuries was observed over northeastern North

260 Extensive research over the past two decades has established a central role for mTOR

261 and small-molecule kinase inhibitors in the past two decades has substantially improved clinical out

262 therapeutic drug discovery programs over the past two decades have yielded some important insights bu

263 Over the past two decades, building on a preceding era of morphol

264 was proposed and has been implemented in the past two decades, in which transplantation is indicated

265 Over the past two decades, multiple studies have focused on eluci

266 ity has gradually reduced eelgrass cover the past two decades, primarily in deeper beds where light i

267 Over the past two decades, the molecular machinery that underlies

268 ttings has increased dramatically during the past two decades, yet gaps in the quality of care persis

269 s purpose with over 118 000 citations in the past two decades.

270 ynthesis and characterization efforts in the past two decades.

271 (RCTs) of mindfulness interventions over the past two decades.

272 ot been subject to substantial change in the past two decades.

273 laim of a "leveling off of warming" over the past two decades.

274 inal populations declined overall during the past two decades; however, the mean trend for 18 dicot p

275 Here, we review the progress made over the past two to three decades toward delineating the structu

276 INTERPRETATION: Past use of mental health services and a diagnosis of no

277 Current or past use of MHT was associated with a modestly increased

278 akes future projections different from these past warm climates?

279 ples were attributable to vaginal sex in the past week.

280 In this review, we highlight how this past work provides valuable context for the use of this

281 Past work showed that Unc-104 (a kinesin-3) is a key ant

282 composed of >/=2 severe exacerbations in the past year (+2 points), history of near-fatal asthma (+1

283 having not had an eye examination within the past year (OR, 1.61) were risk factors for vision loss.

284 th COPD and at least one exacerbation in the past year or FEV1 less than 60% of predicted without exa

285 Individuals who tanned indoors in the past year were not significantly more likely to have und

286 were similar for men (range 0.8%-1.9% in the past year) and women (range 0.4%-2.3% in past year), exc

287 frequent indoor tanners (>/=10 times in the past year) were more likely to report never/rare use of

288 the past year) and women (range 0.4%-2.3% in past year), except in Bougainville, where they were high

289 ing subjects' alcohol consumption during the past year, based on self-reported information: any alcoh

290 (NFAs) have seen remarkable advances in the past year, finally surpassing fullerenes in performance.

291 (7.0%) reported having tanned indoors in the past year.

292 60% of predicted without exacerbation in the past year.

293 fied by their number of exacerbations in the past year: none, few (one to two), or exacerbation prone

294 Studies reporting estimates of past-year abuse prevalence in adults aged 60 years or ol

295 e the association of fluid intelligence with past-year and lifetime psychiatric disorders, disorder a

296 ing and past-year problematic alcohol use of past-year ayahuasca users and comparison drug users; and

297 (SE) IQ was observed among adolescents with past-year bipolar disorder (94.2 [1.69]; P = .004), atte

298 hrooms; demographics, current well-being and past-year problematic alcohol use of past-year ayahuasca

299 c regression analyses examined the number of past-year suicide attempts in a soldier's unit as a pred

300 Over the past years, a number of PET studies imaging the serotoni